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Organelle Structures: Bridging Strategy and Technological Processes
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作者 Rob Dekkers 《厦门大学学报(自然科学版)》 CAS CSCD 北大核心 2002年第S1期249-251,共3页
The shifting requirements as imposed on operations ma nagement require adjusting and tailoring the organisational structure to meet ma rket demands. However, translating these requirements directly into hierarchical s... The shifting requirements as imposed on operations ma nagement require adjusting and tailoring the organisational structure to meet ma rket demands. However, translating these requirements directly into hierarchical structure will not ensure the integration of processes across organisational un its and guarantee desirable performance. Therefore, management and management li terature wonders: · How should we connect processes to the external environment within a strategi c framework · Which organisational structures do meet performance requirements · Which choices and freedom do we have within organisational structures · How and when do we implement organisational structures That the hierarchical structure does not meet as such the performance requiremen ts nor did it relate to these became already clear during case studies performed in the ’70s. The conclusion was drawn that organisational changes should affect working processes before they proof to be viable. This required the development of new approach through empirical studies and base d on literature. This led to the development of the organelle structure. The org anelle structure should connect to the strategy and the product flow. Thereto, a decision model has been developed for revealing these relations and the practic al implication. During a number of case studies this methodology has been refined and includes t he strategic choice between variants for the organelle structure with their own performance capabilities; we distinguish about 20 variants ranging between the f unctional organisation and the product flow organisation. These ranges of choice s however can be connected to different order entry points, stemming from logist ic concepts. This extends the performance to improved lead-times and improved c ontrol. Strategic choices relate the organelle structure to external performance criteria dictated by product/market-combinations: · lead-time · quality · costs and internal choices for performance criteria: · flexibility · productivity · resource utilisation · innovative performance. Case studies reveal the drastic improvements of the performance of operations an d manufacturing. The paper will discuss a few of these implementations to demons trate the impact. They also show how one derives the hierarchical structure from the choice for the organelle structure. Organelle structures do bridge the link of an industrial company to its environm ent and the internal possibilities, dictated by characteristics of product flow and process execution. The link to the environment results in a strategic framew ork for assessment of alternatives and possibilities. Choices for organelle stru ctures depend strongly on choices on the order entry points of the hardware flow and the specification flow. The evaluation of the characteristics takes place a gainst the strategic framework ensuring competitive advantage as well as a high probability of factual implementation and performance improvement. 展开更多
关键词 LINK Bridging Strategy and technological processes Organelle Structures
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An approach to net-centric control automation of technological processes within industrial IoT systems 被引量:3
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作者 Nikita Voinov Igor Chernorutsky +1 位作者 Pavel Drobintsev Vsevolod Kotlyarov 《Advances in Manufacturing》 SCIE CAS CSCD 2017年第4期388-393,共6页
The use of industrial internet networks with net- centric control is the driving trend behind the future material manufacturing of goods and services. The promising future of this approach is provided by these complex... The use of industrial internet networks with net- centric control is the driving trend behind the future material manufacturing of goods and services. The promising future of this approach is provided by these complex net-centric systems functioning with high relia- bility. The problem of intelligent net-centric control and reliable network functioning is fundamental, with the additional requirement that the system should preserve stakeholder security and privacy according to policies. The issue is that such systems are characterized by complex multi-parameter operability modes controlled by various criteria. This study considers an approach to providing reliable management of complicated Internet of things (IoT) systems. This is achieved by solving multi-criteria tasks over many processes of various physical natures. Corresponding methods of hierarchical decomposition of multi-criteria tasks, process levels of multi-criteria opti- mization, specifics of aggregation levels, and the master equation of the optimization process are described. 展开更多
关键词 Net-centric control technological process Internet of things (IoT) Reliability Multi-criteria optimization
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Mathematical Apparatus for Selection of Optimal Parameters of Technical, Technological Systems and Materials Based on Vector Optimization
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作者 Yu Mashunin 《American Journal of Operations Research》 2020年第5期173-239,共67页
We presented Mathematical apparatus of the choice of optimum parameters of technical, technological systems and materials on the basis of vector optimization. We have considered the formulation and solution of three t... We presented Mathematical apparatus of the choice of optimum parameters of technical, technological systems and materials on the basis of vector optimization. We have considered the formulation and solution of three types of tasks presented below. First, the problem of selecting the optimal parameters of technical systems depending on the functional characteristics of the system. Secondly, the problem of selecting the optimal parameters of the process depending on the technological characteristics of the process. Third, the problem of choosing the optimal structure of the material depending on the functional characteristics of this material. The statement of all problems is made in the form of vector problems of mathematical (nonlinear) programming. The theory and the principle of optimality of the solution of vector tasks it is explained in work of https://rdcu.be/bhZ8i. The implementation of the methodology is shown on a numerical example of the choice of optimum parameters of the technical, technological systems and materials. On the basis of mathematical methods of solution of vector problems we developed the software in the MATLAB system. The numerical example includes: input data (requirement specification) for modeling;transformation of mathematical models with uncertainty to the model under certainty;acceptance of an optimal solution with equivalent criteria (the solution of numerical model);acceptance of an optimal solution with the given priority of criterion. 展开更多
关键词 Vector Optimization Methods of Solution of Vector Problems Modeling of a Technical System Modeling Operation of technological processes Modeling of Structure of Material
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Combined Insights from Leachate Structure and Microstructure Characteristics for Eating Quality of Convenience Rice Processed by Super-Heated and Pressurized Steam Technologies
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作者 Mingyo HA Hyo-Young JEONG +1 位作者 Ju Hun LEE Hyun-Jung CHUNG 《Rice science》 SCIE CSCD 2024年第4期475-488,I0035,I0036,共16页
Convenience rice has become widely popular due to its easy availability for cooking. This study investigated the starch structure and composition of leachate and the microstructure of reheated convenience rice using n... Convenience rice has become widely popular due to its easy availability for cooking. This study investigated the starch structure and composition of leachate and the microstructure of reheated convenience rice using novel processing technologies: super-heated steaming(SHS), auto-electric cooking(AEC), and pressurized-steam cooking(PSC). Additionally, the effect of two different target water contents(58% and 63%) was also evaluated. The PSC_63% sample had the highest total solids and amylopectin amount in the leachate. The amylopectin amount in the leachate differed significantly based on the targeted water content. Morphological characterization revealed that the swelling of starch and the coated layer on the surface of rice grains were most pronounced in the PSC_63% sample due to the pressure processing. The textural hardness of the AEC_58% sample was much higher than that of the other samples. The PSC_63% sample had the highest textural adhesiveness value, which can be attributed to the highest amylopectin amount in the leachate. Sensory characterization showed that the PSC_63% sample had the highest glossiness, whiteness, moistness, and overall acceptability. The principal component analysis score plots presented substantial differences in the leachate and textural and sensory characteristics of reheated convenience rice among the different processing technologies. 展开更多
关键词 reheated convenience rice starch structure LEACHATE multi-scale structure eating quality processing technology
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Exploring Nutritional Compositions,Volatile Compounds,Health Benefits,Emerging Processing Technologies,and Potential Food Products of Glutinous Rice:A Review
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作者 Maimunah Mohd ALI Norhashila HASHIM 《Rice science》 SCIE CSCD 2024年第3期251-268,共18页
Glutinous rice(Oryza sativa var.glutinosa)stands out as one of the most popular rice varieties globally,amidst thousands of rice cultivars.Its increasing popularity is attributed to its rich nutritional compositions a... Glutinous rice(Oryza sativa var.glutinosa)stands out as one of the most popular rice varieties globally,amidst thousands of rice cultivars.Its increasing popularity is attributed to its rich nutritional compositions and health benefits.This review aims to summarize the nutritional compositions,volatile compounds,and health benefits of glutinous rice.Further,in-depth studies are necessary to explore the utilization of glutinous rice in enhancing processing technologies and developing new food products.Glutinous rice has been shown to possess numerous health benefits,including antioxidant activity,bioactive compounds,anti-cancer properties,anti-inflammatory effects,anti-diabetic potential,and cholesterol-lowering effects.Besides its nutritional compositions,the major volatile compounds identified in glutinous rice could serve as a functional food for human consumption.Emerging processing technologies related to glutinous rice are elaborated to improve the latest developments for incorporating them into various food products. 展开更多
关键词 glutinous rice health benefit volatile compound nutritional composition processing technology
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Ecosystem Services of Grazed Grasslands in the Flooding Pampa
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作者 Elizabeth J.Jacobo Adriana M.Rodríguez 《Phyton-International Journal of Experimental Botany》 SCIE 2024年第6期1179-1202,共24页
The Flooding Pampa grasslands are the last remnant of the Rio de la Plata grasslands in Argentina.Anthropo-genic interventions have led to severe degradation and,as a result,the ecosystem services provided by the gras... The Flooding Pampa grasslands are the last remnant of the Rio de la Plata grasslands in Argentina.Anthropo-genic interventions have led to severe degradation and,as a result,the ecosystem services provided by the grass-lands are declining,in terms of provisioning,regulating,and supporting services.We synthesized the existing literature on the ecosystem goods and services provided by these grasslands under grazing in different conditions and conservation status.We found that plant and animal diversity and primary production are the most studied ecosystem services,while climate regulation,water supply,nutrient cycling,meat production and erosion control,in that order,are less studied.Cultural services are under-researched.Continuous grazing and glyphosate spraying are the main drivers of grassland degradation.Controlled grazing and conservative stocking rates have been shown to reverse degradation and demonstrate that livestock production is compatible with ecosystem conserva-tion by maintaining regulating and provisioning services.As these management strategies are poorly integrated,improving their implementation will require important changes in farmers’decisions and the development of policies that create the economic conditions for this to happen.Research is needed to understand the conditions that prevent the knowledge generated from being transferred to producers and translated into practices that would improve the provision of ecosystem services. 展开更多
关键词 Salado basin SUSTAINABILITY BIODIVERSITY RANGELANDS meat production adaptative multi paddock grazing process technologies AGROECOLOGY
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Innovations and applications of the thermal recovery techniques for heavy oil
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作者 Huanquan Sun Haitao Wang +5 位作者 Xulong Cao Qinglin Shu Zheyuan Fan Guanghuan Wu Yuanliang Yang Yongchao Wu 《Energy Geoscience》 EI 2024年第4期8-19,共12页
Heavy oil represents a vital petroleum resource worldwide.As one of the major producers,China is facing great challenges in effective and economic production of heavy oil due to reservoir complexity.Plenty of efforts ... Heavy oil represents a vital petroleum resource worldwide.As one of the major producers,China is facing great challenges in effective and economic production of heavy oil due to reservoir complexity.Plenty of efforts have been made to promote innovative advances in thermal recovery modes,methods,and processes for heavy oil in the country.The thermal recovery mode has been shifted from simple steam injection to a more comprehensive“thermal+"strategy,such as a novel N2-steam hybrid process and CO_(2)-enhanced thermal recovery techniques.These advanced techniques break through the challenges of heavy oil extraction from less accessible reservoirs with thinner oil layers and greater burial depths.Regarding thermal recovery methods,China has developed the steam-assisted gravity drainage method integrating flooding and drainage(also referred to as the hybrid flooding-drainage SAGD technology)for highly heterogeneous ultra-heavy oil reservoirs and the fire flooding method for nearly depleted heavy oil reservoirs,substantially improving oil recovery.Furthermore,a range of processes have been developed for heavy oil production,including the open hole completion process using sand control screens for horizontal wells,the process of integrated injection-recovery with horizontal pump for horizontal wells,the steam dryness maintenance,measurement,and control process,efficient and environment-friendly circulating fluidized bed(CFB)boilers with high steam dryness,the recycling process of produced water,and the thermal recovery process for offshore heavy oil.Based on the advances in methodology,technology,and philosophy,a series of supporting technologies for heavy oil production have been developed,leading to the breakthrough of existing technical limit of heavy oil recovery and the expansion into new exploitation targets.For the future heavy oil production in China,it is necessary to embrace a green,low-carbon,and energy-efficient development strategy,and to expand heavy oil extraction in reservoirs with larger burial depth,more viscous oil,thinner oil layers,and lower permeability.Moreover,it is highly recommended to collaboratively maximize oil recovery and oil-to-steam ratio through technological innovations,and boost intelligentization of heavy oil production. 展开更多
关键词 Heavy oil Thermal recovery Process technology Hybrid thermal production
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Flexible Fixture Design for the Top and End Surface Processing of NP2_NP4 Cylinder Heads
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作者 Cheng Chang Junbao Chen 《Journal of Electronic Research and Application》 2024年第3期20-27,共8页
This paper focuses on the design of fixtures for NP2 and NP4 cylinder heads on a horizontal machining center of flexible machining automatic lines.It began with an analysis of the diagrams of part processing and worki... This paper focuses on the design of fixtures for NP2 and NP4 cylinder heads on a horizontal machining center of flexible machining automatic lines.It began with an analysis of the diagrams of part processing and working procedure which formed the basis for the design of the processing technology scheme,a selection of suitable machine tools,and the setting of processing parameters.Fixtures tailored to the chosen machine tools were then designed to meet the processing requirements.Additional aspects of the project included the design of part drawings,calculation of working time quota,design of auxiliary guides,support clamping,and hydraulic circuits,all aimed at fulfilling practical production requirements. 展开更多
关键词 Part processing technology analysis Calculation of working time quota Fixture design
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Processing Technology and Quality of Low-fluoride Brick tea 被引量:1
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作者 李兰英 王云 +4 位作者 尧渝 马伟伟 李春华 张厅 刘飞 《Agricultural Science & Technology》 CAS 2017年第9期1680-1685,共6页
In order to promote the quality of brick tea and reduce its fluoride content, the fluoride contents in leaves of 25 tea varieties at the .stage of one bud and five leaves were determined by the method of fluodde-ion s... In order to promote the quality of brick tea and reduce its fluoride content, the fluoride contents in leaves of 25 tea varieties at the .stage of one bud and five leaves were determined by the method of fluodde-ion selective electrode method. The results showed that the fluodde contents in the 25 varieties were in the range of 181.92-345.06 mg/kg, end the fluoride content in 'Zhongcha 302' was the lowest. Based on traditional production process of brick tea, 3 new low-fluoride brick tea production processes with 'Zhongcha 302' as the raw material at the stage of one bud and five leaves were constructed. The fluoride content, physicochemical in- dex, sensory end main chemical contents in the brick tea samples were determined. The best processing process of Iow-fluodde brick tea was process 3, which included aldng, fixing, rolling, second fixing, second roiling, sun-drying, pile-fermentation, steaming, pile-fermentation, drying and shaping into brick by vapor treating. The re- sults showed that the fluoride content and physicochemical index of the brick tea sample of the third low-fluoride brick tea production process accorded with National Standard GB/T 9833.4-2013. The sensory evaluation of the brick tea sample was better than that of brick tea manufacture by the traditional process. The water extract, tea polyphenols, amino acids, caffeine and water-soluble sugar in the brick tea sample increased by 9.41%, 36.39%, 26.94%, 27.23% and 15.29%, respectively. Low-fluodds bdck tea could be produced by selecting low fluoride tea varieties, controlling the tondemess of fresh leaves, and optimizing the processing technique. 展开更多
关键词 Low-fluodde varieties Low-fluoride brick tea Processing technology QUALITY
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Identification of Sewage Monitoring Data Based on Mathematical Statistics
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作者 万玉山 邹涛 +3 位作者 李大伟 温馨 沈梦 陈艳秋 《Agricultural Science & Technology》 CAS 2017年第4期656-659,共4页
In order to reduce the enormous pressure to environmental monitoring work brought by the false sewage monitoring data, Grubbs method, box plot, t test and other methods are used to make depth analysis to the data, pro... In order to reduce the enormous pressure to environmental monitoring work brought by the false sewage monitoring data, Grubbs method, box plot, t test and other methods are used to make depth analysis to the data, providing a set of technological process to identify the sewage monitoring data, which is convenient and simple. 展开更多
关键词 Mathematical statistics Monitoring data technological process
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Research on Optimized Equipment System with Computer Aid for Water Purification
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作者 葛常清 吴俊民 《Journal of Southeast University(English Edition)》 EI CAS 2001年第1期66-69,共4页
This paper describes pure water making equipment by using applicable datebase, computer languages and drawing software. It gives a general introduction to the systematic designing plan, the division of the different... This paper describes pure water making equipment by using applicable datebase, computer languages and drawing software. It gives a general introduction to the systematic designing plan, the division of the different parts and their functions, and the pure water making technological process. 展开更多
关键词 technological process flow chart water quality pure water super pure water
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Latest research advances on magnesium and magnesium alloys worldwide 被引量:191
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作者 Jiangfeng Song Jia She +1 位作者 Daolun Chen Fusheng Pan 《Journal of Magnesium and Alloys》 SCIE 2020年第1期1-41,共41页
In the past two years,significant progresses have been achieved in high-performance cast and wrought magnesium and magnesium alloys,magnesium-based composites,advanced cast technologies,advanced processing technologie... In the past two years,significant progresses have been achieved in high-performance cast and wrought magnesium and magnesium alloys,magnesium-based composites,advanced cast technologies,advanced processing technologies,and functional magnesium materials,such as Mg ion batteries,hydrogen storage Mg materials,bio-magnesium alloys,etc.Great contributions to the development of new magnesium alloys and their processing technologies have been made by Chongqing University,Shanghai Jiaotong University,Chinese Academy of Sciences,Helmholtz Zentrum Geesthacht,Queensland University,Brunel University,etc.This review paper is aimed to summarize the latest important advances in cast magnesium alloys,wrought magnesium alloys and functional magnesium materials worldwide in 2018–2019,including both the development of new materials and the innovation of their processing technologies.Based on the issues and challenges identified here,some future research directions are suggested,including further development of high-performance magnesium alloys having high strength and superior plasticity together with high corrosion resistance and low cost,and fundamental research on the phase diagram,diffusion,precipitation,etc.,as well as the development of advanced welding and joining technology. 展开更多
关键词 Cast magnesium alloys Wrought magnesium alloys Functional magnesium materials Cast and processing technologies Corrosion and surface treatment International standard
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Research advances of magnesium and magnesium alloys worldwide in 2021 被引量:41
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作者 Jiangfeng Song Jing Chen +3 位作者 Xiaoming Xiong Xiaodong Peng Daolun Chen Fusheng Pan 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2022年第4期863-898,共36页
More than 4000 papers in the field of Mg and Mg alloys were published and indexed in Web of Science(WoS)Core Collection database in 2021.The bibliometric analyses indicate that the microstructure,mechanical properties... More than 4000 papers in the field of Mg and Mg alloys were published and indexed in Web of Science(WoS)Core Collection database in 2021.The bibliometric analyses indicate that the microstructure,mechanical properties,and corrosion of Mg alloys still are the main research focus.Mg ion batteries and hydrogen storage Mg materials have attracted much attention.Significant contributions to the research and development of magnesium alloys were made by Chongqing University,Shanghai Jiaotong University,and Chinese Academy of Sciences in China,Helmholtz Zentrum Hereon in Germany,Ohio State University in the United States,the University of Queensland in Australia,Kumanto University in Japan,and Seoul National University in Korea,University of Tehran in Iran,etc..This review is aimed to summarize the progress in the development of structural and functional Mg and Mg alloys in 2021.Based on the issues and challenges identified here,some future research directions are suggested. 展开更多
关键词 Magnesium alloys Cast magnesium alloys Wrought magnesium alloys Bio-magnesium alloys Mg based energy storage materials Processing technologies Corrosion and protection
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Research advances of magnesium and magnesium alloys worldwide in 2022 被引量:16
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作者 Yan Yang Xiaoming Xiong +3 位作者 Jing Chen Xiaodong Peng Daolun Chen Fusheng Pan 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2023年第8期2611-2654,共44页
More than 4600 papers in the field of Mg and Mg alloys were published and indexed in the Web of Science(WoS)Core Collection database in 2022.The bibliometric analyses indicate that the microstructure,mechanical proper... More than 4600 papers in the field of Mg and Mg alloys were published and indexed in the Web of Science(WoS)Core Collection database in 2022.The bibliometric analyses indicate that the microstructure,mechanical properties,and corrosion of Mg alloys are still the main research focus.Bio-Mg materials,Mg ion batteries and hydrogen storage Mg materials have attracted much attention.Notable contributions to the research and development of magnesium alloys were made by Chongqing University(>200 papers),Chinese Academy of Sciences,Shanghai Jiao Tong University,and Northeastern University(>100 papers)in China,Helmholtz Zentrum Hereon in Germany,Ohio State University in the USA,the University of Queensland in Australia,Kumanto University in Japan,and Seoul National University in Korea,University of Tehran in Iran,and National University of Singapore in Singapore,etc.This review is aimed to summarize the progress in the development of structural and functional Mg and Mg alloys in 2022.Based on the issues and challenges identified here,some future research directions are suggested. 展开更多
关键词 Magnesium alloys Cast magnesium alloys Wrought magnesium alloys Bio-magnesium alloys Mg-based energy storage materials Processing technologies Corrosion and protection
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Fermentation-enabled wellness foods:A fresh perspective 被引量:17
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作者 Huan Xiang Dongxiao Sun-Waterhouse +2 位作者 Geoffrey I.N.Waterhouse Chun Cui Zheng Ruan 《Food Science and Human Wellness》 SCIE 2019年第3期203-243,共41页
Fermented foods represent an important segment of current food markets,especially traditional or ethnic food markets.The demand for efficient utilization of agrowastes,together with advancements in fermentation techno... Fermented foods represent an important segment of current food markets,especially traditional or ethnic food markets.The demand for efficient utilization of agrowastes,together with advancements in fermentation technologies(microbial-and enzyme-based processing),are stimulating rapid growth and innovation in the fermented food sector.In addition,the health-promoting benefits of fermented foods are attracting increasingly attention.The microorganisms contained in many common fermented foods can serve as“microfactories”to generate nutrients and bioactives with specific nutritional and health functionalities.Herein,recent research relating to the manufacture of fermented foods are critically reviewed,placing emphasis on the potential health benefits of fermentation-enabled wellness foods.The importance of the correct selection of microorganisms and raw materials and the need for precise control of fermentation processes are explored.Major knowledge gaps and obstacles to fermented food production and market penetration are discussed.The importance of integrating multidisciplinary knowledge,communicating with consumers,establishing regulatory frameworks specifically for fermentation-enabled wellness foods and functional fermented foods,are highlighted. 展开更多
关键词 Fermented foods Microbial factories Bioactive PROBIOTICS NUTRIENTS Processing technologies
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Virtual Reality:A State-of-the-Art Survey 被引量:4
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作者 Ning-Ning Zhou Yu-Long Deng 《International Journal of Automation and computing》 EI 2009年第4期319-325,共7页
This paper presents a survey on virtual reality systems and provides an in-depth understanding toward the notion of immersion, according to the semantic meanings of the terms "virtual" and "reality". The paper ana... This paper presents a survey on virtual reality systems and provides an in-depth understanding toward the notion of immersion, according to the semantic meanings of the terms "virtual" and "reality". The paper analyses the structure and functions of a virtual reality system and takes the three dimensional display as the immersive medium to identify the key issues for construction of virtual environments. The paper also reviews the development of virtual reality technology and introduces new image processing techniques into the design of virtual reality systems and virtual environments. 展开更多
关键词 Virtual reality IMMERSION VIRTUAL REALITY image processing technology
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Elbow precision machining technology by abrasive flow based on direct Monte Carlo method 被引量:3
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作者 LI Jun-ye ZHU Zhi-bao +4 位作者 WANG Bin-yu ZHANG Xin-ming WANG Fei ZHAO Wei-hong XU Cheng-yu 《Journal of Central South University》 SCIE EI CAS CSCD 2020年第12期3667-3683,共17页
The investigation was carried out on the technical problems of finishing the inner surface of elbow parts and the action mechanism of particles in elbow precision machining by abrasive flow.This work was analyzed and ... The investigation was carried out on the technical problems of finishing the inner surface of elbow parts and the action mechanism of particles in elbow precision machining by abrasive flow.This work was analyzed and researched by combining theory,numerical and experimental methods.The direct simulation Monte Carlo(DSMC)method and the finite element analysis method were combined to reveal the random collision of particles during the precision machining of abrasive flow.Under different inlet velocity,volume fraction and abrasive particle size,the dynamic pressure and turbulence flow energy of abrasive flow in elbow were analyzed,and the machining mechanism of particles on the wall and the influence of different machining parameters on the precision machining quality of abrasive flow were obtained.The test results show the order of the influence of different parameters on the quality of abrasive flow precision machining and establish the optimal process parameters.The results of the surface morphology before and after the precision machining of the inner surface of the elbow are discussed,and the surface roughness Ra value is reduced from 1.125μm to 0.295μm after the precision machining of the abrasive flow.The application of DSMC method provides special insights for the development of abrasive flow technology. 展开更多
关键词 precision machining by abrasive flow direct simulation Monte Carlo method abrasive particle collision processing technology
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Fluidised bed granulation of two APIs:QbD approach and development of a NIR in-line monitoring method 被引量:3
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作者 Alexandru Gavan Sonia Iurian +5 位作者 Tibor Casian Alina Porfire Sebastian Porav Ioana Voina Alexandru Oprea Ioan Tomuta 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2020年第4期506-517,共12页
The study focused on the fluid-bed granulation process of a product with two active pharmaceutical ingredients,intended for coated tablets preparation and further transfer to industrial scale.The work aimed to prove t... The study focused on the fluid-bed granulation process of a product with two active pharmaceutical ingredients,intended for coated tablets preparation and further transfer to industrial scale.The work aimed to prove that an accurate control of the critical granulation parameters can level the input material variability and offer a user-friendly process control strategy.Moreover,an in-line Near-Infrared monitoring method was developed,which offered a real time overview of the moisture level along the granulation process,thus a reliable supervision and control process analytical technology(PAT)tool.The experimental design’s results showed that the use of apparently interchangeable active pharmaceutical ingredients(APIs)and filler sorts that comply with pharmacopoeial specifications,lead to different end-product critical attributes.By adapting critical granulation parameters(i.e.binder spray rate and atomising pressure)as a function of material characteristics,led to granules with average sizes comprised in a narrow range of 280–320μm and low nongranulated fraction of under 5%.Therefore,the accurate control of process parameters according to the formulation particularities achieved the maintenance of product within the design space and removed material related variability.To complete the Quality by design(QbD)strategy,despite its limited spectral domain,the microNIR spectrometer was successfully used as a robust PAT monitoring tool that offered a real time overview of the moisture level and allowed the supervision and control of the granulation process. 展开更多
关键词 Quality by design Design space Risk assessment Process analytical technology Fluid bed granulation MicroNIR
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Raman spectroscopy as process analytical tool in downstream processing of biotechnology 被引量:2
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作者 Yu Kiat Lin Hui Yi Leong +2 位作者 Tau Chuan Ling Dong-Qiang Lin Shan-Jing Yao 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2021年第2期204-211,共8页
Downstream processing or product recovery plays a vital role in the development of bioprocesses.To improve the bioprocess efficiency,some unconventional methods are much required.The continuous manufacturing in downst... Downstream processing or product recovery plays a vital role in the development of bioprocesses.To improve the bioprocess efficiency,some unconventional methods are much required.The continuous manufacturing in downstream processing makes the Process Analytical Technologies(PATs)as an important tool.Monitoring and controlling bioprocess are an essential factor for the principles of PAT and quality by design.Spectroscopic methods can apply to monitor multiple analytes in real-time with less sample processing with significant advancements.Raman spectroscopy is an extensively used technique as an analytical and research tool owing to its modest process form,non-destructive,non-invasive optical molecular spectroscopic imaging with computer-based analysis.Generally,its application is essential for the analysis and characterization of biological samples,and it is easy to operate with minimal sample.The innovation on various types of enhanced Raman spectroscopy was designed to enhance the Raman analytical technique.Raman spectroscopy could couple with chemometrics to provide reliable alternative analysis method of downstream process analysis.Thus,this review aims to provide useful insight on the application of Raman spectroscopy for PAT in downstream processing of biotechnology and Raman data analysis in biological fields. 展开更多
关键词 Raman spectroscopy Process analytical technology Downstream bioprocessing BIOTECHNOLOGY
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Human Respiration Rate Estimation Using Ultra-wideband Distributed Cognitive Radar System 被引量:2
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作者 Predrag Rapajic 《International Journal of Automation and computing》 EI 2008年第4期325-333,共9页
It has been shown that remote monitoring of pulmonary activity can be achieved using ultra-wideband (UWB) systems, which shows promise in home healthcare,rescue,and security applications.In this paper,we first present... It has been shown that remote monitoring of pulmonary activity can be achieved using ultra-wideband (UWB) systems, which shows promise in home healthcare,rescue,and security applications.In this paper,we first present a multi-ray propagation model for UWB signal,which is traveling through the human thorax and is reflected on the air/dry-skin/fat/muscle interfaces,A geometry-based statistical channel model is then developed for simulating the reception of UWB signals in the indoor propagation environment.This model enables replication of time-varying multipath profiles due to the displacement of a human chest.Subsequently, a UWB distributed cognitive radar system (UWB-DCRS) is developed for the robust detection of chest cavity motion and the accurate estimation of respiration rate.The analytical framework can serve as a basis in the planning and evaluation of future rheasurement programs.We also provide a case study on how the antenna beamwidth affects the estimation of respiration rate based on the proposed propagation models and system architecture. 展开更多
关键词 Medical and patient monitoring sensing technologies and signal processing vital sign ULTRA-WIDEBAND distributed cog-nitive radar respiration rate estimation.
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