Rechargeable battery cycling performance and related safety have been persistent concerns.It is crucial to decipher the capacity fading induced by electrode material failure via a range of techniques.Among these,synch...Rechargeable battery cycling performance and related safety have been persistent concerns.It is crucial to decipher the capacity fading induced by electrode material failure via a range of techniques.Among these,synchrotron-based X-ray techniques with high flux and brightness play a key role in understanding degradation mechanisms.In this comprehensive review,we summarize recent advancements in degra-dation modes and mechanisms that were revealed by synchrotron X-ray methodologies.Subsequently,an overview of X-ray absorption spectroscopy and X-ray scattering techniques is introduced for charac-terizing failure phenomena at local coordination atomic environment and long-range order crystal struc-ture scale,respectively.At last,we envision the future of exploring material failure mechanism.展开更多
The development of intestinal anastomosis techniques,including hand suturing,stapling,and compression anastomoses,has been a significant advancement in surgical practice.These methods aim to prevent leakage and minimi...The development of intestinal anastomosis techniques,including hand suturing,stapling,and compression anastomoses,has been a significant advancement in surgical practice.These methods aim to prevent leakage and minimize tissue fibrosis,which can lead to stricture formation.The healing process involves various phases:hemostasis and inflammation,proliferation,and remodeling.Mechanical staplers and sutures can cause inflammation and fibrosis due to the release of profibrotic chemokines.Compression anastomosis devices,including those made of nickel-titanium alloy,offer a minimally invasive option for various surgical challenges and have shown safety and efficacy.However,despite advancements,anastomotic techniques are evaluated based on leakage risk,with complications being a primary concern.Newer devices like Magnamosis use magnetic rings for compression anastomosis,demonstrating greater strength and patency compared to stapling.Magnetic technology is also being explored for other medical treatments.While there are promising results,particularly in animal models,the realworld application in humans is limited,and further research is needed to assess their safety and practicality.展开更多
Epilepsy can be defined as a dysfunction of the brain network,and each type of epilepsy involves different brain-network changes that are implicated diffe rently in the control and propagation of interictal or ictal d...Epilepsy can be defined as a dysfunction of the brain network,and each type of epilepsy involves different brain-network changes that are implicated diffe rently in the control and propagation of interictal or ictal discharges.Gaining more detailed information on brain network alterations can help us to further understand the mechanisms of epilepsy and pave the way for brain network-based precise therapeutic approaches in clinical practice.An increasing number of advanced neuroimaging techniques and electrophysiological techniques such as diffusion tensor imaging-based fiber tra ctography,diffusion kurtosis imaging-based fiber tractography,fiber ball imagingbased tra ctography,electroencephalography,functional magnetic resonance imaging,magnetoencephalography,positron emission tomography,molecular imaging,and functional ultrasound imaging have been extensively used to delineate epileptic networks.In this review,we summarize the relevant neuroimaging and neuroelectrophysiological techniques for assessing structural and functional brain networks in patients with epilepsy,and extensively analyze the imaging mechanisms,advantages,limitations,and clinical application ranges of each technique.A greater focus on emerging advanced technologies,new data analysis software,a combination of multiple techniques,and the construction of personalized virtual epilepsy models can provide a theoretical basis to better understand the brain network mechanisms of epilepsy and make surgical decisions.展开更多
Manipulating the expression of synaptic plasticity of neuromorphic devices provides fascinating opportunities to develop hardware platforms for artifi-cial intelligence.However,great efforts have been devoted to explo...Manipulating the expression of synaptic plasticity of neuromorphic devices provides fascinating opportunities to develop hardware platforms for artifi-cial intelligence.However,great efforts have been devoted to exploring biomimetic mechanisms of plasticity simulation in the last few years.Recent progress in various plasticity modulation techniques has pushed the research of synaptic electronics from static plasticity simulation to dynamic plasticity modulation,improving the accuracy of neuromorphic computing and providing strategies for implementing neuromorphic sensing functions.Herein,several fascinating strategies for synap-tic plasticity modulation through chemical techniques,device structure design,and physical signal sensing are reviewed.For chemical techniques,the underly-ing mechanisms for the modification of functional materials were clarified and its effect on the expression of synaptic plasticity was also highlighted.Based on device structure design,the reconfigurable operation of neuromorphic devices was well demonstrated to achieve programmable neuromorphic functions.Besides,integrating the sensory units with neuromorphic processing circuits paved a new way to achieve human-like intelligent perception under the modulation of physical signals such as light,strain,and temperature.Finally,considering that the relevant technology is still in the basic exploration stage,some prospects or development suggestions are put forward to promote the development of neuromorphic devices.展开更多
Pd-capped nanocrystalline Mg films were prepared by electron beam evaporation and hydrogenated under isothermal conditions to inves-tigate the hydrogen absorption process via ion beam techniques and in situ optical me...Pd-capped nanocrystalline Mg films were prepared by electron beam evaporation and hydrogenated under isothermal conditions to inves-tigate the hydrogen absorption process via ion beam techniques and in situ optical methods.Films were characterized by different techniques such as X-ray diffraction(XRD)and scanning electron microscopy(SEM).Rutherford backscattering spectrometry(RBS)and elastic recoil detection analysis(ERDA)provided a detailed compositional depth profile of the films during hydrogenation.Gas-solid reaction kinetics theory applied to ERDA data revealed a H absorption mechanism controlled by H diffusion.This rate-limiting step was also confirmed by XRD measurements.The diffusion coefficient(D)was also determined via RBS and ERDA,with a value of(1.1±0.1)·10^(−13)cm^(2)/s at 140℃.Results confirm the validity of IBA to monitor the hydrogenation process and to extract the control mechanism of the process.The H kinetic information given by optical methods is strongly influenced by the optical absorption of the magnesium layer,revealing that thinner films are needed to extract further and reliable information from that technique.展开更多
The widespread adoption of the Internet of Things (IoT) has transformed various sectors globally, making themmore intelligent and connected. However, this advancement comes with challenges related to the effectiveness...The widespread adoption of the Internet of Things (IoT) has transformed various sectors globally, making themmore intelligent and connected. However, this advancement comes with challenges related to the effectiveness ofIoT devices. These devices, present in offices, homes, industries, and more, need constant monitoring to ensuretheir proper functionality. The success of smart systems relies on their seamless operation and ability to handlefaults. Sensors, crucial components of these systems, gather data and contribute to their functionality. Therefore,sensor faults can compromise the system’s reliability and undermine the trustworthiness of smart environments.To address these concerns, various techniques and algorithms can be employed to enhance the performance ofIoT devices through effective fault detection. This paper conducted a thorough review of the existing literature andconducted a detailed analysis.This analysis effectively links sensor errors with a prominent fault detection techniquecapable of addressing them. This study is innovative because it paves theway for future researchers to explore errorsthat have not yet been tackled by existing fault detection methods. Significant, the paper, also highlights essentialfactors for selecting and adopting fault detection techniques, as well as the characteristics of datasets and theircorresponding recommended techniques. Additionally, the paper presents amethodical overview of fault detectiontechniques employed in smart devices, including themetrics used for evaluation. Furthermore, the paper examinesthe body of academic work related to sensor faults and fault detection techniques within the domain. This reflectsthe growing inclination and scholarly attention of researchers and academicians toward strategies for fault detectionwithin the realm of the Internet of Things.展开更多
Organizations are adopting the Bring Your Own Device(BYOD)concept to enhance productivity and reduce expenses.However,this trend introduces security challenges,such as unauthorized access.Traditional access control sy...Organizations are adopting the Bring Your Own Device(BYOD)concept to enhance productivity and reduce expenses.However,this trend introduces security challenges,such as unauthorized access.Traditional access control systems,such as Attribute-Based Access Control(ABAC)and Role-Based Access Control(RBAC),are limited in their ability to enforce access decisions due to the variability and dynamism of attributes related to users and resources.This paper proposes a method for enforcing access decisions that is adaptable and dynamic,based on multilayer hybrid deep learning techniques,particularly the Tabular Deep Neural Network Tabular DNN method.This technique transforms all input attributes in an access request into a binary classification(allow or deny)using multiple layers,ensuring accurate and efficient access decision-making.The proposed solution was evaluated using the Kaggle Amazon access control policy dataset and demonstrated its effectiveness by achieving a 94%accuracy rate.Additionally,the proposed solution enhances the implementation of access decisions based on a variety of resource and user attributes while ensuring privacy through indirect communication with the Policy Administration Point(PAP).This solution significantly improves the flexibility of access control systems,making themmore dynamic and adaptable to the evolving needs ofmodern organizations.Furthermore,it offers a scalable approach to manage the complexities associated with the BYOD environment,providing a robust framework for secure and efficient access management.展开更多
Background: Delayed gastric emptying(DGE) is one of the most common complications after pancreaticoduodenectomy(PD). DGE represents impaired gastric motility without significant mechanical obstruction and is associate...Background: Delayed gastric emptying(DGE) is one of the most common complications after pancreaticoduodenectomy(PD). DGE represents impaired gastric motility without significant mechanical obstruction and is associated with an increased length of hospital stay, increased healthcare costs, and a high readmission rate. We reviewed published studies on various technical modifications to reduce the incidence of DGE. Data sources: Studies were identified by searching Pub Med for relevant articles published up to December 2022. The following search terms were used: “pancreaticoduodenectomy”, “pancreaticojejunostomy”, “pancreaticogastrostomy”, “gastric emptying”, “gastroparesis” and “postoperative complications”. The search was limited to English publications. Additional articles were identified by a manual search of references from key articles. Results: In recent years, various surgical procedures and techniques have been explored to reduce the incidence of DGE. Pyloric resection, Billroth II reconstruction, Braun's enteroenterostomy, and antecolic reconstruction may be associated with a decreased incidence of DGE, but more high-powered studies are needed in the future. Neither laparoscopic nor robotic surgery has demonstrated superiority in preventing DGE, and the use of staplers is controversial regarding whether they can reduce the incidence of DGE. Conclusions: Despite many innovations in surgical techniques, there is no surgical procedure that is superior to others to reduce DGE. Further larger prospective randomized studies are needed.展开更多
Image steganography is one of the prominent technologies in data hiding standards.Steganographic system performance mostly depends on the embedding strategy.Its goal is to embed strictly confidential information into ...Image steganography is one of the prominent technologies in data hiding standards.Steganographic system performance mostly depends on the embedding strategy.Its goal is to embed strictly confidential information into images without causing perceptible changes in the original image.The randomization strategies in data embedding techniques may utilize random domains,pixels,or region-of-interest for concealing secrets into a cover image,preventing information from being discovered by an attacker.The implementation of an appropriate embedding technique can achieve a fair balance between embedding capability and stego image imperceptibility,but it is challenging.A systematic approach is used with a standard methodology to carry out this study.This review concentrates on the critical examination of several embedding strategies,incorporating experimental results with state-of-the-art methods emphasizing the robustness,security,payload capacity,and visual quality metrics of the stego images.The fundamental ideas of steganography are presented in this work,along with a unique viewpoint that sets it apart from previous works by highlighting research gaps,important problems,and difficulties.Additionally,it offers a discussion of suggested directions for future study to advance and investigate uncharted territory in image steganography.展开更多
Forecasting travel demand requires a grasp of individual decision-making behavior.However,transport mode choice(TMC)is determined by personal and contextual factors that vary from person to person.Numerous characteris...Forecasting travel demand requires a grasp of individual decision-making behavior.However,transport mode choice(TMC)is determined by personal and contextual factors that vary from person to person.Numerous characteristics have a substantial impact on travel behavior(TB),which makes it important to take into account while studying transport options.Traditional statistical techniques frequently presume linear correlations,but real-world data rarely follows these presumptions,which may make it harder to grasp the complex interactions.Thorough systematic review was conducted to examine how machine learning(ML)approaches might successfully capture nonlinear correlations that conventional methods may ignore to overcome such challenges.An in-depth analysis of discrete choice models(DCM)and several ML algorithms,datasets,model validation strategies,and tuning techniques employed in previous research is carried out in the present study.Besides,the current review also summarizes DCM and ML models to predict TMC and recognize the determinants of TB in an urban area for different transport modes.The two primary goals of our study are to establish the present conceptual frameworks for the factors influencing the TMC for daily activities and to pinpoint methodological issues and limitations in previous research.With a total of 39 studies,our findings shed important light on the significance of considering factors that influence the TMC.The adjusted kernel algorithms and hyperparameter-optimized ML algorithms outperform the typical ML algorithms.RF(random forest),SVM(support vector machine),ANN(artificial neural network),and interpretable ML algorithms are the most widely used ML algorithms for the prediction of TMC where RF achieved an R2 of 0.95 and SVM achieved an accuracy of 93.18%;however,the adjusted kernel enhanced the accuracy of SVM 99.81%which shows that the interpretable algorithms outperformed the typical algorithms.The sensitivity analysis indicates that the most significant parameters influencing TMC are the age,total trip time,and the number of drivers.展开更多
Tyrosine kinase inhibitors(TKIs)have emerged as the first-line small molecule drugs in many cancer therapies,exerting their effects by impeding aberrant cell growth and proliferation through the modulation of tyrosine...Tyrosine kinase inhibitors(TKIs)have emerged as the first-line small molecule drugs in many cancer therapies,exerting their effects by impeding aberrant cell growth and proliferation through the modulation of tyrosine kinase-mediated signaling pathways.However,there exists a substantial inter-individual variability in the concentrations of certain TKIs and their metabolites,which may render patients with compromised immune function susceptible to diverse infections despite receiving theoretically efficacious anticancer treatments,alongside other potential side effects or adverse reactions.Therefore,an urgent need exists for an up-to-date review concerning the biological matrices relevant to bioanalysis and the sampling methods,clinical pharmacokinetics,and therapeutic drug monitoring of different TKIs.This paper provides a comprehensive overview of the advancements in pretreatment methods,such as protein precipitation(PPT),liquid-liquid extraction(LLE),solid-phase extraction(SPE),micro-SPE(μ-SPE),magnetic SPE(MSPE),and vortex-assisted dispersive SPE(VA-DSPE)achieved since 2017.It also highlights the latest analysis techniques such as newly developed high performance liquid chromatography(HPLC)and high-resolution mass spectrometry(HRMS)methods,capillary electrophoresis(CE),gas chromatography(GC),supercritical fluid chromatography(SFC)procedures,surface plasmon resonance(SPR)assays as well as novel nanoprobes-based biosensing techniques.In addition,a comparison is made between the advantages and disadvantages of different approaches while presenting critical challenges and prospects in pharmacokinetic studies and therapeutic drug monitoring.展开更多
The rapid evolution of wireless communication technologies has underscored the critical role of antennas in ensuring seamless connectivity.Antenna defects,ranging from manufacturing imperfections to environmental wear...The rapid evolution of wireless communication technologies has underscored the critical role of antennas in ensuring seamless connectivity.Antenna defects,ranging from manufacturing imperfections to environmental wear,pose significant challenges to the reliability and performance of communication systems.This review paper navigates the landscape of antenna defect detection,emphasizing the need for a nuanced understanding of various defect types and the associated challenges in visual detection.This review paper serves as a valuable resource for researchers,engineers,and practitioners engaged in the design and maintenance of communication systems.The insights presented here pave the way for enhanced reliability in antenna systems through targeted defect detection measures.In this study,a comprehensive literature analysis on computer vision algorithms that are employed in end-of-line visual inspection of antenna parts is presented.The PRISMA principles will be followed throughout the review,and its goals are to provide a summary of recent research,identify relevant computer vision techniques,and evaluate how effective these techniques are in discovering defects during inspections.It contains articles from scholarly journals as well as papers presented at conferences up until June 2023.This research utilized search phrases that were relevant,and papers were chosen based on whether or not they met certain inclusion and exclusion criteria.In this study,several different computer vision approaches,such as feature extraction and defect classification,are broken down and analyzed.Additionally,their applicability and performance are discussed.The review highlights the significance of utilizing a wide variety of datasets and measurement criteria.The findings of this study add to the existing body of knowledge and point researchers in the direction of promising new areas of investigation,such as real-time inspection systems and multispectral imaging.This review,on its whole,offers a complete study of computer vision approaches for quality control in antenna parts.It does so by providing helpful insights and drawing attention to areas that require additional exploration.展开更多
Flexible electronics offer a multitude of advantages,such as flexibility,lightweight property,portability,and high durability.These unique properties allow for seamless applications to curved and soft surfaces,leading...Flexible electronics offer a multitude of advantages,such as flexibility,lightweight property,portability,and high durability.These unique properties allow for seamless applications to curved and soft surfaces,leading to extensive utilization across a wide range of fields in consumer electronics.These applications,for example,span integrated circuits,solar cells,batteries,wearable devices,bio-implants,soft robotics,and biomimetic applications.Recently,flexible electronic devices have been developed using a variety of materials such as organic,carbon-based,and inorganic semiconducting materials.Silicon(Si)owing to its mature fabrication process,excellent electrical,optical,thermal properties,and cost efficiency,remains a compelling material choice for flexible electronics.Consequently,the research on ultra-thin Si in the context of flexible electronics is studied rigorously nowadays.The thinning of Si is crucially important for flexible electronics as it reduces its bending stiffness and the resultant bending strain,thereby enhancing flexibility while preserving its exceptional properties.This review provides a comprehensive overview of the recent efforts in the fabrication techniques for forming ultra-thin Si using top-down and bottom-up approaches and explores their utilization in flexible electronics and their applications.展开更多
Hypoparathyroidism is one of the main complications after total thyroidectomy,severely affecting patients’quality of life.How to effectively protect parathyroid function after surgery and reduce the incidence of hypo...Hypoparathyroidism is one of the main complications after total thyroidectomy,severely affecting patients’quality of life.How to effectively protect parathyroid function after surgery and reduce the incidence of hypoparathyroidism has always been a key research area in thyroid surgery.Therefore,precise localization of parathyroid glands during surgery,effective imaging,and accurate surgical resection have become hot topics of concern for thyroid surgeons.In response to this clinical phenomenon,this study compared several different imaging methods for parathyroid surgery,including nanocarbon,indocyanine green,near-infrared imaging techniques,and technetium-99m methoxyisobutylisonitrile combined with gamma probe imaging technology.The advantages and disadvantages of each method were analyzed,providing scientific recommendations for future parathyroid imaging.In recent years,some related basic and clinical research has also been conducted in thyroid surgery.This article reviewed relevant literature and provided an overview of the practical application progress of various imaging techniques in parathyroid surgery.展开更多
In the increasingly decentralized energy environment,economical power dispatching from distributed generations(DGs)is crucial to minimizing operating costs,optimizing resource utilization,and guaranteeing a consistent...In the increasingly decentralized energy environment,economical power dispatching from distributed generations(DGs)is crucial to minimizing operating costs,optimizing resource utilization,and guaranteeing a consistent and sustainable supply of electricity.A comprehensive review of optimization techniques for economic power dispatching from distributed generations is imperative to identify the most effective strategies for minimizing operational costs while maintaining grid stability and sustainability.The choice of optimization technique for economic power dispatching from DGs depends on a number of factors,such as the size and complexity of the power system,the availability of computational resources,and the specific requirements of the application.Optimization techniques for economic power dispatching from distributed generations(DGs)can be classified into two main categories:(i)Classical optimization techniques,(ii)Heuristic optimization techniques.In classical optimization techniques,the linear programming(LP)model is one of the most popular optimization methods.Utilizing the LP model,power demand and network constraints are met while minimizing the overall cost of generating electricity from DGs.This approach is efficient in determining the best DGs dispatch and is capable of handling challenging optimization issues in the large-scale system including renewables.The quadratic programming(QP)model,a classical optimization technique,is a further popular optimization method,to consider non-linearity.The QP model can take into account the quadratic cost of energy production,with consideration constraints like network capacity,voltage,and frequency.The metaheuristic optimization techniques are also used for economic power dispatching from DGs,which include genetic algorithms(GA),particle swarm optimization(PSO),and ant colony optimization(ACO).Also,Some researchers are developing hybrid optimization techniques that combine elements of classical and heuristic optimization techniques with the incorporation of droop control,predictive control,and fuzzy-based methods.These methods can deal with large-scale systems with many objectives and non-linear,non-convex optimization issues.The most popular approaches are the LP and QP models,while more difficult problems are handled using metaheuristic optimization techniques.In summary,in order to increase efficiency,reduce costs,and ensure a consistent supply of electricity,optimization techniques are essential tools used in economic power dispatching from DGs.展开更多
BACKGROUND The rotator cuff is located below the acromion and deltoid muscles and comprises multiple tendons that wrap around the humeral head,maintaining shoulder joint stability.AIM To explore the effect of electroa...BACKGROUND The rotator cuff is located below the acromion and deltoid muscles and comprises multiple tendons that wrap around the humeral head,maintaining shoulder joint stability.AIM To explore the effect of electroacupuncture combined with rehabilitation techniques on shoulder function in patients with rotator cuff injuries.METHODS We selected 97 patients with rotator cuff injuries treated in the People's Hospital of Yuhuan from February 2020 to May 2023.Patients were grouped using the envelope method.RESULTS After treatment,the study group’s treatment effective rate was 94.90%(46/49 patients),significantly higher than that in the control group(79.17%,38/48 cases;P<0.05).Before treatment,there was no difference in Constant Murley Score(CMS)scores,shoulder mobility,or 36-Item Short Form Health Survey(SF-36)scale scores(P>0.05).Compared with those before treatment,the CMS scores(including pain,daily living ability,shoulder mobility,and muscle strength),all aspects of shoulder mobility(forward flexion,posterior extension,external rotation,internal rotation),and SF-36 scale scores(including physiological,psychological,emotional,physical,vitality,and health status)were higher in both groups after treatment and significantly higher in the study group(P<0.05).There was no difference in the occurrence of complications between the two treatment groups(P>0.05).CONCLUSION Electroacupuncture combined with rehabilitation techniques has a good treatment effect on patients with rotator cuff injuries,helps accelerate the recovery of shoulder function,improves the quality of life,and is highly safe.展开更多
[Objectives]This study was conducted to actively carry out the breeding of new tetraploid common buckwheat varieties and its supporting breeding techniques.[Methods]Pintianqiao 3 is a new tetraploid common buckwheat v...[Objectives]This study was conducted to actively carry out the breeding of new tetraploid common buckwheat varieties and its supporting breeding techniques.[Methods]Pintianqiao 3 is a new tetraploid common buckwheat variety developed by College of Agriculture of Shanxi Agricultural University and Agricultural Genetic Resources Center of Shanxi Agricultural University,using‘Pintianqiao 1’as the parent,through mutation treatment with 0.2%colchicine aqueous solution,grain selection,plant selection,isolation and identification,variety comparison,regional test and field investigation.The variety has chromosomes 2n=4X=32,and shows a spring sowing period of 101 d and a summer sowing period of 80 d,large flowers and seeds(with a 1000-grain weight of 41.4 g),and good resistance to lodging.[Results]From 2021 to 2022,Pintianqiao 3 participated in the independent joint regional test of common buckwheat varieties in Shanxi Province,and the average yield in 10 test positions was 1.8 kg,equivalent to 1800 kg/hm^(2),which was 8.4%higher than the control.It passed the field investigation conducted by Shanxi provincial expert group for identification of non-major crop varieties in Dongyang and Kelan experimental sites on September 2-3,2022.On January 4,2024,it passed the preliminary examination of Shanxi Provincial Crop Variety Approval Committee.The seed reproduction technique of Pintianqiao 3 including land selection,preparation before sowing,sowing,field management and timely harvesting has been developed.[Conclusions]This study provides technical support for the demonstration and popularization of this new variety.展开更多
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor symptoms such as tremors, rigidity, and bradykinesia, as well as non-motor symptoms including cognitive impairment and mood ...Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor symptoms such as tremors, rigidity, and bradykinesia, as well as non-motor symptoms including cognitive impairment and mood disorders. A hallmark of PD is the accumulation of alpha-synuclein, a presynaptic neuronal protein that aggregates to form Lewy bodies, leading to neuronal dysfunction and cell death. The study of alpha-synuclein and its pathological forms is crucial for understanding the etiology of PD and developing effective diagnostic and therapeutic strategies. Analytical techniques play a pivotal role in elucidating the structure, function, and aggregation mechanisms of alpha-synuclein. Biochemical methods such as Western blotting and enzyme-linked immunosorbent assay (ELISA) are employed to detect and quantify alpha-synuclein in biological samples, offering insights into its expression levels and post-translational modifications. Imaging techniques like immunohistochemistry and positron emission tomography (PET) allow for the visualization of alpha-synuclein aggregates in tissue samples and in vivo, respectively, facilitating the study of its spatial distribution and progression in PD Spectroscopic methods, including nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry, provide detailed structural information on alpha-synuclein and its isoforms, aiding in the identification of conformational changes associated with aggregation. Emerging techniques such as cryo-electron microscopy (Cryo-EM) and single-molecule fluorescence enable high-resolution structural analysis and real-time monitoring of alpha-synuclein aggregation dynamics, respectively. The application of these analytical techniques has significantly advanced our understanding of the pathophysiological role of alpha-synuclein in PD. They have contributed to the identification of potential biomarkers for early diagnosis and the evaluation of therapeutic interventions targeting alpha-synuclein aggregation. Despite technical limitations and challenges in clinical translation, ongoing advancements in analytical methodologies hold promise for improving the diagnosis, monitoring, and treatment of Parkinson’s disease through a deeper understanding of alpha-synuclein pathology.展开更多
Continuous cropping can bring economic benefits in a short time and meet the growing demand of agricultural products such as grain,but long-term continuous cropping will accelerate soil degradation,lead to the reducti...Continuous cropping can bring economic benefits in a short time and meet the growing demand of agricultural products such as grain,but long-term continuous cropping will accelerate soil degradation,lead to the reduction of crop yield and the increase of disease rate,and destroy the balance of soil microbial structure.Therefore,it is not conducive to the sustainable development of soil ecosystem.In this paper,the problems caused by continuous cropping,such as imbalance of soil microbial flora,decrease of biodiversity,accumulation of root exudates and their effects on soil fertility and crop growth,were summarized,and some measures were suggested to alleviate the obstacles of continuous cropping,such as reasonable rotation,adjustment of intercropping planting mode and application of biological fertilizers.Moreover,the paper also looked forward to the development trend of continuous cropping obstacle reduction techniques,including the integration and application of biological techniques,the promotion of green ecological techniques and the application of intelligent management system.This study provides theoretical basis and technical support for the research of continuous cropping obstacle reduction techniques and promote the healthy and sustainable development of modern agriculture.展开更多
Chinese chive is a kind of medicinal and edible plant,with many diseases,and chemical fungicides are usually used for control.In order to find out the risk of pesticide residues in Chinese chives,this paper summarized...Chinese chive is a kind of medicinal and edible plant,with many diseases,and chemical fungicides are usually used for control.In order to find out the risk of pesticide residues in Chinese chives,this paper summarized relevant literatures published in recent years,and sorted out and analyzed the types of pesticides used and detection techniques of common diseases in Chinese chives.展开更多
基金supported by the U.S.National Science Foundation (2208972,2120559,and 2323117)
文摘Rechargeable battery cycling performance and related safety have been persistent concerns.It is crucial to decipher the capacity fading induced by electrode material failure via a range of techniques.Among these,synchrotron-based X-ray techniques with high flux and brightness play a key role in understanding degradation mechanisms.In this comprehensive review,we summarize recent advancements in degra-dation modes and mechanisms that were revealed by synchrotron X-ray methodologies.Subsequently,an overview of X-ray absorption spectroscopy and X-ray scattering techniques is introduced for charac-terizing failure phenomena at local coordination atomic environment and long-range order crystal struc-ture scale,respectively.At last,we envision the future of exploring material failure mechanism.
文摘The development of intestinal anastomosis techniques,including hand suturing,stapling,and compression anastomoses,has been a significant advancement in surgical practice.These methods aim to prevent leakage and minimize tissue fibrosis,which can lead to stricture formation.The healing process involves various phases:hemostasis and inflammation,proliferation,and remodeling.Mechanical staplers and sutures can cause inflammation and fibrosis due to the release of profibrotic chemokines.Compression anastomosis devices,including those made of nickel-titanium alloy,offer a minimally invasive option for various surgical challenges and have shown safety and efficacy.However,despite advancements,anastomotic techniques are evaluated based on leakage risk,with complications being a primary concern.Newer devices like Magnamosis use magnetic rings for compression anastomosis,demonstrating greater strength and patency compared to stapling.Magnetic technology is also being explored for other medical treatments.While there are promising results,particularly in animal models,the realworld application in humans is limited,and further research is needed to assess their safety and practicality.
基金supported by the Natural Science Foundation of Sichuan Province of China,Nos.2022NSFSC1545 (to YG),2022NSFSC1387 (to ZF)the Natural Science Foundation of Chongqing of China,Nos.CSTB2022NSCQ-LZX0038,cstc2021ycjh-bgzxm0035 (both to XT)+3 种基金the National Natural Science Foundation of China,No.82001378 (to XT)the Joint Project of Chongqing Health Commission and Science and Technology Bureau,No.2023QNXM009 (to XT)the Science and Technology Research Program of Chongqing Education Commission of China,No.KJQN202200435 (to XT)the Chongqing Talents:Exceptional Young Talents Project,No.CQYC202005014 (to XT)。
文摘Epilepsy can be defined as a dysfunction of the brain network,and each type of epilepsy involves different brain-network changes that are implicated diffe rently in the control and propagation of interictal or ictal discharges.Gaining more detailed information on brain network alterations can help us to further understand the mechanisms of epilepsy and pave the way for brain network-based precise therapeutic approaches in clinical practice.An increasing number of advanced neuroimaging techniques and electrophysiological techniques such as diffusion tensor imaging-based fiber tra ctography,diffusion kurtosis imaging-based fiber tractography,fiber ball imagingbased tra ctography,electroencephalography,functional magnetic resonance imaging,magnetoencephalography,positron emission tomography,molecular imaging,and functional ultrasound imaging have been extensively used to delineate epileptic networks.In this review,we summarize the relevant neuroimaging and neuroelectrophysiological techniques for assessing structural and functional brain networks in patients with epilepsy,and extensively analyze the imaging mechanisms,advantages,limitations,and clinical application ranges of each technique.A greater focus on emerging advanced technologies,new data analysis software,a combination of multiple techniques,and the construction of personalized virtual epilepsy models can provide a theoretical basis to better understand the brain network mechanisms of epilepsy and make surgical decisions.
基金financial support from the National Natural Science Foundation of China(Nos.62104017 and 52072204)Beijing Institute of Technology Research Fund Program for Young Scholars.
文摘Manipulating the expression of synaptic plasticity of neuromorphic devices provides fascinating opportunities to develop hardware platforms for artifi-cial intelligence.However,great efforts have been devoted to exploring biomimetic mechanisms of plasticity simulation in the last few years.Recent progress in various plasticity modulation techniques has pushed the research of synaptic electronics from static plasticity simulation to dynamic plasticity modulation,improving the accuracy of neuromorphic computing and providing strategies for implementing neuromorphic sensing functions.Herein,several fascinating strategies for synap-tic plasticity modulation through chemical techniques,device structure design,and physical signal sensing are reviewed.For chemical techniques,the underly-ing mechanisms for the modification of functional materials were clarified and its effect on the expression of synaptic plasticity was also highlighted.Based on device structure design,the reconfigurable operation of neuromorphic devices was well demonstrated to achieve programmable neuromorphic functions.Besides,integrating the sensory units with neuromorphic processing circuits paved a new way to achieve human-like intelligent perception under the modulation of physical signals such as light,strain,and temperature.Finally,considering that the relevant technology is still in the basic exploration stage,some prospects or development suggestions are put forward to promote the development of neuromorphic devices.
基金support by Spanish MICINN through the project PID2021-126098OB-I00/AEI/FEDER10.13039/501100011033 are gratefully ac-knowledgedthe MiNa Laboratory at IMN,and funding from CAM(project S2018/NMT-4291 TEC2SPACE),MINECO(project CSIC13-4E-1794)and EU(FEDER,FSE)+2 种基金fund-ing from TechnoFusion Project(P2018/EMT-4437)of the CAM(Comunidad Autónoma Madrid)support from the Center for Micro-Analysis of Materials(CMAM)-Univer-sidad Autónoma de Madrid,for the beam time proposals,with codes STD005/23,STD020/23 and STD037/23,and its technical staff for their contribution to the operation of the acceleratorsupport from the research project“Captación de Talento UAM”Ref:#541D300 supervised by the Vice-Chancellor of Research of Universidad Autonoma de Madrid(UAM).
文摘Pd-capped nanocrystalline Mg films were prepared by electron beam evaporation and hydrogenated under isothermal conditions to inves-tigate the hydrogen absorption process via ion beam techniques and in situ optical methods.Films were characterized by different techniques such as X-ray diffraction(XRD)and scanning electron microscopy(SEM).Rutherford backscattering spectrometry(RBS)and elastic recoil detection analysis(ERDA)provided a detailed compositional depth profile of the films during hydrogenation.Gas-solid reaction kinetics theory applied to ERDA data revealed a H absorption mechanism controlled by H diffusion.This rate-limiting step was also confirmed by XRD measurements.The diffusion coefficient(D)was also determined via RBS and ERDA,with a value of(1.1±0.1)·10^(−13)cm^(2)/s at 140℃.Results confirm the validity of IBA to monitor the hydrogenation process and to extract the control mechanism of the process.The H kinetic information given by optical methods is strongly influenced by the optical absorption of the magnesium layer,revealing that thinner films are needed to extract further and reliable information from that technique.
文摘The widespread adoption of the Internet of Things (IoT) has transformed various sectors globally, making themmore intelligent and connected. However, this advancement comes with challenges related to the effectiveness ofIoT devices. These devices, present in offices, homes, industries, and more, need constant monitoring to ensuretheir proper functionality. The success of smart systems relies on their seamless operation and ability to handlefaults. Sensors, crucial components of these systems, gather data and contribute to their functionality. Therefore,sensor faults can compromise the system’s reliability and undermine the trustworthiness of smart environments.To address these concerns, various techniques and algorithms can be employed to enhance the performance ofIoT devices through effective fault detection. This paper conducted a thorough review of the existing literature andconducted a detailed analysis.This analysis effectively links sensor errors with a prominent fault detection techniquecapable of addressing them. This study is innovative because it paves theway for future researchers to explore errorsthat have not yet been tackled by existing fault detection methods. Significant, the paper, also highlights essentialfactors for selecting and adopting fault detection techniques, as well as the characteristics of datasets and theircorresponding recommended techniques. Additionally, the paper presents amethodical overview of fault detectiontechniques employed in smart devices, including themetrics used for evaluation. Furthermore, the paper examinesthe body of academic work related to sensor faults and fault detection techniques within the domain. This reflectsthe growing inclination and scholarly attention of researchers and academicians toward strategies for fault detectionwithin the realm of the Internet of Things.
基金partly supported by the University of Malaya Impact Oriented Interdisci-plinary Research Grant under Grant IIRG008(A,B,C)-19IISS.
文摘Organizations are adopting the Bring Your Own Device(BYOD)concept to enhance productivity and reduce expenses.However,this trend introduces security challenges,such as unauthorized access.Traditional access control systems,such as Attribute-Based Access Control(ABAC)and Role-Based Access Control(RBAC),are limited in their ability to enforce access decisions due to the variability and dynamism of attributes related to users and resources.This paper proposes a method for enforcing access decisions that is adaptable and dynamic,based on multilayer hybrid deep learning techniques,particularly the Tabular Deep Neural Network Tabular DNN method.This technique transforms all input attributes in an access request into a binary classification(allow or deny)using multiple layers,ensuring accurate and efficient access decision-making.The proposed solution was evaluated using the Kaggle Amazon access control policy dataset and demonstrated its effectiveness by achieving a 94%accuracy rate.Additionally,the proposed solution enhances the implementation of access decisions based on a variety of resource and user attributes while ensuring privacy through indirect communication with the Policy Administration Point(PAP).This solution significantly improves the flexibility of access control systems,making themmore dynamic and adaptable to the evolving needs ofmodern organizations.Furthermore,it offers a scalable approach to manage the complexities associated with the BYOD environment,providing a robust framework for secure and efficient access management.
文摘Background: Delayed gastric emptying(DGE) is one of the most common complications after pancreaticoduodenectomy(PD). DGE represents impaired gastric motility without significant mechanical obstruction and is associated with an increased length of hospital stay, increased healthcare costs, and a high readmission rate. We reviewed published studies on various technical modifications to reduce the incidence of DGE. Data sources: Studies were identified by searching Pub Med for relevant articles published up to December 2022. The following search terms were used: “pancreaticoduodenectomy”, “pancreaticojejunostomy”, “pancreaticogastrostomy”, “gastric emptying”, “gastroparesis” and “postoperative complications”. The search was limited to English publications. Additional articles were identified by a manual search of references from key articles. Results: In recent years, various surgical procedures and techniques have been explored to reduce the incidence of DGE. Pyloric resection, Billroth II reconstruction, Braun's enteroenterostomy, and antecolic reconstruction may be associated with a decreased incidence of DGE, but more high-powered studies are needed in the future. Neither laparoscopic nor robotic surgery has demonstrated superiority in preventing DGE, and the use of staplers is controversial regarding whether they can reduce the incidence of DGE. Conclusions: Despite many innovations in surgical techniques, there is no surgical procedure that is superior to others to reduce DGE. Further larger prospective randomized studies are needed.
基金This research was funded by the Ministry of Higher Education(MOHE)through Fundamental Research Grant Scheme(FRGS)under the Grand Number FRGS/1/2020/ICT01/UK M/02/4,and University Kebangsaan Malaysia for open access publication.
文摘Image steganography is one of the prominent technologies in data hiding standards.Steganographic system performance mostly depends on the embedding strategy.Its goal is to embed strictly confidential information into images without causing perceptible changes in the original image.The randomization strategies in data embedding techniques may utilize random domains,pixels,or region-of-interest for concealing secrets into a cover image,preventing information from being discovered by an attacker.The implementation of an appropriate embedding technique can achieve a fair balance between embedding capability and stego image imperceptibility,but it is challenging.A systematic approach is used with a standard methodology to carry out this study.This review concentrates on the critical examination of several embedding strategies,incorporating experimental results with state-of-the-art methods emphasizing the robustness,security,payload capacity,and visual quality metrics of the stego images.The fundamental ideas of steganography are presented in this work,along with a unique viewpoint that sets it apart from previous works by highlighting research gaps,important problems,and difficulties.Additionally,it offers a discussion of suggested directions for future study to advance and investigate uncharted territory in image steganography.
文摘Forecasting travel demand requires a grasp of individual decision-making behavior.However,transport mode choice(TMC)is determined by personal and contextual factors that vary from person to person.Numerous characteristics have a substantial impact on travel behavior(TB),which makes it important to take into account while studying transport options.Traditional statistical techniques frequently presume linear correlations,but real-world data rarely follows these presumptions,which may make it harder to grasp the complex interactions.Thorough systematic review was conducted to examine how machine learning(ML)approaches might successfully capture nonlinear correlations that conventional methods may ignore to overcome such challenges.An in-depth analysis of discrete choice models(DCM)and several ML algorithms,datasets,model validation strategies,and tuning techniques employed in previous research is carried out in the present study.Besides,the current review also summarizes DCM and ML models to predict TMC and recognize the determinants of TB in an urban area for different transport modes.The two primary goals of our study are to establish the present conceptual frameworks for the factors influencing the TMC for daily activities and to pinpoint methodological issues and limitations in previous research.With a total of 39 studies,our findings shed important light on the significance of considering factors that influence the TMC.The adjusted kernel algorithms and hyperparameter-optimized ML algorithms outperform the typical ML algorithms.RF(random forest),SVM(support vector machine),ANN(artificial neural network),and interpretable ML algorithms are the most widely used ML algorithms for the prediction of TMC where RF achieved an R2 of 0.95 and SVM achieved an accuracy of 93.18%;however,the adjusted kernel enhanced the accuracy of SVM 99.81%which shows that the interpretable algorithms outperformed the typical algorithms.The sensitivity analysis indicates that the most significant parameters influencing TMC are the age,total trip time,and the number of drivers.
基金supported by the Natural Science Foundation of Liaoning Province,China(Grant No.:2023-MS-172).
文摘Tyrosine kinase inhibitors(TKIs)have emerged as the first-line small molecule drugs in many cancer therapies,exerting their effects by impeding aberrant cell growth and proliferation through the modulation of tyrosine kinase-mediated signaling pathways.However,there exists a substantial inter-individual variability in the concentrations of certain TKIs and their metabolites,which may render patients with compromised immune function susceptible to diverse infections despite receiving theoretically efficacious anticancer treatments,alongside other potential side effects or adverse reactions.Therefore,an urgent need exists for an up-to-date review concerning the biological matrices relevant to bioanalysis and the sampling methods,clinical pharmacokinetics,and therapeutic drug monitoring of different TKIs.This paper provides a comprehensive overview of the advancements in pretreatment methods,such as protein precipitation(PPT),liquid-liquid extraction(LLE),solid-phase extraction(SPE),micro-SPE(μ-SPE),magnetic SPE(MSPE),and vortex-assisted dispersive SPE(VA-DSPE)achieved since 2017.It also highlights the latest analysis techniques such as newly developed high performance liquid chromatography(HPLC)and high-resolution mass spectrometry(HRMS)methods,capillary electrophoresis(CE),gas chromatography(GC),supercritical fluid chromatography(SFC)procedures,surface plasmon resonance(SPR)assays as well as novel nanoprobes-based biosensing techniques.In addition,a comparison is made between the advantages and disadvantages of different approaches while presenting critical challenges and prospects in pharmacokinetic studies and therapeutic drug monitoring.
文摘The rapid evolution of wireless communication technologies has underscored the critical role of antennas in ensuring seamless connectivity.Antenna defects,ranging from manufacturing imperfections to environmental wear,pose significant challenges to the reliability and performance of communication systems.This review paper navigates the landscape of antenna defect detection,emphasizing the need for a nuanced understanding of various defect types and the associated challenges in visual detection.This review paper serves as a valuable resource for researchers,engineers,and practitioners engaged in the design and maintenance of communication systems.The insights presented here pave the way for enhanced reliability in antenna systems through targeted defect detection measures.In this study,a comprehensive literature analysis on computer vision algorithms that are employed in end-of-line visual inspection of antenna parts is presented.The PRISMA principles will be followed throughout the review,and its goals are to provide a summary of recent research,identify relevant computer vision techniques,and evaluate how effective these techniques are in discovering defects during inspections.It contains articles from scholarly journals as well as papers presented at conferences up until June 2023.This research utilized search phrases that were relevant,and papers were chosen based on whether or not they met certain inclusion and exclusion criteria.In this study,several different computer vision approaches,such as feature extraction and defect classification,are broken down and analyzed.Additionally,their applicability and performance are discussed.The review highlights the significance of utilizing a wide variety of datasets and measurement criteria.The findings of this study add to the existing body of knowledge and point researchers in the direction of promising new areas of investigation,such as real-time inspection systems and multispectral imaging.This review,on its whole,offers a complete study of computer vision approaches for quality control in antenna parts.It does so by providing helpful insights and drawing attention to areas that require additional exploration.
基金supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. RS-2024-00353768)the Yonsei Fellowship, funded by Lee Youn Jae. This study was funded by the KIST Institutional Program Project No. 2E31603-22-140 (K J Y). S M W acknowledges the support by National Research Foundation of Korea (NRF) grant funded by the Korea government (Grant Nos. NRF-2021R1C1C1009410, NRF2022R1A4A3032913 and RS-2024-00411904)
文摘Flexible electronics offer a multitude of advantages,such as flexibility,lightweight property,portability,and high durability.These unique properties allow for seamless applications to curved and soft surfaces,leading to extensive utilization across a wide range of fields in consumer electronics.These applications,for example,span integrated circuits,solar cells,batteries,wearable devices,bio-implants,soft robotics,and biomimetic applications.Recently,flexible electronic devices have been developed using a variety of materials such as organic,carbon-based,and inorganic semiconducting materials.Silicon(Si)owing to its mature fabrication process,excellent electrical,optical,thermal properties,and cost efficiency,remains a compelling material choice for flexible electronics.Consequently,the research on ultra-thin Si in the context of flexible electronics is studied rigorously nowadays.The thinning of Si is crucially important for flexible electronics as it reduces its bending stiffness and the resultant bending strain,thereby enhancing flexibility while preserving its exceptional properties.This review provides a comprehensive overview of the recent efforts in the fabrication techniques for forming ultra-thin Si using top-down and bottom-up approaches and explores their utilization in flexible electronics and their applications.
基金Supported by The 2024 Hospital Research Funding,No.KYQ2024008.
文摘Hypoparathyroidism is one of the main complications after total thyroidectomy,severely affecting patients’quality of life.How to effectively protect parathyroid function after surgery and reduce the incidence of hypoparathyroidism has always been a key research area in thyroid surgery.Therefore,precise localization of parathyroid glands during surgery,effective imaging,and accurate surgical resection have become hot topics of concern for thyroid surgeons.In response to this clinical phenomenon,this study compared several different imaging methods for parathyroid surgery,including nanocarbon,indocyanine green,near-infrared imaging techniques,and technetium-99m methoxyisobutylisonitrile combined with gamma probe imaging technology.The advantages and disadvantages of each method were analyzed,providing scientific recommendations for future parathyroid imaging.In recent years,some related basic and clinical research has also been conducted in thyroid surgery.This article reviewed relevant literature and provided an overview of the practical application progress of various imaging techniques in parathyroid surgery.
文摘In the increasingly decentralized energy environment,economical power dispatching from distributed generations(DGs)is crucial to minimizing operating costs,optimizing resource utilization,and guaranteeing a consistent and sustainable supply of electricity.A comprehensive review of optimization techniques for economic power dispatching from distributed generations is imperative to identify the most effective strategies for minimizing operational costs while maintaining grid stability and sustainability.The choice of optimization technique for economic power dispatching from DGs depends on a number of factors,such as the size and complexity of the power system,the availability of computational resources,and the specific requirements of the application.Optimization techniques for economic power dispatching from distributed generations(DGs)can be classified into two main categories:(i)Classical optimization techniques,(ii)Heuristic optimization techniques.In classical optimization techniques,the linear programming(LP)model is one of the most popular optimization methods.Utilizing the LP model,power demand and network constraints are met while minimizing the overall cost of generating electricity from DGs.This approach is efficient in determining the best DGs dispatch and is capable of handling challenging optimization issues in the large-scale system including renewables.The quadratic programming(QP)model,a classical optimization technique,is a further popular optimization method,to consider non-linearity.The QP model can take into account the quadratic cost of energy production,with consideration constraints like network capacity,voltage,and frequency.The metaheuristic optimization techniques are also used for economic power dispatching from DGs,which include genetic algorithms(GA),particle swarm optimization(PSO),and ant colony optimization(ACO).Also,Some researchers are developing hybrid optimization techniques that combine elements of classical and heuristic optimization techniques with the incorporation of droop control,predictive control,and fuzzy-based methods.These methods can deal with large-scale systems with many objectives and non-linear,non-convex optimization issues.The most popular approaches are the LP and QP models,while more difficult problems are handled using metaheuristic optimization techniques.In summary,in order to increase efficiency,reduce costs,and ensure a consistent supply of electricity,optimization techniques are essential tools used in economic power dispatching from DGs.
文摘BACKGROUND The rotator cuff is located below the acromion and deltoid muscles and comprises multiple tendons that wrap around the humeral head,maintaining shoulder joint stability.AIM To explore the effect of electroacupuncture combined with rehabilitation techniques on shoulder function in patients with rotator cuff injuries.METHODS We selected 97 patients with rotator cuff injuries treated in the People's Hospital of Yuhuan from February 2020 to May 2023.Patients were grouped using the envelope method.RESULTS After treatment,the study group’s treatment effective rate was 94.90%(46/49 patients),significantly higher than that in the control group(79.17%,38/48 cases;P<0.05).Before treatment,there was no difference in Constant Murley Score(CMS)scores,shoulder mobility,or 36-Item Short Form Health Survey(SF-36)scale scores(P>0.05).Compared with those before treatment,the CMS scores(including pain,daily living ability,shoulder mobility,and muscle strength),all aspects of shoulder mobility(forward flexion,posterior extension,external rotation,internal rotation),and SF-36 scale scores(including physiological,psychological,emotional,physical,vitality,and health status)were higher in both groups after treatment and significantly higher in the study group(P<0.05).There was no difference in the occurrence of complications between the two treatment groups(P>0.05).CONCLUSION Electroacupuncture combined with rehabilitation techniques has a good treatment effect on patients with rotator cuff injuries,helps accelerate the recovery of shoulder function,improves the quality of life,and is highly safe.
基金Supported by Scientific and Technological Achievements Transformation Guidance Special Project of Shanxi Province(202304021301054)Science and Technology Innovation Promotion Project of Shanxi Agricultural University(CXGC2023001)Biological Breeding Project of Shanxi Agricultural University in the 14^(th) Five-Year Plan(YZGC106).
文摘[Objectives]This study was conducted to actively carry out the breeding of new tetraploid common buckwheat varieties and its supporting breeding techniques.[Methods]Pintianqiao 3 is a new tetraploid common buckwheat variety developed by College of Agriculture of Shanxi Agricultural University and Agricultural Genetic Resources Center of Shanxi Agricultural University,using‘Pintianqiao 1’as the parent,through mutation treatment with 0.2%colchicine aqueous solution,grain selection,plant selection,isolation and identification,variety comparison,regional test and field investigation.The variety has chromosomes 2n=4X=32,and shows a spring sowing period of 101 d and a summer sowing period of 80 d,large flowers and seeds(with a 1000-grain weight of 41.4 g),and good resistance to lodging.[Results]From 2021 to 2022,Pintianqiao 3 participated in the independent joint regional test of common buckwheat varieties in Shanxi Province,and the average yield in 10 test positions was 1.8 kg,equivalent to 1800 kg/hm^(2),which was 8.4%higher than the control.It passed the field investigation conducted by Shanxi provincial expert group for identification of non-major crop varieties in Dongyang and Kelan experimental sites on September 2-3,2022.On January 4,2024,it passed the preliminary examination of Shanxi Provincial Crop Variety Approval Committee.The seed reproduction technique of Pintianqiao 3 including land selection,preparation before sowing,sowing,field management and timely harvesting has been developed.[Conclusions]This study provides technical support for the demonstration and popularization of this new variety.
文摘Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor symptoms such as tremors, rigidity, and bradykinesia, as well as non-motor symptoms including cognitive impairment and mood disorders. A hallmark of PD is the accumulation of alpha-synuclein, a presynaptic neuronal protein that aggregates to form Lewy bodies, leading to neuronal dysfunction and cell death. The study of alpha-synuclein and its pathological forms is crucial for understanding the etiology of PD and developing effective diagnostic and therapeutic strategies. Analytical techniques play a pivotal role in elucidating the structure, function, and aggregation mechanisms of alpha-synuclein. Biochemical methods such as Western blotting and enzyme-linked immunosorbent assay (ELISA) are employed to detect and quantify alpha-synuclein in biological samples, offering insights into its expression levels and post-translational modifications. Imaging techniques like immunohistochemistry and positron emission tomography (PET) allow for the visualization of alpha-synuclein aggregates in tissue samples and in vivo, respectively, facilitating the study of its spatial distribution and progression in PD Spectroscopic methods, including nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry, provide detailed structural information on alpha-synuclein and its isoforms, aiding in the identification of conformational changes associated with aggregation. Emerging techniques such as cryo-electron microscopy (Cryo-EM) and single-molecule fluorescence enable high-resolution structural analysis and real-time monitoring of alpha-synuclein aggregation dynamics, respectively. The application of these analytical techniques has significantly advanced our understanding of the pathophysiological role of alpha-synuclein in PD. They have contributed to the identification of potential biomarkers for early diagnosis and the evaluation of therapeutic interventions targeting alpha-synuclein aggregation. Despite technical limitations and challenges in clinical translation, ongoing advancements in analytical methodologies hold promise for improving the diagnosis, monitoring, and treatment of Parkinson’s disease through a deeper understanding of alpha-synuclein pathology.
基金Supported by Key Project of Yunnan Provincial Science and Technology Plan(202202AE090015)Scientific Research Fund of Yunnan Education Department(2024Y742+3 种基金2023Y0863)National Natural Science Foundation of China(42067009)2023 Undergraduate Innovation and Entrepreneurship Training Program of Yunnan Education Department(S202311393044S202311393061).
文摘Continuous cropping can bring economic benefits in a short time and meet the growing demand of agricultural products such as grain,but long-term continuous cropping will accelerate soil degradation,lead to the reduction of crop yield and the increase of disease rate,and destroy the balance of soil microbial structure.Therefore,it is not conducive to the sustainable development of soil ecosystem.In this paper,the problems caused by continuous cropping,such as imbalance of soil microbial flora,decrease of biodiversity,accumulation of root exudates and their effects on soil fertility and crop growth,were summarized,and some measures were suggested to alleviate the obstacles of continuous cropping,such as reasonable rotation,adjustment of intercropping planting mode and application of biological fertilizers.Moreover,the paper also looked forward to the development trend of continuous cropping obstacle reduction techniques,including the integration and application of biological techniques,the promotion of green ecological techniques and the application of intelligent management system.This study provides theoretical basis and technical support for the research of continuous cropping obstacle reduction techniques and promote the healthy and sustainable development of modern agriculture.
基金Supported by Special Project of the Central Government in Guidance of Local Science and Technology Development (Scientific and Technological Innovation Base Project) (226Z5504G)The Fourth Batch of High-end Talent Project in Hebei Province.
文摘Chinese chive is a kind of medicinal and edible plant,with many diseases,and chemical fungicides are usually used for control.In order to find out the risk of pesticide residues in Chinese chives,this paper summarized relevant literatures published in recent years,and sorted out and analyzed the types of pesticides used and detection techniques of common diseases in Chinese chives.