AIM:To investigate the association between tear film break up time(TBUT)and blinking interval in visual display terminal(VDT)users.METHODS:Nine hundred and thirty VDT users underwent dry eye testing,and function...AIM:To investigate the association between tear film break up time(TBUT)and blinking interval in visual display terminal(VDT)users.METHODS:Nine hundred and thirty VDT users underwent dry eye testing,and functional visual acuity(FVA)test.The blinking interval during FVA was compared with TBUT.Subjects with longer blinking interval than TBUT were considered as unstable tear film.Logistic regression analysis revealed the risk factors for unstable tear group.RESULTS:Among 930 workers,858 subjects(92.3%)participated in this study.Almost 80% of the subjects were categorized into the unstable tear group.Unstable tear group has significantly lower Schirmer values and TBUT(17.5±11.6 vs 21.1±11.5 mm,3.7±2.6 vs 5.7±2.7s,both P〈0.001).There were no significant differences in epithelial staining or severity of symptoms.Logistic regression showed that over 40y was a risk for being unstable tear group[odds ratio(OR)=1.53;95%confidence interval(CI)=1.06-2.20].Contact lens use was protective factor for being in the unstable tear group(OR=0.37;95%CI=0.26-0.53).CONCLUSION:Subjects with shorter TBUT than blinking interval are prevalent among VDT users.Subjects over the age of 40 shows an increased risk for unstable tear film.展开更多
AIM:To evaluate the quantitative and qualitative results of the noninvasive tear film break-up time(NI-BUT)test and investigate the predictive ability of the new NIBUT parameter in discriminating between normal Ocular...AIM:To evaluate the quantitative and qualitative results of the noninvasive tear film break-up time(NI-BUT)test and investigate the predictive ability of the new NIBUT parameter in discriminating between normal Ocular Surface Disease Index(OSDI;scores≤12)and abnormal OSDI(scores≥13).METHODS:A total of 341 eyes of 341 volunteers who applied for routine eye outpatient control were included in the prospective study.All participants'noninvasive first tear film break-up time(NIF-BUT),noninvasive average tear film break-up time(NIAvg-BUT)and average value of the first three break-up time(A3F-BUT)were analyzed.A3F-BUT,the new NI-BUT parameter,is calculated by adding the NIF-BUT value to the 2^(nd )break-up time value that has a difference of at most 1 second from the NIF-BUT value and to the 3^(rd) break-up time and then dividing the respective sum by 3.Receiver operating characteristic(ROC)curve and forward logistic regression analyses were performed to determine the parameter that had the best predictive ability between the OSDI groups.RESULTS:The NI-BUT values of 255 eyes of 255 volunteers included in the study were analyzed statistically.The mean NIF-BUT,NIAvg-BUT,and A3F-BUT values were calculated as 5.3±3.0,8±3.1,and 5.8±3.0 seconds,respectively.All three parameters were found to be significantly lower in the abnormal OSDI group(P=0.014,0.034,and 0.011,respectively).The area under the curve(AUC)of the A3F-BUT to predict abnormal OSDI was AUC=0.625(0.529-0.720),P=0.011 and NIF-BUT was AUC=0.599(0.502-0.696),P=0.043.The A3F-BUT parameter and NIF-BUT parameters were found to be significantly efficient in discriminating abnormal OSDI.CONCLUSION:The new parameter for the NI-BUT test has more predictive ability in the discrimination of OSDI groups.展开更多
<strong>Background:</strong> Dry eye is characterized by tear film instability, decreased tear volume and a high Ocular Surface Disease Index (OSDI) score. Face masks have been linked to dry eye complaints...<strong>Background:</strong> Dry eye is characterized by tear film instability, decreased tear volume and a high Ocular Surface Disease Index (OSDI) score. Face masks have been linked to dry eye complaints in recent studies. <strong>Purpose:</strong> To evaluate the changes in tear-film status and Ocular Surface Disease Index (OSDI) score following prolonged use of face mask. <strong>Design:</strong> Cross-sectional study. <strong>Method:</strong> Patients between 18 to 70 years using masks regularly for at least 2 hours/day for at least 5 days/week from different eye-care centres in Dhaka were included. All subjects were divided into 4 groups. Mask use lasted approximately 2 hours/day in Group 1, 4 hours/day in Group 2, 6 hours/day in Group 3 and 8 hours or more/day in Group 4. Evaluation of symptoms, tear- film stability and tear volume was done by Ocular Surface Disease Index (OSDI) scores, Tear-film Break-Up Time (TBUT) and Schirmer-1 test. Average of right & left eye’s Tear-film Break Up time (TBUT) and Schirmer-1 value were noted. <strong>Results:</strong> Total 100 patients were enrolled (n = 100). The TBUT (p < 0.001) and Schirmer-1 measurement (p = 0.01) were significantly lesser and Ocular Surface Disease Index (OSDI) score were significantly higher in patients using face-masks for longer time (p < 0.001). <strong>Conclusion:</strong> Patients who wore masks for prolonged time had tear film instability, reduced tear volume and higher Ocular Surface Disease Index (OSDI) score.展开更多
目的研究泪膜破裂时间(tear film rupture time,TBUT)测定在青少年干眼症诊断中的准确性和可靠性评价。方法选取2021年9月至2023年9月,于笔者医院就诊的青少年干眼症患者185例作为观察组,并选取20例健康青少年作为对照组,分析TBUT测定...目的研究泪膜破裂时间(tear film rupture time,TBUT)测定在青少年干眼症诊断中的准确性和可靠性评价。方法选取2021年9月至2023年9月,于笔者医院就诊的青少年干眼症患者185例作为观察组,并选取20例健康青少年作为对照组,分析TBUT测定在青少年干眼症诊断中的准确性和可靠性评价。结果185例患者,侵入性TBUT检测检出132例,总检出率为71.35%,非侵入性TBUT检测检出160例,总检出率为84.49%,组间差异有统计学意义(P<0.05);185例患者,非睑板腺功能障碍128例、睑板腺功能障碍57例,侵入性TBUT检测非睑板腺功能障碍检出率为41.62%、睑板腺功能障碍检出率为29.73%,非侵入性TBUT检测非睑板腺功能障碍检出率为63.24%、睑板腺功能障碍检出率为23.24%,组间差异有统计学意义(P<0.05);与对照组比较,观察组TBUT、首次TBUT、平均TBUT显著降低(P<0.05);与A组比较,B组TBUT、首次TBUT、平均TBUT显著降低,组间差异有统计学意义(P<0.05);侵入性TBUT检测的敏感度为72.49%,特异性为75.88%,AUC为0.762,非侵入性TBUT检测敏感度为87.24%,特异性为90.05%,曲线下面积(areaunder the curve,AUC)为0.926。结论TBUT测定在青少年干眼症诊断中具有诊断价值,且与侵入性TBUT检测比较,非侵入TBUT检测的准确性及可靠性更好。展开更多
目的:探讨一种最新的眼表综合分析仪Keratograph对于泪膜稳定性评估的重复性和准确性,将其测量值与传统的检查方法进行比较。方法:采用Keratograph测量包括首次泪膜破裂时间(the first tear film break-up time,BUT-f)和平均泪膜破裂时...目的:探讨一种最新的眼表综合分析仪Keratograph对于泪膜稳定性评估的重复性和准确性,将其测量值与传统的检查方法进行比较。方法:采用Keratograph测量包括首次泪膜破裂时间(the first tear film break-up time,BUT-f)和平均泪膜破裂时间(the average tear film break-up time,BUT-ave)在内的非侵入式泪膜破裂时间(noninvasive tear film break-up time,NI_BUT)结果。测量结果的重复性使用变异系数(coefficient of variation,CV)和组内相关系数(intraclass correlation coefficient,ICC)进行评价,NI-BUT与传统的荧光素泪膜破裂时间(fluorescein tear film break-up time,FBUT)的比较采用Wilcoxon符号秩和检验,确定NI-BUT与FBUT,SchirmerⅠ试验结果的相关关系,采用BlandAltman分析进行一致性评价。结果:本研究纳入了48个受检者(48眼),平均年龄38.7±15.2岁。BUT-f的CV和ICC分别为12.6%和0.95,BUT-ave的为9.8%和0.96。BUT-f值低于FBUT值,差异有统计学意义(6.16±2.46s vs 7.46±1.92s,P<0.01)。NI-BUT与FBUT,SchirmerⅠ试验结果之间存在显著的正相关关系(P<0.01)。BUT-f与FBUT的95%一致性界限(limits of agreement,Lo A)范围为4.46s,BUT-ave与FBUT的Lo A范围为3.64s。结论:Keratograph能够提供具有较好重复性和可靠性的NI-BUT数据,在干眼诊治和角膜屈光性手术等领域有很好的应用前景。展开更多
目的观察角膜绷带镜对生物工程角膜移植术后的临床治疗作用。方法收集我院2017年1月至2018年6月住院并使用生物工程角膜进行板层角膜移植手术治疗的感染性角膜溃疡患者30例30眼的临床资料,随机分为A、B两组,各15例。A组角膜上皮愈合后...目的观察角膜绷带镜对生物工程角膜移植术后的临床治疗作用。方法收集我院2017年1月至2018年6月住院并使用生物工程角膜进行板层角膜移植手术治疗的感染性角膜溃疡患者30例30眼的临床资料,随机分为A、B两组,各15例。A组角膜上皮愈合后给予戴角膜绷带镜联合滴眼液点眼治疗,2周更换1次,术后3个月拆线后停用。B组患者不戴角膜绷带镜,药物治疗同A组。观察生物工程角膜移植术后角膜植片上皮化时间,比较术后第1、2、3、4周两组角膜植片水肿程度,比较术后第1、2、3个月两组角膜植片上皮完整性和泪膜破裂时间(breakup time of tear film,BUT),比较两组角膜植片水肿消退时间和术后3个月两组角膜植片存活率。结果术后3~5 d角膜植片上皮化,2~4周植片水肿消退。A组患者术后第2~3周角膜植片水肿消退,B组患者第3~4周角膜植片水肿消退,时间长于A组(P <0.001),术后第2~3周A组角膜植片水肿程度明显轻于B组(第2周P=0.002,第3周P <0.001)。术后第1、2、3个月时A组患者角膜荧光素染色评分均低于B组(均P <0.001),BUT时长高于B组(P=0.009、0.002、0.33)。A组患者中1例未按时复诊戴角膜绷带镜近5周,继发细菌感染,退出研究,术后3个月A组植片存活率93.3%(14/15);B组患者有2例1个月后出现角膜上皮无菌性缺损,另有1例术后2个月出现角膜溶解,3例均退出研究,术后3个月B组植片存活率80.0%(12/15),与A组相比差异无统计学意义(P=0.283)。结论生物工程角膜上皮化后戴角膜绷带镜可加速角膜植片水肿消退,保护角膜上皮完整性,维持眼表泪液稳定,有利于维护眼表微环境健康,对生物工程角膜术后角膜植片修复有明显促进作用。展开更多
文摘AIM:To investigate the association between tear film break up time(TBUT)and blinking interval in visual display terminal(VDT)users.METHODS:Nine hundred and thirty VDT users underwent dry eye testing,and functional visual acuity(FVA)test.The blinking interval during FVA was compared with TBUT.Subjects with longer blinking interval than TBUT were considered as unstable tear film.Logistic regression analysis revealed the risk factors for unstable tear group.RESULTS:Among 930 workers,858 subjects(92.3%)participated in this study.Almost 80% of the subjects were categorized into the unstable tear group.Unstable tear group has significantly lower Schirmer values and TBUT(17.5±11.6 vs 21.1±11.5 mm,3.7±2.6 vs 5.7±2.7s,both P〈0.001).There were no significant differences in epithelial staining or severity of symptoms.Logistic regression showed that over 40y was a risk for being unstable tear group[odds ratio(OR)=1.53;95%confidence interval(CI)=1.06-2.20].Contact lens use was protective factor for being in the unstable tear group(OR=0.37;95%CI=0.26-0.53).CONCLUSION:Subjects with shorter TBUT than blinking interval are prevalent among VDT users.Subjects over the age of 40 shows an increased risk for unstable tear film.
文摘AIM:To evaluate the quantitative and qualitative results of the noninvasive tear film break-up time(NI-BUT)test and investigate the predictive ability of the new NIBUT parameter in discriminating between normal Ocular Surface Disease Index(OSDI;scores≤12)and abnormal OSDI(scores≥13).METHODS:A total of 341 eyes of 341 volunteers who applied for routine eye outpatient control were included in the prospective study.All participants'noninvasive first tear film break-up time(NIF-BUT),noninvasive average tear film break-up time(NIAvg-BUT)and average value of the first three break-up time(A3F-BUT)were analyzed.A3F-BUT,the new NI-BUT parameter,is calculated by adding the NIF-BUT value to the 2^(nd )break-up time value that has a difference of at most 1 second from the NIF-BUT value and to the 3^(rd) break-up time and then dividing the respective sum by 3.Receiver operating characteristic(ROC)curve and forward logistic regression analyses were performed to determine the parameter that had the best predictive ability between the OSDI groups.RESULTS:The NI-BUT values of 255 eyes of 255 volunteers included in the study were analyzed statistically.The mean NIF-BUT,NIAvg-BUT,and A3F-BUT values were calculated as 5.3±3.0,8±3.1,and 5.8±3.0 seconds,respectively.All three parameters were found to be significantly lower in the abnormal OSDI group(P=0.014,0.034,and 0.011,respectively).The area under the curve(AUC)of the A3F-BUT to predict abnormal OSDI was AUC=0.625(0.529-0.720),P=0.011 and NIF-BUT was AUC=0.599(0.502-0.696),P=0.043.The A3F-BUT parameter and NIF-BUT parameters were found to be significantly efficient in discriminating abnormal OSDI.CONCLUSION:The new parameter for the NI-BUT test has more predictive ability in the discrimination of OSDI groups.
文摘<strong>Background:</strong> Dry eye is characterized by tear film instability, decreased tear volume and a high Ocular Surface Disease Index (OSDI) score. Face masks have been linked to dry eye complaints in recent studies. <strong>Purpose:</strong> To evaluate the changes in tear-film status and Ocular Surface Disease Index (OSDI) score following prolonged use of face mask. <strong>Design:</strong> Cross-sectional study. <strong>Method:</strong> Patients between 18 to 70 years using masks regularly for at least 2 hours/day for at least 5 days/week from different eye-care centres in Dhaka were included. All subjects were divided into 4 groups. Mask use lasted approximately 2 hours/day in Group 1, 4 hours/day in Group 2, 6 hours/day in Group 3 and 8 hours or more/day in Group 4. Evaluation of symptoms, tear- film stability and tear volume was done by Ocular Surface Disease Index (OSDI) scores, Tear-film Break-Up Time (TBUT) and Schirmer-1 test. Average of right & left eye’s Tear-film Break Up time (TBUT) and Schirmer-1 value were noted. <strong>Results:</strong> Total 100 patients were enrolled (n = 100). The TBUT (p < 0.001) and Schirmer-1 measurement (p = 0.01) were significantly lesser and Ocular Surface Disease Index (OSDI) score were significantly higher in patients using face-masks for longer time (p < 0.001). <strong>Conclusion:</strong> Patients who wore masks for prolonged time had tear film instability, reduced tear volume and higher Ocular Surface Disease Index (OSDI) score.
文摘目的研究泪膜破裂时间(tear film rupture time,TBUT)测定在青少年干眼症诊断中的准确性和可靠性评价。方法选取2021年9月至2023年9月,于笔者医院就诊的青少年干眼症患者185例作为观察组,并选取20例健康青少年作为对照组,分析TBUT测定在青少年干眼症诊断中的准确性和可靠性评价。结果185例患者,侵入性TBUT检测检出132例,总检出率为71.35%,非侵入性TBUT检测检出160例,总检出率为84.49%,组间差异有统计学意义(P<0.05);185例患者,非睑板腺功能障碍128例、睑板腺功能障碍57例,侵入性TBUT检测非睑板腺功能障碍检出率为41.62%、睑板腺功能障碍检出率为29.73%,非侵入性TBUT检测非睑板腺功能障碍检出率为63.24%、睑板腺功能障碍检出率为23.24%,组间差异有统计学意义(P<0.05);与对照组比较,观察组TBUT、首次TBUT、平均TBUT显著降低(P<0.05);与A组比较,B组TBUT、首次TBUT、平均TBUT显著降低,组间差异有统计学意义(P<0.05);侵入性TBUT检测的敏感度为72.49%,特异性为75.88%,AUC为0.762,非侵入性TBUT检测敏感度为87.24%,特异性为90.05%,曲线下面积(areaunder the curve,AUC)为0.926。结论TBUT测定在青少年干眼症诊断中具有诊断价值,且与侵入性TBUT检测比较,非侵入TBUT检测的准确性及可靠性更好。
文摘目的:探讨一种最新的眼表综合分析仪Keratograph对于泪膜稳定性评估的重复性和准确性,将其测量值与传统的检查方法进行比较。方法:采用Keratograph测量包括首次泪膜破裂时间(the first tear film break-up time,BUT-f)和平均泪膜破裂时间(the average tear film break-up time,BUT-ave)在内的非侵入式泪膜破裂时间(noninvasive tear film break-up time,NI_BUT)结果。测量结果的重复性使用变异系数(coefficient of variation,CV)和组内相关系数(intraclass correlation coefficient,ICC)进行评价,NI-BUT与传统的荧光素泪膜破裂时间(fluorescein tear film break-up time,FBUT)的比较采用Wilcoxon符号秩和检验,确定NI-BUT与FBUT,SchirmerⅠ试验结果的相关关系,采用BlandAltman分析进行一致性评价。结果:本研究纳入了48个受检者(48眼),平均年龄38.7±15.2岁。BUT-f的CV和ICC分别为12.6%和0.95,BUT-ave的为9.8%和0.96。BUT-f值低于FBUT值,差异有统计学意义(6.16±2.46s vs 7.46±1.92s,P<0.01)。NI-BUT与FBUT,SchirmerⅠ试验结果之间存在显著的正相关关系(P<0.01)。BUT-f与FBUT的95%一致性界限(limits of agreement,Lo A)范围为4.46s,BUT-ave与FBUT的Lo A范围为3.64s。结论:Keratograph能够提供具有较好重复性和可靠性的NI-BUT数据,在干眼诊治和角膜屈光性手术等领域有很好的应用前景。
文摘目的观察角膜绷带镜对生物工程角膜移植术后的临床治疗作用。方法收集我院2017年1月至2018年6月住院并使用生物工程角膜进行板层角膜移植手术治疗的感染性角膜溃疡患者30例30眼的临床资料,随机分为A、B两组,各15例。A组角膜上皮愈合后给予戴角膜绷带镜联合滴眼液点眼治疗,2周更换1次,术后3个月拆线后停用。B组患者不戴角膜绷带镜,药物治疗同A组。观察生物工程角膜移植术后角膜植片上皮化时间,比较术后第1、2、3、4周两组角膜植片水肿程度,比较术后第1、2、3个月两组角膜植片上皮完整性和泪膜破裂时间(breakup time of tear film,BUT),比较两组角膜植片水肿消退时间和术后3个月两组角膜植片存活率。结果术后3~5 d角膜植片上皮化,2~4周植片水肿消退。A组患者术后第2~3周角膜植片水肿消退,B组患者第3~4周角膜植片水肿消退,时间长于A组(P <0.001),术后第2~3周A组角膜植片水肿程度明显轻于B组(第2周P=0.002,第3周P <0.001)。术后第1、2、3个月时A组患者角膜荧光素染色评分均低于B组(均P <0.001),BUT时长高于B组(P=0.009、0.002、0.33)。A组患者中1例未按时复诊戴角膜绷带镜近5周,继发细菌感染,退出研究,术后3个月A组植片存活率93.3%(14/15);B组患者有2例1个月后出现角膜上皮无菌性缺损,另有1例术后2个月出现角膜溶解,3例均退出研究,术后3个月B组植片存活率80.0%(12/15),与A组相比差异无统计学意义(P=0.283)。结论生物工程角膜上皮化后戴角膜绷带镜可加速角膜植片水肿消退,保护角膜上皮完整性,维持眼表泪液稳定,有利于维护眼表微环境健康,对生物工程角膜术后角膜植片修复有明显促进作用。