Using Majorana representation of symmetric N-qubit pure states, we have examined the monogamous nature of the family of states with two-distinct spinors, the W class of states. We have evaluated the N-concurrence tang...Using Majorana representation of symmetric N-qubit pure states, we have examined the monogamous nature of the family of states with two-distinct spinors, the W class of states. We have evaluated the N-concurrence tangle and showed that all the states in this family have vanishing concurrence tangle. The negativity tangle for the W class of states is shown to be non-zero, illustrating the fact that the concurrence tangle is always lesser than or equal to the negativity tangle in a pure N-qubit state.展开更多
As a key contributor to memory storage, the synapse is one of the earliest affected neuronal components in Alzheimer's disease (AD). Under physiological conditions, the synaptic con- nections between neurons underg...As a key contributor to memory storage, the synapse is one of the earliest affected neuronal components in Alzheimer's disease (AD). Under physiological conditions, the synaptic con- nections between neurons undergo activity-dependent func- tional and morphological re-organisation. This dynamic, 'plastic' neural ability critically depends on the structural integrity of the synapse. Thus, proteins that are implicated in preserving the organisation and dynamics of synaptic connections, including microtubules of the cytoskeleton and associated proteins, have attracted much focus for their involvement in the malfunction- ing AD synapse.展开更多
In this article , we report 139 autopsy cases of medical tangle , which were examined by the Department of Forensic Pathology, Faculty of Medicine, Tongji Medical University from Jan. 1972 to Dec. 1992.The emphasis is...In this article , we report 139 autopsy cases of medical tangle , which were examined by the Department of Forensic Pathology, Faculty of Medicine, Tongji Medical University from Jan. 1972 to Dec. 1992.The emphasis is put on analyses of the status of medical tangle autopsy in forensic pathology, involved medical departments , distribution of victim's age and sex , differences between clinical diagnosis and autoptical conclusion, the composition and causes of medical tangle. The associated problems in forensic pathological autopsy are also discussed.展开更多
The concept of linear tangle was introduced as an obstruction to mixed searching number. The concept of (maximal) single ideal has been introduced as an obstruction to linear-width. Moreover, it was already known that...The concept of linear tangle was introduced as an obstruction to mixed searching number. The concept of (maximal) single ideal has been introduced as an obstruction to linear-width. Moreover, it was already known that mixed search number is equivalent to linear-width. Hence, by combining those results, we obtain a proof of the equivalence between linear tangle and maximal single ideal. This short report gives an alternative proof of the equivalence.展开更多
We evaluate the monogamy inequality for symmetric, non-symmetric pure states of importance in terms of squared concurrence, squared entanglement of formation, squared negativity of partial transpose and compare the co...We evaluate the monogamy inequality for symmetric, non-symmetric pure states of importance in terms of squared concurrence, squared entanglement of formation, squared negativity of partial transpose and compare the corresponding tangles. We show that though concurrence and concurrence tangle are zero for two special classes of mixed entangled states, both negativity tangle and entanglement of formation(EOF) tangle turn out to be non-zero. A comparison of different tangles is carried out in each case and it is shown that while the concurrence tangle captures the genuine multiqubit entanglement in N-qubit pure states with N distinct spinors(containing GHZ and superposition of W-, obverse W states)either negativity tangle or EOF tangle is to be used as a better measure of entanglement in the W-class of states with two distinct spinors and in the special classes of mixed multiqubit states.展开更多
WHEN a mutinous band of the Democratic Republic of the Congo (DRC) military precipitated the latest eruption of war in June, it was hardly surprising given the fragile situation in Africa's second largest and natur...WHEN a mutinous band of the Democratic Republic of the Congo (DRC) military precipitated the latest eruption of war in June, it was hardly surprising given the fragile situation in Africa's second largest and natural resources endowed country. DRC has not known a continuous period of peace and tranquility since the mid-1990s.展开更多
In this paper,we present a categorical version of the first and second fundamental theorems of the invariant theory for the quantized symplectic groups.Our methods depend on the theory of braided strict monoidal categ...In this paper,we present a categorical version of the first and second fundamental theorems of the invariant theory for the quantized symplectic groups.Our methods depend on the theory of braided strict monoidal categories which are pivotal,more explicitly,the diagram category of framed tangles.展开更多
In view of the fact that current data delivery methods are not enough to meet the security requirements of today’s distributed crowd sensing,and the data delivery methods are not flexible enough,this paper proposes a...In view of the fact that current data delivery methods are not enough to meet the security requirements of today’s distributed crowd sensing,and the data delivery methods are not flexible enough,this paper proposes a crowd sensing data interaction method based on tangle directed acyclic graph(DAG)network.In this method,users and platforms are regarded as nodes of the network in the process of performing crowd sensing tasks.First,the heaviest chain is generated through the main chain strategy to ensure the stability of the network.Then,the hidden Markov model(HMM)prediction model is used to improve the correlation of the perceived data to improve the performance.Then,the confidential transaction and commitment algorithm is used to ensure the reliability of the transaction,overcome the security risks faced by the trusted third party,and simplify the group intelligence aware transaction mode.Finally,through simulation experiments,the security and feasibility of the group intelligence aware data delivery method based on tangle DAG network are verified.展开更多
Declining recognition of top university lists prompts China to look for new ways to evaluate its higher learning institutions Zhejiang University for the first time has overtaken Peking University and Tsinghua Univers...Declining recognition of top university lists prompts China to look for new ways to evaluate its higher learning institutions Zhejiang University for the first time has overtaken Peking University and Tsinghua University to rank No.1 on the latest list of Chinese college rankings.The rankings are an important part of the book Picking Your University展开更多
Syria’s ties to Russia and Iran make Western intervention unlikely After the fall of Muammar Gaddafi in Libya,Syria appeared to be the next target of Western powers.They have declared sanctions against Syria and publ...Syria’s ties to Russia and Iran make Western intervention unlikely After the fall of Muammar Gaddafi in Libya,Syria appeared to be the next target of Western powers.They have declared sanctions against Syria and publicly demanded Syrian President Bashar al-Assad step down.This Middle Eastern country now展开更多
How does it feel,to be sitting at a Bob Dylan concert in Beijing?I had to keep asking myself that question when the living legend sauntered on to the stage at the Beijing Worker’s Gymnasium.The troubadour who blew in...How does it feel,to be sitting at a Bob Dylan concert in Beijing?I had to keep asking myself that question when the living legend sauntered on to the stage at the Beijing Worker’s Gymnasium.The troubadour who blew in the wind like the pied piper all those years ago and has managed to roll展开更多
The Mao-era public radio speakers are disappearing from China’s villages,but not everyone is happy中国农村的“大喇叭”广播曾给一代人留下了难忘的记忆,而现在它正离我们远去Wake up at 7 a.m.in rural China and you’ll lik...The Mao-era public radio speakers are disappearing from China’s villages,but not everyone is happy中国农村的“大喇叭”广播曾给一代人留下了难忘的记忆,而现在它正离我们远去Wake up at 7 a.m.in rural China and you’ll likely hear the melodic strains of a love song,a popular talk show,or the local news wafting from an old speaker strung up on a telephone pole in the largest public space in the village.展开更多
Alzheimer's disease is characterized by two major neuropathological hallmarks—the extracellularβ-amyloid plaques and intracellular neurofibrillary tangles consisting of aggregated and hyperphosphorylated Tau pro...Alzheimer's disease is characterized by two major neuropathological hallmarks—the extracellularβ-amyloid plaques and intracellular neurofibrillary tangles consisting of aggregated and hyperphosphorylated Tau protein.Recent studies suggest that dysregulation of the microtubuleassociated protein Tau,especially specific proteolysis,could be a driving force for Alzheimer's disease neurodegeneration.Tau physiologically promotes the assembly and stabilization of microtubules,whereas specific truncated fragments are sufficient to induce abnormal hyperphosphorylation and aggregate into toxic oligomers,resulting in them gaining prion-like characteristics.In addition,Tau truncations cause extensive impairments to neural and glial cell functions and animal cognition and behavior in a fragment-dependent manner.This review summarizes over 60 proteolytic cleavage sites and their corresponding truncated fragments,investigates the role of specific truncations in physiological and pathological states of Alzheimer's disease,and summarizes the latest applications of strategies targeting Tau fragments in the diagnosis and treatment of Alzheimer's disease.展开更多
Wireless Sensor Network(WSN)is a distributed sensor network composed a large number of nodes with low cost,low performance and self-management.The special structure of WSN brings both convenience and vulnerability.For...Wireless Sensor Network(WSN)is a distributed sensor network composed a large number of nodes with low cost,low performance and self-management.The special structure of WSN brings both convenience and vulnerability.For example,a malicious participant can launch attacks by capturing a physical device.Therefore,node authentication that can resist malicious attacks is very important to network security.Recently,blockchain technology has shown the potential to enhance the security of the Internet of Things(IoT).In this paper,we propose a Blockchain-empowered Authentication Scheme(BAS)for WSN.In our scheme,all nodes are managed by utilizing the identity information stored on the blockchain.Besides,the simulation experiment about worm detection is executed on BAS,and the security is evaluated from detection and infection rate.The experiment results indicate that the proposed scheme can effectively inhibit the spread and infection of worms in the network.展开更多
All retinoids, which can be natural and synthetic, are chemically related to vitamin A. Both natural and synthetic retinoids use specific nuclear receptors such as retinoic acid receptors and retinoid X receptors to a...All retinoids, which can be natural and synthetic, are chemically related to vitamin A. Both natural and synthetic retinoids use specific nuclear receptors such as retinoic acid receptors and retinoid X receptors to activate specific signaling pathways in the cells. Retinoic acid signaling is extremely important in the central nervous system. Impairment of retinoic acid signaling pathways causes severe pathological processes in the central nervous system, especially in the adult brain. Retinoids have major roles in neural patterning, differentiation, axon outgrowth in normal development, and function of the brain. Impaired retinoic acid signaling results in neuroinflammation, oxidative stress, mitochondrial malfunction, and neurodegeneration leading to progressive Alzheimer’s disease, which is pathologically characterized by extra-neuronal accumulation of amyloid plaques(aggregated amyloid-beta) and intra-neurofibrillary tangles(hyperphosphorylated tau protein) in the temporal lobe of the brain. Alzheimer’s disease is the most common cause of dementia and loss of memory in old adults. Inactive cholinergic neurotransmission is responsible for cognitive deficits in Alzheimer’s disease patients. Deficiency or deprivation of retinoic acid in mice is associated with loss of spatial learning and memory. Retinoids inhibit expression of chemokines and neuroinflammatory cytokines in microglia and astrocytes, which are activated in Alzheimer’s disease. Stimulation of retinoic acid receptors and retinoid X receptors slows down accumulation of amyloids, reduces neurodegeneration, and thereby prevents pathogenesis of Alzheimer’s disease in mice. In this review, we described chemistry and biochemistry of some natural and synthetic retinoids and potentials of retinoids for prevention of neuroinflammation and neurodegeneration in Alzheimer’s disease.展开更多
基金supported by Department of Science and Technology,Government of India through the award of INSPIRE fellowship
文摘Using Majorana representation of symmetric N-qubit pure states, we have examined the monogamous nature of the family of states with two-distinct spinors, the W class of states. We have evaluated the N-concurrence tangle and showed that all the states in this family have vanishing concurrence tangle. The negativity tangle for the W class of states is shown to be non-zero, illustrating the fact that the concurrence tangle is always lesser than or equal to the negativity tangle in a pure N-qubit state.
基金supported by grant SDU2020 to Prof.Bente Finsen and Prof.Martin R.Larsen(COPING AD–Collaborative Project on the Interaction between Neurons and Glia in Alzheimer’s Disease)
文摘As a key contributor to memory storage, the synapse is one of the earliest affected neuronal components in Alzheimer's disease (AD). Under physiological conditions, the synaptic con- nections between neurons undergo activity-dependent func- tional and morphological re-organisation. This dynamic, 'plastic' neural ability critically depends on the structural integrity of the synapse. Thus, proteins that are implicated in preserving the organisation and dynamics of synaptic connections, including microtubules of the cytoskeleton and associated proteins, have attracted much focus for their involvement in the malfunction- ing AD synapse.
文摘In this article , we report 139 autopsy cases of medical tangle , which were examined by the Department of Forensic Pathology, Faculty of Medicine, Tongji Medical University from Jan. 1972 to Dec. 1992.The emphasis is put on analyses of the status of medical tangle autopsy in forensic pathology, involved medical departments , distribution of victim's age and sex , differences between clinical diagnosis and autoptical conclusion, the composition and causes of medical tangle. The associated problems in forensic pathological autopsy are also discussed.
文摘The concept of linear tangle was introduced as an obstruction to mixed searching number. The concept of (maximal) single ideal has been introduced as an obstruction to linear-width. Moreover, it was already known that mixed search number is equivalent to linear-width. Hence, by combining those results, we obtain a proof of the equivalence between linear tangle and maximal single ideal. This short report gives an alternative proof of the equivalence.
基金support of the Department of Science and Technology (DST),Govt.of India through the award of the INSPIRE fellowship
文摘We evaluate the monogamy inequality for symmetric, non-symmetric pure states of importance in terms of squared concurrence, squared entanglement of formation, squared negativity of partial transpose and compare the corresponding tangles. We show that though concurrence and concurrence tangle are zero for two special classes of mixed entangled states, both negativity tangle and entanglement of formation(EOF) tangle turn out to be non-zero. A comparison of different tangles is carried out in each case and it is shown that while the concurrence tangle captures the genuine multiqubit entanglement in N-qubit pure states with N distinct spinors(containing GHZ and superposition of W-, obverse W states)either negativity tangle or EOF tangle is to be used as a better measure of entanglement in the W-class of states with two distinct spinors and in the special classes of mixed multiqubit states.
文摘WHEN a mutinous band of the Democratic Republic of the Congo (DRC) military precipitated the latest eruption of war in June, it was hardly surprising given the fragile situation in Africa's second largest and natural resources endowed country. DRC has not known a continuous period of peace and tranquility since the mid-1990s.
基金supported by National Natural Science Foundation of China(Grant No.11301195)China Scholarship Council and a research foundation of Huaqiao University(Grant No.2014KJTD14)。
文摘In this paper,we present a categorical version of the first and second fundamental theorems of the invariant theory for the quantized symplectic groups.Our methods depend on the theory of braided strict monoidal categories which are pivotal,more explicitly,the diagram category of framed tangles.
文摘In view of the fact that current data delivery methods are not enough to meet the security requirements of today’s distributed crowd sensing,and the data delivery methods are not flexible enough,this paper proposes a crowd sensing data interaction method based on tangle directed acyclic graph(DAG)network.In this method,users and platforms are regarded as nodes of the network in the process of performing crowd sensing tasks.First,the heaviest chain is generated through the main chain strategy to ensure the stability of the network.Then,the hidden Markov model(HMM)prediction model is used to improve the correlation of the perceived data to improve the performance.Then,the confidential transaction and commitment algorithm is used to ensure the reliability of the transaction,overcome the security risks faced by the trusted third party,and simplify the group intelligence aware transaction mode.Finally,through simulation experiments,the security and feasibility of the group intelligence aware data delivery method based on tangle DAG network are verified.
文摘Declining recognition of top university lists prompts China to look for new ways to evaluate its higher learning institutions Zhejiang University for the first time has overtaken Peking University and Tsinghua University to rank No.1 on the latest list of Chinese college rankings.The rankings are an important part of the book Picking Your University
文摘Syria’s ties to Russia and Iran make Western intervention unlikely After the fall of Muammar Gaddafi in Libya,Syria appeared to be the next target of Western powers.They have declared sanctions against Syria and publicly demanded Syrian President Bashar al-Assad step down.This Middle Eastern country now
文摘How does it feel,to be sitting at a Bob Dylan concert in Beijing?I had to keep asking myself that question when the living legend sauntered on to the stage at the Beijing Worker’s Gymnasium.The troubadour who blew in the wind like the pied piper all those years ago and has managed to roll
文摘The Mao-era public radio speakers are disappearing from China’s villages,but not everyone is happy中国农村的“大喇叭”广播曾给一代人留下了难忘的记忆,而现在它正离我们远去Wake up at 7 a.m.in rural China and you’ll likely hear the melodic strains of a love song,a popular talk show,or the local news wafting from an old speaker strung up on a telephone pole in the largest public space in the village.
基金supported by the Neural Regeneration Co-innovation Center of Jiangsu Province,Nantong University(to DC)the National Natural Science Foundation of China,Nos.81872853(to DC),81870941(to JHG)the Science and Technology Project of Nantong City,Nos.JC22022022(to FW)and JC2021059(to JM)。
文摘Alzheimer's disease is characterized by two major neuropathological hallmarks—the extracellularβ-amyloid plaques and intracellular neurofibrillary tangles consisting of aggregated and hyperphosphorylated Tau protein.Recent studies suggest that dysregulation of the microtubuleassociated protein Tau,especially specific proteolysis,could be a driving force for Alzheimer's disease neurodegeneration.Tau physiologically promotes the assembly and stabilization of microtubules,whereas specific truncated fragments are sufficient to induce abnormal hyperphosphorylation and aggregate into toxic oligomers,resulting in them gaining prion-like characteristics.In addition,Tau truncations cause extensive impairments to neural and glial cell functions and animal cognition and behavior in a fragment-dependent manner.This review summarizes over 60 proteolytic cleavage sites and their corresponding truncated fragments,investigates the role of specific truncations in physiological and pathological states of Alzheimer's disease,and summarizes the latest applications of strategies targeting Tau fragments in the diagnosis and treatment of Alzheimer's disease.
基金supported by the Natural Science Foundation under Grant No.61962009Major Scientific and Technological Special Project of Guizhou Province under Grant No.20183001Foundation of Guizhou Provincial Key Laboratory of Public Big Data under Grant No.2018BDKFJJ003,2018BDKFJJ005 and 2019BDKFJJ009.
文摘Wireless Sensor Network(WSN)is a distributed sensor network composed a large number of nodes with low cost,low performance and self-management.The special structure of WSN brings both convenience and vulnerability.For example,a malicious participant can launch attacks by capturing a physical device.Therefore,node authentication that can resist malicious attacks is very important to network security.Recently,blockchain technology has shown the potential to enhance the security of the Internet of Things(IoT).In this paper,we propose a Blockchain-empowered Authentication Scheme(BAS)for WSN.In our scheme,all nodes are managed by utilizing the identity information stored on the blockchain.Besides,the simulation experiment about worm detection is executed on BAS,and the security is evaluated from detection and infection rate.The experiment results indicate that the proposed scheme can effectively inhibit the spread and infection of worms in the network.
基金supported in part by an award from the Soy Health Research Program(SHRP,United Soybean Board,Chesterfield,MO,USA)(to SKR)a grant(SCIRF-2015-I-01) from South Carolina Spinal Cord Injury Research Fund(Columbia,SC,USA)(to SKR)earlier R01 grants(CA-091460,and NS-057811)(to SKR) from the National Institutes of Health(Bethesda,MD,USA)
文摘All retinoids, which can be natural and synthetic, are chemically related to vitamin A. Both natural and synthetic retinoids use specific nuclear receptors such as retinoic acid receptors and retinoid X receptors to activate specific signaling pathways in the cells. Retinoic acid signaling is extremely important in the central nervous system. Impairment of retinoic acid signaling pathways causes severe pathological processes in the central nervous system, especially in the adult brain. Retinoids have major roles in neural patterning, differentiation, axon outgrowth in normal development, and function of the brain. Impaired retinoic acid signaling results in neuroinflammation, oxidative stress, mitochondrial malfunction, and neurodegeneration leading to progressive Alzheimer’s disease, which is pathologically characterized by extra-neuronal accumulation of amyloid plaques(aggregated amyloid-beta) and intra-neurofibrillary tangles(hyperphosphorylated tau protein) in the temporal lobe of the brain. Alzheimer’s disease is the most common cause of dementia and loss of memory in old adults. Inactive cholinergic neurotransmission is responsible for cognitive deficits in Alzheimer’s disease patients. Deficiency or deprivation of retinoic acid in mice is associated with loss of spatial learning and memory. Retinoids inhibit expression of chemokines and neuroinflammatory cytokines in microglia and astrocytes, which are activated in Alzheimer’s disease. Stimulation of retinoic acid receptors and retinoid X receptors slows down accumulation of amyloids, reduces neurodegeneration, and thereby prevents pathogenesis of Alzheimer’s disease in mice. In this review, we described chemistry and biochemistry of some natural and synthetic retinoids and potentials of retinoids for prevention of neuroinflammation and neurodegeneration in Alzheimer’s disease.