STUDY ON THE SYNTHESIS OF A NEW TYPE OF PHOSPHORUS HETEROCYCLIC COMPOUNDS-PYRAZOLO[3,4-d]-1,3,2-DIAZAPHOSPHORIN-6-ONE

1-substituted-5-benzoylamino-4-pyrazolecarboxamides(2)were prepared by the reaction of 1-substituted pyrazolo[3,4-d]-oxazinone(1) with amines in benzene.The compound 2 was refluxed with excess LiAlH_4 in a mixture of THF and ether,one of the two carbamoyl groups in the molecule 2 was reduced selectively.As the results,1-substituted-5- benzylamino-4-pyrazolecarboxamides(3)were obtained.Compounds 3 reacted with Cl_2PPh-X,or P(NET_2)_3,producing the title compounds(4). The conditions of the reactions were studied.

Synthesis and High Pressure Study on Ca_(1-x)Ln_xSiO_3

In this paper, for the first time, Ca1-xLnxSiO3 (Ln=Y. La, x=0.1, 0.2) was synthesized with three methods of high temperature (HT) under atmospheric pressure (AP), high temperature (HT) combined with high pressure (HP) and sol-gel method. The sample obtained at the stable range of 4.3-5.0 GPa pressure and 1050-1100℃ temperature with HT and HP method has a cubic perovskite structure, which has the minimum lattice parameter of 0.3535 nm so far,the sample with triclinic structure was obtained by sintering at atmosphere, and the sample synthesized with sol-gel method has monoclinic structure. SEM analysis shows that rare earth ions take the lattice site of Ca, but the distribution of rare earth ions in the samples synthesized with HT and HP is not homogeneous.

STUDY ON THE SYNTHESIS AND PROPERTIES OF MACRORETICULAR IPN POLYACRYLAMIDE—POLY(VINYL—ETHYLENEDIAMINE)CHELATE SORBENTS

A new series of MR-IPN polyacrylamide—poly(vinyl-ethylenediamine)chelate sorbents were prepared by the reaction of ethylenediamine with MR-IPN matrixes.The new chelate sorbent showed good sorption properties for auric and platinic ions.

THE STUDY OF ENZYMATIC SYNTHESIS OF MACROCYCLIC LACTONES

The effects of the chain length and stereo-factor of substrates and solvents on the lipase catalysed lactonization of ω-hydroxy-ester were studied, And also the catalytic effects of various enzymes were compared.

STUDY ON SYNTHESIS,CHARACTERIZATION AND STRUCTURE OF A NEW RARE EARTH COORDINATION COMPOUND WITH BENZOIC ACID

In this paper,a new rare earth benzoate coordination compound,[TbL_3(HL)(H_2O)]_2 (HL=C_7H_6O_2=benzoic acid) is synthesized and characterized by elemental analysis DTA,TG,DTC,and IR spectra.The title compound crystallizes in triclinic,space.group P with a=9.148(1),b=11.460(2), c=13.506(2);α=112.76(1),β=91.83(1),γ=91.99(1)°;Z=1;V=1303.3.The final R factor is 0.0235.The rare earth ion is nine-coordinated to form a distorted monocapped square antiprism.

STUDY ON THE SYNTHESIS OF BRASSINOLIDE AND RELATED COMPOUNDS 15.FORMAL SYNTHESIS OF BRASSINOLIDE VIA STEREOSELECTIVE SULFENATE-SULFOXIDE TRANSFORMATION

A formal synthesis of the natural growth promoting steroid brassinolide is described,which involves construction of side chain by 1,3-sulfoxide-hydroxyl transposition with methylation from(24S)- 22-E-24-sulfoxide 6 and(24R)-22-E-24-sulfoxide 9,respectively to (22S)-23-E-24-methyl compound 4.

Study on the Total Synthesis of Hainanolide (Ⅱ)──An Unexpected Hydroperoxide Containing Tricyclic Skeleton

An unexpected compound, hydroperoxide (4) formed from (3), the exo-cycloaddition product, which was synthesized through the Lewis acid catlyzed intramolecular Diels-Alder (IMDA) reaction. Its structure was confirmed by spectra and X-Ray diffraction analysis, An 1O2oxidation mechanism was proposed.

STUDY ON THE SYNTHESIS OF TETRACYCLIC DITERPENOID 7 Preparation of the Key Intermediate 5 for the Synthesis of Grandiflorenic Acid and its Analogues

The key intermediate 5 for synthesis of the contragestationally active diterpenoid grandiflorenic acid(1)and its analogues 2 and 3 was prepared and an acetyl transposition reaction occurred in the SeO_2 oxida- tion of 8.

Study on the Total Synthesis of 3-Oxo-9β-Acetoxyilicic Acid─The Synthesis of 9β-Acetoxy-3(4),11(13)-Dien-5αH,7αH-12-Eudesmanoic Acid Methyl Ester

The synthesis of 99-acetoxy-3(4), 11(13)-dien-5αH 7αH-12-eudesmanoic acid methyl ester (2) was achieved from oxycarvone. The key step is the p-toluenesulfonhydrazide assisted reductiv rearrangement reaction

THE ADVANCES IN SYNTHESIS AND STUDY OF NEW NUCLIDES IN CHINA

This paper introduces the importance of synthesis and study of new nuclides far from the stability line. Following the example of new nuclides 208Hg, 185Hf and 237Th, which were synthesized for the first time by the scientists in the Institute of Modern Physics, the progress of physics and technology in this aspect in our country are summarized. This paper also outlines a proposal about farther development of the synthesis and study of new nuclides and the construction of relevant key facilities in our country at the beginning of the next century.

STUDIES ON THE PRENYLFLAVONOIDS PART V.SYNTHESIS OF(±)LESPEDEZAFLAVANONE D

(±)Lespedezaflavanone D,8,5'-di(γ,γ-dimethylallyl)-5,7,2',4'-tetrahydroxyflavanone,has been synthesized by the condensation of 4,6-dimethoxymethoxy-3-(γ,γ-dimethylallyl)-2-hydroxy- acetophenone with 2,4-dimethoxymethoxy-5-(γ,γ-dimethylallyl)benzaldehydc followed by cyclization and demethoxymethylation.

STUDIES ON THE SYNTHESIS AND BIOLOGICAL ACTIVITY OF 1-ARYLOXYACETYL-4-AROYLTHIOSEMICARBAZIDE DERIVATIVES

A series of new 1-aryloxyacetyl-4-aroylthiosemicarbazides were synthesized by means of solid-liguid phase transfer catalysis. The promoting effects of these new compounds on wheat growth were observed.

Studies on the Synthesis of Villosol

The stereocontrolled synthesis of 2, the structure proposed for villosol, was described. The synthetic work has shown that the proposed structure was incorrect.

Studies on Synthesis of Diadenylyl Sulfites

Diadenylyl sulfites were obtained by the condensation of protected adenosines using O,O-bis (1-ben- zotriazolyl) sulfite as a coupling reagent.

STUDIES ON THE SYNTHESIS OF(±)-CEMBRENE-A

A precursor 2 of cembrene-A(a termite trail pheromone)was prepared from geraniol through 7 steps.

STUDIES ON THE SYNTHESIS OF THE SPIROKETAL FRAGMENT OF AZADIRACHTIN(Ⅰ)

The stereoselective synthesis of substituted [2,2,1]-bicyclo- heptan-2-one 12,a supposed intermediate to the spiroketal fragment of azadi- rachtin was described.When 12 was treated with mCPBA in CH_2Cl_2 in the pres- ence of excess amount of solid sodium bicarbonate,only 13 was obtained.The spiroketal intermediate 20 was converted from 9 through 5 steps by an alterna- tive route.

Studies on the synthesis and antifungal activity of thiochromanone derivatives

In this paper nine New Mannich bases of 6-fluoro-thiochromanone and eight new 3-substituted-6.8-dichloro thiochromanones were synthesized and their structures were confirmed by IR, H-1-NMR and elementary analysis. Most of these compounds showed excellent antifungal activity.

STUDIES ON THE SYNTHESIS OF SINULARIOE-D,SINULARIAL-A AND SINULARIC ACID-A

A precursor 12 of sinulariol-D,sinularial-A and sinularic acid-A(marine cembranoids)was prepared from geraniol through nine steps

STUDIES ON THE SYNTHESIS OF RABDOSIA DITERPENOID Ⅱ,PREPARATION OF A KEY BUILDING BLOCK,α,β-UNSATURATED LACTONE

The main half molecule(4a)of the trichorabdal B(1) was synthesized from pentadienol(6).The key step is the intramolecular Diels-Alder reaction of 8.