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Preparation and Pharmacokinetic Characterization of Sustained Release Melatonin Tablet 被引量:1
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作者 何仲贵 张天虹 +1 位作者 唐星 张汝华 《Journal of Chinese Pharmaceutical Sciences》 CAS 2003年第2期82-86,共5页
Aim To prepare the sustained release melatonin tablet with HPMC matrix and study its pharmacokinetics and bioavailatility. Methods HPMC was used as matrix to formulate the sustained release tablet. The influences of t... Aim To prepare the sustained release melatonin tablet with HPMC matrix and study its pharmacokinetics and bioavailatility. Methods HPMC was used as matrix to formulate the sustained release tablet. The influences of the size of melatonin, type and amount of HPMC, drug loading, type and amount of additives, and compressing pressure were investigated. Plasma concentration of melatonin in dogs after intravenous injection of two doses and oral administration of sustained release tablets and unmodified release capsules was detected by HPLC using fluorescence detector. Results The drug release from sustained release tablets was influenced by the size of melatonin, type and amount of HPMC, drug loading, and type and amount of additives. Melatonin was found to fit two compartment model after intravenous injection, AUC was proportional to doses, and t(1/2β) of two doses has no significant difference. Relative bioavailability of melatonin sustained release tablet to normal capsule was 83.8%, and absolute bioavailability was 3.75% for sustained release tablet and 4.49% for capsule. Conclusion The melatonin sustained release tablet was well formulated. The absolute bioavilability for oral administration of either sustained release tablet or unmodified release capsule of melatonin was less than 5%. The bioavailability of melatonin sustained release tablet was lower than that of unmodified release capsule, but MRT of sustained release tablet was significantly longer than that of capsule. 展开更多
关键词 MELATONIN HPMC sustained release tablet BIOAVAILABILITY pharmacokinetics
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Study of Sustained Release Phenylpropanolamine Hydrochloride Hydrophilic Matrix Tablets Containing Hydroxypropylmethylcellulose K100M and Carbopol 971P 被引量:1
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作者 吕丹 裴元英 《Journal of Chinese Pharmaceutical Sciences》 CAS 2000年第4期185-190,共6页
选用HPMC K100M和卡波普971P为骨架材料,粉末直接压片法制备骨架片,考察释放度,反相高效液相色谱法检测盐酸苯丙醇胺(PPA·HCl)的浓度。释药曲线均符合Higuchi方程(R>0.98,P<0.01)。运用正交设计法,以美国市场的PPA&#... 选用HPMC K100M和卡波普971P为骨架材料,粉末直接压片法制备骨架片,考察释放度,反相高效液相色谱法检测盐酸苯丙醇胺(PPA·HCl)的浓度。释药曲线均符合Higuchi方程(R>0.98,P<0.01)。运用正交设计法,以美国市场的PPA·HCl缓释片Acutrim^R为对照,相似因子f2值为指标,筛选获得了最优处方。其工艺重现性合格。研制片在0.1mol·L^-1 HCl,H2O(pH6.5),磷酸盐缓冲液(PBS)pH5.0,6.8和7.4的介质中,以及在0.1mol·L^-1HCl中释放2h,转移至PBS6.8中释放10h,相对于对照品的f2值为63-74,表明在各介质中两制剂的释药曲线相似。释药影响因素的考察结果表明:在本实验考察的范围内,骨架片在水中的释药速率与HPMC K100M和卡波普971P的用量呈负相关。HPMC K100M和卡波普971P的比例(保持聚合物总用量相同),硬脂酸镁量和骨架片硬度对释药速率无显著性影响。 展开更多
关键词 Hydroxypropylmethylcellulose(HPMC K100M) Carbopol 971P Phenylpropanolamine Hydrochloride Hydrophilic sustained release matrix tablets Similarity factor
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Pharmacokinetics of Moclobemide Sustained Release Tablets after Multiple Oral Dose Administration in Healthy Volunteers
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作者 胡道德 毛丹卓 裴元英 《Journal of Chinese Pharmaceutical Sciences》 CAS 2004年第4期249-253,共5页
To investigate the pharmacokinetic characteristics of moclobemide sustainedrelease tablets after multiple oral dose administration in healthy Chinese volunteers. MethodsMoclobemide sustained release tablets were given... To investigate the pharmacokinetic characteristics of moclobemide sustainedrelease tablets after multiple oral dose administration in healthy Chinese volunteers. MethodsMoclobemide sustained release tablets were given as a multiple oral dose regimen of 300 mg oncedaily for five consecutive days to 12 healthy volunteers. The concentrations of moclobemide inplasma were determined by reversed-phase high performance liquid chromatography. The partialpharmacokinetic parameters were calculated using 3p97 pharmacokinetic program. Results Theconcentration-time profile fitted an one-compartment model best. The steady-state pharmacokineticparameters of moclobemide sustained release tablets after multiple oral doses were as follows:C_(max) was (1 950 +- 156) μg· L^(-1), T_(max) was (6.00 +-1.55) h, T_(1/2(kel)) was (3.14 +-0.12)h, AUC_(ss 0-24) was (22 836 +- 1 842) μg·h· L^(-1), MRT was (7.68+-0.36) h, CL/F_((s)) was(20.2+-2.1) L·h^(-1), and V/F_((c)) was (91.4+-9.4) L, respectively. No marked adverse events werenoted during this study. Conclusion The formulation has a sustained-release effect and goodtolerance in the healthy volunteers, which provides useful information for clinical practice. 展开更多
关键词 moclobemide sustained release tablets high performance liquidchromatography phar- macokinetics multiple dose
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Efficacy of Metoprolol Succinate Sustained Release Tablets Combined with Wenxin Granules in the Treatment of Coronary Heart Disease Arrhythmia 被引量:1
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作者 Guangqing Zhao Liling Yao 《Journal of Clinical and Nursing Research》 2021年第2期42-45,共4页
Objective:To explore the effect of metoprolol succinate sustained-release tablets combined with Wenxin Granules in the treatment of coronary heart disease patients with arrhythmia.Methods:The research objects were 50 ... Objective:To explore the effect of metoprolol succinate sustained-release tablets combined with Wenxin Granules in the treatment of coronary heart disease patients with arrhythmia.Methods:The research objects were 50 patients with arrhythmia who were treated in our hospital from September 2019 to September 2020.According to different treatment methods,they were divided into observation group(Wenxin Granule+metoprolol succinate treatment)and control group(metoprolol succinate treatment),25 cases in each group.The curative effects of the two groups were compared.Results:After treatment,there was no significant difference in rnn50,RMSSD,sdnni and SDANN between the two groups(P>0.05).Compared with the control group,the SDNN in the observation group was higher than that in the control group(P<0.05);Before treatment,there was no significant difference in the above indexes between the two groups(P>0.05);The effective rates of the observation group and the control group were 92.00%and 68.00%respectively,and the curative effect of the observation group was higher than that of the control group(P<0.05);There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:In the treatment of patients with coronary heart disease and arrhythmia,Wenxin Granule Combined with metoprolol succinate sustained-release tablets has significant effect,which can effectively improve the dynamic electrocardiogram indexes of patients,improve the clinical efficacy,and has high safety. 展开更多
关键词 ARRHYTHMIA Coronary heart disease Wenxin Granule Metoprolol succinate sustained release tablets
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HPLC Method for the Determination of Tamsulosin Hydrochloride in Sustained Release Tablets
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作者 齐美玲 王鹏 +1 位作者 耿颖姝 顾峻岭 《Journal of Beijing Institute of Technology》 EI CAS 2003年第2期194-197,共4页
The development and validation of an isocratic high performance liquid chromatographic method is described for the determination of tamsulosin hydrochloride in sustained release tablets. The determination was performe... The development and validation of an isocratic high performance liquid chromatographic method is described for the determination of tamsulosin hydrochloride in sustained release tablets. The determination was performed on a Diamonsil BDS C18 column with a mobile phase consisting of a mixture of acetonitrile, methanol and 0 5% phosphoric acid solution (20∶30∶50, V/V/V ) at a flow rate of 1 0 mL/min. UV detection was made at 274 nm. The linear range for tamsulosin hydrochloride was 0 81-8 10 μg/mL. The mean recovery was 99 8% ( S R=0 7%, n =9), and the precision was found to be 0 45% ( n =9). The proposed method can be used for routine analysis of tamsulosin hydrochloride in sustained release tablets. 展开更多
关键词 HPLC tamsulosin hydrochloride sustained release tablets
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Clinical Study on Sustained Release Tablat ot TripterygiumWilfordii in Treating Rheumatoid Arthritis
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作者 李瑞琳 刘沛霖 +2 位作者 吴旭初 魏建军 夏利华 《Chinese Journal of Integrative Medicine》 SCIE CAS 1996年第2期111-114,共4页
Adopting prospective, multi-center, random, single-blind and equal rank-control methods,226 patients with rlieumatoid arthritis (RA) were divided into two groups. The 114 patients ot the test groupwere treated with or... Adopting prospective, multi-center, random, single-blind and equal rank-control methods,226 patients with rlieumatoid arthritis (RA) were divided into two groups. The 114 patients ot the test groupwere treated with oral sustained release tablets of Tripterygium Wiltordii (TW-SR) , 2 tablets twice a day for4 weeks, 112 patients of the control group received tablets of Tripterygium Wiltordii(TW) orally 2 tablets 3times per day for 4 weeks. Testing results showed thetotal effective rates of the two groups were 92 . 11%and 90. 65 % , respectively (P >0. 05) . The adverse reaction rate of TW-SR was 20 . 18% , which was low-er than that of TW group of 70. 54% (P < 0. 01 ) . Results of pre-clinical pharmacologic experimental studydemonstrated that TW-SR has obvious anti-inflammatory , analgesic and immunosuppressive actions the sameas TW, while the toxicity of TW-SR was less than that of TW significantly. 展开更多
关键词 rheumatoid arthritis Tripterygium Wilfordii sustained release tablet ot Tripterygium Wil-fordii
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