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Metastatic apocrine sweat gland adenocarcinoma in a terrier dog 被引量:1
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作者 Akhtardanesh Baharak Kheirandish Reza +3 位作者 Dabiri Shahriar Azari Omid Vosoogh Daruoosh Askari Nasrin 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2012年第8期670-672,共3页
This report describes the clinical and pathological aspects of an apocrine sweat gland carcinoma with distant metastasis in an aged dog.A 7-year-old male terrier dog was referred to small animal hospital of Shuhid Bah... This report describes the clinical and pathological aspects of an apocrine sweat gland carcinoma with distant metastasis in an aged dog.A 7-year-old male terrier dog was referred to small animal hospital of Shuhid Bahonar University of Kerman with a 5.5×3.5 centimeter pedunculated mass on its head near left auricular region which had been progressively growing since tliree months ago.The radiography showed no local and distant metastasis.Surgical excision and histological evaluation was done.Histologically,the mass was composed of epithelial cells arranged in glandular and solid patterns.The morphologic findings suggested either a primary or metastatic apocrine-gland carcinoma.Immunohistochemically,the tumor cells were intensely positive for cytokeratin 7 and 20 and negative for S100 protein.On the basis of histopathological and clinical findings,the tumor was diagnosed as a malignant apocrine gland tumor,arising from apocrine sweat glands of the skin.Local tumor recurrence with anorexia and weight loss was reported by the owner nine month later.Severe submandibular and prescapular lymphadenomegaly was noted in clinical examination.Several large pulmonary nodules were noted in chest radiographs resembling mediastinal lymph node metastasis.Second surgery and chemotherapy was rejected by the owner due to grave prognosis of the patient.The animal was died 45 days later due to respiratory complications.Tumors of apocrine sweat glands are relatively uncommon in dogs whereas apocrine gland adenocarcinoma with distant metastasis is extremely rare. 展开更多
关键词 APOCRINE sweat gland adenocarcinoma DOG Metastasis Tumor recurrence Diagnosis
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阴囊Paget’s病伴大汗腺癌2例及文献复习 被引量:3
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作者 蒋萍 李景和 +2 位作者 姜乃光 黄英 马洋 《国际病理科学与临床杂志》 CAS 2011年第2期107-111,共5页
目的:探讨阴囊Paget’s病伴大汗腺癌病例的临床病理学特点。方法:回顾性分析1998年至2010年哈尔滨市第一医院收治的阴囊Paget’s病伴大汗腺癌患者2例,对其进行光镜观察,免疫组织化学染色,并复习文献。结果:2例Paget’s病变均为老年男性... 目的:探讨阴囊Paget’s病伴大汗腺癌病例的临床病理学特点。方法:回顾性分析1998年至2010年哈尔滨市第一医院收治的阴囊Paget’s病伴大汗腺癌患者2例,对其进行光镜观察,免疫组织化学染色,并复习文献。结果:2例Paget’s病变均为老年男性。肉眼皮损呈湿疹样改变。光镜下表皮内可见数目不等的Paget细胞呈单个散在、巢状或条索状分布,真皮深层均见大汗腺癌组织。2例肿瘤细胞均表达CK7,GCDFP-15,EMA,CerbB-2;不表达CK20,HMB45和S100。结论:阴囊Paget’s病为阴囊皮下大汗腺癌侵犯表皮所致,阴囊Paget’s病有特殊的临床及组织学特点,免疫表型有助于探讨阴囊Paget’s病的起源。 展开更多
关键词 阴囊肿瘤 Paget’s病 免疫组织化学 大汗腺癌
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皮肤透明细胞汗腺瘤23例临床病理特征 被引量:2
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作者 吴玲玲 夏燕 +4 位作者 封扬 王雪寒 关静文 吴璇 王小双 《中国基层医药》 CAS 2022年第7期1054-1058,共5页
目的探讨皮肤透明细胞汗腺瘤的临床病理特征、免疫表型及鉴别诊断,分析透明细胞汗腺瘤的来源及发生机制。方法回顾性分析宿州市立医院2017年12月至2021年7月行手术切除的皮肤透明细胞汗腺瘤患者23例的临床资料。分析患者的临床表现、影... 目的探讨皮肤透明细胞汗腺瘤的临床病理特征、免疫表型及鉴别诊断,分析透明细胞汗腺瘤的来源及发生机制。方法回顾性分析宿州市立医院2017年12月至2021年7月行手术切除的皮肤透明细胞汗腺瘤患者23例的临床资料。分析患者的临床表现、影像学特征、病理学特点及预后。采用免疫组织化学EnVision法检测上皮膜抗原(EMA)、细胞角蛋白20(CK20)、细胞角蛋白7(CK7)、细胞角蛋白14(CK14)、癌胚抗原(CEA)、特异性大囊肿病液体蛋白-15(GCDPF-15)等表达情况;过碘酸雪夫染色(PAS)显示糖原。结果23例患者中男性9例,女性14例,年龄范围14~94岁,中位年龄55岁。18例以表皮隆起型肿块为首发症状;影像学超声显示皮下囊实性回声团块,实性部分内血流丰富。组织学肿瘤由两型细胞组成:分泌上皮或腺上皮和透明细胞。其中20例为良性透明细胞汗腺瘤特征;2例表现为非典型透明细胞汗腺瘤:细胞异型、可见核分裂象;1例为恶性透明细胞汗腺瘤。免疫表型显示肿瘤细胞:EMA、CK7、CK14、CEA、GCDPF-15阳性、PAS阳性。23例随访2~36个月,4例失访,其余未见复发。结论透明细胞汗腺瘤比较少见,预后好,恶性罕见,预后较差。确诊主要依据其病理学特征、免疫表型等综合分析,诊断时需与转移性透明细胞癌、螺旋腺瘤、皮质腺瘤、恶性黑色素瘤等肿瘤鉴别。 展开更多
关键词 腺瘤 汗腺 皮肤 腺癌 透明细胞 黏蛋白-1 角蛋白细胞 病理学 临床 诊断 鉴别 免疫组织化学
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