New application of open source data and Rock Engineering System for debris flow susceptibility analysis

This research describes a quantitative,rapid,and low-cost methodology for debris flow susceptibility evaluation at the basin scale using open-access data and geodatabases.The proposed approach can aid decision makers in land management and territorial planning,by first screening for areas with a higher debris flow susceptibility.Five environmental predisposing factors,namely,bedrock lithology,fracture network,quaternary deposits,slope inclination,and hydrographic network,were selected as independent parameters and their mutual interactions were described and quantified using the Rock Engineering System(RES)methodology.For each parameter,specific indexes were proposed,aiming to provide a final synthetic and representative index of debris flow susceptibility at the basin scale.The methodology was tested in four basins located in the Upper Susa Valley(NW Italian Alps)where debris flow events are the predominant natural hazard.The proposed matrix can represent a useful standardized tool,universally applicable,since it is independent of type and characteristic of the basin.

Isolation,Identification and Susceptibility Analysis of Bacillus pyocyaners from a Canine Pyometra

In order to clarify the causes of the fester disease in companion animals,this study involved isolation,identification and drug susceptibility analysis of pathogenic bacteria from the uterus of an 11-year-old female dog who was admitted to the veterinary hospital of Tianjin Agricultural University.According to the results of colony morphology,smear staining microscopy,physiological and biochemical reaction and 16 S rRNA gene analysis,the bacteria was identified as a Bacillus pyocyaners.The susceptibility analysis showed that the isolate is highly sensitive to aztreonam,cefdinir,cefotaxime,cefepime,ceftazidime,ofloxacin,streptomycin,kanamycin,piperacillin and tobramycin.Moreover,the isolate is moderately sensitive to ceftriaxone,cefuroxime and cefoxitin,but resistant to ampicillin,cefazolin,cefazine and medemycin.The research results provide references for controlling infection caused by B.pyocyaners.

Estimation of Shallow Landslide Susceptibility Incorporating the Impacts of Vegetation on Slope Stability

This study aimed to develop a physical-based approach for predicting the spatial likelihood of shallow landslides at the regional scale in a transition zone with extreme topography.Shallow landslide susceptibility study in an area with diverse vegetation types as well as distinctive geographic factors(such as steep terrain,fractured rocks,and joints)that dominate the occurrence of shallow landslides is challenging.This article presents a novel methodology for comprehensively assessing shallow landslide susceptibility,taking into account both the positive and negative impacts of plants.This includes considering the positive efects of vegetation canopy interception and plant root reinforcement,as well as the negative efects of plant gravity loading and preferential fow of root systems.This approach was applied to simulate the regional-scale shallow landslide susceptibility in the Dadu River Basin,a transition zone with rapidly changing terrain,uplifting from the Sichuan Plain to the Qinghai–Tibet Plateau.The research fndings suggest that:(1)The proposed methodology is efective and capable of assessing shallow landslide susceptibility in the study area;(2)the proposed model performs better than the traditional pseudo-static analysis method(TPSA)model,with 9.93%higher accuracy and 5.59%higher area under the curve;and(3)when the ratio of vegetation weight loads to unstable soil mass weight is high,an increase in vegetation biomass tends to be advantageous for slope stability.The study also mapped the spatial distribution of shallow landslide susceptibility in the study area,which can be used in disaster prevention,mitigation,and risk management.

New insight into genes in association with asthma： literature-based mining and network centrality analysis

Background Asthma is a heterogeneous disease for which a strong genetic basis has been firmly established. Until now no studies have been undertaken to systemically explore the network of asthma-related genes using an internally developed literature-based discovery approach. This study was to explore asthma-related genes by using literature- based mining and network centrality analysis. Methods Literature involving asthma-related genes were searched in PubMed from 2001 to 2011. Integration of natural language processing with network centrality analysis was used to identify asthma susceptibility genes and their interaction network. Asthma susceptibility genes were classified into three functional groups by gene ontology （GO） analysis and the key genes were confirmed by establishing asthma-related networks and pathways. Results Three hundred and twenty-six genes related with asthma such as IGHE （IgE）, interleukin （IL）-4, 5, 6, 10, 13, 17A, and tumor necrosis factor （TNF）-alpha were identified. GO analysis indicated some biological processes （developmental processes, signal transduction, death, etc.）, cellular components （non-structural extracellular, plasma membrane and extracellular matrix）, and molecular functions （signal transduction activity） that were involved in asthma. Furthermore, 22 asthma-related pathways such as the Toll-like receptor signaling pathway, hematopoietic cell lineage, JAK-STAT signaling pathway, chemokine signaling pathway, and cytokine-cytokine receptor interaction, and 17 hub genes, such as JAK3, CCR1-3, CCR5-7, CCR8, were found. Conclusions Our study provides a remarkably detailed and comprehensive picture of asthma susceptibility genes and their interacting network. Further identification of these genes and molecular pathways may play a prominent role in establishing rational therapeutic approaches for asthma.

An Overview of Genome-Wide Association Studies in Alzheimer＇s Disease

Genome-wide association studies（GWASs）have revealed a plethora of putative susceptibility genes for Alzheimer＇s disease（AD）. With the sole exception of the APOE gene, these AD susceptibility genes have not been unequivocally validated in independent studies. No single novel functional risk genetic variant has been identified. In this review, we evaluate recent GWASs of AD, and discuss their significance, limitations, and challenges in the investigation of the genetic spectrum of AD.