Clinical testing of patients for hereditary breast and ovarian cancer syndromes began in the mid-1990s with the identification of the BRCA1 and BRCA2 genes.Since then,mutations in dozens of other genes have been corre...Clinical testing of patients for hereditary breast and ovarian cancer syndromes began in the mid-1990s with the identification of the BRCA1 and BRCA2 genes.Since then,mutations in dozens of other genes have been correlated to increased breast,ovarian,and other cancer risk.The following decades of data collection and patient advocacy allowed for improvements in medical,legal,social,and ethical advances in genetic testing.Technological advances have made it possible to sequence multiple genes at once in a panel to give patients a more thorough evaluation of their personal cancer risk.Panel testing increases the detection of mutations that lead to increased risk of breast,ovarian,and other cancers and can better guide individualized screening measures compared to limited BRCA testing alone.At the same time,multi-gene panel testing is more time-and cost-efficient.While the clinical application of panel testing is in its infancy,many problems arise such as lack of guidelines for management of newly identified gene mutations,high rates of variants of uncertain significance,and limited ability to screen for some cancers.Through on-going concerted efforts of pooled data collection and analysis,it is likely that the benefits of multi-gene panel testing will outweigh the risks in the near future.展开更多
The sonic fatigue life of the aluminium rectangular panel was calculated using the concise method[1], and the sonic fatigue test was conducted on progressive wave tube (PWT) test facility. A comparison was made betwee...The sonic fatigue life of the aluminium rectangular panel was calculated using the concise method[1], and the sonic fatigue test was conducted on progressive wave tube (PWT) test facility. A comparison was made between the results of calculation and test, and it shows reasonable agreement between these two results.展开更多
This study tests the hysteresis hypothesis of unemployment in fifteen OECD countries by using panel unit root tests which allow for structural breaks. We apply annual unemployment rates covering 1985-2008 periods. We ...This study tests the hysteresis hypothesis of unemployment in fifteen OECD countries by using panel unit root tests which allow for structural breaks. We apply annual unemployment rates covering 1985-2008 periods. We test whether unemployment rates are stationary by using second generation tests which allow cross section dependency among series and panel unit root test based on structural break advanced by Carrion-i-Silvestre, Barrio-Castro and Lopez-Bazo （2005）. We find series as a stationary process with structural breaks according to Carrion-i Silvestre et al. （2005） test, while we find series as unit root process with second generation panel unit root test. According to the Carrion-i Silvestre et al. （2005） test, we find the evidence of absence of hysteresis in analyzed countries. As a result, temporary shocks have temporary effects on unemployment instead of permanent effect. Structural factors can affect the natural rate of unemployment and, therefore, unemployment would be stationary around a process that is subject to structural breaks. So, there still exists a unique natural rate of unemployment to which the economy eventually will converge.展开更多
Dent resistance of automobile body panels is an important property for automobile design and manufacture, but the study on this aspect is not still profound. This study is to summarize the testing methods and physical...Dent resistance of automobile body panels is an important property for automobile design and manufacture, but the study on this aspect is not still profound. This study is to summarize the testing methods and physical significations of static and dynamic dent resistance of automobile body panels combined with the author＇s study, and to analyze the dent behaviors in the round. Several influence factors on dent resistance are expatiated including the mechanical properties of materials, stress states after forming, bake hardening ability, modulus, methods of testing, and structure of specimens and so on. The automotive lightweight and application of high strength steel sheets and aluminum alloys sheets are analyzed, and the significance of testing of dent resistance, especially for dynamic dent resistance of auto-panels, and the finite element simulation analysis are emphasized. To explain the physical phenomenon of dent behaviors, the latest and concerned study results are also discussed. According to this study, a dent resistance test and evaluation standard of Society of Automotive Engineers of China for automotive body panel is presented and is being carried out, and an industry conference is hold to discuss the working-out of the standard, a primary schedule of this standard is confirmed now. The study can guide the further testing and study of dent resistant of auto-panels.展开更多
Severe damage to suspended ceilings of metal grids and lay-in panels was observed in public buildings during the 2013 M7.0 Lushan earthquake in China. Over the past several years, suspended ceilings have been widely u...Severe damage to suspended ceilings of metal grids and lay-in panels was observed in public buildings during the 2013 M7.0 Lushan earthquake in China. Over the past several years, suspended ceilings have been widely used practice in public buildings throughout China, including government offices, schools and hospitals. To investigate the damage mechanism of suspended ceilings, a series of three-dimensional shake table tests was conducted to reproduce the observed damage. A full-scale reinforced concrete frame was constructed as the testing frame for the ceiling, which was single-story and infilled with brick masonry walls to represent the local construction of low-rise buildings. In general, the ceiling in the tests exhibited similar damage phenomena as the field observations, such as higher vulnerability of perimeter elements and extensive damage to the cross runners. However, it exhibited lower fragility in terms of peak ground/roof accelerations at the initiation of damage. Further investigations are needed to clarify the reasons for this behavior.展开更多
A retrofitting technology using precast steel reinforced concrete（PSRC） panels is developed to improve the seismic performance of old masonry buildings. The PSRC panels are built up as an external PSRC wall system s...A retrofitting technology using precast steel reinforced concrete（PSRC） panels is developed to improve the seismic performance of old masonry buildings. The PSRC panels are built up as an external PSRC wall system surrounding the existing masonry building. The PSRC walls are well connected to the existing masonry building, which provides enough confinement to effectively improve the ductility, strength, and stiffenss of old masonry structures. The PSRC panels are prefabricated in a factory, significantly reducing the situ work and associated construction time. To demonstrate the feasibility and mechanical effectivenss of the proposed retrofitting system, a full-scale five-story specimen was constructed. The retrofitting process was completed within five weeks with very limited indoor operation. The specimen was then tested in the lateral direction, which could potentially suffer sigifnicant damage in a large earthquake. The technical feasibility, construction workability, and seismic performance were thoroughly demonstrated by a full-scale specimen construction and pseudo-dynamic tests.展开更多
In the present work the dynamic characteristics of Multilayer Polyurethane foam glass/fiber composite sandwich panels have been determined through Experimental Investigations. Using a Multilayer Polyurethane foam sand...In the present work the dynamic characteristics of Multilayer Polyurethane foam glass/fiber composite sandwich panels have been determined through Experimental Investigations. Using a Multilayer Polyurethane foam sandwich panel with rectangular cross-section, the natural frequencies, mode shapes and the damping ratio of sandwich panels were evaluated. Three types of boundary conditions were simulated namely, C-F-F-F (Clamped Free-Free-Free), C-F-C-F (Clam-ped-Free-Clamped-Free), C-C-C-C-(Clamped-Clamped-Clamped-Clamped). Experimental modal tests were conducted on sandwich panels with available polyurethane foam of densities 56 kg/m3, 82 kg/m3and 289 kg/m3.The traditional “strike method” has been used to measure vibration properties. The modal characteristics of the specimens have been obtained by studying their impulse response. Each specimen has been subjected to impulses through a hard tipped hammer which is provided with a force transducer and the response has been measured through the accelerometer. The impulse and the response are processed through a computer aided FFT Analyzing test system in order to extract the modal parameters. Finite Element modeling was carried out treating the facing and core as orthotropic with different elastic constants as recommended in the literature. The experimental results were validated with FEA and were found to be in good agreement.The results obtained through modal test on multilayer sandwich panels are presented. They indicate a significant variation in the dynamic parameters in case of multilayer sandwich panels for the same core density as compared to a monolayer sandwich panel.展开更多
The joints connecting vertical and horizontal elements are the ＂weak link＂ in structural systems assembled from wood panels. If they are too weak, local failures may occur, resulting in performance that is significa...The joints connecting vertical and horizontal elements are the ＂weak link＂ in structural systems assembled from wood panels. If they are too weak, local failures may occur, resulting in performance that is significantly below expectations. If they are too resistant, the joints may be unable to dissipate energy during vibrations, thus possibly initiating a fast progressive failure. This paper re-processes and re-elaborates the results of shaking table tests previously carried out by the author and other co-workers. The goal is to assess the feasibility of a joint which is able to dissipate energy during vibration, without degrading the connection performance.展开更多
In this paper, we present the results of our numerical seakeeping analyses of a 6750-TEU containership, which were subjected to the benchmark test of the 2 nd ITTC–ISSC Joint Workshop held in 2014. We performed the s...In this paper, we present the results of our numerical seakeeping analyses of a 6750-TEU containership, which were subjected to the benchmark test of the 2 nd ITTC–ISSC Joint Workshop held in 2014. We performed the seakeeping analyses using three different methods based on a 3D Rankine panel method, including 1) a rigid-body solver, 2) a flexible-body solver using a beam model, and 3) a flexible-body solver using the eigenvectors of a 3D Finite Element Model(FEM). The flexible-body solvers adopt a fully coupled approach between the fluid and structure. We consider the nonlinear Froude–Krylov and restoring forces using a weakly nonlinear approach. In addition, we calculate the slamming loads on the bow flare and stern using a 2D generalized Wagner model. We compare the numerical and experimental results in terms of the linear response, the time series of the nonlinear response, and the longitudinal distribution of the sagging and hogging moments. The flexible-body solvers show good agreement with the experimental model with respect to both the linear and nonlinear results, including the high-frequency oscillations due to springing and whipping vibrations. The rigid-body solver gives similar results except for the springing and whipping.展开更多
文摘Clinical testing of patients for hereditary breast and ovarian cancer syndromes began in the mid-1990s with the identification of the BRCA1 and BRCA2 genes.Since then,mutations in dozens of other genes have been correlated to increased breast,ovarian,and other cancer risk.The following decades of data collection and patient advocacy allowed for improvements in medical,legal,social,and ethical advances in genetic testing.Technological advances have made it possible to sequence multiple genes at once in a panel to give patients a more thorough evaluation of their personal cancer risk.Panel testing increases the detection of mutations that lead to increased risk of breast,ovarian,and other cancers and can better guide individualized screening measures compared to limited BRCA testing alone.At the same time,multi-gene panel testing is more time-and cost-efficient.While the clinical application of panel testing is in its infancy,many problems arise such as lack of guidelines for management of newly identified gene mutations,high rates of variants of uncertain significance,and limited ability to screen for some cancers.Through on-going concerted efforts of pooled data collection and analysis,it is likely that the benefits of multi-gene panel testing will outweigh the risks in the near future.
文摘The sonic fatigue life of the aluminium rectangular panel was calculated using the concise method[1], and the sonic fatigue test was conducted on progressive wave tube (PWT) test facility. A comparison was made between the results of calculation and test, and it shows reasonable agreement between these two results.
文摘This study tests the hysteresis hypothesis of unemployment in fifteen OECD countries by using panel unit root tests which allow for structural breaks. We apply annual unemployment rates covering 1985-2008 periods. We test whether unemployment rates are stationary by using second generation tests which allow cross section dependency among series and panel unit root test based on structural break advanced by Carrion-i-Silvestre, Barrio-Castro and Lopez-Bazo （2005）. We find series as a stationary process with structural breaks according to Carrion-i Silvestre et al. （2005） test, while we find series as unit root process with second generation panel unit root test. According to the Carrion-i Silvestre et al. （2005） test, we find the evidence of absence of hysteresis in analyzed countries. As a result, temporary shocks have temporary effects on unemployment instead of permanent effect. Structural factors can affect the natural rate of unemployment and, therefore, unemployment would be stationary around a process that is subject to structural breaks. So, there still exists a unique natural rate of unemployment to which the economy eventually will converge.
基金supported by National Hi-tech Research and Development Program of China(863 Program, Grant No. 2007AA03z551)Chongqing Municipal Technology Project of China (Grant No. 2007AA4008-4-4)
文摘Dent resistance of automobile body panels is an important property for automobile design and manufacture, but the study on this aspect is not still profound. This study is to summarize the testing methods and physical significations of static and dynamic dent resistance of automobile body panels combined with the author＇s study, and to analyze the dent behaviors in the round. Several influence factors on dent resistance are expatiated including the mechanical properties of materials, stress states after forming, bake hardening ability, modulus, methods of testing, and structure of specimens and so on. The automotive lightweight and application of high strength steel sheets and aluminum alloys sheets are analyzed, and the significance of testing of dent resistance, especially for dynamic dent resistance of auto-panels, and the finite element simulation analysis are emphasized. To explain the physical phenomenon of dent behaviors, the latest and concerned study results are also discussed. According to this study, a dent resistance test and evaluation standard of Society of Automotive Engineers of China for automotive body panel is presented and is being carried out, and an industry conference is hold to discuss the working-out of the standard, a primary schedule of this standard is confirmed now. The study can guide the further testing and study of dent resistant of auto-panels.
基金Research fund for earthquake engineering of China Earthquake Administration(201508023)a project of the National Science&Technology Support Program during the Twelfth Five-year Plan Period of China(2015BAK17B03)a general program of National Natural Science Foundation of China(51578515)
文摘Severe damage to suspended ceilings of metal grids and lay-in panels was observed in public buildings during the 2013 M7.0 Lushan earthquake in China. Over the past several years, suspended ceilings have been widely used practice in public buildings throughout China, including government offices, schools and hospitals. To investigate the damage mechanism of suspended ceilings, a series of three-dimensional shake table tests was conducted to reproduce the observed damage. A full-scale reinforced concrete frame was constructed as the testing frame for the ceiling, which was single-story and infilled with brick masonry walls to represent the local construction of low-rise buildings. In general, the ceiling in the tests exhibited similar damage phenomena as the field observations, such as higher vulnerability of perimeter elements and extensive damage to the cross runners. However, it exhibited lower fragility in terms of peak ground/roof accelerations at the initiation of damage. Further investigations are needed to clarify the reasons for this behavior.
基金Scientific Research Fund of Institute of Engineering Mechanics,CEA under Grant No.2016A06International Science & Technology Cooperation Program of China under Grant No.2014DFA70950National Natural Science Foundation of China under Grant Nos.51378478,51161120360
文摘A retrofitting technology using precast steel reinforced concrete（PSRC） panels is developed to improve the seismic performance of old masonry buildings. The PSRC panels are built up as an external PSRC wall system surrounding the existing masonry building. The PSRC walls are well connected to the existing masonry building, which provides enough confinement to effectively improve the ductility, strength, and stiffenss of old masonry structures. The PSRC panels are prefabricated in a factory, significantly reducing the situ work and associated construction time. To demonstrate the feasibility and mechanical effectivenss of the proposed retrofitting system, a full-scale five-story specimen was constructed. The retrofitting process was completed within five weeks with very limited indoor operation. The specimen was then tested in the lateral direction, which could potentially suffer sigifnicant damage in a large earthquake. The technical feasibility, construction workability, and seismic performance were thoroughly demonstrated by a full-scale specimen construction and pseudo-dynamic tests.
文摘In the present work the dynamic characteristics of Multilayer Polyurethane foam glass/fiber composite sandwich panels have been determined through Experimental Investigations. Using a Multilayer Polyurethane foam sandwich panel with rectangular cross-section, the natural frequencies, mode shapes and the damping ratio of sandwich panels were evaluated. Three types of boundary conditions were simulated namely, C-F-F-F (Clamped Free-Free-Free), C-F-C-F (Clam-ped-Free-Clamped-Free), C-C-C-C-(Clamped-Clamped-Clamped-Clamped). Experimental modal tests were conducted on sandwich panels with available polyurethane foam of densities 56 kg/m3, 82 kg/m3and 289 kg/m3.The traditional “strike method” has been used to measure vibration properties. The modal characteristics of the specimens have been obtained by studying their impulse response. Each specimen has been subjected to impulses through a hard tipped hammer which is provided with a force transducer and the response has been measured through the accelerometer. The impulse and the response are processed through a computer aided FFT Analyzing test system in order to extract the modal parameters. Finite Element modeling was carried out treating the facing and core as orthotropic with different elastic constants as recommended in the literature. The experimental results were validated with FEA and were found to be in good agreement.The results obtained through modal test on multilayer sandwich panels are presented. They indicate a significant variation in the dynamic parameters in case of multilayer sandwich panels for the same core density as compared to a monolayer sandwich panel.
基金Italian National Research Council (CNR) Unde Grant No. CU07.00016 ST/97
文摘The joints connecting vertical and horizontal elements are the ＂weak link＂ in structural systems assembled from wood panels. If they are too weak, local failures may occur, resulting in performance that is significantly below expectations. If they are too resistant, the joints may be unable to dissipate energy during vibrations, thus possibly initiating a fast progressive failure. This paper re-processes and re-elaborates the results of shaking table tests previously carried out by the author and other co-workers. The goal is to assess the feasibility of a joint which is able to dissipate energy during vibration, without degrading the connection performance.
基金Supported by Lloyd’s Register Foundation(LRF)-Funded Research Center at SNU(LRFC)
文摘In this paper, we present the results of our numerical seakeeping analyses of a 6750-TEU containership, which were subjected to the benchmark test of the 2 nd ITTC–ISSC Joint Workshop held in 2014. We performed the seakeeping analyses using three different methods based on a 3D Rankine panel method, including 1) a rigid-body solver, 2) a flexible-body solver using a beam model, and 3) a flexible-body solver using the eigenvectors of a 3D Finite Element Model(FEM). The flexible-body solvers adopt a fully coupled approach between the fluid and structure. We consider the nonlinear Froude–Krylov and restoring forces using a weakly nonlinear approach. In addition, we calculate the slamming loads on the bow flare and stern using a 2D generalized Wagner model. We compare the numerical and experimental results in terms of the linear response, the time series of the nonlinear response, and the longitudinal distribution of the sagging and hogging moments. The flexible-body solvers show good agreement with the experimental model with respect to both the linear and nonlinear results, including the high-frequency oscillations due to springing and whipping vibrations. The rigid-body solver gives similar results except for the springing and whipping.
