BACKGROUND Many studies have addressed safety and effectiveness of non-anaesthesiologist propofol sedation(NAPS)for gastrointestinal(GI)endoscopy Target controlled infusion(TCI)is claimed to provide an optimal sedatio...BACKGROUND Many studies have addressed safety and effectiveness of non-anaesthesiologist propofol sedation(NAPS)for gastrointestinal(GI)endoscopy Target controlled infusion(TCI)is claimed to provide an optimal sedation regimen by avoiding under-or oversedation.AIM To assess safety and performance of propofol TCI sedation in comparison with nurse-administered bolus-sedation.METHODS Fouty-five patients undergoing endoscopy under TCI propofol sedation were prospectively included from November 2016 to May 2017 and compared to 87 patients retrospectively included that underwent endoscopy with NAPS.Patients were matched for age and endoscopic procedure.We recorded time of sedation and endoscopy,dosage of medication and adverse events.RESULTS There was a significant reduction in dose per time of propofol administered in the TCI group,compared to the NAPS group(8.2±2.7 mg/min vs 9.3±3.4 mg/min;P=0.046).The time needed to provide adequate sedation levels was slightly but significantly lower in the control group(5.3±2.7 min vs 7.7±3.3 min;P<0.001),nonetheless the total endoscopy time was similar in both groups.No differences between TCI and bolus-sedation was observed for mean total-dosage of propofol rate as well as adverse events.CONCLUSION This study indicates that sedation using TCI for GI endoscopy reduces the dose of propofol necessary per minute of endoscopy.This may translate into less adverse events.However,further and randomized trials need to confirm this trend.展开更多
Nanoparticles conjugated with antibody were designed as active drug delivery system to reduce the toxicity and side effects of drugs for acute myeloid leukemia(AML).Moreover,methotrexate(MTX)was chosen as modeldru...Nanoparticles conjugated with antibody were designed as active drug delivery system to reduce the toxicity and side effects of drugs for acute myeloid leukemia(AML).Moreover,methotrexate(MTX)was chosen as modeldrug and encapsulate within folic acid modified carboxymethylchitosan(FACMCS)nanoparticles through self-assembling.The chemicalstructure,morphology,release and targeting of nanoparticles were characterized by routine detection.It is demonstrated that the mean diameter is about 150 nm,the release rate increases with the decreasing of p H,the binding rate of CD33 antibody and FA-CMCS nanoparticles is about 5:2,and nanoparticles can effectively bind onto HL60 cells in vitro.The experimentalresults indicate that the FA-CMCS nanoparticles conjugated with antibody may be used as a potentialp Hsensitive drug delivery system with leukemic targeting properties.展开更多
Microbubbles can enhance the detection in noninvasive ultrasound imaging.Recently,targeted microbubbles have been developed to selectively adhere to specific and overexpressed p molecules in endothelial cells in some ...Microbubbles can enhance the detection in noninvasive ultrasound imaging.Recently,targeted microbubbles have been developed to selectively adhere to specific and overexpressed p molecules in endothelial cells in some pathologic conditions.However,the law of展开更多
Focusing on the three-dimensional guidance problem in case of target maneuvers and response delay of the autopilot, the missile guidance law utilizing active disturbance rejection control (ADRC) is proposed. Based o...Focusing on the three-dimensional guidance problem in case of target maneuvers and response delay of the autopilot, the missile guidance law utilizing active disturbance rejection control (ADRC) is proposed. Based on the nonlinear three-dimensional missile target engagement kinematics, the guidance model is es- tablished, The target acceleration is treated as a disturbance and the dynamics of the autopilot is considered by using a first-order model. A nonlinear continuous robust guidance law is designed by using a cascaded structure ADRC controller. In this method the disturbance is estimated by using the extended state observer (ESO) and compensated during each sampling period. Simulation results show that the proposed cascaded loop structure is a viable solution to the guidance law design and has strong robustness with respect to target maneuvers and response delay of the autopilot.展开更多
This article presents an equivalence theorem for three different kinds of optimal control problems, which are optimal target control problems, optimal norm control problems, and optimal time control problems. Controll...This article presents an equivalence theorem for three different kinds of optimal control problems, which are optimal target control problems, optimal norm control problems, and optimal time control problems. Controlled systems in this study are internally controlled Stokes equations.展开更多
In this research, the result of the cloud seeding over Yazd province during three months of February, March and April in 1999 has been evaluated using the historical regression method. Hereupon, the rain-gages in Yazd...In this research, the result of the cloud seeding over Yazd province during three months of February, March and April in 1999 has been evaluated using the historical regression method. Hereupon, the rain-gages in Yazd province as the target stations and the rain-gages of the neighboring provinces as the control stations have been selected. The rainfall averages for the three aforementioned months through 25 years (1973-1997) in all control and target stations have been calculated. In the next step, the correlations between the rainfalls of control and target stations have been estimated about 75%, which indicates a good consistency in order to use the historical regression. Then, through the obtained liner correlation equation between the control and target stations the precipitation amount for February, March and April in 1999, over the target region (Yazd province) was estimated about 27.57 mm, whiles the observed amount was 34.23 mm. In fact the precipitation increasing around 19.5% over Yazd province confirmed the success of this cloud seeding project.展开更多
Projection models are commonly used to evaluate the impacts of fishing.However,previously developed projection tools were not suitable for China’s fisheries as they are either overly complex and data-demanding or too...Projection models are commonly used to evaluate the impacts of fishing.However,previously developed projection tools were not suitable for China’s fisheries as they are either overly complex and data-demanding or too simple to reflect the realistic management measures.Herein,an intermediate-complexity projection model was developed that could adequately describe fish population dynamics and account for management measures including mesh size limits,summer closure,and spatial closure.A two-patch operating model was outlined for the projection model and applied to the heavily depleted but commercially important small yellow croaker(Larimichthys polyactis)fishery in the Haizhou Bay,China,as a case study.The model was calibrated to realistically capture the fisheries dynamics with hindcasting.Three simulation scenarios featuring different fishing intensities based on status quo and maximum sustainable yield(MSY)were proposed and evaluated with projections.Stochastic projections were additionally performed to investigate the influence of uncertainty associated with recruitment strengths and the implementation of control targets.It was found that fishing at FMSY level could effectively rebuild the depleted stock biomass,while the stock collapsed rapidly in the status quo scenario.Uncertainty in recruitment and implementation could result in variabilities in management effects;but they did not much alter the management effects of the FMSY scenario.These results indicate that the lack of science-based control targets in fishing mortality or catch limits has hindered the achievement of sustainable fisheries in China.Overall,the presented work highlights that the developed projection model can promote the understanding of the possible consequences of fishing under uncertainty and is applicable to other fisheries in China.展开更多
Mythimna separata is a notorious phytophagous pest which poses serious threats to cereal crops owing to the gluttony of the larvae.Because short neuropeptide F(sNPF)and its receptor sNPFR are involved in a diversity o...Mythimna separata is a notorious phytophagous pest which poses serious threats to cereal crops owing to the gluttony of the larvae.Because short neuropeptide F(sNPF)and its receptor sNPFR are involved in a diversity of physiological functions,especially in functions related to feeding in insects,it is a molecular target for pest control.Herein,an sNPF and 2 sNPFRs were identified and cloned from M.separata.Bioinformatics analysis revealed that the sNPF and its receptors had a highly conserved RLRFamide C-terminus and 7 transmembrane domains,respectively.The sNPF and its receptor genes were distributed across larval periods and tissues,but 2 receptors had distinct expression patterns.The starvation-induced assay elucidated that sNPF and sNPFR expression levels were downregulated under food deprivation and recovered with subsequent re-feeding.RNA interference knockdown of sNPF,sNPFR1,and sNPFR2 by injection of double-stranded RNA into larvae not only suppressed food consumption and increased body size and weight,but also led to decrease of glycogen and total lipid contents,and increase of trehalose compared with double-stranded green fluorescent protein injection.Furthermore,molecular docking was performed on the interaction mode between sNPFR protein and its ligand sNPF based on the 3-dimensional models constructed by AlphaFold;the results indicated that both receptors were presumably activated by the mature peptide sNPF-2.These results revealed that sNPF signaling played a considerably vital role in the feeding regulation of M.separata and represents a potential control target for this pest.展开更多
Chemosensors and imaging probes have been the focus of significant research interest over the past few decades.In part due to ease of preparation and simplicity in manipulation,fluorescent probes have been extensively...Chemosensors and imaging probes have been the focus of significant research interest over the past few decades.In part due to ease of preparation and simplicity in manipulation,fluorescent probes have been extensively used for biomedical applications.When used for in vitro cell imaging[1,2]。展开更多
文摘BACKGROUND Many studies have addressed safety and effectiveness of non-anaesthesiologist propofol sedation(NAPS)for gastrointestinal(GI)endoscopy Target controlled infusion(TCI)is claimed to provide an optimal sedation regimen by avoiding under-or oversedation.AIM To assess safety and performance of propofol TCI sedation in comparison with nurse-administered bolus-sedation.METHODS Fouty-five patients undergoing endoscopy under TCI propofol sedation were prospectively included from November 2016 to May 2017 and compared to 87 patients retrospectively included that underwent endoscopy with NAPS.Patients were matched for age and endoscopic procedure.We recorded time of sedation and endoscopy,dosage of medication and adverse events.RESULTS There was a significant reduction in dose per time of propofol administered in the TCI group,compared to the NAPS group(8.2±2.7 mg/min vs 9.3±3.4 mg/min;P=0.046).The time needed to provide adequate sedation levels was slightly but significantly lower in the control group(5.3±2.7 min vs 7.7±3.3 min;P<0.001),nonetheless the total endoscopy time was similar in both groups.No differences between TCI and bolus-sedation was observed for mean total-dosage of propofol rate as well as adverse events.CONCLUSION This study indicates that sedation using TCI for GI endoscopy reduces the dose of propofol necessary per minute of endoscopy.This may translate into less adverse events.However,further and randomized trials need to confirm this trend.
基金Funded by the National Natural Science Foundation of China(No.50973088)
文摘Nanoparticles conjugated with antibody were designed as active drug delivery system to reduce the toxicity and side effects of drugs for acute myeloid leukemia(AML).Moreover,methotrexate(MTX)was chosen as modeldrug and encapsulate within folic acid modified carboxymethylchitosan(FACMCS)nanoparticles through self-assembling.The chemicalstructure,morphology,release and targeting of nanoparticles were characterized by routine detection.It is demonstrated that the mean diameter is about 150 nm,the release rate increases with the decreasing of p H,the binding rate of CD33 antibody and FA-CMCS nanoparticles is about 5:2,and nanoparticles can effectively bind onto HL60 cells in vitro.The experimentalresults indicate that the FA-CMCS nanoparticles conjugated with antibody may be used as a potentialp Hsensitive drug delivery system with leukemic targeting properties.
基金supported by National Natural Science Foundation of China,No.30700151
文摘Microbubbles can enhance the detection in noninvasive ultrasound imaging.Recently,targeted microbubbles have been developed to selectively adhere to specific and overexpressed p molecules in endothelial cells in some pathologic conditions.However,the law of
基金supported by the Aviation Science Foundation(2013ZC12004)
文摘Focusing on the three-dimensional guidance problem in case of target maneuvers and response delay of the autopilot, the missile guidance law utilizing active disturbance rejection control (ADRC) is proposed. Based on the nonlinear three-dimensional missile target engagement kinematics, the guidance model is es- tablished, The target acceleration is treated as a disturbance and the dynamics of the autopilot is considered by using a first-order model. A nonlinear continuous robust guidance law is designed by using a cascaded structure ADRC controller. In this method the disturbance is estimated by using the extended state observer (ESO) and compensated during each sampling period. Simulation results show that the proposed cascaded loop structure is a viable solution to the guidance law design and has strong robustness with respect to target maneuvers and response delay of the autopilot.
基金partially supported by the National Natural Science Foundation of China under grants 11371285 and 91130022
文摘This article presents an equivalence theorem for three different kinds of optimal control problems, which are optimal target control problems, optimal norm control problems, and optimal time control problems. Controlled systems in this study are internally controlled Stokes equations.
文摘In this research, the result of the cloud seeding over Yazd province during three months of February, March and April in 1999 has been evaluated using the historical regression method. Hereupon, the rain-gages in Yazd province as the target stations and the rain-gages of the neighboring provinces as the control stations have been selected. The rainfall averages for the three aforementioned months through 25 years (1973-1997) in all control and target stations have been calculated. In the next step, the correlations between the rainfalls of control and target stations have been estimated about 75%, which indicates a good consistency in order to use the historical regression. Then, through the obtained liner correlation equation between the control and target stations the precipitation amount for February, March and April in 1999, over the target region (Yazd province) was estimated about 27.57 mm, whiles the observed amount was 34.23 mm. In fact the precipitation increasing around 19.5% over Yazd province confirmed the success of this cloud seeding project.
基金The Fund of the China Scholarship Council under contract Nos 201806330043 and 201806330042the Marine Science and Technology Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology(Qingdao)under contract No.2018SDKJ0501-2the National Key Research and Development Program of China under contract Nos2018YFD0900904 and 2018YFD0900906。
文摘Projection models are commonly used to evaluate the impacts of fishing.However,previously developed projection tools were not suitable for China’s fisheries as they are either overly complex and data-demanding or too simple to reflect the realistic management measures.Herein,an intermediate-complexity projection model was developed that could adequately describe fish population dynamics and account for management measures including mesh size limits,summer closure,and spatial closure.A two-patch operating model was outlined for the projection model and applied to the heavily depleted but commercially important small yellow croaker(Larimichthys polyactis)fishery in the Haizhou Bay,China,as a case study.The model was calibrated to realistically capture the fisheries dynamics with hindcasting.Three simulation scenarios featuring different fishing intensities based on status quo and maximum sustainable yield(MSY)were proposed and evaluated with projections.Stochastic projections were additionally performed to investigate the influence of uncertainty associated with recruitment strengths and the implementation of control targets.It was found that fishing at FMSY level could effectively rebuild the depleted stock biomass,while the stock collapsed rapidly in the status quo scenario.Uncertainty in recruitment and implementation could result in variabilities in management effects;but they did not much alter the management effects of the FMSY scenario.These results indicate that the lack of science-based control targets in fishing mortality or catch limits has hindered the achievement of sustainable fisheries in China.Overall,the presented work highlights that the developed projection model can promote the understanding of the possible consequences of fishing under uncertainty and is applicable to other fisheries in China.
基金funded by Special Fund for Agro-scientific Research in the Public Interest of China(201403031)the National Key R&D Program of China(2017YFD0201807).
文摘Mythimna separata is a notorious phytophagous pest which poses serious threats to cereal crops owing to the gluttony of the larvae.Because short neuropeptide F(sNPF)and its receptor sNPFR are involved in a diversity of physiological functions,especially in functions related to feeding in insects,it is a molecular target for pest control.Herein,an sNPF and 2 sNPFRs were identified and cloned from M.separata.Bioinformatics analysis revealed that the sNPF and its receptors had a highly conserved RLRFamide C-terminus and 7 transmembrane domains,respectively.The sNPF and its receptor genes were distributed across larval periods and tissues,but 2 receptors had distinct expression patterns.The starvation-induced assay elucidated that sNPF and sNPFR expression levels were downregulated under food deprivation and recovered with subsequent re-feeding.RNA interference knockdown of sNPF,sNPFR1,and sNPFR2 by injection of double-stranded RNA into larvae not only suppressed food consumption and increased body size and weight,but also led to decrease of glycogen and total lipid contents,and increase of trehalose compared with double-stranded green fluorescent protein injection.Furthermore,molecular docking was performed on the interaction mode between sNPFR protein and its ligand sNPF based on the 3-dimensional models constructed by AlphaFold;the results indicated that both receptors were presumably activated by the mature peptide sNPF-2.These results revealed that sNPF signaling played a considerably vital role in the feeding regulation of M.separata and represents a potential control target for this pest.
文摘Chemosensors and imaging probes have been the focus of significant research interest over the past few decades.In part due to ease of preparation and simplicity in manipulation,fluorescent probes have been extensively used for biomedical applications.When used for in vitro cell imaging[1,2]。