Global optimality conditions for quadratic 0-1 programming with inequality constraints

Quadratic 0-1 problems with linear inequality constraints are briefly considered in this paper.Global optimality conditions for these problems,including a necessary condition and some sufficient conditions,are presented.The necessary condition is expressed without dual variables.The relations between the global optimal solutions of nonconvex quadratic 0-1 problems and the associated relaxed convex problems are also studied.

A Tabu Search Algorithm for Quadratic 0-1 Programming Problem

In this paper,quadratic 0-1 programming problem (I) is considered, in terms of its features quadratic 0-1 programming problem is solved by linear approxity heurstic algrothm and a developed tabu search ahgrothm .

Nondifferentiable Multiobjective Programming under Generalized d_I-G-Type I Invexity

To relax convexity assumptions imposed on the functions in theorems on sufficient conditions and duality,new concepts of generalized dI-G-type Ⅰ invexity were introduced for nondifferentiable multiobjective programming problems.Based upon these generalized invexity,G-Fritz-John （G-F-J） and G-Karnsh-Kuhn-Tucker （G-K-K-T） types sufficient optimality conditions were established for a feasible solution to be an efficient solution.Moreover,weak and strict duality results were derived for a G-Mond-Weir type dual under various types of generalized dI-G-type Ⅰ invexity assumptions.

Pivotal role of long non-coding ribonucleic acid-X-inactive specific transcript in regulating immune checkpoint programmed death ligand 1 through a shared pathway between miR-194-5p and miR-155-5p in hepatocellular carcinoma

BACKGROUND Anti-programmed death therapy has thrust immunotherapy into the spotlight.However,such therapy has a modest response in hepatocellular carcinoma(HCC).Epigenetic immunomodulation is a suggestive combinatorial therapy with immune checkpoint blockade.Non-coding ribonucleic acid(ncRNA)driven regulation is a major mechanism of epigenetic modulation.Given the wide range of ncRNAs that co-opt in programmed cell-death protein 1(PD-1)/programmed death ligand 1(PD-L1)regulation,and based on the literature,we hypothesized that miR-155-5p,miR-194-5p and long non-coding RNAs(lncRNAs)X-inactive specific transcript(XIST)and MALAT-1 are involved in a regulatory upstream pathway for PD-1/PD-L1.Recently,nutraceutical therapeutics in cancers have received increasing attention.Thus,it is interesting to study the impact of oleuropein on the respective study key players.AIM To explore potential upstream regulatory ncRNAs for the immune checkpoint PD-1/PD-L1.METHODS Bioinformatics tools including microrna.org and lnCeDB software were adopted to detect targeting of miR-155-5p,miR-194-5p and lncRNAs XIST and MALAT-1 to PD-L1 mRNA,respectively.In addition,Diana tool was used to predict targeting of both aforementioned miRNAs to lncRNAs XIST and MALAT-1.HCC and normal tissue samples were collected for scanning of PD-L1,XIST and MALAT-1 expression.To study the interaction among miR-155-5p,miR-194-5p,lncRNAs XIST and MALAT-1,as well as PD-L1 mRNA,a series of transfections of the Huh-7 cell line was carried out.RESULTS Bioinformatics software predicted that miR-155-5p and miR-194-5p can target PDL1,MALAT-1 and XIST.MALAT-1 and XIST were predicted to target PD-L1 mRNA.PD-L1 and XIST were significantly upregulated in 23 HCC biopsies compared to healthy controls;however,MALAT-1 was barely detected.MiR-194 induced expression elevated the expression of PD-L1,XIST and MALAT-1.However,overexpression of miR-155-5p induced the upregulation of PD-L1 and XIST,while it had a negative impact on MALAT-1 expression.Knockdown of XIST did have an impact on PD-L1 expression;however,following knockdown of the negative regulator of X-inactive specific transcript(TSIX),PD-L1 expression was elevated,and abolished MALAT-1 activity.Upon co-transfection of miR-194-5p with siMALAT-1,PD-L1 expression was elevated.Co-transfection of miR-194-5p with siXIST did not have an impact on PD-L1 expression.Upon co-transfection of miR-194 with siTSIX,PD-L1 expression was upregulated.Interestingly,the same PD-L1 expression pattern was observed following miR-155-5p cotransfections.Oleuropein treatment of Huh-7 cells reduced the expression profile of PD-L1,XIST,and miR-155-5p,upregulated the expression of miR-194-5p and had no significant impact on the MALAT-1 expression profile.CONCLUSION This study reported a novel finding revealing that opposing acting miRNAs in HCC,have the same impact on PD-1/PD-L1 immune checkpoint by sharing a common signaling pathway.

Some Practical Issues Regarding Java Programming

Java programming language is a major . new development which involves object-oriented programming and computer networking. Here, several examples of Java programs are presented. These examples show some major features that Java language provides, such as multi-thread, exception handling, network application writing, and the usage of Java applets. This article also shows some ways of setting up a Java language programming environment. All these examples are correct and ready to run.

A Hybrid Dynamic Programming Method for Concave Resource Allocation Problems

Concave resource allocation problem is an integer programming problem of minimizing a nonincreasing concave function subject to a convex nondecreasing constraint and bounded integer variables. This class of problems are encountered in optimization models involving economies of scale. In this paper, a new hybrid dynamic programming method was proposed for solving concave resource allocation problems. A convex underestimating function was used to approximate the objective function and the resulting convex subproblem was solved with dynamic programming technique after transforming it into a 0-1 linear knapsack problem. To ensure the convergence, monotonicity and domain cut technique was employed to remove certain integer boxes and partition the revised domain into a union of integer boxes. Computational results were given to show the efficiency of the algorithm.

Verifying the Effects of an Education Program Leveraging Information Technology to Promote Cervical Cancer Screening in Women Aged 20 - 29—A One-Year Longitudinal Study

The purpose of this research is to implement an IT-based education program in order to promote cervical cancer screenings for women aged 20 - 29 years, as well as to examine the results of said program. This is a longitudinal/comparative study of two groups, one for which the program was implemented (the intervention group), and the other for which it was not (the control group). The program consisted of attending a health lecture and encouragement to be screened one month, six months, and one year later sent through IT-based methods. The target was unmarried women aged 20 - 29 who had neither previously given birth nor had been screened for cervical cancer in a period one year prior. They were divided into two groups, the intervention group (n = 142) and control group (n = 145). The effectiveness of the program was assessed via an initial survey and further surveys six months and one year later. Results were based on the Japanese version of the Health Belief Model Scale for Cervical Cancer and the Pap Smear Test (HBMSCCPST), knowledge scores in the categories of Healthy Lifestyles, Cervical Cancer, Cervical Cancer Screening, and screening behavior. A two-way ANOVA of the HBMSCCPST subscales and knowledge scores in the initial, six-month, and one-year surveys was performed, showing interaction in Cervical Cancer (p = 0.00). Main effects were observed in Cervical Cancer Screening (p = 0.00) and Healthy Lifestyles (p = 0.00). Regarding the amount of change from the initial survey, knowledge scores in the Cervical Cancer (p = 0.027) and Cervical Cancer Screening (p = 0.016) categories were significantly higher in the intervention group than in the control group. There was no significant difference in cervical cancer screening rates (p = 0.26) between the two groups. However, a small-degree effect size was observed for Benefits, Seriousness, and Susceptibility subscales in both examinees and non-examinees. Although the educational program of this study was effective in improving the knowledge of women in their twenties, there was little improvement in HBMSCCPST and it did not lead to the promotion of cervical cancer screening. In order to raise interest in cervical cancer screening, it is necessary to consider useful content to guide women to consult with healthcare professionals, a long-term population approach, and organizational structure of consultation.

Nonconvex Quadratic Programming Method for k－Coloring Problem：Algorithm and Computation

In this paper, we consider the socalled k-coloring problem in general case.Firstly, a special quadratic 0-1 programming is constructed to formulate k-coloring problem. Secondly, by use of the equivalence between above quadratic0-1 programming and its relaxed problem, k-coloring problem is converted intoa class of (continuous) nonconvex quadratic programs, and several theoreticresults are also introduced. Thirdly, linear programming approximate algorithmis quoted and verified for this class of nonconvex quadratic programs. Finally,examining problems which are used to test the algorithm are constructed andsufficient computation experiments are reported.

The Develoyment Program of Energy Conservation and Comprehensive Utilization 2005-2007

Jointly published by 14 Department headed by Standardization Administraion ofChina(SAC) Subtitle: China will formulate and reformulate 926 standards for energy conservation andcomprehensive u-tilization during 2005 and 2007. In the past few days, 14 departments jointlypublished the Development Program of Energy Conservation and Comprehensive Utilization 2005-2007,(Program for short). They are Standardization Administration of China, National Development andReform Commission, Ministry of Land and Resources, Ministry of Establishment, Ministry ofCommunications, Ministry of Information Industry, Ministry of Waster Resources, Ministry ofAgriculture, Ministry of Commerce, General Administration of Quality Supervision, Inspection andQuarantine of the PRC, State Environmental Protection Administration, State Forestry Bureau, StateOceanic Administration and China Meteorological Bureau.

应用VB实现AGA8-92DC气体压缩因子计算方法

天然气压缩因子在天然气工程计算中具有重要的地位,其计算方法有多种,其中就包括由美国燃气协会提出的基于气体组成来计算压缩因子的AGA8-92DC方程。根据GB/T 17747.2-2011标准所给出的AGA8-92DC方法计算过程,用Visual Basic6.0 program编写了计算程序。为了验证程序的正确性,分别将程序计算值与GB/T 17747.2标准提供的计算值和含碳贫气气样实测值进行了对比,且获得了较小的计算误差。由计算值与实测值的对比结果可知,通过Visual Basic6.0 program所编写的AGA8-92DC方法计算程序而得到的计算结果能够满足工程上的要求;对于中高压含碳贫气,AGA8-92DC方法具有较高的计算准确度;当气体温度升高时,AGA8-92DC方法的计算误差将有所减小。

基于ε-ADP的一类离散非线性系统最优跟踪控制

针对实际工业常见的定点跟踪控制问题,通过数学变换,将原系统最优跟踪控制问题转化为新系统最优调节问题,以跟踪误差作为新系统的状态量,引入ε-自适应动态规划算法(ε-ADP)求解HJB方程,并以两个BP神经网络分别用于近似性能指标函数和最优控制,从而得到ε-最优跟踪控制。仿真实验表明,所设计的控制器可以在有限时间内将状态跟踪到目标值,并使得性能指标函数近似最优。

Compact Model for the Obnoxious <i>p</i>-Median Problem

Obnoxious facilities are those crucial to human living, yet antagonistic to the public or environment. However, the interactions between obnoxious facilities and their clients have been less frequently investigated. A state-of-the-art model for this problem involves numerous 0 - 1 variables, rendering it difficult to solve. This study aims at removing most of these 0 - 1 variables to enhanced model efficiency. A compact model is presented in this study, with the equivalence between the new and original models proved. Additionally, numerical tests were conducted to show that the proposed compact model is more efficient than the original one.

Effects of aerobic training on serum paraoxonase activity and its relationship with PON1-192 phenotypes in women

Background：Paraoxonase 1（PON1） is an antioxidant enzyme that protects high-density lipoprotein（HDL） and low-density lipoprotein against oxidation.Limited studies have addressed the influenc of exercise on PON1 activity and its relationship with PON1 phenotypes.We investigated relationships between PON1-192 phenotypes,PON1 activity,aerobic exercise,and blood lipid and lipoprotein concentrations in middle-aged women.Methods：An exercise group（n=50） engaging in regular aerobic exercise and a control group（n=41） were selected from a subset of 300 Caucasian women that met the inclusion criteria.Serum PON1,salt-stimulated PON1（SSPON1）,and arylesterase（ARE） activities;cholesterol levels and ARE activities of total HDL and HDL subgroups（HDLs）（supernatants obtained by polyethylene glycol）;and blood lipid and lipoprotein concentrations were determined by standardized enzymatic methods.PON1-192 QQ（low activity）,QR（moderate activity）,and RR（high activity） phenotype groups were define using serum SSPON1/ARE activity ratios.The R-carries（RC） phenotype group consisted of the QR and RR groups combined.Results：All lipid and lipoprotein concentrations were greater in the exercise group than in the control group.Regardless of phenotype,no significan differences were observed between the exercise and control groups in terms of serum PON1,SSPON1,or ARE activity associated with HDLs（p〉 0.05）,whereas PON1 activities in QQ-phenotyped women in the exercise group were significant y higher than those in the control group（p〈0.01）,but not the RC group.A statistically significan interaction between PON1 phenotypes（QQ and RC groups） and exercise（exercise and control groups） on PON1 activity was found.Conclusion：These results showed that a regular aerobic exercise program can improve PON1 activity depending on PON1-192 phenotype,but not on lipid and lipoprotein levels,in middle-aged Turkish women.

Computer-aided Pattern Design of Multi-bar Warp Knitted Fabrics

To meet the development trend of multi-bar warp knit-ting machine towards high-speed,advanced technologyand computer control and the requirements of variousproducts with small quantity,there are many researcheson the computer-aided pattern design of multi-barwarp knitted fabrics.In terms of the special propertiesof the computer-aided pattern design of multi-barwarp knitted fabrics,the Object Oriented Program(OOP)programming-Object Windows class Library(OWL)programming is selected.According to thecharacters of the OWL programming,various functionsare defined.Pattern design and technical parameters canbe output,which offers a great convenience for the fac-tory.

Expression and significance of B7-H1 in peripheral blood dendritic cells from patients with bladder cancer

Objective： The aim of this study was to study the expression and the clinical significance of B7-H1 on dendritic cells （DCs） in peripheral blood from patients with bladder cancer. Methods： Peripheral blood mononuclear cell were disparted from 30 bladder cancer patients and 7 healthy controls by density gradient centfifugation and then co-cultured. The expres- sion of B7-H1 on DCs were analyzed by flow cytometry. Results： Expression of BT-H1 on DCs in bladder cancer was higher than healthy controls （P 〈 0.01）. And the expression were strongly associated with the pathological grade and clinical stage of bladder cancer （P 〈 0,05）. Conclusion： The up-regulation of B7-H1 on DCs was strongly associated with neoplastic progres-sion of bladder cancer. B7-H1/programmed death （PD）-1 signal pathway may also play an important role in immune escape of bladder cancer during initial phase of T cell immune response.

Recent Advances in Mathematical Programming with Semi-continuous Variables and Cardinality Constraint

Mathematical programming problems with semi-continuous variables and cardinality constraint have many applications,including production planning,portfolio selection,compressed sensing and subset selection in regression.This class of problems can be modeled as mixed-integer programs with special structures and are in general NP-hard.In the past few years,based on new reformulations,approximation and relaxation techniques,promising exact and approximate methods have been developed.We survey in this paper these recent developments for this challenging class of mathematical programming problems.

A class of polynomially solvable 0-1 programming problems and an application

It is well known that general 0-1 programming problems are NP-Complete and their optimal solutions cannot be found with polynomial-time algorithms unless P=NP. In this paper, we identify a specific class of 0-1 programming problems that is polynomially solvable, and propose two polynomial-time algorithms to find its optimal solutions. This class of 0-1 programming problems commits to a wide range of real-world industrial applications. We provide an instance of representative in the field of supply chain management.

空间机器人遥操作系统设计及研制

针对空间机器人的特点设计了多种遥操作控制模式,提出了空间机器人遥操作分层控制结构LATSR(Layered Architecture for Teleoperation of Space Robot),并研制了一套遥操作系统,包括任务规划子系统、主从控制子系统、预测仿真子系统、信息处理子系统和地面验证子系统.最后利用该系统开展了多项遥操作实验,对整个系统及各子系统的功能和性能进行了检验.该系统具有灵活的操作接口,既为一般用户提供了简便的用户界面,也为机器人专家提供了底层控制能力.

远程教育系统中教案实时演示的一种实现方法

介绍了远程教学系统中利用WMF文件来进行实时教案演示的办法 ,着重介绍了OLEAutomation 。