Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

基于RUN-XGBoost算法的土石坝渗流预测模型

针对传统土石坝渗流预测模型存在局部最优、抗干扰性差和预测精度低等问题,通过RUN算法优化XGBoost算法得到RUN-XGBoost算法,构建了RUN-XGBoost模型以获得更优的土石坝渗流预测结果。该模型在种群初始化时采用RUN算法对XGBoost算法的3个主要参数进行改进,使预测结果有较高的有效性;通过自动寻找最优参数增进算法的整体收敛速度和预测精度,同时引入随机解,使算法能够排除局部最小值并继续搜索,从而获得全局最优结果。工程实例验证结果表明,RUN-XGBoost模型具有简洁、高效、预测精度高、鲁棒性强等优点。

RUN和FYVE结构域蛋白1在胰腺癌中的表达特征及功能作用

目的探究RUN和FYVE结构域蛋白1(RUFY1)在胰腺癌中的表达特征及功能作用。方法通过分析癌症基因组图谱、临床蛋白质组肿瘤分析协作组、基因表达综合数据库等,探究RUFY1在胰腺癌中mRNA、蛋白的表达水平以及与胰腺癌患者预后关系。采用免疫组织化学染色比对胰腺癌患者肿瘤组织与正常胰腺组织中RUFY1蛋白表达水平。在胰腺癌细胞系中敲低RUFY1,并通过肿瘤成球、CCK-8、克隆形成实验验证RUFY1在胰腺癌细胞系中发挥的功能与作用。联合CTRP和PRISM等数据库探究RUFY1与部分抗肿瘤药物敏感性的关系。结果通过分析公共数据库发现,与正常胰腺组织相比,胰腺癌肿瘤组织中RUFY1 mRNA和蛋白表达水平显著升高(P<0.05,P<0.01);RUFY1的高表达与胰腺癌患者的预后呈显著负相关(P<0.05)。免疫组织化学染色结果表明,相较于癌旁组织,RUFY1蛋白表达水平在胰腺癌肿瘤组织中升高。肿瘤成球、CCK-8、克隆形成实验结果显示RUFY1敲低会显著抑制胰腺癌细胞系的增殖功能(P<0.01)。由CTRP和PRISM数据库分析得出,低RUFY1表达的患者对PD318088(P<0.01)、RITA(P<0.01)、selumetinib(P<0.05)、AZD8931(P<0.01)等药物更加敏感。结论RUFY1 mRNA及蛋白水平在胰腺癌肿瘤组织中升高,RUFY1的高表达与胰腺癌患者的预后呈负相关,敲低RUFY1可抑制胰腺癌细胞系的增殖能力,RUFY1有望成为用来预测临床用药治疗敏感性的靶点。

Voluntary wheel running ameliorated the deleterious effects of high-fat diet on glucose metabolism,gut microbiota and microbial-associated metabolites

Exercise training is critical for the early prevention and treatment of obesity and diabetes mellitus.However,the mechanism with gut microbiota and fecal metabolites underlying the effects of voluntary wheel running on high-fat diet induced abnormal glucose metabolism has not been fully elaborated.C57BL/6 male mice were randomly assigned to 4 groups according to diets(fed with normal chow diet or high-fat diet)and running paradigm(housed in static cage or with voluntary running wheel).An integrative 16S rDNA sequencing and metabolites profiling was synchronously performed to characterize the effects of voluntary wheel running on gut microbiota and metabolites.It showed that voluntary wheel running prevented the detrimental effects of high-fat feeding on glucose metabolism 16S rDNA sequencing showed remarkable changes in Rikenella and Marvinbryantia genera.Metabolic profiling indicated multiple altered metabolites,which were enriched in secondary bile acid biosynthesis signaling.In conclusion,our study indicated that voluntary wheel running significantly improved glucose metabolism and counteracted the deleterious effects of high-fat feeding on body weight and glucose intolerance.We further found that voluntary wheel running could integratively program gut microbiota composition and fecal metabolites changes,and may regulate muricholic acid metabolism and secondary bile acid biosynthesis in high-fat fed mice.

Influence of pier height on the safety of trains running on high-speed railway bridges during earthquakes

Sudden earthquakes pose a threat to the running safety of trains on high-speed railway bridges,and the stiffness of piers is one of the factors affecting the dynamic response of train-track-bridge system.In this paper,a experiment of a train running on a high-speed railway bridge is performed based on a dynamic experiment system,and the corresponding numerical model is established.The reliability of the numerical model is verified by experiments.Then,the experiment and numerical data are analyzed to reveal the pier height effects on the running safety of trains on bridges.The results show that when the pier height changes,the frequency of the bridge below the 30 m pier height changes greater;the increase of pier height causes the transverse fundamental frequency of the bridge close to that of the train,and the shaking angle and lateral displacement of the train are the largest for bridge with 50 m pier,which increases the risk of derailment;with the pier height increases from 8 m to 50 m,the derailment coefficient obtained by numerical simulations increases by 75% on average,and the spectral intensity obtained by experiments increases by 120% on average,two indicators exhibit logarithmic variation.

Running safety assessment method of trains under seismic conditions based on the derailment risk domain

The accurate assessment of running safety during earthquakes is of significant importance for ensuring the safety of railway lines.Currently,assessment methods based on a single index suffer from issues such as misjudgment of operational safety and difficulty in evaluating operational margin,making them unsuitable for assessing train safety during earthquakes.Therefore,in order to propose an effective evaluation method for the running safety of trains during earthquakes,this study employs three indexes,namely lateral displacement of the wheel–rail contact point,wheel unloading rate,and wheel lift,to describe the lateral and vertical contact states between the wheel and rail.The corresponding evolution characteristics of the wheel–rail contact states are determined,and the derailment forms under different frequency components of seismic motion are identified through dynamic numerical simulations of the train–track coupled system under sine excitation.The variations in the wheel–rail contact states during the transition from a safe state to the critical state of derailment are analyzed,thereby constructing the evolutionary path of train derailment and seismic derailment risk domain.Lastly,the wheel–rail contact and derailment states under seismic conditions are analyzed,thus verifying the effectiveness of the evaluation method for assessing running safety under earthquakes proposed in this study.The results indicate that the assessment method based on the derailment risk domain accurately and comprehensively reflects the wheel–rail contact states under seismic conditions.It successfully determines the forms of train derailment,the risk levels of derailment,and the evolutionary paths of derailment risk.

Acute effect of foot strike patterns on in vivo tibiotalar and subtalar joint kinematics during barefoot running

Background:Foot kinematics,such as excessive eversion and malalignment of the hindfoot,are believed to be associated with running-related injuries.The maj ority of studies to date show that different foot strike patterns influence these specific foot and ankle kinematics.However,technical deficiencies in traditional motion capture approaches limit knowledge of in vivo joint kinematics with respect to rearfoot and forefoot strike patterns(RFS and FFS,respectively).This study uses a high-speed dual fluoroscopic imaging system(DFIS)to determine the effects of different foot strike patterns on 3D in vivo tibiotalar and subtalar joints kinematics.Methods:Fifteen healthy male recreational runners underwent foot computed tomography scanning for the construction of 3-dimensional models.A high-speed DFIS(100 Hz)was used to collect 6 degrees of freedom kinematics for participants’tibiotalar and subtalar joints when they adopted RFS and FFS in barefoot condition.Results:Compared with RFS,FFS exhibited greater internal rotation at 0%-20%of the stance phase in the tibiotalar joint.The peak internal rotation angle of the tibiotalar joint under FFS was greater than under RFS(p<0.001,Cohen’s d=0.92).RFS showed more dorsiflexion at 0%-20%of the stance phase in the tibiotalar joint than FFS.RFS also presented a larger anterior translation(p<0.001,Cohen’s d=1.28)in the subtalar joint at i nitial contact than FFS.Conclusion:Running with acute barefoot FFS increases the internal rotation of the tibiotalar joint in the early stance.The use of high-speed DFIS to quantify the movement of the tibiotalar and subtalar joint was critical to revealing the effects of RF S and FFS during running.

A novel refined dynamic model of high-speed maglev train-bridge coupled system for random vibration and running safety assessment

Running safety assessment and tracking irregularity parametric sensitivity analysis of high-speed maglev train-bridge system are of great concern,especially need perfect refinement models in which all properties can be well characterized based on various stochastic excitations.A three-dimensional refined spatial random vibration analysis model of high-speed maglev train-bridge coupled system is established in this paper,in which multi-source uncertainty excitation can be considered simultaneously,and the probability density evolution method(PDEM)is adopted to reveal the system-specific uncertainty dynamic characteristic.The motion equation of the maglev vehicle model is composed of multi-rigid bodies with a total 210-degrees of freedom for each vehicle,and a refined electromagnetic force-air gap model is used to account for the interaction and coupling effect between the moving train and track beam bridges,which are directly established by using finite element method.The model is proven to be applicable by comparing with Monte Carlo simulation.By applying the proposed stochastic framework to the high maglev line,the random dynamic responses of maglev vehicles running on the bridges are studied for running safety and stability assessment.Moreover,the effects of track irregularity wavelength range under different amplitude and running speeds on the coupled system are investigated.The results show that the augmentation of train speed will move backward the sensitive wavelength interval,and track irregularity amplitude influences the response remarkably in the sensitive interval.

SmartMicro Grid Energy System Management Based on Optimum Running Cost for Rural Communities in Rwanda

The governmental electric utility and the private sector are joining hands to meet the target of electrifying all households by 2024.However,the aforementioned goal is challenged by households that are scattered in remote areas.So far,Solar Home Systems(SHS)have mostly been applied to increase electricity access in rural areas.SHSs have continuous constraints to meet electricity demands and cannot run income-generating activities.The current research presents the feasibility study of electrifying Remera village with the smart microgrid as a case study.The renewable energy resources available in Remera are the key sources of electricity in that village.The generation capacity is estimated based on the load profile.The microgrid configurations are simulated with HOMER,and the genetic algorithm is used to analyze the optimum cost.By analyzing the impact of operation and maintenance costs,the results show that the absence of subsidies increases the levelized cost of electricity(COE)five times greater than the electricity price from the public utility.The microgrid made up of PV,diesel generator,and batteries proved to be the most viable solution and ensured continuous power supply to customers.By considering the subsidies,COE reaches 0.186$/kWh,a competitive price with electricity from public utilities in Rwanda.

Review of Research on English Translation of Chinese Running Sentences

In order to convey complete meanings,there is a phenomenon in Chinese of using multiple running sentences.Xu Jingning(2023,p.66)states,“In communication,a complete expression of meaning often requires more than one clause,which is common in human languages.”Domestic research on running sentences includes discussions on defining the concept and structural features of running sentences,sentence properties,sentence pattern classifications and their criteria,as well as issues related to translating running sentences into English.This article primarily focuses on scholarly research into the English translation of running sentences in China,highlighting recent achievements and identifying existing issues in the study of running sentence translation.However,by reviewing literature on the translation of running sentences,it is found that current research in the academic community on non-core running sentences is limited.Therefore,this paper proposes relevant strategies to address this issue.

Modified DS np Chart Using Generalized Multiple Dependent State Sampling under Time Truncated Life Test

This study presents the design of a modified attributed control chart based on a double sampling(DS)np chart applied in combination with generalized multiple dependent state(GMDS)sampling to monitor the mean life of the product based on the time truncated life test employing theWeibull distribution.The control chart developed supports the examination of the mean lifespan variation for a particular product in the process of manufacturing.Three control limit levels are used:the warning control limit,inner control limit,and outer control limit.Together,they enhance the capability for variation detection.A genetic algorithm can be used for optimization during the in-control process,whereby the optimal parameters can be established for the proposed control chart.The control chart performance is assessed using the average run length,while the influence of the model parameters upon the control chart solution is assessed via sensitivity analysis based on an orthogonal experimental design withmultiple linear regression.A comparative study was conducted based on the out-of-control average run length,in which the developed control chart offered greater sensitivity in the detection of process shifts while making use of smaller samples on average than is the case for existing control charts.Finally,to exhibit the utility of the developed control chart,this paper presents its application using simulated data with parameters drawn from the real set of data.

Safety of the express freight train running over a long-span bridge

Purpose-Express freight transportation is in rapid development currently.Owing to the higher speed of express freight train,the deformation of the bridge deck worsens the railway line condition under the action of wind and train moving load when the train runs over a long-span bridge.Besides,the blunt car body of vehicle has poor aerodynamic characteristics,bringing a greater challenge on the running stability in the crosswind.Design/methodology/approach-In this study,the aerodynamic force coefficients of express freight vehicles on the bridge are measured by scale model wind tunnel test.The dynamic model of the train-long-span steel truss bridge coupling system is established,and the dynamic response as well as the running safety of vehicle are evaluated.Findings-The results show that wind speed has a significant influence on running safety,which is mainly reflected in the over-limitation of wheel unloading rate.The wind speed limit decreases with train speed,and it reduces to 18.83 m/s when the train speed is 160 km/h.Originality/value-This study deepens the theoretical understanding of the interaction between vehicles and bridges and proposes new methods for analyzing similar engineering problems.It also provides a new theoretical basis for the safety assessment of express freight trains.

汽车零部件Milk-run业务公铁联运模式下的铁路货运站选址研究

能否精准科学地选择汽车零部件循环取货(Milk-run)业务中公铁联运模式的铁路货运站,将直接影响物流总成本。随着公铁联运模式在节能减排与降本增效中的优势逐渐呈现,汽车生产商也开始在零部件物流领域探索Milk-run业务采用公铁联运方式。基于以往研究基础,对汽车零部件Milk-run业务中采用公铁联运的背景进行分析,以重庆长安福特汽车有限公司华东片区的Milk-run业务为例,构建基于公铁联运的Milk-run物流运作模式,发现在运作过程中需要确定Milk-run业务中的铁路货运站地址。为精确、合理地进行选址,采用定量与定性相结合的方法,运用精确重心法计算出铁路货运站备选地址范围,再利用综合指标评级法在备选地址中确定地址,最终通过优化选址,提高企业Milk-run业务中物流的运作效率。

基于Milk Run模式的库存运输整合优化

为解决库存与运输的效益背反性,建立了基于Milk Run取货模式的汽车零部件库存运输整合优化的双层规划模型。通过上下层的博弈关系研究库存与运输,逐步平衡二者的效益背反关系,达到整个取货物流网络的最优化。根据模型的特点设计了分层迭代算法,通过数值仿真验证了模型的实用价值和有效性。

外语教学中的非词语化现象研究——以常用词gain,run为例

非词语化是大部分常用词汇的主要意义趋向和行为特征,是搭配词之间在使用中意义共享的必然结果。本文基于语料库,以常用词gain,run为例,研究外语教学中的非词语化现象及其对词汇产出的影响,发现常用词的非词语化用法是词汇意义变化的趋势,但也是中国英语学习者的难点所在。非词语化用法普遍存在难以产出的现象。

火电机组RUN BACK试验的研究

介绍了RUN BACK试验的内容、方法、步骤和综合评价,并重点探讨了RUN BACK试验方案的选择和参数设置的优化。

归来庄金矿矿体和岩体中Au等成分的Runs检验及意义

Runs检验是研究序列分布规律的一种数学方法。用这种方法检验归来庄金矿和铜石杂岩体的某些成分,得出归来庄金矿TC30中Au的高品位值的出现不是随机的,而是具有集中出现的规律性;铜石杂岩体中SiO2和Au都是具有随机变化性,说明杂岩体没有明显的演化关系,不同岩体的形成时间先后对成矿元素Au的富集没有明显影响;杂岩体中Al2O3和TiO2比值在闪长玢岩和二长斑岩中无明显差异,说明二者为同源成因。

汉英“跑+名/run+n.”搭配的对比研究

本文基于一定数量的实际语料,从分析语义成分入手,对比分析汉英"跑+名/run+n."搭配的异同。研究发现:无论是基本义还是隐喻义用法,"跑+名/run+n."搭配差异都很明显,异远大于同。"跑+名"的语义组合是"受事/承受对象、结果、时间、方式和处所";run+n.的语义组合没有"方式",只有run复合体才接处所名词,其他跟汉语有相同的语义成分。在分析搭配差异原因的同时,本文还指出探讨英汉词汇搭配差异对英语教学有启示作用。

Tactical planning and optimization of a milk run system of parts pickup for an engine manufacturer

A real-life milk run system designing problem of an engine manufacturer adopted JIT(just-in-time)production is studied.In the process of milk run system planning and design,the supply base is identified and a supplier site map is plotted for an arrangement of routes on which parts are periodically collected in a JIT manner from many scattered suppliers.With unit load designing,vehicle choosing and fleet sizing,pickup routing,vehicle assigning and scheduling problems are studied.Among these problems,a CVRP problem is identified and formulated as the key optimization in designing this milk run system,and it is solved through an optimization process.This tactical planning and optimization process gives a good solution to the real problem,and may shed light on the planning of similar systems.

RuH和RuN分子及其分子离子的基态结构与性质

在Ru原子相对论有效原子实势和LanL2DZ基函数近似下,使用密度泛函理论B3LYP方法和H、N原子6-311G**基函数分别对RuH、RuN分子与RuH+、RuN+分子离子进行几何优化,得到基态电子状态分别为X4、X2、X3和X1,基态势能函数可用Murrell-Sorb ie函数表达,并计算得到相应的力常数与光谱数据以及RuH、RuN分子的垂直电离势.