The norepinephrine transporter gene is associated with the retardation symptoms of major depressive disorder in the Han Chinese population

The norepinephrine transporter plays an important role in the pathophysiology and pharmacological treatment of major depressive disorder. Consequently, the norepinephrine transporter gene is an attractive candidate in major depressive disorder research. In the present study, we evaluated the depression symptoms of subjects with major depressive disorder, who were all from the North of China and of Hart Chinese origin, using the Hamilton Depression Scale. We examined the relationship between two single nucleotide polymorphisms in the norepinephrine transporter, rs2242446 and rs5569, and the retardation symptoms of major depressive disorder using quantitative trait testing with the UNPHASED program, rs5569 was associated with depressed mood, and the GG genotype may be a risk factor for this; rs2242446 was associated with work and interest, and the TT genotype may be a risk factor for loss of interest. Our findings suggest that rs2242446 and rs5569 in the norepinephrine transporter gene are associated with the retardation symptoms of depression in the Hart Chinese population.

Leukoaraiosis is associated with clinical symptom severity,poor neurological function prognosis and stroke recurrence in mild intracerebral hemorrhage:a prospective multi-center cohort study

Leukoaraiosis(LA)results from ischemic injury in small cerebral vessels,which may be attributable to decreased vascular density,reduced cerebrovascular angiogenesis,decreased cerebral blood flow,or microcirculatory dysfunction in the brain.In this study,we enrolled 357 patients with mild intracerebral hemorrhage(ICH)from five hospitals in China and analyzed the relationships between LA and clinical symptom severity at admission,neurological function prognosis at 3 months,and 1-year stroke recurrence.Patients were divided into groups based on Fazekas scale scores:no LA(n=83),mild LA(n=64),moderate LA(n=98)and severe LA(n=112).More severe LA,larger hematoma volume,and higher blood glucose level at admission were associated with more severe neurological deficit.More severe LA,older age and larger hematoma volume were associated with worse neurological function prognosis at 3 months.In addition,moderate-to-severe LA,admission glucose and symptom-free cerebral infarction were associated with 1-year stroke recurrence.These findings suggest that LA severity may be a potential marker of individual ICH vulnerability,which can be characterized by poor tolerance to intracerebral attack or poor recovery ability after ICH.Evaluating LA severity in patients with mild ICH may help neurologists to optimize treatment protocols.This study was approved by the Ethics Committee of Ruijin Hospital Affiliated to Shanghai Jiao Tong University(approval No.12)on March 10,2011.

Association between gastrointestinal symptoms and affectivity in patients with bipolar disorder

AIM To study if anxiety, depression and experience of stress are associated with gastrointestinal(GI) symptoms in patients with bipolar disorder.METHODS A total of 136 patients with bipolar disorder(mean age 49.9 years; 61% women) and 136 controls from the general population(mean age 51.0 years; 60% women) were included in the study. GI symptoms were assessed with The Gastrointestinal Symptom Rating Scale-irritable bowel syndrome(GSRS-IBS), level of anxiety and depression with The Hospital Anxiety and Depression Scale(HADS) and stress-proneness with Perceived Stress Questionnaire. Over a ten year period, all visits in primary care were retrospectively recorded in order to identify functional GI disorders.RESULTS In subjects with low total HADS-score, there were no significant differences in GI-symptoms between patients and controls(GSRS-IBS 7.0 vs 6.5, P = 0.513). In the patients with bipolar disorder there were significant correlations between all GSRS and HADS subscores for all symptom clusters except for "constipation" and "reflux". Factors associated to GI symptoms in the patient group were female sex(adjusted OR = 2.37, 95%CI: 1.07-5.24) and high HADS-Depression score(adjusted OR = 3.64, 95%CI: 1.07-12.4). These patients had also significantly more visits for IBS than patients with low HADS-Depression scores(29% vs 8%, P = 0.008). However, there was no significant differences in consulting behaviour for functional GI disorders between patients and controls(25% vs 17%, P = 0.108).CONCLUSION Female patients and patients with high HADS depression score reported significantly more GI symptoms, whereas patients with low HADS scores did not differ from control subjects.

Japanese apricot improves symptoms of gastrointestinal dysmotility associated with gastroesophageal reflux disease

AIM: To investigate the effects of Japanese apricot(JA) consumption on gastroesophageal reflux disease(GERD)-related symptoms.METHODS: Participants included individuals living in Minabe-cho,a well-known JA-growing region,who received specific medical check-ups by the local community health service in 2010.GERD-related symptoms were examined in 1303 Japanese individuals using a validated questionnaire,the Frequency Scale for Symptoms of GERD(FSSG),which consists of 7 questions associated with acid reflux symptoms and 5 questions asking about gastrointestinal dysmotility symptoms.Each question was answered using a 4-point scale,with higher scores indicating more severe GERDrelated symptoms.Subjects were divided into two groups according to their intake of dried and pickled JA: daily intake(≥ 1 JA daily)(392 subjects) and none oroccasional intake(< 1 JA daily)(911 subjects).FSSG scores were compared between subjects who consumed JA daily and those who did not.Next,subjects were stratified by age,gender and Helicobacter pylori(H.pylori) status for subanalyses.RESULTS: Those who ate JA daily were significantly older than those who did not(60.6 ± 10.5 years vs 56.0 ± 11.0 years,P < 0.001).Total FSSG scores were significantly lower in subjects with daily JA intake than in those with none or only occasional intake(2.13 ± 3.14 vs 2.70 ± 3.82,P = 0.005).In particular,subjects who consumed JA daily showed significantly improved FSSG dysmotility scores compared with subjects who did not(1.05 ± 1.58 vs 1.46 ± 2.11,P < 0.001).In contrast,the FSSG reflux score did not differ between subjects with and without daily intake of JA(1.08 ± 1.90 vs 1.24 ± 2.11,P = 0.177).Subanalysis indicated that improvement in dysmotility by JA intake was specifically observed in non-elderly(1.24 ± 1.68 vs 1.62 ± 2.22,P = 0.005) and H.pylori-negative subjects(0.99 ± 1.58 vs 1.57 ± 2.06,P < 0.001).GERD patients(total FSSG score ≥ 8) were less frequently observed among subjects with daily intake of JA as compared to those without daily intake of JA(6.1% vs 9.7%,P = 0.040).CONCLUSION: Daily JA intake may improve digestive dysmotility symptoms,resulting in relief of GERD symptoms.The effect is more obvious in non-elderly and H.pylori-negative subjects.

Differences in Male Climacteric Symptoms and Lifestyle Depending on the Duration of Working among Rotating Night Shift Workers

Background: There are various health problems in rotating shift workers. There have been few studies on the associations of male climacteric symptoms with duration of working and lifestyle. Objective: The aim of this study was to determine the differences in male climacteric symptoms depending on the number of working years and to determine whether lifestyle habits differ depending on the number of working years in rotating shift workers. Methods: We collected participant’s data from the manufacturing companies in Japan during the period from March to May in 2017. We conducted a self-administered questionnaire survey in 1561 male rotating night shift workers. Male climacteric symptoms were evaluated by using the Aging Males’ Symptoms (AMS) rating scale. We analyzed 636 rotating shift workers aged over 40 years old whose all AMS data was collected. Results: A significant difference in psychological AMS score was found between men who had worked for 10 - 19 years (9.4 ± 3.9) and men who had worked for more than 40 years (7.6 ± 3.0) (p = 0.011). Sexual functional AMS score significantly differed depending on the number of working years (less than 10 years: 8.1 ± 3.9, 10 - 19 years: 9.8 ± 4.1, 20 - 29 years: 7.9 ± 3.3, 30 - 39 years: 9.3 ± 3.5, more than 40 years: 9.3 ± 3.5) (p < 0.001). The proportion of workers with a balanced meal intake was significantly lower in men who had worked for less than 10 years and the proportions of such workers were significantly higher in men who had worked for 10 - 19 years and for more than 40 years. The proportions of men who did not drink alcohol were high in men who had worked for less than 10 years and 20 - 29 years and low in men who had worked more than 30 years. Conclusion: Psychological AMS score and sexual functional AMS score are significantly different among the 5 groups according to the number of working years on rotating shift. In addition, well-balanced diet on day shift and reduction of alcohol drinking is a related-factor for long-term rotating night shift workers.

Correlation of Equol (7-Hydroxy-3-(4-Hydroxyphenyl)Chroman) in Woman Urine with the Symptoms of Menopause

Objective: In order to identify the correlation between equol excreted through human urine and the symptom of menopause. Methods: The method used is cross sectional study examined to 99 postmenopausal women fulfilling the inclusion criteria from February 2014 to July 2014. This research was taken in the Endocrinology Clinic, Department of Obstetrics and Gynecology, Hasan Sadikin Hospital and Unpad’s Pharmacokinetic Laboratory. All objects were interviewed using menopause rating scale (MRS) questionnaire. Their urine samples were analyzed using high performance liquid chromatography (HPLC). Then the results of questionnaire and HPLC test were evaluated. Results: The result is 97 objects (98%) detected having menopausal symptoms, produced equol. There is significant correlation between the level of equol in post-menopausal women that showed correlation (-0.71) which mean the higher the equol level, the lower the MRS score (p < 0.001) that mean the symptom is milder. Conclusion: Equol level in menopause women urine is a good predictor to identify the level of menopause symptoms.

Identifying the factors associated with depressive symptoms among postpartum mothers in Kathmandu, Nepal

Purpose:This study aimed to identify the factors associated with depressive symptoms among postpartum mothers in Kathmandu,Nepal.Method:A hospital-based cross-sectional study that included 346 postpartum mothers at 4-14 weeks after delivery was carried out.Validated Nepalese version of Edinburgh Postnatal Depression Scale with cut-off value of≥12 was used to screen depressive symptoms and structured questionnaires were used to identify the associated factors.Possible factors associated with depressive symptoms were identified by logistic regression analysis.Result:The mean age of the mothers was 22.75(SD=4.51).The prevalence of depressive symptoms among postpartum mothers was 17.1%(95%CI=15.07-19.12).No significant association existed between postpartum depressive symptoms and socio demographic and economic characteristics.In multivariate analysis,risk factors for postpartum depressive symptoms were identified as follows:women without adequate rest during pregnancy(aOR=4.023,95%CI=1.294-12.501),abortion history(aOR=3.25,95%CI=1.208-9.065),poor relationship with husband(aOR=1.67,95%CI=1.073-8.384),marital dissatisfaction(aOR=4.053,95%CI=2.281-12.819)and stressful life events(aOR=3.89,95%CI=1.504-9.810).Conclusions:This study aids to draw attention on the incorporation of routine screening for basic support and intervention for identified risk factors in postpartum period.Policies can be formulated to encourage postpartum women to obtain adequate rest during pregnancy,support women with poor partner relationship,reduce marital dissatisfaction,help women adjust with stressful life events,and prevent and manage abortion appropriately.These policies may reduce harmful consequences of postpartum depressive symptoms for women,newborn and their family.

Research on the Intervention Effect of ArtMaking on the Anxiety Symptoms of CollegeStudents

This research was to investigate the intervention effect of art-making on the anxiety symptoms of college students. A sample of 400college students took part in this research. They were assigned to the experiment group (n = 200) and the control group (n = 200)according to Self-Rating Anxiety Scale (SAS) scores. Unlike the control group, the experiment group received a standard artmaking program under the supervision of trained instructors for a period of twelve sessions two times weekly which wascontinued for six weeks. Self-Rating Anxiety Seale (SAS) and Hamilton Anxiety Scale (HAMA) were used to assess anxietysymptoms level. Significant decreases in anxiety symptoms (p < 0.05) were found in the experiment group compared with thecontrol group. Using the art-making program to relieve anxiety, the shortest intervention period is three weeks. Art-makingcan effectively alleviate college students’ anxiety, and also can effectively improve the physical health, mental health, and socialhealth levels of college students.

不同首发年龄精神分裂症患者临床特征及影响因素

目的:探讨不同首发年龄精神分裂症患者的临床特征,以及社会人口学影响因素。方法:根据美国精神障碍诊断与统计手册第5版的精神分裂症诊断标准,选取15~70岁患者2016例,由精神科医生采用简明国际神经精神访谈、精神症状维度评定量表(CRDPSS)和阳性与阴性症状量表(PANSS)进行诊断和评估。以18岁和25岁作为精神分裂症早发、中发及晚发的分组界值。采用方差分析、多重相关分析和多重线性回归的方法进行统计分析。结果:早发型患者的PANSS量表总分(73.8±28.0)和CRDPSS量表总分(11.7±5.4)均为最高。女性、受教育程度高、汉族、首发年龄较早、起病形式较慢等特征与PANSS量表和CRDPSS量表总分及其各维度分数正关联(标化回归系数:0.04~0.47),收入水平和吸烟与PANSS量表和CRDPSS量表总分及其各维度分数负关联(标化回归系数:-0.04~-0.14)。结论:早发型精神分裂症患者的症状严重程度更高,女性、受教育水平高、早发病、慢性起病是精神分裂症患者症状严重的危险因素。

骨质疏松性骨折病人症状评估量表的构建

目的:构建骨质疏松性骨折病人症状评估量表,为骨质疏松性骨折病人的症状评估与管理提供科学依据。方法:通过文献回顾、半结构式访谈及德尔菲专家函询法,构建骨质疏松性骨折病人症状评估量表。结果:共进行了2轮专家函询,问卷的有效回收率均为100%,专家权威系数为0.91。第1轮、第2轮肯德尔和谐系数分别为0.130~0.249和0.163~0.344。构建的骨质疏松性骨折症状评估量表包括4个维度(特异性症状、一般生理症状、治疗及并发症相关症状、心理症状),共31个症状条目。结论:构建的骨质疏松性骨折病人症状评估量表具有较高的权威性和科学性,可作为骨质疏松性骨折病人症状评估工具,为个性化的症状管理提供依据。

神阙穴穴位贴敷联合推拿对脑卒中后便秘患者胃肠道功能、粪便性状和特质焦虑的影响

目的:观察神阙穴穴位贴敷联合推拿对脑卒中后便秘患者胃肠道功能、粪便性状和特质焦虑的影响。方法:选取155例脑卒中后便秘患者,按照护理方式的不同分为常规组79例和试验组76例。常规组实施神经外科常规护理,试验组在常规护理基础上给予神阙穴穴位贴敷联合推拿治疗。比较2组胃肠道功能[胃肠道症状评定量表(GSRS)评分]、粪便性状[Bristol粪便性状量表(BSFS)评分]、特质焦虑[焦虑状态特质问卷(ST-AI)评分]、生活质量[便秘患者生活质量量表(PAC-QOL)评分]以及护理满意度。结果:治疗后,2组GSRS评分均较治疗前降低(P<0.05),且试验组GSRS评分低于常规组(P<0.05);2组BSFS评分均较治疗前升高(P<0.05),且试验组BSFS评分高于常规组(P<0.05);2组S-AI、T-AI评分及总分均较治疗前下降(P<0.05),且试验组S-AI、T-AI评分及总分均低于常规组(P<0.05);2组PAC-QOL量表中躯体功能、心理社会不适、负面情绪、满意度评分均较治疗前降低(P<0.05),且试验组PAC-QOL量表各项评分均低于常规组(P<0.05)。治疗后,试验组护理满意度为93.42%,常规组为82.28%,2组比较,差异有统计学意义(P<0.05)。结论:神阙穴穴位贴敷联合推拿可以改善脑卒中后便秘患者胃肠道功能、粪便性状和特质焦虑,提高患者生活质量及护理满意度。

家庭参与式护理在肝癌经导管动脉栓塞化疗患者中的应用效果

目的:观察家庭参与式护理肝癌经导管动脉栓塞化疗患者中的应用效果。方法:选取2021年3月至2022年3月该院收治的72例肝癌经导管动脉栓塞化疗患者进行前瞻性研究,按照随机数字表法将其分为观察组与对照组各36例。对照组采用常规护理,观察组在对照组基础上采用家庭参与式护理,比较两组营养指标(转铁蛋白、白蛋白)水平、T细胞亚群指标(CD4^(+)、CD4^(+)/CD8^(+))水平、Connor-Davidson心理弹性量表(CD-RISC)评分、汉密尔顿抑郁量表(HAMD)评分和胃肠道不适症状发生率。结果:护理后,两组转铁蛋白、白蛋白等营养指标水平和CD4^(+)、CD4^(+)/CD8^(+)等T细胞亚群指标水平,以及CD-RISC评分高于护理前,且观察组高于对照组,两组HAMD评分低于护理前,且观察组低于对照组,差异均有统计学意义(P<0.05);观察组胃肠道不适症状发生率为2.78%,明显低于对照组的22.22%,差异有统计学意义(P<0.05)。结论:在常规护理基础上采用家庭参与式护理可提高肝癌经导管动脉栓塞化疗患者营养指标水平、T细胞亚群指标水平和CD-RISC评分,以及降其HAMD评分和胃肠道不适症状发生率,效果优于单纯常规护理。

精神分裂症临床特征及影响因素

目的:探讨精神分裂症临床特征及其相关影响因素。方法:采用方便取样的方式招募铜陵市某二级甲等精神专科医院的精神分裂症患者630例,采用简明国际神经精神访谈(MINI)、精神症状维度评定量表(CRDPSS)和阳性与阴性症状量表(PANSS)进行诊断和评估,采用SAS 9.4进行方差分析、Pearson相关分析和多重线性回归等对数据进行统计分析。结果:不同病程特征的精神分裂症患者的CRDPSS(F=22.46,P<0.01)和PANSS(F=7.99,P<0.01)得分差异有统计学意义,其中持续恶化型患者的CRDPSS总分[(11.88±4.16)分]和PANSS总分[(75.63±23.95)分]均为最高。年龄、性别、受教育水平、家庭人口数、腰臀比、婚姻状况、工作状态、吸烟量、首次诊断年龄、首次治疗年龄、总发作次数、总住院次数、停药次数、起病形式和病程特征等因素与CRDPSS量表和PANSS量表总分及各维度得分有不同程度的关联。结论:持续恶化型精神分裂症患者的临床症状严重程度更高,腰臀比、平均每天吸烟量、停药次数、总住院次数、慢性起病是精神分裂症患者症状严重的危险因素。

脑卒中症状群评估量表的编制及信效度检验

目的编制脑卒中患者症状群评估量表,进行信效度检验,为精准护理提供评估工具。方法以症状管理理论为框架,通过文献回顾、德尔菲法、预调查形成量表初稿后,选取353例脑卒中患者进行调查,采用项目分析、探索性因子分析、信度分析筛选条目、检验信效度。结果编制的脑卒中症状群评估量表包括躯体活动、认知言语、感知觉、吞咽、消化排泄、情绪心理6个症状群共35个条目,累积方差贡献率为69.095%。量表总Cronbach’sα系数为0.905,折半信度为0.728。量表水平的内容效度指数为0.886,条目水平的内容效度指数为0.920~1.000。结论脑卒中患者症状群评估量表具有良好的信效度,可用于脑卒中患者症状群的评估。

癌症患者自我报告的症状负担及影响因素分析

目的:评估住院癌症患者的症状负担,探析癌症患者的症状负担现状及其影响因素。方法:通过方便抽样方法确定样本量,采用埃德蒙顿症状评估量表(edmonton symptom assessment scale,ESAS),于2022年10月至2023年5月对甘肃省人民医院放疗中心的343例癌症住院患者进行横断面描述性调查。结果:最终纳入统计的343例癌症患者中,60.1%(206/343)的患者身体症状负担报告为中重度,21.6%(74/343)的患者心理症状负担报告为中重度;个体症状中,最普遍的中重度症状是乏力(47.2%,162/343),最少报告的症状是呼吸困难(16.0%,55/343);多变量回归分析显示,女性更有可能出现中重度身体症状(P=0.048),呼吸系统肿瘤患者更容易出现中重度疼痛(P=0.021);中晚期肿瘤、放射治疗与中重度症状评分相关(P<0.05)。结论:目前癌症患者的症状负担较重,且身体症状较心理症状更明显,而患者年龄、家庭月收入、居住地与症状强度无关。

监测血清泌乳素对男性精神分裂症使用利培酮的价值

目的:探讨监测血清泌乳素对男性精神分裂症使用利培酮的价值。方法:收集2023年4月—2023年10月江西省吉安市第三人民医院收治的男性精神分裂症患者60例,采用随机数字表法分成两组各30例。利培酮组接受利培酮片治疗,阿立哌唑组接受阿立哌唑片治疗,共治疗8周。比较两组患者治疗前后血清泌乳素(PRL)、阳性和阴性症状量表(PANSS)评分以及治疗后副反应量表(TESS)评分的差异。结果:利培酮组治疗后第4周末、第8周末血清PRL值均高于治疗前(P<0.05);阿立哌唑组治疗前后血清PRL值未见明显改变(P>0.05)。治疗第4周末、第8周末时,两组PANSS阳性量表、阴性量表、一般精神病理问题及总评分均低于同组治疗前(P<0.05),但两组间差异无统计学意义(P>0.05)。治疗第4周末、第8周末时,利培酮组TESS评分高于阿立哌唑组(P<0.05)。结论:使用利培酮治疗男性精神分裂症会因服药时间增加而导致血清PRL出现明显变化和副反应,临床用药时需谨慎,基层医院也可以通过PRL水平来监测患者服用利培酮的依从性及用药剂量。

血管性认知障碍肾阳虚证症状辨识量表信效度检验

目的评价肾阳虚证症状辨识量表的可行性、信度及效度。方法使用前期制定的肾阳虚证症状辨识量表,于2020年9月-2022年9月对200例血管性认知障碍患者进行量表调查,通过回收率、完成率和完成时间分析量表可行性;通过重测信度、分半信度、同质性信度分析量表信度;通过区分效度、结构效度分析量表效度。结果共发出量表200份,均全部配合并在20 min内完成及回收。信度分析结果显示,重测信度中量表阳虚维度为0.828,肾气虚维度为0.718;分半信度中斯皮尔曼相关系数为0.784;同质性信度中阳虚维度克朗巴赫系数为0.799,肾气虚维度克朗巴赫系数为0.670。效度分析结果显示,区分效度中肾阳虚证组与非肾阳虚证组阳虚维度、肾气虚维度得分和量表总得分差异有统计学意义(P<0.001);结构效度中KMO值为0.842,共提取到2个特征值均大于1的因子,累积方差百分比为58.227%。结论本研究中肾阳虚证症状辨识量表具有一定信效度,可较好地预测血管性认知障碍肾阳虚证,但效度相对较低,需要进一步修订后应用于临床。

奥氮平联合阿戈美拉汀对精神分裂症伴抑郁症状患者PANSS评分及抑郁水平的影响

目的:探讨奥氮平联合阿戈美拉汀对精神分裂症伴抑郁症状患者阳性和阴性症状量表(PANSS)评分及抑郁水平的影响。方法:选取2021年9月—2022年6月赣州市第三人民医院收治的精神分裂症伴抑郁症状患者82例,以抽签法分为对照组(41例)、研究组(41例);对照组予奥氮平联合度洛西汀治疗,研究组予奥氮平联合阿戈美拉汀治疗;对比两组PANSS评分、抑郁水平、睡眠状况、认知状况及不良反应。结果:治疗3个月,研究组PANSS、汉密尔顿抑郁量表(HAMD)、匹兹堡睡眠质量指数量表(PSQI)评分均较对照组低,蒙特利尔认知评估量表(MoCA)评分较对照组高,差异均有统计学意义(P<0.05);两组间不良反应发生率对比,差异无统计学意义(P>0.05)。结论:奥氮平联合阿戈美拉汀治疗精神分裂症伴抑郁症状患者可降低PANSS评分,减轻抑郁水平,改善睡眠与认知状况,且不良反应少,安全性佳。

压力感知在中医体质与心理健康状态间的中介效应分析

目的探讨压力感知在中医体质与心理健康状态间的中介效应。方法以5889名体检人员作为研究对象,并收集中医体质量表、症状自评量表(Self-rating Scale,SCL-90)、压力自评量表(stress self-rating Scale,SSQ-53)。采用Pearson相关分析和中介效应检验分析压力在中医体质与心理健康状态间的中介效应。结果平和质与压力感知总分、心理健康状态总分均呈负相关;偏颇体质与压力感知总分、心理健康状态总分均呈正相关。压力感知在湿热质、阴虚质、特禀质与心理健康状态间起完全中介作用;在平和质、阳虚质、气虚质、瘀血质、气郁质、痰湿质与心理健康状态间起部分中介作用,中介效应占总效应的比例分别为89.3%、88.2%、81.7%、79.1%、77.0%。结论压力感知在中医体质与心理健康状态间起部分或完全的中介作用,偏颇体质能直接或间接增加人们发生心理健康问题的风险。

团体绘画治疗在恢复期精神分裂症住院患者中的应用

目的探讨团体绘画治疗对恢复期精神分裂症住院患者阴性和阳性症状、社会功能和认知功能的影响,为患者提供非药物治疗方法。方法将2022年1月至9月45例本院住院恢复期精神分裂症患者设为对照组,并予以常规药物及康复训练;2022年10月至2023年6月45例恢复期精神分裂症住院患者设为观察组,在对照组基础上团体绘画治疗干预。干预时间8w。干预前后分别采用阳性与阴性症状量表(positive and negative syndrome scale,PANSS)、住院精神患者社会功能量表(scale of social function in psychosis inpatients,SSPI)、重复性成套神经心理状态测验(repeatable battery for the assessment of neuropsychological status,RBANS)比较两组患者阳性与阴性症状、社会功能和认知功能。结果两组各45例患者完成研究。观察组患者阳性阴性症状量表评分干预前后差值高于对照组;观察组患者SSPI评分干预前后差值高于对照组;观察组RBANS评分干预前后差值高于对照组,差异具有统计学意义(均P<0.001)。结论团体绘画治疗可改善患者临床症状,提高患者认知功能,促进社会功能恢复。