Objective: To investigate the pharmaceutical equivalence of ten brands of ibuprofen tablets(400 mg) purchased from pharmacies in Benin City, Nigeria.Methods: The drug samples were subjected to uniformity of weight, cr...Objective: To investigate the pharmaceutical equivalence of ten brands of ibuprofen tablets(400 mg) purchased from pharmacies in Benin City, Nigeria.Methods: The drug samples were subjected to uniformity of weight, crushing strength,friability, melting point, disintegration and dissolution tests following acceptable and official protocols. The ibuprofen content was determined using UV and high performance liquid chromatography method.Results: Crushing strength values of the drug samples ranged between 6 and 16 kp while the disintegration times were between 7.43 and 10.40 min(for uncoated tablets) and3.25–37.32 min(for coated tablets). Friability values were less than 1% and the melting points of recrystallized ibuprofen from the samples ranged from 73.5 to 76.0 C. The amount of ibuprofen released within 1 h ranged between 18% and 102% and two brands failed the content of active ingredient in the UV method of assay while all the brands passed the test using HPLC.Conclusions: Ibuprofen(400 mg) tablets marketed in Benin City, Nigeria vary in pharmaceutical quality.展开更多
Recently a lot of medical tablets with special packets in the global market are available. For the safety and purity of the tablet, we need to scan it by developed scanner technology, which should be not more expensiv...Recently a lot of medical tablets with special packets in the global market are available. For the safety and purity of the tablet, we need to scan it by developed scanner technology, which should be not more expensive and easily available in the market. The THz technology is one of them. In the proposed work, we have tasted tablet images with the help of the THz super-resolution scanner, which is already available in our lab. The AI machine learning data concept has been investigated. Good resolution of images has been obtained. Furthermore, the challenging research problems are discussed. Finally, it summarizes the recent updates in terahertz technology for drug inspection and medical applications with potential research challenges.展开更多
文摘Objective: To investigate the pharmaceutical equivalence of ten brands of ibuprofen tablets(400 mg) purchased from pharmacies in Benin City, Nigeria.Methods: The drug samples were subjected to uniformity of weight, crushing strength,friability, melting point, disintegration and dissolution tests following acceptable and official protocols. The ibuprofen content was determined using UV and high performance liquid chromatography method.Results: Crushing strength values of the drug samples ranged between 6 and 16 kp while the disintegration times were between 7.43 and 10.40 min(for uncoated tablets) and3.25–37.32 min(for coated tablets). Friability values were less than 1% and the melting points of recrystallized ibuprofen from the samples ranged from 73.5 to 76.0 C. The amount of ibuprofen released within 1 h ranged between 18% and 102% and two brands failed the content of active ingredient in the UV method of assay while all the brands passed the test using HPLC.Conclusions: Ibuprofen(400 mg) tablets marketed in Benin City, Nigeria vary in pharmaceutical quality.
文摘Recently a lot of medical tablets with special packets in the global market are available. For the safety and purity of the tablet, we need to scan it by developed scanner technology, which should be not more expensive and easily available in the market. The THz technology is one of them. In the proposed work, we have tasted tablet images with the help of the THz super-resolution scanner, which is already available in our lab. The AI machine learning data concept has been investigated. Good resolution of images has been obtained. Furthermore, the challenging research problems are discussed. Finally, it summarizes the recent updates in terahertz technology for drug inspection and medical applications with potential research challenges.
