Metabolites from marine organisms have proven to be a rich source for the discovery of multiple potent bioactive moleculeswith diverse structures. In recent years, we initiated a program to investigate the diversity o...Metabolites from marine organisms have proven to be a rich source for the discovery of multiple potent bioactive moleculeswith diverse structures. In recent years, we initiated a program to investigate the diversity of the secondary metabolites frommarine invertebrates and their symbiotic microorganisms collected from the South China Sea. In this review, representativecases are summarized focusing on molecular diversity, mining, and application of natural products from these marineorganisms. To provide a comprehensive introduction to the field of marine natural products, we highlight typical moleculesincluding their structures, chemical synthesis, bioactivities and mechanisms, structure-activity relationships as well as biogenesis. The mining of marine-derived microorganisms to produce novel secondary metabolites is also discussed through theOSMAC strategy and via partial chemical epigenetic modification. A broad prospectus has revealed a plethora of bioactivenatural products with novel structures from marine organisms, especially from soft corals, gorgonians, sponges, and theirsymbiotic fungi and bacteria.展开更多
The application of overgrowth microorganisms in ocean research was discussed,using the China National Knowledge Infrastructure(CNKI)network database to retrieve papers on the topic of symbiotic microbes(=198)and symbi...The application of overgrowth microorganisms in ocean research was discussed,using the China National Knowledge Infrastructure(CNKI)network database to retrieve papers on the topic of symbiotic microbes(=198)and symbiotic marine microorganisms(n=94).Bibliometric Analysis are conducted in terms of the published trends,subject headings and other aspects.The output of literature in this field has increased rapidly in the past15years.57.4%of the papers were published in the last five years.And the relevance of research topics has increased in recent years.The current research focuses on community diversity,secondary metabolites,biological activities and antibacterial activities.Literature analysis is helpful to understand the overall development trend of overgrowth microorganisms in ocean research.展开更多
Four new chlorinated carbazole alkaloids,chlocarbazomycins(CCBs)A-D,were isolated from sponge associated bacterium Streptomyces diacarni LHW51701.Their structures were elucidated via spectroscopic techniques(including...Four new chlorinated carbazole alkaloids,chlocarbazomycins(CCBs)A-D,were isolated from sponge associated bacterium Streptomyces diacarni LHW51701.Their structures were elucidated via spectroscopic techniques(including HRESIMS,ID&2D NMR),and X-ray crystallographic analysis.Structurally,the 4-chloro coupled with 3-methoxyl substituents in the tricycle nucleus of CCBs A-D and the A/-methoxyl group of CCB-D are rare in naturally occurred tricyclic carbazole alkaloids.Moreover,CCBs A-D do not bear the typical Cl poro-alkyl and C2 meto-methyl side chains of bacterial tricycle carbazoles,suggesting a novel mechanism of aromatic ring formation in biosynthesis.The biological evaluation showed that CCB-C possessed inhibitory activities against pathogenic microorganisms including methicillin-resistant Staphylococcus aureus(MRSA),Mycobacterium smegmatis,Bacillus mycoides,and Candida albicans.展开更多
基金supported by the National NaturalScience Foundation of China (nos. 4183053581673350+2 种基金U1706210)the Fundamental Research Funds for the Central Universities of China(no. 201962002)the Taishan Scholars Program, China.
文摘Metabolites from marine organisms have proven to be a rich source for the discovery of multiple potent bioactive moleculeswith diverse structures. In recent years, we initiated a program to investigate the diversity of the secondary metabolites frommarine invertebrates and their symbiotic microorganisms collected from the South China Sea. In this review, representativecases are summarized focusing on molecular diversity, mining, and application of natural products from these marineorganisms. To provide a comprehensive introduction to the field of marine natural products, we highlight typical moleculesincluding their structures, chemical synthesis, bioactivities and mechanisms, structure-activity relationships as well as biogenesis. The mining of marine-derived microorganisms to produce novel secondary metabolites is also discussed through theOSMAC strategy and via partial chemical epigenetic modification. A broad prospectus has revealed a plethora of bioactivenatural products with novel structures from marine organisms, especially from soft corals, gorgonians, sponges, and theirsymbiotic fungi and bacteria.
文摘The application of overgrowth microorganisms in ocean research was discussed,using the China National Knowledge Infrastructure(CNKI)network database to retrieve papers on the topic of symbiotic microbes(=198)and symbiotic marine microorganisms(n=94).Bibliometric Analysis are conducted in terms of the published trends,subject headings and other aspects.The output of literature in this field has increased rapidly in the past15years.57.4%of the papers were published in the last five years.And the relevance of research topics has increased in recent years.The current research focuses on community diversity,secondary metabolites,biological activities and antibacterial activities.Literature analysis is helpful to understand the overall development trend of overgrowth microorganisms in ocean research.
基金the National Key R&D Program of China(No.2019YFC0312501)the National Natural Science Foundation of China(No.31929001)+2 种基金the Special Project for Marine Economic Development(Six Major Marine Industries)of Guangdong Province Department of Natural Resources of Guangdong Province(No.[2020]039)the Construction Project of Shanghai Key Laboratory of Molecular Imaging(No.18DZ2260400)the Innovative Research Team of High-Level Local Universities in Shanghai,and the Taishan Scholar Project from Shandong Province to H.L.The authors are grateful to Ying Wu for QTOF mass analysis,Hong-Yan Liu for NMR analysis,and Prof.Meifeng Tao from School of Life Sciences and Biotechnology,Shanghai Jiao Tong University for kindly providing the indicator strains for bioactivity assay.
文摘Four new chlorinated carbazole alkaloids,chlocarbazomycins(CCBs)A-D,were isolated from sponge associated bacterium Streptomyces diacarni LHW51701.Their structures were elucidated via spectroscopic techniques(including HRESIMS,ID&2D NMR),and X-ray crystallographic analysis.Structurally,the 4-chloro coupled with 3-methoxyl substituents in the tricycle nucleus of CCBs A-D and the A/-methoxyl group of CCB-D are rare in naturally occurred tricyclic carbazole alkaloids.Moreover,CCBs A-D do not bear the typical Cl poro-alkyl and C2 meto-methyl side chains of bacterial tricycle carbazoles,suggesting a novel mechanism of aromatic ring formation in biosynthesis.The biological evaluation showed that CCB-C possessed inhibitory activities against pathogenic microorganisms including methicillin-resistant Staphylococcus aureus(MRSA),Mycobacterium smegmatis,Bacillus mycoides,and Candida albicans.