By constructing a model,this study seeks to provide suggestions for strengthening pre-service teachers’informatization teaching ability.It aims to answer the following research questions:(1)What do the pre-service te...By constructing a model,this study seeks to provide suggestions for strengthening pre-service teachers’informatization teaching ability.It aims to answer the following research questions:(1)What do the pre-service teachers know about informatization instruction?What is their level of informatization teaching ability?(2)What factors influence pre-service teachers’ability to deliver informatization instruction?How to overcome the obstacles?The inquiry focuses on the theoretical exploration of informatization teaching ability,questionnaire,and interview analysis on the current condition and improvement of pre-service teachers’informatization teaching ability.The data from the questionnaire and interview of the pre-service teachers were evaluated from three dimensions:awareness and attitude towards informatization teaching,knowledge of informatization teaching,and the ability to apply informatization teaching skills innovatively and comprehensively.The 3S-7D(Three Subjects and Seven Duties)model consisting of three subjects and the seven duties that go with them is established.The three subjects include pre-service teachers,teacher educators,and higher education schools.The seven duties involve pre-service teachers demonstrating learning motivation,cross-discipline thinking,and information and communications technology mastery;teacher educators actively constructing informatization teaching practice and formative assessment;and higher education schools providing adequate hardware and software equipment while offering cooperative opportunities with primary and junior schools through institutionalization.展开更多
With the arrival of the age of large information data, the education also gradually tends to educate the information, which has forced the demand of the teachers’ educational information technology application abilit...With the arrival of the age of large information data, the education also gradually tends to educate the information, which has forced the demand of the teachers’ educational information technology application ability of the major universities and universities to be higher and higher. Therefore, in order to meet the needs of the development of higher education in the information age and to meet the needs of the college English teaching innovation, this paper will explore the application ability of the educational information technology of the college English teachers from various angles.展开更多
With the more frequent international communication, to enhance students English learning ability is a very important target in modem English education, n this study ,to promote students' English learning ability as a...With the more frequent international communication, to enhance students English learning ability is a very important target in modem English education, n this study ,to promote students' English learning ability as a point of penetration ,from the perspective of psychology ,sociology and pedagogy ,based on the teacher expectation effect theory researching methods to practice and exploring at the micro level of classroom teaching ,demonstrating the relationship of positive and inverse between teacher expectation and students' English learning ability and to explore the feasibility strategies to enhance students' English learning ability finally.展开更多
Music teachers in colleges and universities play a great role in training the students with the quality of aesthetic education, and their teaching ability can influence the implementation of aesthetic education. The t...Music teachers in colleges and universities play a great role in training the students with the quality of aesthetic education, and their teaching ability can influence the implementation of aesthetic education. The teaching ability of a music teacher comprises of the professional ethics, professional knowledge and teaching competence, etc. In this paper, the teaching ability of music teachers in colleges and universities is studied ~om its value, composition, and standards, etc.展开更多
The curriculum development ability of secondary vocational school teachers is a necessary professional ability for teachers.It has important practical significance and practical value for promoting secondary vocationa...The curriculum development ability of secondary vocational school teachers is a necessary professional ability for teachers.It has important practical significance and practical value for promoting secondary vocational education curriculum and teaching reform.On the basis of analyzing the connotation and composition of curriculum development ability of teachers in secondary vocational schools,this article proposes three strategies to improve the curriculum development ability of teachers in secondary vocational schools.展开更多
This article consists of the following parts: First, explains what the teacher efficacy is. Second, analyzes current situation of College English teachers integrating academic ability. Third, talks about the relation...This article consists of the following parts: First, explains what the teacher efficacy is. Second, analyzes current situation of College English teachers integrating academic ability. Third, talks about the relationship between the efficacy level of College English teachers and the ability to improve the integration of academic from four aspects. Finally, analyzes College English teachers' training about integrating academic ability under the efficacy perspective from college English teachers, colleges and social aspects.展开更多
In order to improve the English teachers' education ability evaluation accuracy, promote the upgrading of the level of English teacher education, the evaluation model of English teacher education ability is proposed ...In order to improve the English teachers' education ability evaluation accuracy, promote the upgrading of the level of English teacher education, the evaluation model of English teacher education ability is proposed in MOOC environment. Data fusion model of English teacher education ability evaluation index is obtained based on big data analysis method, data clustering analysis of English teaching evaluation indicators is carried out, Characteristic data of English Teaching are extracted, and combining fuzzy C means algorithm to analyze the characteristics of English teachers' educational ability in MOOC environment, adaptive mining evaluation of English teachers' educational ability is realized. Then we develop and design the evaluation system of English teacher education ability under the MOOC environment. The empirical data analysis is taken, and results show that it has good accuracy by using this method for evaluation of English teacher's ability, it improves the comprehensive evaluation level of English teachers.展开更多
The teaching ability of college teachers is analyzed and there is a realization of the necessity to improve the teaching ability in colleges and universities in view of the new era.The core purpose of this paper is to...The teaching ability of college teachers is analyzed and there is a realization of the necessity to improve the teaching ability in colleges and universities in view of the new era.The core purpose of this paper is to summarize the factors that affect the teachers'teaching ability,construct targeted strategies to improve the comprehensive quality of college teachers,as well as to provide reference for educational innovation and the education system reform.展开更多
In this study,an assessment scale for evaluating the experimental design ability of elementary science teachers was constructed based on primary trait analysis.This assessment scale contains three first-level indexes ...In this study,an assessment scale for evaluating the experimental design ability of elementary science teachers was constructed based on primary trait analysis.This assessment scale contains three first-level indexes and eleven second-level indexes.The corresponding weights of indexes were determined by the objective weighting method.The scores of all the descriptions of the indexes were also assigned.After a trial test,this assessment scale was verified to be reliable and valid for evaluating the experimental design ability of elementary science teachers.展开更多
Among students' abilities,the important one is the ability of studying independently.It is the teachers' indispensable task to foster students' ability of studying independently.This essay deals with the p...Among students' abilities,the important one is the ability of studying independently.It is the teachers' indispensable task to foster students' ability of studying independently.This essay deals with the problem that how a teacher can foster the ability of student self-study,especially English study,from these perspectives:the nature,the characteristics,the conditions and the structure of the ability of independent study.The appropriate methods that the teacher should take in the process of fostering the ability are discussed in the last part of this essay.展开更多
The recyclable and stable ZnFe_(2)O_(4) small particle decorated one‐dimensional perylene diimide(PDI)S‐scheme heterojunction(1D PDI/ZnFe_(2)O_(4))is prepared by the hydrochloric acid‐mediated(HCl‐mediated)strateg...The recyclable and stable ZnFe_(2)O_(4) small particle decorated one‐dimensional perylene diimide(PDI)S‐scheme heterojunction(1D PDI/ZnFe_(2)O_(4))is prepared by the hydrochloric acid‐mediated(HCl‐mediated)strategy,interestingly,the morphology of the 1D PDI/ZnFe_(2)O_(4) can also be effectively regulated by HCl‐mediated process,the existence of HCl can regulate PDI into a uniform rod structure,while the co‐existence of HCl and PDI can limit ZnFe_(2)O_(4) to become the uniform small particles.More importantly,based on the 1D rod structure of PDI and the small size effect of ZnFe_(2)O_(4),carriers can migrate to the surface more easily,which can improve the photocatalytic activity.Meanwhile,due to the appropriate energy level structure,the S‐scheme heterojunction structure is formed between PDI and ZnFe_(2)O_(4),which eliminates meaningless photo‐generated charge carriers through recombination and introduces strong redox to further enhance the photodegradation effect,thereby,1D PDI/ZnFe_(2)O_(4) exhibits excellent photocatalytic ability,under the visible light irradiation,the degradation rate of tetracycline(TC)with 1D PDI/ZnFe_(2)O_(4)(66.67%)is 9.18 times that with PDI(7.26%)and 9.73 times that with ZnFe_(2)O_(4)(6.85%).This work proposes new ideas for the assembly of magnetic organic‐inorganic S‐scheme heterojunction photocatalysts.展开更多
Although the story continuation writing task(SCWT) has attracted much research attention, few studies have investigated the construct of the task, particularly with respect to which language competence it focuses on. ...Although the story continuation writing task(SCWT) has attracted much research attention, few studies have investigated the construct of the task, particularly with respect to which language competence it focuses on. In addition, although some studies have demonstrated that China’s Standards of English Language Ability(CSE) provides comprehensive insights into the development of Chinese learners’ English language proficiency, little research has investigated the relationship between CSE and SCWT. This study drew upon the CSE to develop an SCWT language use inventory to address the above research gaps. A total of 358 high school students were asked to complete the questionnaire, of which 277 valid responses were analyzed. Exploratory factor analysis(EFA) on the CSE-based questionnaire revealed the presence of six factors, namely language correctness, language variety, task planning, connecting-and-generating, selecting-andmining, and organizing. The strategy of connecting-and-generating was the only significant predictor of the learners’ SCWT scores. The paper also discusses the findings relating to the SCWT rating and other integrated writing tasks.展开更多
This paper deeply analyzes the practical application of Herbart’s educational concept in contemporary education and teaching,especially its guiding significance to the primary school Chinese classroom in Shenzhen are...This paper deeply analyzes the practical application of Herbart’s educational concept in contemporary education and teaching,especially its guiding significance to the primary school Chinese classroom in Shenzhen area.Herbart proposed that teachers should play a key role in students’cognitive process,that is,help students better understand and master new knowledge by combining it with existing knowledge.The survey results show that although teachers have some understanding of Herbart’s educational philosophy,it is not widely used in the concrete teaching process.However,the study also shows that there is a positive relationship between Herbart’s theory and students’academic performance,indicating that it plays an important role in improving students’interest and engagement in learning.The research also reveals the differences between educational concepts and practices,as well as the uneven distribution of educational resources,and puts forward measures to alleviate these contradictions,such as strengthening teacher training,improving teaching methods,and emphasizing moral education.At the same time,the study also highlights the critical role of teachers in promoting knowledge integration,arousing learning enthusiasm,shaping students’moral character,and promoting personal and professional growth.展开更多
A novel b-cyclodextrin dimer bearing 2, 9-diformyl-1, 10-phenanthroline tether 4 has been synthesized and its inclusion complexation behavior with two triangular model substrates (RhB and BG) has been investigated thr...A novel b-cyclodextrin dimer bearing 2, 9-diformyl-1, 10-phenanthroline tether 4 has been synthesized and its inclusion complexation behavior with two triangular model substrates (RhB and BG) has been investigated through fluorescence and ultraviolet spectrometry. The result obtained indicated that novel bridged bis(b-cyclodextrin)s could significantly enhance the original molecular binding ability of native b-cyclodextrin by cooperative binding of two hydrophobic cavities.展开更多
Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative diseases.However,little is k...Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative diseases.However,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°C.We aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large cohort.Plasma samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline project.These samples were stored at-80°C for up to 6 years before being used in this study.Our results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage time.However,the level of total tau showed a negative correlation with sample storage time.Notably,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage time.This was not observed in individuals with cognitive impairment.Consequently,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage time.Therefore,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's disease.Furthermore,in cohort studies,it is important to consider the impact of storage time on the overall results.展开更多
Background For the purpose of utilising hybrid vigour to produce possible hybrids with a suitable level of stability,the knowledge of gene activity and combining ability is a crucial prerequisite before choosing desir...Background For the purpose of utilising hybrid vigour to produce possible hybrids with a suitable level of stability,the knowledge of gene activity and combining ability is a crucial prerequisite before choosing desirable parents.The present study was carried out with six parents crossed in full diallel fashion and generated 30 F1 hybrids.These hybrids were evaluated in two replications in Randomized Block Design at Department of Cotton,TNAU for combining ability and gene action.Diallel analysis was carried out according to Griffing’s method-I(parents + F_(1) + reciprocals) and model-I and Hayman’s graphical approach by using INDOSTAT software.Results Analysis of variance for combining ability indicated that mean square values of GCA,SCA and reciprocals were highly significant for all the traits except for the uniformity index.RG763 and K12 showed highly positively significant GCA effects for most of the yield traits while PA838 and K12 for fibre quality traits,so they were found as best general combiners.PAIG379 × K12 and PDB29 × K12 for yield traits,and PDB29 × PA838,RG763 × PA838,and CNA1007 × RG763 cross combinations for fibre quality traits could be recommended for future breeding programms.Conclusion The results of both Griffing’s and Hayman’s approaches showed that non-additive gene action predominates as SCA variance was bigger than GCA variance,so heterosis breeding is thought to be a more fruitful option for enhancing GCA of many traits.展开更多
Teachers' teaching innovation abilities in financial management courses are very important to train the major of financial management undergraduate students' innovation sense, spirits and abilities. This paper first...Teachers' teaching innovation abilities in financial management courses are very important to train the major of financial management undergraduate students' innovation sense, spirits and abilities. This paper firstly explores the structure of teaching innovation abilities, characteristics of creative teachers. Secondly, combined with teaching practice, this paper inquires into how to explore students' innovative abilities, how to teach differently according to different students, and how to guide correctly. Finally, from the perspective of department and office environments, continuing education and teachers' self-questioning, this paper probes into how to train professional teachers' teaching innovation abilities in financial management courses.展开更多
Scientific teaching quality evaluation system and the effective operation mechanism have a positive meaning for promoting teaching reform. Teachers’ specialization is the core of education, and is the starting point ...Scientific teaching quality evaluation system and the effective operation mechanism have a positive meaning for promoting teaching reform. Teachers’ specialization is the core of education, and is the starting point and end-result of education reform. Teachers’ professional development has three kinds of orientation rational orientation, reflection-evaluation orientation, and ecological orientation. Some new research suggests that re? ection-evaluation orientation is the best way to improve teachers’ professional abilities. At present, reflective teacher education has become worldwide trend. Compared with experiential teaching, reflective teaching is a sort of positive tool which is used to help teachers conduct their active and professional work. The main purpose of reflective teaching is to allow teachers to reffect on their own work and self-evaluation, and improve their methodology, eventually improve teaching methods and promote student learning. Nevertheless, there are many problems in the teaching quality evaluation system in the aspects of concept, subject, standard, organization, etc. Therefore, we have to reffect and reconstruct the teaching quality evaluation system in colleges and universities.展开更多
文摘By constructing a model,this study seeks to provide suggestions for strengthening pre-service teachers’informatization teaching ability.It aims to answer the following research questions:(1)What do the pre-service teachers know about informatization instruction?What is their level of informatization teaching ability?(2)What factors influence pre-service teachers’ability to deliver informatization instruction?How to overcome the obstacles?The inquiry focuses on the theoretical exploration of informatization teaching ability,questionnaire,and interview analysis on the current condition and improvement of pre-service teachers’informatization teaching ability.The data from the questionnaire and interview of the pre-service teachers were evaluated from three dimensions:awareness and attitude towards informatization teaching,knowledge of informatization teaching,and the ability to apply informatization teaching skills innovatively and comprehensively.The 3S-7D(Three Subjects and Seven Duties)model consisting of three subjects and the seven duties that go with them is established.The three subjects include pre-service teachers,teacher educators,and higher education schools.The seven duties involve pre-service teachers demonstrating learning motivation,cross-discipline thinking,and information and communications technology mastery;teacher educators actively constructing informatization teaching practice and formative assessment;and higher education schools providing adequate hardware and software equipment while offering cooperative opportunities with primary and junior schools through institutionalization.
文摘With the arrival of the age of large information data, the education also gradually tends to educate the information, which has forced the demand of the teachers’ educational information technology application ability of the major universities and universities to be higher and higher. Therefore, in order to meet the needs of the development of higher education in the information age and to meet the needs of the college English teaching innovation, this paper will explore the application ability of the educational information technology of the college English teachers from various angles.
文摘With the more frequent international communication, to enhance students English learning ability is a very important target in modem English education, n this study ,to promote students' English learning ability as a point of penetration ,from the perspective of psychology ,sociology and pedagogy ,based on the teacher expectation effect theory researching methods to practice and exploring at the micro level of classroom teaching ,demonstrating the relationship of positive and inverse between teacher expectation and students' English learning ability and to explore the feasibility strategies to enhance students' English learning ability finally.
文摘Music teachers in colleges and universities play a great role in training the students with the quality of aesthetic education, and their teaching ability can influence the implementation of aesthetic education. The teaching ability of a music teacher comprises of the professional ethics, professional knowledge and teaching competence, etc. In this paper, the teaching ability of music teachers in colleges and universities is studied ~om its value, composition, and standards, etc.
基金School-level scientific research development fund project of Jilin Engineering Normal University"Research on the current situation and promotion strategy of curriculum development ability of secondary vocational teachers in Jilin Province"(X2015046).
文摘The curriculum development ability of secondary vocational school teachers is a necessary professional ability for teachers.It has important practical significance and practical value for promoting secondary vocational education curriculum and teaching reform.On the basis of analyzing the connotation and composition of curriculum development ability of teachers in secondary vocational schools,this article proposes three strategies to improve the curriculum development ability of teachers in secondary vocational schools.
文摘This article consists of the following parts: First, explains what the teacher efficacy is. Second, analyzes current situation of College English teachers integrating academic ability. Third, talks about the relationship between the efficacy level of College English teachers and the ability to improve the integration of academic from four aspects. Finally, analyzes College English teachers' training about integrating academic ability under the efficacy perspective from college English teachers, colleges and social aspects.
文摘In order to improve the English teachers' education ability evaluation accuracy, promote the upgrading of the level of English teacher education, the evaluation model of English teacher education ability is proposed in MOOC environment. Data fusion model of English teacher education ability evaluation index is obtained based on big data analysis method, data clustering analysis of English teaching evaluation indicators is carried out, Characteristic data of English Teaching are extracted, and combining fuzzy C means algorithm to analyze the characteristics of English teachers' educational ability in MOOC environment, adaptive mining evaluation of English teachers' educational ability is realized. Then we develop and design the evaluation system of English teacher education ability under the MOOC environment. The empirical data analysis is taken, and results show that it has good accuracy by using this method for evaluation of English teacher's ability, it improves the comprehensive evaluation level of English teachers.
基金supported by Teacher Development Research Project of Luoyang Normal University(Project number:2020jsfz06)Higher Education Teaching Reform Research and Practice Project of Education Department of Henan Province(Project number:2019SJGLX396)Project of Deepening Comprehensive Reform of Education and Teaching of Harbin Normal University(Project number:X2015-1010).
文摘The teaching ability of college teachers is analyzed and there is a realization of the necessity to improve the teaching ability in colleges and universities in view of the new era.The core purpose of this paper is to summarize the factors that affect the teachers'teaching ability,construct targeted strategies to improve the comprehensive quality of college teachers,as well as to provide reference for educational innovation and the education system reform.
基金Introduce Talent Foundation of Wenzhou University(135010120719)College Students Innovative Entrepreneurial Training of Wenzhou University(JWSC2019023).
文摘In this study,an assessment scale for evaluating the experimental design ability of elementary science teachers was constructed based on primary trait analysis.This assessment scale contains three first-level indexes and eleven second-level indexes.The corresponding weights of indexes were determined by the objective weighting method.The scores of all the descriptions of the indexes were also assigned.After a trial test,this assessment scale was verified to be reliable and valid for evaluating the experimental design ability of elementary science teachers.
文摘Among students' abilities,the important one is the ability of studying independently.It is the teachers' indispensable task to foster students' ability of studying independently.This essay deals with the problem that how a teacher can foster the ability of student self-study,especially English study,from these perspectives:the nature,the characteristics,the conditions and the structure of the ability of independent study.The appropriate methods that the teacher should take in the process of fostering the ability are discussed in the last part of this essay.
文摘The recyclable and stable ZnFe_(2)O_(4) small particle decorated one‐dimensional perylene diimide(PDI)S‐scheme heterojunction(1D PDI/ZnFe_(2)O_(4))is prepared by the hydrochloric acid‐mediated(HCl‐mediated)strategy,interestingly,the morphology of the 1D PDI/ZnFe_(2)O_(4) can also be effectively regulated by HCl‐mediated process,the existence of HCl can regulate PDI into a uniform rod structure,while the co‐existence of HCl and PDI can limit ZnFe_(2)O_(4) to become the uniform small particles.More importantly,based on the 1D rod structure of PDI and the small size effect of ZnFe_(2)O_(4),carriers can migrate to the surface more easily,which can improve the photocatalytic activity.Meanwhile,due to the appropriate energy level structure,the S‐scheme heterojunction structure is formed between PDI and ZnFe_(2)O_(4),which eliminates meaningless photo‐generated charge carriers through recombination and introduces strong redox to further enhance the photodegradation effect,thereby,1D PDI/ZnFe_(2)O_(4) exhibits excellent photocatalytic ability,under the visible light irradiation,the degradation rate of tetracycline(TC)with 1D PDI/ZnFe_(2)O_(4)(66.67%)is 9.18 times that with PDI(7.26%)and 9.73 times that with ZnFe_(2)O_(4)(6.85%).This work proposes new ideas for the assembly of magnetic organic‐inorganic S‐scheme heterojunction photocatalysts.
文摘Although the story continuation writing task(SCWT) has attracted much research attention, few studies have investigated the construct of the task, particularly with respect to which language competence it focuses on. In addition, although some studies have demonstrated that China’s Standards of English Language Ability(CSE) provides comprehensive insights into the development of Chinese learners’ English language proficiency, little research has investigated the relationship between CSE and SCWT. This study drew upon the CSE to develop an SCWT language use inventory to address the above research gaps. A total of 358 high school students were asked to complete the questionnaire, of which 277 valid responses were analyzed. Exploratory factor analysis(EFA) on the CSE-based questionnaire revealed the presence of six factors, namely language correctness, language variety, task planning, connecting-and-generating, selecting-andmining, and organizing. The strategy of connecting-and-generating was the only significant predictor of the learners’ SCWT scores. The paper also discusses the findings relating to the SCWT rating and other integrated writing tasks.
文摘This paper deeply analyzes the practical application of Herbart’s educational concept in contemporary education and teaching,especially its guiding significance to the primary school Chinese classroom in Shenzhen area.Herbart proposed that teachers should play a key role in students’cognitive process,that is,help students better understand and master new knowledge by combining it with existing knowledge.The survey results show that although teachers have some understanding of Herbart’s educational philosophy,it is not widely used in the concrete teaching process.However,the study also shows that there is a positive relationship between Herbart’s theory and students’academic performance,indicating that it plays an important role in improving students’interest and engagement in learning.The research also reveals the differences between educational concepts and practices,as well as the uneven distribution of educational resources,and puts forward measures to alleviate these contradictions,such as strengthening teacher training,improving teaching methods,and emphasizing moral education.At the same time,the study also highlights the critical role of teachers in promoting knowledge integration,arousing learning enthusiasm,shaping students’moral character,and promoting personal and professional growth.
基金This work was supported by the National Natural Science Foundation (No.299925908 and 29972029) of China Tianjin Natural Science Foundation (No.013613511) the Foundation of Ministry of Education, which are gratefully acknowledged.
文摘A novel b-cyclodextrin dimer bearing 2, 9-diformyl-1, 10-phenanthroline tether 4 has been synthesized and its inclusion complexation behavior with two triangular model substrates (RhB and BG) has been investigated through fluorescence and ultraviolet spectrometry. The result obtained indicated that novel bridged bis(b-cyclodextrin)s could significantly enhance the original molecular binding ability of native b-cyclodextrin by cooperative binding of two hydrophobic cavities.
基金supported by the National Key Research&Development Program of China,Nos.2021YFC2501205(to YC),2022YFC24069004(to JL)the STI2030-Major Project,Nos.2021ZD0201101(to YC),2022ZD0211800(to YH)+2 种基金the National Natural Science Foundation of China(Major International Joint Research Project),No.82020108013(to YH)the Sino-German Center for Research Promotion,No.M-0759(to YH)a grant from Beijing Municipal Science&Technology Commission(Beijing Brain Initiative),No.Z201100005520018(to JL)。
文摘Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative diseases.However,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°C.We aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large cohort.Plasma samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline project.These samples were stored at-80°C for up to 6 years before being used in this study.Our results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage time.However,the level of total tau showed a negative correlation with sample storage time.Notably,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage time.This was not observed in individuals with cognitive impairment.Consequently,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage time.Therefore,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's disease.Furthermore,in cohort studies,it is important to consider the impact of storage time on the overall results.
文摘Background For the purpose of utilising hybrid vigour to produce possible hybrids with a suitable level of stability,the knowledge of gene activity and combining ability is a crucial prerequisite before choosing desirable parents.The present study was carried out with six parents crossed in full diallel fashion and generated 30 F1 hybrids.These hybrids were evaluated in two replications in Randomized Block Design at Department of Cotton,TNAU for combining ability and gene action.Diallel analysis was carried out according to Griffing’s method-I(parents + F_(1) + reciprocals) and model-I and Hayman’s graphical approach by using INDOSTAT software.Results Analysis of variance for combining ability indicated that mean square values of GCA,SCA and reciprocals were highly significant for all the traits except for the uniformity index.RG763 and K12 showed highly positively significant GCA effects for most of the yield traits while PA838 and K12 for fibre quality traits,so they were found as best general combiners.PAIG379 × K12 and PDB29 × K12 for yield traits,and PDB29 × PA838,RG763 × PA838,and CNA1007 × RG763 cross combinations for fibre quality traits could be recommended for future breeding programms.Conclusion The results of both Griffing’s and Hayman’s approaches showed that non-additive gene action predominates as SCA variance was bigger than GCA variance,so heterosis breeding is thought to be a more fruitful option for enhancing GCA of many traits.
文摘Teachers' teaching innovation abilities in financial management courses are very important to train the major of financial management undergraduate students' innovation sense, spirits and abilities. This paper firstly explores the structure of teaching innovation abilities, characteristics of creative teachers. Secondly, combined with teaching practice, this paper inquires into how to explore students' innovative abilities, how to teach differently according to different students, and how to guide correctly. Finally, from the perspective of department and office environments, continuing education and teachers' self-questioning, this paper probes into how to train professional teachers' teaching innovation abilities in financial management courses.
文摘Scientific teaching quality evaluation system and the effective operation mechanism have a positive meaning for promoting teaching reform. Teachers’ specialization is the core of education, and is the starting point and end-result of education reform. Teachers’ professional development has three kinds of orientation rational orientation, reflection-evaluation orientation, and ecological orientation. Some new research suggests that re? ection-evaluation orientation is the best way to improve teachers’ professional abilities. At present, reflective teacher education has become worldwide trend. Compared with experiential teaching, reflective teaching is a sort of positive tool which is used to help teachers conduct their active and professional work. The main purpose of reflective teaching is to allow teachers to reffect on their own work and self-evaluation, and improve their methodology, eventually improve teaching methods and promote student learning. Nevertheless, there are many problems in the teaching quality evaluation system in the aspects of concept, subject, standard, organization, etc. Therefore, we have to reffect and reconstruct the teaching quality evaluation system in colleges and universities.