Utilizing standard microelectrode stimulation and recording techniques, the electrophysiologic effects of the new antiarrhythmic agent sotalol were studied in Purkinje′s fibers obtained from six nascent mongrel canin...Utilizing standard microelectrode stimulation and recording techniques, the electrophysiologic effects of the new antiarrhythmic agent sotalol were studied in Purkinje′s fibers obtained from six nascent mongrel canines (ages 5～15 days) and were compared to changes observed in the adult canine Purkinje′s fibers (n=6). A dose dependent lengthening of the faction potential duration (APD) was observed in the nascent group and the overall increase in APD was significantly greater than that observed in the adult group. Sotalol also produced dose dependent changes in the effective refractory. period (ERP) in both groups though the overall increase in ERP in the nascent group was again greater. We conclude that the immature canine heart appears to be quite sensitive to the class Ⅲactions of sotalol, with changes in APD and ERP being comparable if not greater in magnitude than that observed in the adult.展开更多
The reaction of Ca with HN3 has been investigated theoretically by an ah initio MO methodwith electron correlation being taken into account by second-order MLLER-PLESSET(MP2)perturbation theory Two possible product ch...The reaction of Ca with HN3 has been investigated theoretically by an ah initio MO methodwith electron correlation being taken into account by second-order MLLER-PLESSET(MP2)perturbation theory Two possible product channels. CaN3+H. CaNH+N2, on the potential energysurfaces(PESs) have been examined and the reaction mechanism discussed. Values of tile HN-NZ,HN3, Ca-N3 and Ca-AH bond dissociation energy are also calculated, which are in good agreement withexperiment展开更多
The numeral trait of aquiferous zones in flowage studies and estimations is under most parts of nation. In this study Karaj aquiferous zone in Alborz province was surveyed from the view point of form, the agglomeratio...The numeral trait of aquiferous zones in flowage studies and estimations is under most parts of nation. In this study Karaj aquiferous zone in Alborz province was surveyed from the view point of form, the agglomeration of drainage net length of channel and space. The orientation of hillside was specified as the affective factor on creating and streaming the flowage. A flow aggregating hydrological model for the studied zone was prepared and amount of the flow is mostly in which parts of the zone the delay and centralization time in the zone was evaluated and the related diagrams were derived. Finally, the zone was divided into 4 main subzones and their drainage nets were ranked and by 4 factors namely, space, length of canal, drainage aggregation and branch ratio affecting on performance of the zone from the view of from and appearance was surveyed. The factors interfering in SPSS software and their correlations were specified and specific coefficients stand in their related charts. By considering in the zone width and charts it is specified which of the sub zones has the most flowage potential from the view of the zones physical and numeral qualifications. All plots were prepared using GIS and WMS software and the studied zone’s hydrograph was depicted.展开更多
Northern regional folk culture and art is colorful, bright vibrant, showing a flourishing pomp, The paper-cut art is one of the essential of the Pearl.The following article is based on the premise of the relationship ...Northern regional folk culture and art is colorful, bright vibrant, showing a flourishing pomp, The paper-cut art is one of the essential of the Pearl.The following article is based on the premise of the relationship between the North and the surrounding area customs and cultural heritage of folk art paper-cut, carrys on the review and analysis, focuses on northern folk paper-cut of origin, schools,, characteristics and the differences between the North and South.展开更多
A research study collected intensive longitudinal data from cancer patients on a daily basis as well as non-intensive longitudinal survey data on a monthly basis. Although the daily data need separate analysis, those ...A research study collected intensive longitudinal data from cancer patients on a daily basis as well as non-intensive longitudinal survey data on a monthly basis. Although the daily data need separate analysis, those data can also be utilized to generate predictors of monthly outcomes. Alternatives for generating daily data predictors of monthly outcomes are addressed in this work. Analyses are reported of depression measured by the Patient Health Questionnaire 8 as the monthly survey outcome. Daily measures include numbers of opioid medications taken, numbers of pain flares, least pain levels, and worst pain levels. Predictors are averages of recent non-missing values for each daily measure recorded on or prior to survey dates for depression values. Weights for recent non-missing values are based on days between measurement of a recent value and a survey date. Five alternative averages are considered: averages with unit weights, averages with reciprocal weights, weighted averages with reciprocal weights, averages with exponential weights, and weighted averages with exponential weights. Adaptive regression methods based on likelihood cross-validation (LCV) scores are used to generate fractional polynomial models for possible nonlinear dependence of depression on each average. For all four daily measures, the best LCV score over averages of all types is generated using the average of recent non-missing values with reciprocal weights. Generated models are nonlinear and monotonic. Results indicate that an appropriate choice would be to assume three recent non-missing values and use the average with reciprocal weights of the first three recent non-missing values.展开更多
文摘Utilizing standard microelectrode stimulation and recording techniques, the electrophysiologic effects of the new antiarrhythmic agent sotalol were studied in Purkinje′s fibers obtained from six nascent mongrel canines (ages 5～15 days) and were compared to changes observed in the adult canine Purkinje′s fibers (n=6). A dose dependent lengthening of the faction potential duration (APD) was observed in the nascent group and the overall increase in APD was significantly greater than that observed in the adult group. Sotalol also produced dose dependent changes in the effective refractory. period (ERP) in both groups though the overall increase in ERP in the nascent group was again greater. We conclude that the immature canine heart appears to be quite sensitive to the class Ⅲactions of sotalol, with changes in APD and ERP being comparable if not greater in magnitude than that observed in the adult.
文摘The reaction of Ca with HN3 has been investigated theoretically by an ah initio MO methodwith electron correlation being taken into account by second-order MLLER-PLESSET(MP2)perturbation theory Two possible product channels. CaN3+H. CaNH+N2, on the potential energysurfaces(PESs) have been examined and the reaction mechanism discussed. Values of tile HN-NZ,HN3, Ca-N3 and Ca-AH bond dissociation energy are also calculated, which are in good agreement withexperiment
文摘The numeral trait of aquiferous zones in flowage studies and estimations is under most parts of nation. In this study Karaj aquiferous zone in Alborz province was surveyed from the view point of form, the agglomeration of drainage net length of channel and space. The orientation of hillside was specified as the affective factor on creating and streaming the flowage. A flow aggregating hydrological model for the studied zone was prepared and amount of the flow is mostly in which parts of the zone the delay and centralization time in the zone was evaluated and the related diagrams were derived. Finally, the zone was divided into 4 main subzones and their drainage nets were ranked and by 4 factors namely, space, length of canal, drainage aggregation and branch ratio affecting on performance of the zone from the view of from and appearance was surveyed. The factors interfering in SPSS software and their correlations were specified and specific coefficients stand in their related charts. By considering in the zone width and charts it is specified which of the sub zones has the most flowage potential from the view of the zones physical and numeral qualifications. All plots were prepared using GIS and WMS software and the studied zone’s hydrograph was depicted.
文摘Northern regional folk culture and art is colorful, bright vibrant, showing a flourishing pomp, The paper-cut art is one of the essential of the Pearl.The following article is based on the premise of the relationship between the North and the surrounding area customs and cultural heritage of folk art paper-cut, carrys on the review and analysis, focuses on northern folk paper-cut of origin, schools,, characteristics and the differences between the North and South.
文摘A research study collected intensive longitudinal data from cancer patients on a daily basis as well as non-intensive longitudinal survey data on a monthly basis. Although the daily data need separate analysis, those data can also be utilized to generate predictors of monthly outcomes. Alternatives for generating daily data predictors of monthly outcomes are addressed in this work. Analyses are reported of depression measured by the Patient Health Questionnaire 8 as the monthly survey outcome. Daily measures include numbers of opioid medications taken, numbers of pain flares, least pain levels, and worst pain levels. Predictors are averages of recent non-missing values for each daily measure recorded on or prior to survey dates for depression values. Weights for recent non-missing values are based on days between measurement of a recent value and a survey date. Five alternative averages are considered: averages with unit weights, averages with reciprocal weights, weighted averages with reciprocal weights, averages with exponential weights, and weighted averages with exponential weights. Adaptive regression methods based on likelihood cross-validation (LCV) scores are used to generate fractional polynomial models for possible nonlinear dependence of depression on each average. For all four daily measures, the best LCV score over averages of all types is generated using the average of recent non-missing values with reciprocal weights. Generated models are nonlinear and monotonic. Results indicate that an appropriate choice would be to assume three recent non-missing values and use the average with reciprocal weights of the first three recent non-missing values.
