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Clinical Observation of the Therapeutic Effects of Wenzhong Hewei Formula in Treating Spleen and Stomach Qi Deficiency Syndrome in Internal Medicine Diseases
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作者 Silin Song 《Journal of Clinical and Nursing Research》 2024年第10期195-201,共7页
Objective:To observe the clinical efficacy and safety of Wenzhong Hewei Formula in treating spleen and stomach qi deficiency syndrome in internal medicine diseases.Methods:Sixty patients with spleen and stomach qi def... Objective:To observe the clinical efficacy and safety of Wenzhong Hewei Formula in treating spleen and stomach qi deficiency syndrome in internal medicine diseases.Methods:Sixty patients with spleen and stomach qi deficiency syndrome admitted to the hospital from April 2022 to June 2023 were randomly divided into observation and control groups,with 30 patients in each group.The control group received conventional internal medicine treatment,while the observation group was additionally treated with Wenzhong Hewei Formula on the basis of conventional treatment.Both groups were treated for 4 weeks.Results:The total effective rate of treatment in the observation group was higher than that of the control group(P<0.05).After treatment,the traditional Chinese medicine syndrome scores of both groups were significantly lower than before treatment,with the observation group showing a more pronounced reduction(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Wenzhong Hewei Formula can effectively improve clinical symptoms in patients with spleen and stomach qi deficiency syndrome,enhance clinical efficacy,and have a high level of safety,making it worthy of clinical promotion. 展开更多
关键词 Wenzhong Hewei formula Internal medicine diseases spleen and stomach qi deficiency syndrome
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Network pharmacology-based exploration of molecular mechanisms underlying therapeutic effects of Jianpi Huatan Quyu recipe on chronic heart failure with spleen Qi deficiency syndrome
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作者 Si-Qi Li Dong-Yu Min +7 位作者 Jun-Wen Jiang Xiao-Ying Li Xu-Na Yang Wen-Bo Gu Jia-Hui Jiang Li-Hao Chen Han Nan Ze-Yu Chen 《World Journal of Cardiology》 2024年第7期422-435,共14页
BACKGROUND Chronic heart failure is a complex clinical syndrome.The Chinese herbal compound preparation Jianpi Huatan Quyu recipe has been used to treat chronic heart failure;however,the underlying molecular mechanism... BACKGROUND Chronic heart failure is a complex clinical syndrome.The Chinese herbal compound preparation Jianpi Huatan Quyu recipe has been used to treat chronic heart failure;however,the underlying molecular mechanism is still not clear.AIM To identify the effective active ingredients of Jianpi Huatan Quyu recipe and explore its molecular mechanism in the treatment of chronic heart failure.METHODS The effective active ingredients of eight herbs composing Jianpi Huatan Quyu recipe were identified using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform.The target genes of chronic heart failure were searched in the Genecards database.The target proteins of active ingredients were mapped to chronic heart failure target genes to obtain the common drugdisease targets,which were then used to construct a key chemical componenttarget network using Cytoscape 3.7.2 software.The protein-protein interaction network was constructed using the String database.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed through the Metascape database.Finally,our previously published relevant articles were searched to verify the results obtained via network pharmacology.RESULTS A total of 227 effective active ingredients for Jianpi Huatan Quyu recipe were identified,of which quercetin,kaempferol,7-methoxy-2-methyl isoflavone,formononetin,and isorhamnetin may be key active ingredients and involved in the therapeutic effects of TCM by acting on STAT3,MAPK3,AKT1,JUN,MAPK1,TP53,TNF,HSP90AA1,p65,MAPK8,MAPK14,IL6,EGFR,EDN1,FOS,and other proteins.The pathways identified by KEGG enrichment analysis include pathways in cancer,IL-17 signaling pathway,PI3K-Akt signaling pathway,HIF-1 signaling pathway,calcium signaling pathway,cAMP signaling pathway,NF-kappaB signaling pathway,AMPK signaling pathway,etc.Previous studies on Jianpi Huatan Quyu recipe suggested that this Chinese compound preparation can regulate the TNF-α,IL-6,MAPK,cAMP,and AMPK pathways to affect the mitochondrial structure of myocardial cells,oxidative stress,and energy metabolism,thus achieving the therapeutic effects on chronic heart failure.CONCLUSION The Chinese medicine compound preparation Jianpi Huatan Quyu recipe exerts therapeutic effects on chronic heart failure possibly by influencing the mitochondrial structure of cardiomyocytes,oxidative stress,energy metabolism,and other processes.Future studies are warranted to investigate the role of the IL-17 signaling pathway,PI3K-Akt signaling pathway,HIF-1 signaling pathway,and other pathways in mediating the therapeutic effects of Jianpi Huatan Quyu recipe on chronic heart failure. 展开更多
关键词 Jianpi Huatan Quyu recipe Traditional Chinese medicine Chronic heart failure Data mining Network pharmacology BIOINFORMATICS spleen qi deficiency syndrome
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Rules of Ren Shunping's prescription for trearing Spleen Deficiency and Qi Stagnation Syndrome of Functional Dyspepsia Based on Data Mining
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作者 Yan-Bo Liu Xin-Tong Wang Shun-Ping Ren 《Journal of Hainan Medical University》 2020年第24期53-59,共7页
Objective:To explore the medication rules of Professor Ren Shunping treating spleen deficiency and qi stagnation syndrome of functional dyspepsia,so as to provide reference for clinical prevention and development of n... Objective:To explore the medication rules of Professor Ren Shunping treating spleen deficiency and qi stagnation syndrome of functional dyspepsia,so as to provide reference for clinical prevention and development of new drugs.Methods:The 144 Chinese herbal formulas considered as active prescribed by professor Ren Shunping for the first time treating the patients with spleen deficiency and qi stagnation syndrome of functional dyspepsia were collected,entered into TCM inheritance auxiliary platform(V2.5),and then mined by some data mining methods of the software,such as the association rules and unsupervised entropy hierarchical clustering.Results:This study involved 144 Chinese herbal formulas,including a total of 56 Chinese herbal medicines.Of these Chinese herbal medicines,the herbs of cold and warm nature,and pungent,bitter and sweet in flavors were used in a quite high frequency,all of which act on spleen,stomach,lungs,large intestine,liver and gallbladder meridians.One core Chinese herbal formula was excavated,composed of patchouli,perilla stem,radix bupleuri,scutellaria,ginger pinellia,codonopsispilosula,magnolia bark,tangerine peel,large-headed atractylodes,immature bitter orange,wood incense,fructus amomi,inula britannica chinensis,ginger,medicated leaven,fried rice and fried malt based on the association rules.And a total of 17 groups of core used drugs and 2 groups of new Chinese herbal formulas undiscovered were mined based on unsupervised entropy hierarchical clustering.Conclusion:In treating spleen deficiency and qi stagnation syndrome of functional dyspepsia,professor Ren is good at treating spleen deficiency and qi stagnation syndrome of functional dyspepsia from the perspective of"tong jiang",using the"five-in-one"strategy of strengthening the spleen,evacuating the liver,coming down qi from the stomach,dispersing lung,and bowel-reflexing to treat patients as a whole.And the herbal medicines were light in dose,lovely and mild in nature for the formulars.At the same time,he paid attention to the combination of syndromes and symptoms,and flexible arbitration. 展开更多
关键词 TCM inheritance support platfom Functional dyspepsia spleen deficiency and qi stagnation syndrome Ren Shun-ping Rules of prescription
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Efficacy of Gastrosis No.1 Compound on Functional Dyspepsia of Spleen and Stomach Deficiency-Cold Syndrome:A Multi-Center,Double-Blind,Placebo-Controlled Clinical Trial 被引量:13
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作者 张声生 赵鲁卿 +6 位作者 汪红兵 吴兵 王垂杰 黄穗平 沈洪 魏玮 来要良 《Chinese Journal of Integrative Medicine》 SCIE CAS 2013年第7期498-504,共7页
To assess the efficacy and safety of Gastrosis No.1 compound in the treatment of functional dyspepsia with Spleen (Pi) and Stomach (Wei) deficiency-cold syndrome. Methods: A randomized, double-blind, placebo-cont... To assess the efficacy and safety of Gastrosis No.1 compound in the treatment of functional dyspepsia with Spleen (Pi) and Stomach (Wei) deficiency-cold syndrome. Methods: A randomized, double-blind, placebo-controlled trial was performed in 5 centers. Patients with functional dyspepsia (FD) of Spleen-deficiency and qi-stagnation syndrome (162 cases) were randomly assigned to groups given Chinese herbal medicine (CHM) Gastrosis No.1 compound or placebo in a 2:1 ratio. This trial included a 4-week treatment period and a 4-week follow-up period. The outcomes were the dyspepsia symptom scores (measured by total dyspepsia symptom scale and single dyspepsia symptom scale) and syndromes of traditional Chinese medicine score (measured by traditional Chinese medicine syndrome scale). The outcomes were noted at weeks 0, 4 and 8. Results: Compared with patients in the placebo group, patients in the CHM group showed significant improvement in the dyspepsia symptom scores as rated by patients and investigators (P〈0.01), and also showed improvement in syndromes of traditional Chinese medicine score (P〈0.01). No serious adverse event was reported. Safety tests obtained after 4 weeks of treatment showed no abnormal values. Conclusion: CHM Gastrosis No.1 compound was effective and safe in the treatment of functional dyspepsia with Spleen and Stomach deficiency-cold syndrome. 展开更多
关键词 functional dyspepsia spleen and Stomach deficiency-cold syndrome randomized controlled trial
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Study of establishing disease-syndrome combined with animal model for immune thrombocytopenic purpura without additional conditions 被引量:2
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作者 Haiyan Lang Ming Guo +4 位作者 Yuting Chu Wei Ma Yayue Zhang Ling Zhang Xinyi Chen 《Journal of Traditional Chinese Medical Sciences》 2016年第3期135-140,共6页
Objective:To explore the feasibility of establishing the disease-syndrome combined animal model for immune thrombocytopenic purpura(ITP)without additional conditions.Methods:Three batches of data related to the ITP mo... Objective:To explore the feasibility of establishing the disease-syndrome combined animal model for immune thrombocytopenic purpura(ITP)without additional conditions.Methods:Three batches of data related to the ITP model mice obtained by replication at different time were analyzed,and whether the APS-injected model mice replicated through the passive immune modeling method could simulate the pathogenesis and clinical characteristics of human ITP was evaluated according to the differentiation criteria for diseasesyndrome combined model.Results:The APS-injected replicated ITP model mice possessed the following traits:(1)Compared with the normal group,the platelet count was significantly decreased,and coagulation time was significantly increased in the model group(P<.01).(2)Compared with the normal group,the medullary thrombocytogenous megakaryocytes were significantly decreased(P<.05,.01,.001).(3)The APS-injected sites and other parts of the model mice had spontaneous hemorrhage.(4)Behavioral changing signs were observed 1 week after the modeling(i.e.low activity,delayed activity,poor appetite,skin petechia/hemorrhage and spontaneous hemorrhage at the injected sites or other parts),and were getting more and more severe.Conclusion:According to the syndrome differentiation criteria for disease-syndrome combined model of ITP,the APS-injected animal model of ITP replicated through the passive immune modeling method without additional conditions possesses the characteristics of disease-syndrome combined model.It provides an ideal tool for the development of traditional Chinese medicine pharmacology experiment. 展开更多
关键词 Immune thrombocytopenic purpura syndrome of failure of spleen qi to control blood due to deficiency of spleen qi Disease-syndrome combined animal model
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Randomized Controlled Trial on Treatment of Bronchial Asthma of Qi-deficiency Cold Syndrome Type by Pingchuan Yiqi Granule (平喘益气颗粒) 被引量:3
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作者 张颖 常静 +6 位作者 迟焕海 毛兵 唐文富 王蕾 黄素珍 李廷谦 张瑞明 《Chinese Journal of Integrative Medicine》 SCIE CAS 2007年第1期27-32,共6页
Objective: To evaluate the effect and safety of Pingchuan Yiqi Granule (平喘益气颗粒, PYG) in treating bronchial asthma of qi-deficiency cold syndrome type (BS-QDC). Methods: With the randomized, positive agent ... Objective: To evaluate the effect and safety of Pingchuan Yiqi Granule (平喘益气颗粒, PYG) in treating bronchial asthma of qi-deficiency cold syndrome type (BS-QDC). Methods: With the randomized, positive agent parallel controlled design adopted, the 80 subjects enrolled were assigned in the ratio of 3:1 to two groups, the 60 patients in the trial group were treated with PYG and the 20 in the control group treated with Ruyi Dingchuan Pill (如意定喘丸,RDP), with the therapeutic course consisting of 7 days for both groups. The clinical effects, effects on TCM syndrome and the changes of lung function after treatment were observed. Results: The effect of the treatment on asthma in the trial group: clinically controlled rate was 6.67%, markedly effective rate 51.67%, improved rate 33.33% and ineffective rate 8.33%; and the corresponding rates in the control group were 5.00%, 50.00%, 30.00%, and 15.00% respectively. Comparison between the two groups showed insignificant difference (P〉0.05). The effect on TCM syndrome in the treated group: clinically controlled rate was 11.67%, markedly effective rate 58.33%, effective rate 21.67% and ineffective rate 8.33%; and those in the control group were 10.00%, 50.00%, 30.00% and 10.00% respectively, also showing insignificant difference between the two groups (P〉0.05). Lung function test showed that the change on forced expiratory volume in 1 second (FEV1) after treatment in the trial group was of statistical significance (P〈0.05), but no significant difference was shown in the change of peak expiratory flow (PEE P〉0.05); while the changes in the control group were just the opposite, showing insignificance in FEV1 (P〉0.05) but significance in PEF (P〈0.05). Comparison of the therapeutic effect on lung function between the two groups showed no significant difference (P〉0.05). No adverse reaction was found in either group in the course of treatment. Conclusion: PYG used to treat BS-QDC is effective and safe, it's effect is similar to that of RDP. 展开更多
关键词 Pingchuan Yiqi Granule randomized controlled trial bronchial asthma qi-deficiency cold syndrome type
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Chinmedomics facilitated quality-marker discovery of Sijunzi decoction to treat spleen qi deficiency syndrome 被引量:11
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作者 Qiqi Zhao Xin Gao +6 位作者 Guangli Yan Aihua Zhang Hui Sun Ying Han Wenxiu Li Liang Liu Xijun Wang 《Frontiers of Medicine》 SCIE CAS CSCD 2020年第3期335-356,共22页
Sijunzi decoction (SJZD) is a Chinese classical formula to treat spleen qi deficiency syndrome (SQDS) and has been widely used for thousands of years.However,the quality control (QC) standards of SJZD are insufficient... Sijunzi decoction (SJZD) is a Chinese classical formula to treat spleen qi deficiency syndrome (SQDS) and has been widely used for thousands of years.However,the quality control (QC) standards of SJZD are insufficient.Chinmedomics has been designed to discover and verify bioactive compounds of a variety of formularapidly.In this study,we used Chinmedomics to evaluate the SJZD's efficacy against SQDS to discover the potential quality-markers (q-markers) for QC.A total of 56 compounds in SJZD were characterized in vitro,and 23 compounds were discovered in vivo.A total of 58 biomarkers were related to SQDS,and SJZD can adjust a large proportion of marker metabolites to normal level and then regulate the metabolic profile to the health status.A total of 10 constituents were absorbed as effective ingredients that were associated with overall efficacy.We preliminarily determined malonyl-ginsenoside Rb2 and ginsenoside Ro as the q-markers of ginseng;dehydrotumulosic acid and dihydroxy lanostene-triene-21-acid as the q-markers of poria;glycyrrhizic acid,isoglabrolide,and glycyrrhetnic acid as the q-markers of licorice;and 2-atractylenolide as the q-marker of macrocephala.According to the discovery of the SJZD q-markers,we can establish the quality standard that is related to efficacy. 展开更多
关键词 traditional Chinese medicine Sijunzi decoction spleen qi deficiency syndrome Chinmedomics quality-marker
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五物甘草生摩膏穴位推拿防治肺脾气虚证脑瘫患儿反复呼吸道感染临床研究
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作者 张争艳 王俊玲 +2 位作者 李洁 白青云 都修波 《新中医》 2025年第2期143-147,共5页
目的:观察五物甘草生摩膏穴位推拿防治肺脾气虚证脑瘫患儿反复呼吸道感染(RRTI)的临床疗效。方法:将60例2022年3月—2023年4月于河南中医药大学第一附属医院就诊的肺脾气虚证RRTI脑瘫患儿,采用随机数字表法分为观察组与对照组各30例。... 目的:观察五物甘草生摩膏穴位推拿防治肺脾气虚证脑瘫患儿反复呼吸道感染(RRTI)的临床疗效。方法:将60例2022年3月—2023年4月于河南中医药大学第一附属医院就诊的肺脾气虚证RRTI脑瘫患儿,采用随机数字表法分为观察组与对照组各30例。观察组以五物甘草生摩膏为介质进行穴位推拿治疗,对照组给予口服脾氨肽治疗。疗程8周,观察2组临床疗效、中医证候评分;随访12个月,记录2组呼吸道感染减少次数及不良反应。结果:观察组总有效率为93.33%(27/30),对照组为63.33%(19/30),2组比较,差异有统计学意义(P<0.05)。治疗后,2组恶风、自汗、气短、面色苍白、少气懒言、不思饮食、形体消瘦、大便溏薄等中医证候评分均较治疗前降低(P<0.05),且观察组各项评分均低于对照组(P<0.05)。随访12个月,观察组呼吸道感染减少次数明显多于对照组(P<0.05);其中观察组上呼吸道感染减少次数多于对照组(P<0.05),2组下呼吸道感染(包括气管炎/支气管炎感染、肺炎感染)减少次数比较,差异无统计学意义(P>0.05)。治疗期间,2组患儿均未见明显不良反应。结论:五物甘草生摩膏穴位推拿治疗能改善肺脾气虚证脑瘫患儿RRTI的临床症状,减少上呼吸道感染次数,且远期疗效较好。 展开更多
关键词 反复呼吸道感染 儿童 肺脾气虚证 五物甘草生摩膏 膏摩疗法 穴位推拿
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基于“一气周流”理论运用苓蔻人参汤治疗腹泻型肠易激综合征临床研究
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作者 高强强 艾霞 +4 位作者 姜华 甘会平 尚用冉 谭书法 黄水兰 《陕西中医药大学学报》 2025年第1期119-123,共5页
目的基于黄元御的“一气周流”理论,观察其所创苓蔻人参汤治疗肝郁脾虚证腹泻型肠易激综合征的临床疗效,为中医药治疗该病提供新的诊治思路。方法选取68例肝郁脾虚证腹泻型肠易激综合征患者随机分为治疗组34例和对照组34例,对照组口服... 目的基于黄元御的“一气周流”理论,观察其所创苓蔻人参汤治疗肝郁脾虚证腹泻型肠易激综合征的临床疗效,为中医药治疗该病提供新的诊治思路。方法选取68例肝郁脾虚证腹泻型肠易激综合征患者随机分为治疗组34例和对照组34例,对照组口服马来酸曲美布汀胶囊治疗,治疗组在对照组的用药基础上配合苓蔻人参汤治疗,比较两组治疗前后临床疗效、肠道菌群参数、Bristol粪便性状评分、排粪频率(SBM/W)、肠易激综合征病情严重程度量表(IBS-SSS)评分,6周后进行疗效评价。结果对照组和治疗组总有效率分别为73.53%(25/34)、93.75%(31/34),差异有统计学意义(P<0.05)。两组患者在接受治疗后肠道乳酸杆菌、双歧杆菌含量均增多,同时,消化杆菌、肠杆菌数量均减少(P<0.05),且治疗组变化程度大于对照组(P<0.05)。治疗后,Bristol治疗组粪便性状评分、排粪频率(SBM/W)明显优于对照组,差异具有统计学意义(P<0.05)。治疗前,两组IBS-SSS积分差异无统计学意义(P>0.05);治疗后,两组IBS-SSS积分较治疗前均有下降(P<0.05)。两组患者在治疗过程中均未出现胃肠道不良反应。结论苓蔻人参汤联合马来酸曲美布汀可有效调控肠道菌群,显著改善临床症状,提高患者的生活质量,是一种安全有效的治疗方法。 展开更多
关键词 一气周流 肝郁脾虚证 肠易激综合征 黄元御 苓蔻人参汤
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热敏灸治疗脾气虚弱型慢性疲劳综合征临床研究
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作者 杨萍 冼卓妍 曹淑华 《新中医》 2025年第1期110-114,共5页
目的:观察比较热敏灸与常规温和灸治疗脾气虚弱型慢性疲劳综合征的疗效。方法:选取2023年5—12月广州中医药大学附属广东中西医结合医院收治的70例脾气虚弱型慢性疲劳综合征患者,按随机数字表法分为治疗组(35例,脱落4例)和对照组(35例,... 目的:观察比较热敏灸与常规温和灸治疗脾气虚弱型慢性疲劳综合征的疗效。方法:选取2023年5—12月广州中医药大学附属广东中西医结合医院收治的70例脾气虚弱型慢性疲劳综合征患者,按随机数字表法分为治疗组(35例,脱落4例)和对照组(35例,脱落4例)。2组均给予健康宣教,治疗组在健康宣教基础上给予热敏灸治疗,对照组在健康宣教基础上给予常规温和灸治疗。2组均为2 d 1次,治疗12次(共24 d)。评价2组临床疗效,比较2组治疗前后的疲劳量表FS-14评分、慢性疲劳综合征临床症状积分总分以及各子项目评分、中医证候积分。结果:治疗组总有效率为93.55%(29/31),高于对照组74.19%(23/31)(P<0.05)。治疗后,2组疲劳量表FS-14评分、中医证候积分较治疗前降低(P<0.05),且治疗组疲劳量表FS-14评分、中医证候积分低于对照组(P<0.05)。治疗后,2组慢性疲劳综合征临床症状积分总分以及各子项目评分较治疗前降低(P<0.05),且治疗组慢性疲劳综合征临床症状积分总分及肌肉疼痛、关节疼痛、头痛、睡眠障碍、劳累后疲劳不适持续时间、疲劳评分低于对照组(P<0.05)。结论:热敏灸和常规温和灸均可以改善脾气虚弱型慢性疲劳综合征患者的临床症状,缓解脾虚情况,热敏灸疗效优于常规温和灸。 展开更多
关键词 慢性疲劳综合征 脾气虚弱证 热敏灸 温和灸 疲劳量表FS-14评分 慢性疲劳综合征临床症状积分 中医证候积分
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火针补法治疗肝郁脾虚型腹泻型肠易激综合征的临床研究
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作者 郭苏爱 郑光宪 +3 位作者 邓丽兴 胡育丰 梁景凡 许英铭 《中国医学创新》 2025年第3期62-66,共5页
目的:探讨火针补法治疗肝郁脾虚型腹泻型肠易激综合征(irritable bowel syndrome with diarrhea,IBS-D)的临床效果。方法:选择阳江市中医医院2022年4月—2024年3月收治的肝郁脾虚型IBS-D患者90例,按照随机数字表法分为三组,分别为常规... 目的:探讨火针补法治疗肝郁脾虚型腹泻型肠易激综合征(irritable bowel syndrome with diarrhea,IBS-D)的临床效果。方法:选择阳江市中医医院2022年4月—2024年3月收治的肝郁脾虚型IBS-D患者90例,按照随机数字表法分为三组,分别为常规西药组(n=30,予以常规西药治疗)、常规针刺组(n=30,予以常规针刺治疗)与火针补法组(n=30,予以火针补法治疗),均接受为期4周的治疗。比较三组IBS症状严重程度量表(IBS-symptom severity scale,IBS-SSS)、IBS生活质量量表(IBS-quality of life,IBS-QOL)、肝郁脾虚型证候积分、疗效及安全性。结果:治疗前三组IBS-SSS、IBS-QOL评分比较,差异均无统计学意义(P>0.05);治疗后火针补法组IBS-SSS、IBS-QOL评分均低于常规针刺组、常规西药组,差异均有统计学意义(P<0.05)。治疗前三组肝郁脾虚型证候积分比较,差异均无统计学意义(P>0.05);治疗后火针补法组肝郁脾虚型证候积分均低于常规针刺组、常规西药组,差异均有统计学意义(P<0.05)。火针补法组总有效率高于常规针刺组、常规西药组,差异均有统计学意义(P<0.05)。三组均未发生严重不良反应。结论:火针补法治疗肝郁脾虚型IBS-D的效果优于常规针刺、西药,能有效减轻患者症状,提升生活质量,且安全性高。 展开更多
关键词 火针补法 肝郁脾虚型 腹泻型肠易激综合征 生活质量
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黄芪建中汤合暖胃汤治疗患儿脾胃虚寒型急性肠胃炎 被引量:1
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作者 李海华 宋金岭 +1 位作者 张志国 王芳 《吉林中医药》 2024年第4期440-443,共4页
目的观察黄芪建中汤合暖胃汤治疗脾胃虚寒型急性肠胃炎患儿的疗效。方法选取2021年2月-2023年5月医院收治的74例脾胃虚寒型急性肠胃炎患儿,以随机数字表法分为研究组与对照组,各37例。2组均接受对症治疗,对照组在此基础上采用奥美拉唑... 目的观察黄芪建中汤合暖胃汤治疗脾胃虚寒型急性肠胃炎患儿的疗效。方法选取2021年2月-2023年5月医院收治的74例脾胃虚寒型急性肠胃炎患儿,以随机数字表法分为研究组与对照组,各37例。2组均接受对症治疗,对照组在此基础上采用奥美拉唑肠溶胶囊治疗,研究组在对照组的基础上接受黄芪建中汤合暖胃汤治疗。2组均治疗14 d。对比2组中医证候评分、病症恢复时间、临床疗效、炎症反应、胃肠激素及不良反应。结果治疗后,2组主症评分、次症评分、总评分明显降低(P<0.05),且研究组降低更为明显(P<0.05)。研究组发热、腹痛、呕吐、腹泻等病症恢复时间短于对照组(P<0.05)。研究组总有效率高于对照组(P<0.05)。治疗后,2组白细胞介素-17(IL-17)、基质金属蛋白酶-3(MMP-3)、中性粒细胞与淋巴细胞比值(NLR)水平明显降低(P<0.05),且研究组降低更为明显(P<0.05)。治疗后,2组胃泌素(GSA)水平明显降低(P<0.05),且研究组降低更为明显(P<0.05)。治疗后,2组胃动力素(MTL)水平明显升高(P<0.05),且研究组升高更为明显(P<0.05)。2组不良反应总发生率比较差异无统计学意义(P>0.05)。结论黄芪建中汤合暖胃汤治疗脾胃虚寒型急性肠胃炎患儿疗效确切,可改善患儿临床症状与胃肠功能,促进患儿康复,减轻炎症反应,且安全可靠。 展开更多
关键词 黄芪建中汤 暖胃汤 脾胃虚寒型 急性胃肠炎 小儿 临床疗效 安全性
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参苓白术散加减治疗肺脾气虚津亏干燥综合征疗效及对Toll样受体4/核因子-κB水平的影响 被引量:1
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作者 宋亚丽 马艳苗 +1 位作者 胡桂芬 来晓炜 《中华中医药学刊》 CAS 北大核心 2024年第5期186-190,共5页
目的探究参苓白术散加减治疗肺脾气虚津亏干燥综合征的疗效及对血清Toll样受体4(TLR4)和核因子-κB(NF-κB)水平的影响。方法选取2019年3月—2022年3月收治的107例干燥综合征患者为研究对象,采用信封法从密封箱子抽取带有数字的纸团,大... 目的探究参苓白术散加减治疗肺脾气虚津亏干燥综合征的疗效及对血清Toll样受体4(TLR4)和核因子-κB(NF-κB)水平的影响。方法选取2019年3月—2022年3月收治的107例干燥综合征患者为研究对象,采用信封法从密封箱子抽取带有数字的纸团,大于等于54的号码为观察组,小于54的号码为对照组。观察组54例,对照组53例。对照组给予硫酸羟氯喹片、甲泼尼龙片治疗,观察组在此基础上联合使用参苓白术散加减治疗。观察两组患者治疗前后中医证候评分、疾病活动指数(ESSDAI)和自我报告指数(ESSPRI)评分、γ-干扰素(IFN-γ)、白介素-17(IL-17)、免疫功能(CD_(8)^(+)、CD_(4)^(+)和CD^(+)_(4/)CD_(8)^(+))、血清TLR4和NF-κB水平。观察两组患者临床疗效。结果治疗前两组患者两目干涩、关节疼痛、口燥咽干、皮肤干燥、体倦乏力和唾液腺肿评分差异无统计学意义(P>0.05)。治疗后观察组两目干涩、关节疼痛、口燥咽干、皮肤干燥、体倦乏力和唾液腺肿评分显著低于对照组(P<0.05)。治疗前两组患者ESSDAI和ES⁃SPRI评分差异无统计学意义(P>0.05)。治疗后观察组ESSDAI和ESSPRI评分显著低于对照组(P<0.05)。治疗前两组患者IFN-γ、IL-17水平差异无统计学意义(P>0.05)。治疗后观察组IFN-γ、IL-17水平显著低于对照组(P<0.05)。两组患者治疗前CD_(4)^(+)、CD_(8)^(+)、CD_(4)^(+)/CD^(+)8水平差异无统计学意义(P>0.05)。治疗后观察组的CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)水平较对照组显著升高,而CD^(+)8水平较对照组显著降低(P<0.05)。两组患者治疗前TLR4/NF-κB水平差异无统计学意义(P>0.05)。治疗后观察组TLR4/NF-κB水平较对照组显著降低(P<0.05)。观察组总有效率为96.30%(52/54),显著高于对照组的84.91%(45/53)(χ^(2)=4.096,P=0.043)。结论参苓白术散加减能有效提高干燥综合征患者临床疗效、降低ESSDAI和ESSPRI评分、改善TLR4/NF-κB的水平,有利于提高患者免疫力。 展开更多
关键词 参苓白术散 肺脾气虚 津亏 干燥综合征 TLR4 NF-κB 临床疗效
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四君子汤调控AMPK-SIRT1蛋白改善运动性疲劳小鼠学习记忆的机制研究 被引量:1
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作者 庞贤妹 耿雪 +2 位作者 陈楚杰 陈道睿 刘刚 《新中医》 CAS 2024年第11期23-28,共6页
目的:观察四君子汤对运动性疲劳(EF)小鼠AMPK/SIRT1信号通路的影响,并探讨其改善EF认知损伤和学习记忆能力的机制。方法:将60只C57BL/6小鼠随机分为空白组、模型组、四君子汤高剂量组、四君子汤中剂量组、四君子汤低剂量组。除空白组外... 目的:观察四君子汤对运动性疲劳(EF)小鼠AMPK/SIRT1信号通路的影响,并探讨其改善EF认知损伤和学习记忆能力的机制。方法:将60只C57BL/6小鼠随机分为空白组、模型组、四君子汤高剂量组、四君子汤中剂量组、四君子汤低剂量组。除空白组外,其他各组小鼠构建脾气虚证EF小鼠模型。四君子汤高、中、低剂量组小鼠分别给予不同浓度的四君子汤灌胃,空白组和模型组以等体积蒸馏水灌胃,各组连续灌胃4周。采用Morris水迷宫实验评估小鼠的认知功能,采用ELISA法检测小鼠血清中乳酸、血糖、肝糖原、肌糖原的水平,Western Blot法检测小鼠脑组织中AMPK和SIRT1的蛋白表达量。结果:实验后,模型组小鼠体质量、摄食量、血糖、肝糖原含量、肌糖原含量、目标象限游泳时间、穿越平台次数、AMPK蛋白表达量、SIRT1蛋白表达量低于空白组,血清乳酸水平高于空白组(P<0.05)。给药干预后,四君子汤高、中、低剂量组小鼠体质量、摄食量、力竭游泳时间、肝糖原含量、肌糖原含量、目标象限游泳时间、穿越平台次数高于模型组,血清乳酸水平低于模型组(P<0.05)。四君子汤高剂量小鼠游泳力竭时间高于低剂量组,乳酸水平低于低剂量组(P<0.05)。四君子汤高、中剂量组肝糖原、肌糖原含量高于低剂量组(P<0.05)。与模型组比较,四君子汤高、中剂量组AMPK及SIRT1蛋白表达量增多(P<0.05),四君子汤低剂量组SIRT1蛋白表达量增多(P<0.05)。与四君子汤低剂量组比较,四君子汤高、中剂量组AMPK及SIRT1蛋白表达量增多(P<0.05)。结论:四君子汤可在一定程度调控AMPK/SIRT1的活性,进而改善EF小鼠脾虚症状。 展开更多
关键词 运动性疲劳 脾气虚证 四君子汤 AMPK/SIRT1蛋白 乳酸 糖原
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HIV/AIDS肺脾气虚证相关心脑血管疾病风险因素探析
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作者 潘万旗 张淼 +1 位作者 许前磊 郭会军 《中华中医药学刊》 CAS 北大核心 2024年第7期108-111,共4页
目的通过检测血脂四项、血管内皮损伤因子、炎症相关因子,并结合前期的基因芯片结果,初步探讨人类免疫缺陷病毒(HIV)/艾滋病(AIDS)肺脾气虚证相关心脑血管疾病风险因素及机制,为中医药早期干预心脑血管疾病提供依据。方法2020年9月—202... 目的通过检测血脂四项、血管内皮损伤因子、炎症相关因子,并结合前期的基因芯片结果,初步探讨人类免疫缺陷病毒(HIV)/艾滋病(AIDS)肺脾气虚证相关心脑血管疾病风险因素及机制,为中医药早期干预心脑血管疾病提供依据。方法2020年9月—2020年11月选取河南省某地区确诊的20例HIV/AIDS肺脾气虚证患者作为研究对象,同地区20例HIV抗体阴性作为健康对照组。检测CD_(3)^(+)、CD_(4)^(+)、CD_(8)^(+)计数,并计算CD_(4)^(+)/CD_(8)^(+)比值;检测血脂四项甘油三酯(TG)、胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C);检测氧化低密度脂蛋白(Ox-LDL)、载脂蛋白A-I(ApoAⅠ)、载脂蛋白A-Ⅱ(ApoAⅡ)、载脂蛋白B(ApoB)、锌-α2-糖蛋白1(AZGP1)、可溶性血栓调节蛋白(sTM)、血管性血友病因子(vWF)、脂联素、瘦素(LEP)、超敏C反应蛋白(Hs-CRP)、单核细胞趋化因子1(MCP-1)、肿瘤坏死因子α(TNF-α)。结果HIV/AIDS肺脾气虚证患者与健康对照组比较CD_(4)^(+)降低,CD_(4)^(+)/CD_(8)^(+)比值倒置,TC降低,sTM、AZGP1、Ox-LDL、Hs-CRP升高。结论HIV/AIDS肺脾气虚证患者存在炎性反应、血脂异常的表现,罹患心脑血管疾病风险增加。为中医药早期干预心脑血管疾病的发生提供新思路。 展开更多
关键词 HIV/AIDS 肺脾气虚证 心脑血管疾病 风险因素
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基于脾火论辨治原发性干燥综合征
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作者 刘洁 何晓瑾 《南京中医药大学学报》 CAS CSCD 北大核心 2024年第5期435-439,共5页
基于脾火论辨治原发性干燥综合征(pSS)。论述了脾火论的理论内涵,并区分脾火与阴火及其他脏腑之火的差异。阐释了脾火论与pSS的相关性,认为脾气亏虚,运化无权,脾不升清,郁而化火是pSS病机关键;久而病及他脏,导致络脉瘀滞是pSS的病机转... 基于脾火论辨治原发性干燥综合征(pSS)。论述了脾火论的理论内涵,并区分脾火与阴火及其他脏腑之火的差异。阐释了脾火论与pSS的相关性,认为脾气亏虚,运化无权,脾不升清,郁而化火是pSS病机关键;久而病及他脏,导致络脉瘀滞是pSS的病机转化特点。以健脾益气,除火润燥,生津通络为pSS的治疗大法,为pSS的中医辨治提供思路与方法。 展开更多
关键词 干燥综合征 燥痹 脾火论 脾气亏虚 脾不升清 郁而化火
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益胃宁胶囊联合瑞巴派特片治疗慢性萎缩性胃炎脾胃气虚证临床研究
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作者 叶春荣 何友成 +1 位作者 汤水华 严锦贤 《中国中医药信息杂志》 CAS CSCD 2024年第1期142-146,共5页
目的观察益胃宁胶囊联合瑞巴派特片治疗慢性萎缩性胃炎(CAG)脾胃气虚证的临床疗效。方法采用随机数字表法将80例CAG患者分为研究组和对照组各40例,2组均予瑞巴派特片,0.1 g/次,每日3次,口服;研究组在此基础上予益胃宁胶囊,2 g/次,每日3... 目的观察益胃宁胶囊联合瑞巴派特片治疗慢性萎缩性胃炎(CAG)脾胃气虚证的临床疗效。方法采用随机数字表法将80例CAG患者分为研究组和对照组各40例,2组均予瑞巴派特片,0.1 g/次,每日3次,口服;研究组在此基础上予益胃宁胶囊,2 g/次,每日3次,口服。2组均连续治疗12周。观察2组治疗前后中医疗效、胃镜疗效和病理疗效,比较2组治疗前后中医症状评分,监测2组不良反应。结果2组均无病例脱落。研究组中医疗效总有效率为92.5%(37/40),对照组为70.0%(28/40),研究组中医疗效优于对照组(P<0.01)。与本组治疗前比较,2组治疗后中医症状总分下降(P<0.05,P<0.01);2组治疗后比较,研究组中医症状总分低于对照组(P<0.01)。研究组胃镜疗效总有效率(82.5%)优于对照组(67.5%),研究组病理疗效总有效率(87.5%)优于对照组(70.0%),差异均有统计学意义(P<0.05,P<0.01)。2组未见明显不良反应。结论益胃宁胶囊联合瑞巴派特片可有效改善CAG患者的临床症状、胃镜表现及黏膜病变程度,疗效显著。 展开更多
关键词 益胃宁胶囊 慢性萎缩性胃炎 脾胃气虚证 临床疗效
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益元宣肺汤对25例新冠肺炎CT值的影响
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作者 李松林 张晶 +5 位作者 刘玉娟 邓欣 刘亚峰 李琳娜 莫雨平 梁雁 《中国中医药现代远程教育》 2024年第1期132-135,共4页
目的分析深圳地区2022年新型冠状病毒肺炎患者的舌象、症状及用药史,多辨为三焦壅滞、肺脾肾虚,拟益元宣肺汤,观察其对CT值恢复的临床疗效。方法选取25例符合益元宣肺汤证型者进行治疗观察,选同期对照组25例,观察益元宣肺汤对CT值的影... 目的分析深圳地区2022年新型冠状病毒肺炎患者的舌象、症状及用药史,多辨为三焦壅滞、肺脾肾虚,拟益元宣肺汤,观察其对CT值恢复的临床疗效。方法选取25例符合益元宣肺汤证型者进行治疗观察,选同期对照组25例,观察益元宣肺汤对CT值的影响。结果治疗前对照组的N基因(31.99±1.16)、O基因(33.49±1.94)与治疗组的N基因(31.45±2.85)、O基因(33.40±3.96)比较,差异无统计学意义(P>0.05);对照组治疗到CT值符合出院标准所需时间为(4.28±1.88)d,治疗组为(2.80±1.26)d,差异有统计学意义(P<0.05)。结论治疗组通过服用益元宣肺汤,CT值恢复明显比对照组快,表明以调动肺脾肾之气、疏通三焦气机为主的益元宣肺汤效果明显。扶正补肺脾肾、通宣三焦的治疗方法,在促进病情好转,加快人体清除病毒的速度方面作用明显,利于新型冠状病毒肺炎患者康复。 展开更多
关键词 疫病 新型冠状病毒肺炎 证型特征 肺脾肾虚 寒湿
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王有鹏教授治疗寒地儿童荨麻疹的临证经验
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作者 王佳 郭峥 王有鹏 《长春中医药大学学报》 2024年第1期26-29,共4页
王有鹏教授基于对寒地地域特点及小儿生理病理特点认识,立足临床实践,对寒地儿童荨麻疹的诊疗具有独到见解。王有鹏教授从发病邪气、脏腑、体质三个层面总结其病因病机为风邪主导,寒、热、湿邪兼杂为患;肺脾肾三脏虚损,心肝亢盛为本;同... 王有鹏教授基于对寒地地域特点及小儿生理病理特点认识,立足临床实践,对寒地儿童荨麻疹的诊疗具有独到见解。王有鹏教授从发病邪气、脏腑、体质三个层面总结其病因病机为风邪主导,寒、热、湿邪兼杂为患;肺脾肾三脏虚损,心肝亢盛为本;同时受先天禀赋及体质因素的影响。根据寒地儿童荨麻疹发病特点将其分为风邪袭表证、湿热蕴肤证、肺脾气虚证,治疗以调和脏腑为本,祛除病邪为标,运用合方随证施治,同时兼顾调体养护,防患于未然,可取得较好疗效。 展开更多
关键词 严寒地域 荨麻疹 儿童 风邪袭表 湿热蕴肤 肺脾气虚
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艾灸治疗脾胃虚寒型胃炎研究进展
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作者 王红霞 车旭 +2 位作者 曹海英 何莹莹 乔东鸽 《光明中医》 2024年第10期2087-2090,共4页
慢性胃炎是由多种病理因素引起的胃黏膜的慢性炎症,是最常见的消化系统疾患之一。而脾胃虚寒是慢性胃炎中最为常见的证型,在中医特色疗法中,艾灸疗法的应用相对广泛。因此,文章总结了艾灸治疗脾胃虚寒型胃炎患者的应用,以艾灸的不同方式... 慢性胃炎是由多种病理因素引起的胃黏膜的慢性炎症,是最常见的消化系统疾患之一。而脾胃虚寒是慢性胃炎中最为常见的证型,在中医特色疗法中,艾灸疗法的应用相对广泛。因此,文章总结了艾灸治疗脾胃虚寒型胃炎患者的应用,以艾灸的不同方式,如隔药灸、隔姜灸、悬起灸、雷火灸、温针灸、温灸器灸等方面进行综述,以期为艾灸疗法改善脾胃虚寒型胃炎患者症状提供综合参考。 展开更多
关键词 胃痛 胃炎 脾胃虚寒证 灸法
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