Multi-fountional hollow structures have emerged as promising platforms for intelligent drug delivery due to their unique properties,such as high loading capacities and programmed drug release.In particular,hollow mult...Multi-fountional hollow structures have emerged as promising platforms for intelligent drug delivery due to their unique properties,such as high loading capacities and programmed drug release.In particular,hollow multishell structures(HoMSs)with multilevel shell and space can regulate the molecular-level interaction between drugs and materials,so as to achieve the temporal-spatial order and sequential release of drugs.The anisotropic hollow structures can control the drug diffusion process by inducing the macroscopic interface flow through autonomous movement,realizing the targeted drug transport and release.In this paper,a key focus will be HoMSs with their temporal-ordered architectures and anisotropic hollow carriers with directional movement.Their synthesis mechanisms,structure-property relationships,smartly programmed drug delivery and biomedical applications will be discussed,providing insights into designing next-generation intelligent drug carriers.展开更多
A numerical simulation method for parachute Fluid-Structure Interaction （FSI） problem using Semi-Implicit Method for Pres- sure-Linked Equations （SIMPLE） algorithm is proposed. This method could be used in both co...A numerical simulation method for parachute Fluid-Structure Interaction （FSI） problem using Semi-Implicit Method for Pres- sure-Linked Equations （SIMPLE） algorithm is proposed. This method could be used in both coupling computation of para- chute FSI and flow field analysis. Both fiat circular parachute and conical parachute are modeled and simulated by this new method. Flow field characteristics at various angles of attack are further simulated for the conical parachute model. Compari- son with the space-time FSI technique shows that this method also provides similar and reasonable results.展开更多
Hollow multishelled structure(HoMs)has drawn tremendous attention due to its abundant attractive properties and promising applications.However,for a long time,the limited synthesis method hindered the development of H...Hollow multishelled structure(HoMs)has drawn tremendous attention due to its abundant attractive properties and promising applications.However,for a long time,the limited synthesis method hindered the development of HoMs.The sequential templating approach developed by our group,has greatly enriched its composition and'structure diversity.The progress in HoMS synthesis promotes the discovery of its characteristics as well as widens its application area.Typicall,the recently explored temporal-spatial ordering characteristic of HoMS has shown great promise in drug delivery and cascade catalysis application areas.Here,we summarize the current development progress of HoMS in the aspects of both synthesis and application,with a focus discussion on how to shape its application performance by manipulating its composition and structure features.In addition,we discuss the current challenges and providethe future potentials holdingfor HoMs.展开更多
In this study,we analyze spring precipitation from 92 meteorological stations spanning between 1961 and 2012 to understand temporal-spatial variability and change of spring precipitation over Southwest China.Various a...In this study,we analyze spring precipitation from 92 meteorological stations spanning between 1961 and 2012 to understand temporal-spatial variability and change of spring precipitation over Southwest China.Various analysis methods are used for different purposes,including empirical orthogonal function（EOF） analysis and rotated EOF（REOF） for analyzing spatial structure change of precipitation anomaly,and the Mann-Kendall testing method to determine whether there were abrupt changes during the analyzed time span.We find that the first spatial mode of the precipitation has a domain uniform structure;the second is dominated by a spatial dipole;and the third contains five variability centers.The 2000 s is the decade with the largest amount of precipitation while the 1990 s is the decade with the smallest amount of precipitation.The year-to-year difference of that region is large：the amount of the largest precipitation year doubles that of the smallest precipitation year.We also find that spring precipitation in Southwest China experienced a few abrupt changes：a sudden increase at 1966,a sudden decrease at 1979,and a sudden increase at 1995.We speculate that the spring precipitation will increase gradually in the next two decades.展开更多
基金This work was supported by the National Natural Science Foundation of China(Nos.92163209,21821005 and 51932001)the Beijing Natural Science Foundation,China(No.JQ22004).
文摘Multi-fountional hollow structures have emerged as promising platforms for intelligent drug delivery due to their unique properties,such as high loading capacities and programmed drug release.In particular,hollow multishell structures(HoMSs)with multilevel shell and space can regulate the molecular-level interaction between drugs and materials,so as to achieve the temporal-spatial order and sequential release of drugs.The anisotropic hollow structures can control the drug diffusion process by inducing the macroscopic interface flow through autonomous movement,realizing the targeted drug transport and release.In this paper,a key focus will be HoMSs with their temporal-ordered architectures and anisotropic hollow carriers with directional movement.Their synthesis mechanisms,structure-property relationships,smartly programmed drug delivery and biomedical applications will be discussed,providing insights into designing next-generation intelligent drug carriers.
基金supported by the National Natural Science Foundation of China (Grant No. 10577003)Monash University of Australia
文摘A numerical simulation method for parachute Fluid-Structure Interaction （FSI） problem using Semi-Implicit Method for Pres- sure-Linked Equations （SIMPLE） algorithm is proposed. This method could be used in both coupling computation of para- chute FSI and flow field analysis. Both fiat circular parachute and conical parachute are modeled and simulated by this new method. Flow field characteristics at various angles of attack are further simulated for the conical parachute model. Compari- son with the space-time FSI technique shows that this method also provides similar and reasonable results.
基金This work was supported by the National Natural Science Foundation of China(Grant Nos.21820102002,21931012,22111530178 and 51972305)the DNLCooperation Fund,CAS(DNL202020).
文摘Hollow multishelled structure(HoMs)has drawn tremendous attention due to its abundant attractive properties and promising applications.However,for a long time,the limited synthesis method hindered the development of HoMs.The sequential templating approach developed by our group,has greatly enriched its composition and'structure diversity.The progress in HoMS synthesis promotes the discovery of its characteristics as well as widens its application area.Typicall,the recently explored temporal-spatial ordering characteristic of HoMS has shown great promise in drug delivery and cascade catalysis application areas.Here,we summarize the current development progress of HoMS in the aspects of both synthesis and application,with a focus discussion on how to shape its application performance by manipulating its composition and structure features.In addition,we discuss the current challenges and providethe future potentials holdingfor HoMs.
基金supported by the National Basic Research Program of China(Grant No.2013CB430200(2013CB430206))the Sixth Program Ten Talented People of the Meteorological Bureau of Gansu Province,China
文摘In this study,we analyze spring precipitation from 92 meteorological stations spanning between 1961 and 2012 to understand temporal-spatial variability and change of spring precipitation over Southwest China.Various analysis methods are used for different purposes,including empirical orthogonal function（EOF） analysis and rotated EOF（REOF） for analyzing spatial structure change of precipitation anomaly,and the Mann-Kendall testing method to determine whether there were abrupt changes during the analyzed time span.We find that the first spatial mode of the precipitation has a domain uniform structure;the second is dominated by a spatial dipole;and the third contains five variability centers.The 2000 s is the decade with the largest amount of precipitation while the 1990 s is the decade with the smallest amount of precipitation.The year-to-year difference of that region is large：the amount of the largest precipitation year doubles that of the smallest precipitation year.We also find that spring precipitation in Southwest China experienced a few abrupt changes：a sudden increase at 1966,a sudden decrease at 1979,and a sudden increase at 1995.We speculate that the spring precipitation will increase gradually in the next two decades.
