Aim: To investigate the relationship between 2D:4D and testosterone in men attending an infertility clinic and men drawn from the general population. Methods: Data on 2D:4D and testosterone from two samples were colle...Aim: To investigate the relationship between 2D:4D and testosterone in men attending an infertility clinic and men drawn from the general population. Methods: Data on 2D:4D and testosterone from two samples were collected: (1) 43 men attending an infertility clinic, and (2) 51 men drawn from the general population without regard to fertility. Results: In sample (1) there were negative associations between 2D:4D and testicular function, and men with lower 2D:4D in their right compared to left hand had higher testosterone levels than men with higher 2D:4D in their right compared to left hand. Sample (2) showed no significant associations between 2D:4D or side differences in 2E>:4D and testosterone. Conclusion: Adult levels of testosterone may be related to aspects of 2D:4D in samples which contain men with compromised testicular function, but not in men from normative samples. Associations between 2D:4D and fertility-associated traits probably arise from early organisational effects of testosterone rather than from activational effects of current testosterone.展开更多
Objective To explore the endocfinal factors which influence the aggressive behavior of adolescents. Methods The levels of cortisol （CORT）, testosterone （T）, prolactin （PRL）, and growth hormone （GH） in saliva f...Objective To explore the endocfinal factors which influence the aggressive behavior of adolescents. Methods The levels of cortisol （CORT）, testosterone （T）, prolactin （PRL）, and growth hormone （GH） in saliva from 20 aggressive students and 20 non-aggressive control students were measured by radioimmunoassay （RIA）. The students were matched for their gender, age, grade, stage of pubertal development, and economic status of their families. Results The salivary T levels were 22.20±14.50 pg/mL and 19.54±12.52 pg/mL in aggressive male and female students, 13.20±6.85 pg/mL and 5.24±3.03 pg/mL in non-aggressive male and female students （P〈0.05）. The male aggressive students had a lower level of CORT in saliva than non-aggressive male students （P〈0.05）. There were no significant differences in the salivary levels of PRL or GH between the aggressive and non-aggressive groups. Correlation analysis revealed a negative relationship in male students between the salivary CORT levels and the aggression factor scores of the child behavior checklist （CBCL）. In addition, the data also showed a positive relationship between the salivary T levels and the aggression factor scores of CBCL in female students. Multiple linear regression analysis showed that the salivary CORT level was an independent predictive factor for aggressive behaviors in adolescent boys. The higher the CORT level, the less aggressive the boys were. Conclusion CORT and T levels may play a certain role in adolescent aggressive behaviors.展开更多
BACKGROUND:The aim of the study was to investigate the procalcitonin-to-cortisol ratio(P/C ratio)as a prognostic predictor among septic patients with abdominal source.METHODS:We retrospectively enrolled 132 post-surge...BACKGROUND:The aim of the study was to investigate the procalcitonin-to-cortisol ratio(P/C ratio)as a prognostic predictor among septic patients with abdominal source.METHODS:We retrospectively enrolled 132 post-surgery patients between 18 and 90 years old with sepsis of the abdominal source.On the second day of sepsis onset,cortisol,procalcitonin(PCT),Acute Physiology and Chronic Health Evaluation(APACHE)II score,Sequential Organ Failure Assessment(SOFA)score,C-response protein(CRP),and other baseline characteristics were collected.In addition,the length of ICU stay,length of mechanical ventilation(MV)days,length of shock days,and 28-day mortality were also recorded.Univariate analysis was performed to screen potential risk factors.Stratified analysis was used to identify the interaction among the risk factors.Multivariate analysis was also utilized to demonstrate the relationship between the risk factors and mortality.The receiver operator characteristic(ROC)curve analysis was conducted to evaluate the risk factors.A restricted cubic spline(RCS)demonstrated the association between survival outcome and the P/C ratio variation.RESULTS:A total of twenty-nine patients died,and 103 patients survived within 28 d.There were significant differences in cortisol,PCT,P/C ratio,interleukin(IL)-6,SOFA,and APACHE II scores between the survival and non-survival groups.No significant interaction was observed in the stratified analysis.Logistic regression analysis revealed that P/C ratio(P=0.033)was significantly related to 28-day mortality.Based on ROC curves,P/C ratio(AUC=0.919)had a higher AUC value than cortisol or PCT.RCS analysis depicted a positive relationship between survival possibility and P/C ratio decrement.CONCLUSION:P/C ratio might be a potential prognostic predictor in septic patients with abdominal sources.展开更多
A stochastic SIR influenza vertical transmission model is examined in this paper where vaccination and an incidence rate that is not linear are considered.To determine whether testosterone regulates lower sintering HP...A stochastic SIR influenza vertical transmission model is examined in this paper where vaccination and an incidence rate that is not linear are considered.To determine whether testosterone regulates lower sintering HPA axis function in males,we used a stochastic SIR epidemic procedure with divergent influences on ACTH and cortisol.The suppressive effects on cortisol can be attributed to a peripheral(adrenal)locus.Following that,we came to the conclusion that experimental solutions have been discovered and the requisite statistical findings have been examined.Finally,we deduce that the given mathematical model and the results are relevant to medical research.In the future,this research can be further extended to simulate more results in the medical field.展开更多
文摘Aim: To investigate the relationship between 2D:4D and testosterone in men attending an infertility clinic and men drawn from the general population. Methods: Data on 2D:4D and testosterone from two samples were collected: (1) 43 men attending an infertility clinic, and (2) 51 men drawn from the general population without regard to fertility. Results: In sample (1) there were negative associations between 2D:4D and testicular function, and men with lower 2D:4D in their right compared to left hand had higher testosterone levels than men with higher 2D:4D in their right compared to left hand. Sample (2) showed no significant associations between 2D:4D or side differences in 2E>:4D and testosterone. Conclusion: Adult levels of testosterone may be related to aspects of 2D:4D in samples which contain men with compromised testicular function, but not in men from normative samples. Associations between 2D:4D and fertility-associated traits probably arise from early organisational effects of testosterone rather than from activational effects of current testosterone.
基金supported by Health Department of Hubei Province(No.JX1B161).
文摘Objective To explore the endocfinal factors which influence the aggressive behavior of adolescents. Methods The levels of cortisol （CORT）, testosterone （T）, prolactin （PRL）, and growth hormone （GH） in saliva from 20 aggressive students and 20 non-aggressive control students were measured by radioimmunoassay （RIA）. The students were matched for their gender, age, grade, stage of pubertal development, and economic status of their families. Results The salivary T levels were 22.20±14.50 pg/mL and 19.54±12.52 pg/mL in aggressive male and female students, 13.20±6.85 pg/mL and 5.24±3.03 pg/mL in non-aggressive male and female students （P〈0.05）. The male aggressive students had a lower level of CORT in saliva than non-aggressive male students （P〈0.05）. There were no significant differences in the salivary levels of PRL or GH between the aggressive and non-aggressive groups. Correlation analysis revealed a negative relationship in male students between the salivary CORT levels and the aggression factor scores of the child behavior checklist （CBCL）. In addition, the data also showed a positive relationship between the salivary T levels and the aggression factor scores of CBCL in female students. Multiple linear regression analysis showed that the salivary CORT level was an independent predictive factor for aggressive behaviors in adolescent boys. The higher the CORT level, the less aggressive the boys were. Conclusion CORT and T levels may play a certain role in adolescent aggressive behaviors.
文摘BACKGROUND:The aim of the study was to investigate the procalcitonin-to-cortisol ratio(P/C ratio)as a prognostic predictor among septic patients with abdominal source.METHODS:We retrospectively enrolled 132 post-surgery patients between 18 and 90 years old with sepsis of the abdominal source.On the second day of sepsis onset,cortisol,procalcitonin(PCT),Acute Physiology and Chronic Health Evaluation(APACHE)II score,Sequential Organ Failure Assessment(SOFA)score,C-response protein(CRP),and other baseline characteristics were collected.In addition,the length of ICU stay,length of mechanical ventilation(MV)days,length of shock days,and 28-day mortality were also recorded.Univariate analysis was performed to screen potential risk factors.Stratified analysis was used to identify the interaction among the risk factors.Multivariate analysis was also utilized to demonstrate the relationship between the risk factors and mortality.The receiver operator characteristic(ROC)curve analysis was conducted to evaluate the risk factors.A restricted cubic spline(RCS)demonstrated the association between survival outcome and the P/C ratio variation.RESULTS:A total of twenty-nine patients died,and 103 patients survived within 28 d.There were significant differences in cortisol,PCT,P/C ratio,interleukin(IL)-6,SOFA,and APACHE II scores between the survival and non-survival groups.No significant interaction was observed in the stratified analysis.Logistic regression analysis revealed that P/C ratio(P=0.033)was significantly related to 28-day mortality.Based on ROC curves,P/C ratio(AUC=0.919)had a higher AUC value than cortisol or PCT.RCS analysis depicted a positive relationship between survival possibility and P/C ratio decrement.CONCLUSION:P/C ratio might be a potential prognostic predictor in septic patients with abdominal sources.
文摘A stochastic SIR influenza vertical transmission model is examined in this paper where vaccination and an incidence rate that is not linear are considered.To determine whether testosterone regulates lower sintering HPA axis function in males,we used a stochastic SIR epidemic procedure with divergent influences on ACTH and cortisol.The suppressive effects on cortisol can be attributed to a peripheral(adrenal)locus.Following that,we came to the conclusion that experimental solutions have been discovered and the requisite statistical findings have been examined.Finally,we deduce that the given mathematical model and the results are relevant to medical research.In the future,this research can be further extended to simulate more results in the medical field.
