High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and neuroscience.High-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain injury.Several drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system disorders.Although it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system disorders.In this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory role.Research targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

金融机构ESG投资的“漂绿”与“反漂绿”——基于DWSGroup的案例分析

深化绿色金融发展、助力经济绿色发展,是实现“双碳”目标的重要途径,特别是在ESG理念盛行的今天,金融机构的ESG投资行为因其深远影响而颇受投资者青睐,但层出不穷的“漂绿”现象也牢牢制约着绿色金融的发展,制约着ESG投资的发展。西方国家作为绿色金融发展先驱,从信息披露、制度监管、实践探索等方面对“漂绿”现象进行了研究和治理。本文在学习其先进经验的基础上,基于舞弊三角理论对DWSGroup案例进行分析,从压力、机会和自我合理化因素角度对金融机构ESG投资“漂绿”行为的动因进行分析,并据此提出我国“反漂绿”体系框架,以期为绿色金融的平稳发展和“双碳”目标的实现作出贡献。

Assessment of the Impact of the Grand Ethiopian Renaissance Dam on the Performance of the High Aswan Dam

A Large scale hydropower dam known as Grand Ethiopian Renaissance Dam (GERD) is under construction on the Blue Nile River just upstream of the Ethiopian-Sudan border in Ethiopia. The GERD has an active storage capacity of more than 60,000 Mm3 and is anticipated to produce 6000 MW of hydropower energy. The aim of this study was to assess the potential impact of the dam on the performance of the High Aswan Dam (HAD) during filling and operation phases using a simulation model using Mike Basin river basin simulation model. The results indicate the planned 6 years filling period is sufficient to fill the reservoir with little impact on the current irrigation water demands from HAD in Egypt without additional management investment. There will be about 12% and 7% of reduction of annual energy output from High Aswan Dam during the filling and after filling stage of GERD respectively. Cumulative Energy production from the two dams will increase significantly Water loss at HAD due to evaporation will decreases by 22%. Overall performance of HAD during and after filling of the GERD remains at a reliability level of 96%. The study advises to utilize the results cautiously as it is based on only one historical realization of the many possible scenarios that may evolve in the future.

The Love Theme of the Renaissance——A Comment on Two Renaissance Poems

Poetry is one of the most important literary forms in the English Renaissance. Love is an eternal theme of the tremendous amount of the English Renaissance poems. In the two famous love poems,Valediction:Forbidding Mourning and The Passionate Shepherd to His Love,the poets express their strong feelings in different ways. By employing the method of literature review and centering around the two vivid love poems,this paper attempts to explore their images,themes and many other literary characteristics. The objective of it is to help us to have a deeper understanding about the literature in the English Renaissance,and know more about love which is a beautiful emotion.

Renaissance Humanists:Defenders of Medieval Christian worldview

The Renaissance is a new golden age of intellectual achievement with a sharp contrast with the Middle Ages.Though new secular and scientific values begin to supplant traditional religious belief,there exists the continuity between the Middle Ages and the Renaissance,and humanists bear strong Christian character.They never change their devotion to Christianity and keep making their effort to maintain the primacy of Jesus.Humanists in Renaissance are defenders of medieval Christian view of the world.

The Influence of Renaissance On Marvel Comics Movies

Nowadays,in the movie industry,marvel comics movies play an inevitable role,plenty of super heroes are becoming more and more popular to our spectators,such as:superman,Spider Man,Batman,lron Man,Captain America,Hulk,Thor even the alliances Fantastic 4,The Avengers,Guardians of The Galaxy and so on,and this kind of movies occupies a significant part in the movie market.So why people like the super stares so much?And what sort of national culture can we find in these movies?This thesis concentrate on the questions l just mentioned,from the perspective of the renaissance,I will show you how and in what extent renaissance has influenced the marvel comics movies.

A Comparison Between the Stonework Application in Italian Renaissance Garden and Placing Stone Technique in Classical Chinese Garden

The study introduced the development of stone elements in Italian Renaissance Garden and Chinese classical garden, analyzed the stonework of Renaissance Garden and the placing stone technique of Chinese classical garden from different angles and made a comparative analysis of the two from the aesthetic thought, stone selection and technique.

Management of Secondary Leyll Syndrome Due to Anti-Covid Vaccine in a Case, at the Renaissance University Teaching Hospital, Ndjamena (CHAD)

Introduction: Lyell’s syndrome (SL), called Toxic Epidermal Necrolysis is one of the most serious forms of medication accidents. It is an acute, rare pathology, its incidence is estimated at 1 to 2 cases out of one million inhabitants per year and its evolution can be fatal. Materials and Methods: We report the observation of a 60-year-old patient, with no significant pathological history, admitted to our intensive care unit at the Renaissance University Teaching Hospital in N’Djamena for the treatment of Toxic Epidermal Necrolysis. In whom the onset of symptoms dates back to few hours after vaccination against COVID-19 with Ag Johnson and Johnson. Results: An ophthalmology opinion was requested and the patient was put on Fucithalmic. In our case, in addition to the advanced age of the patient (60 years old), her SCORTEN was ≥5. Conclusion: The late management as well as the absence of a specific department for severe burns, which condition the presence of a technical plate was fatal to her despite multidisciplinary care: Resuscitators, Traumato-Orthopedist and ophthalmologist.

Combined Promoting Effects of Specific Organic Functional Groups and Alumina Surface Characteristics for the Design of a Highly Efficient NiMo/Al_(2)O_(3) Hydrodesulfurization Catalyst

To prepare a highly efficient NiMo/Al_(2)O_(3) hydrodesulfurization catalyst,the combined effects of specific organic functional groups and alumina surface characteristics were investigated.First,the correlation between the surface characteristics of four different alumina and the existing Mo species states was established.It was found that the Mo equilibrium adsorption capacity can be used as a specific descriptor to quantitatively evaluate the changes in surface characteristics of different alumina.A lower Mo equilibrium adsorption capacity for alumina means weaker metal-support interaction and the loaded Mo species are easier to transform into MoS2.However,the Mo-O-Al bonds still exist at the metal-support interface.The introduction of cationic surfactant hecadecyl trimethyl ammonium bromide(CTAB)can further improve Mo species dispersion through electrostatic attraction with Mo anions and interaction of its alkyl chain with the alumina surface;meanwhile,the introduction of ethylenediamine tetraacetic acid(EDTA)can complex with Ni ions to enhance the Ni-promoting effect on Mo.Therefore,the NiMo catalyst designed using alumina with lower Mo equilibrium adsorption capacity and the simultaneous addition of EDTA and CTAB exhibits the highest hydrodesulfurization activity for 4,6-dimethyl dibenzothiophene because of its proper metal-support interaction and more well-dispersed Ni-Mo-S active phases.

Social Research On Renaissance Period

The historical period known as the Renaissance spans the fifteenth and sixteenth centuries. ‘Renaissance’ means ‘re-birth’ in French and during this time Europe left behind the mindset of the Middle Ages and created the beginnings of the modern world. This thesis mainly rotates on the background, the main features and significance of Renaissance, especially focuses on the discovery of man and the humanism and the detailed unfolding of the society on several aspect in Renaissance.

Vision and Imagination in the Renaissance Theatre

To see what lacks representation on stage is a fully creative act that the spectator performs thanks to his or her imagination, as （s）he is called to retrieve via memory what is objectively absent from the scene. The Renaissance audience accomplished such a creative act by making use of rhetoric and figurative arts. However, it is pre-eminently words that trigger and support the imagination, as Shakespeare＇s drama best exemplifies. Both in the Elizabethan drama and in the Italian Renaissance theatre, with its perspectival vision, the spectator＇s creative act takes place in an ideal space where the stage space turns into the locus of stereoscopic vision. Consequently, the creation and consumption of the vision originates first and foremost in drama （comedy and tragedy）. The psychological, aesthetic, and anthropological mechanisms at the heart of vision, and the fruition of the images deriving from words, can be found as operating within the dramatic text, from the point of view of both the playwright and of the spectator/listener, in a direct relationship of cause and effect. Religious and especially Jesuitical drama, whose theatrical experience aims at discovering a correspondence between words and images, testifies to the visual power of the theatre.

The Study on Humanistic Educational Thought during Renaissance in Europe

As economics’development,society’s progress,mankind accumulates much wisdom about life and existence.Philosophy appears when the wisdom sublimation.Then,how to pass on it from generation to generation?Education plays an immeasurable role.In this regard,education has closed relationship with philosophy.To say education,it must be the teaching of wisdom;to say philosophy,it has to pass by through education.This paper tries to study the educational thought of humanists during the period of renaissance in Europe and probe its aim,contents,methods,features and significance.

Channel Correlation Based User Grouping Algorithm for Nonlinear Precoding Satellite Communication System

Low Earth Orbit(LEO)multibeam satellites will be widely used in the next generation of satellite communication systems,whose inter-beam interference will inevitably limit the performance of the whole system.Nonlinear precoding such as Tomlinson-Harashima precoding(THP)algorithm has been proved to be a promising technology to solve this problem,which has smaller noise amplification effect compared with linear precoding.However,the similarity of different user channels(defined as channel correlation)will degrade the performance of THP algorithm.In this paper,we qualitatively analyze the inter-beam interference in the whole process of LEO satellite over a specific coverage area,and the impact of channel correlation on Signal-to-Noise Ratio(SNR)of receivers when THP is applied.One user grouping algorithm is proposed based on the analysis of channel correlation,which could decrease the number of users with high channel correlation in each precoding group,thus improve the performance of THP.Furthermore,our algorithm is designed under the premise of co-frequency deployment and orthogonal frequency division multiplexing(OFDM),which leads to more users under severe inter-beam interference compared to the existing research on geostationary orbit satellites broadcasting systems.Simulation results show that the proposed user grouping algorithm possesses higher channel capacity and better bit error rate(BER)performance in high SNR conditions relative to existing works.

Gothic Heritage in Renaissance Mantua

The aim of this paper is to present the less known phenomenon of late-Gothic Mantuan architecture in the second half of the 15th century. Indeed Mantua is famous for its Renaissance monuments. However, some of the Gonzaga palaces show Gothic details, such as towers or battlements. In addition, some patricians, merchants, and priests continued to follow the Gothic tradition until the final decade of the ＂Quattrocento＂. This paper will present a first list of these interesting architectures--both public and private, religious and profane--which, in some cases and despite the Gothic language, the archival research has demonstrated a late 15th century executions.

A Novel On-Site-Real-Time Method for Identifying Characteristic Parameters Using Ultrasonic Echo Groups and Neural Network

On-site and real-time non-destructive measurement of elastic constants for materials of a component in a in-service structure is a challenge due to structural complexities,such as ambiguous boundary,variable thickness,nonuniform material properties.This work develops for the first time a method that uses ultrasound echo groups and artificial neural network(ANN)for reliable on-site real-time identification of material parameters.The use of echo groups allows the use of lower frequencies,and hence more accommodative to structural complexity.To train the ANNs,a numerical model is established that is capable of computing the waveform of ultrasonic echo groups for any given set of material properties of a given structure.The waveform of an ultrasonic echo groups at an interest location on the surface the structure with material parameters varying in a predefined range are then computed using the numerical model.This results in a set of dataset for training the ANN model.Once the ANN is trained,the material parameters can be identified simultaneously using the actual measured echo waveform as input to the ANN.Intensive tests have been conducted both numerically and experimentally to evaluate the effectiveness and accuracy of the currently proposed method.The results show that the maximum identification error of numerical example is less than 2%,and the maximum identification error of experimental test is less than 7%.Compared with currently prevailing methods and equipment,the proposefy the density and thickness,in addition to the elastic constants.Moreover,the reliability and accuracy of inverse prediction is significantly improved.Thus,it has broad applications and enables real-time field measurements,which has not been fulfilled by any other available methods or equipment.

From the Clash of Civilization to the Renaissance of the World

The Western civilization came to its modernity in the Renaissance,which in the end,made the West human beings’leader.The clash of civilization between China and the West after 1800s is firstly and mainly the clash of modernization and traditionalism.There is no way for China to make progress but to learn the Western way,and so did China try the catholic revolution,the industrial revolution,constitutional reform,republic revolution,democratic movement,democratic revolution,socialism revolution and market reform.At last,China is coming to be a modernized state,and the Chinese civilization is coming to its renaissance.The Western renaissance has been gone for a long time,and the Western civilization needs its new renaissance.It is not time for the clash of civilization,but the new era for the renaissance of the world,if only human beings can learn the lessons of history and avoid wars.

Effect on the Emergence of Cultural School of the Diversity of British Novel in the Renaissance

The diversified development of British novels in the Renaissance mainly displays in several aspects,that is,lateral reflection of the social development background,specific expression of forming complex psychology of developing social mission,and macro manifestation of the basic needs of the public.This is the important factor of contemporary cultural school to find the innovative development road,and also the crucial effect to explore and excavate the development characteristics of contemporary cultural school,expressing the time promoting effect of the development of the diversified development of British novels in the Renaissance.Seen from the development characteristics of the C ultural School,the development direction between the social characteristics of times and the basic demand of social groups on social culture agrees with the diversified development of British novels in the Renaissance,and fully demonstrates the effect and value of the latter on the overall development of social cultural school.

Italy as the Cradle of the Renaissance: From the Perspective of Its Particular Reasons

The Renaissance is a period from the 14thto the 17thcenturies,considered as a shift from Middle Ages to Modern times ofEuropean history.It developed from Middle Ages which laid its political,economical,cultural and social foundation.Owing to thedevelopment of capitalist production relations in Europe during the late Middle Ages,bourgeoisie initiated this cultural movementwhose essence is humanism as a fight against feudalism.The Renaissance originated in the form of a cultural movement from Italyin the 14th century and swept over the whole Europe.Apart from the common factors contributing to this movement,the peculiarreasons why Italy became the bellwether of this essential cultural movement are as follows:direct inherit of ancient Roman tradi-tion,the favorable geographical position,the unparalleled cities with the development of commerce,city republics and secularism.

A Study on Renaissance Humanism’s Positive Ifluences on European Politics

"Renaissance Humanism"is a very important philosophical and cultural movement in the history of the Middle Ages in Europe.This thesis tries to discuss the positive influences of Renaissance human- ism on European politics.

Revisiting History Through Crime Fiction： Shiono Nanami＇s Scarlet Venice in The Renaissance Trilogy of Murder

The paper explores an ambiguous intersection between history and fiction in Scarlet Venice （Hi no Venezia, in original） （1988） by Japanese novelist and historiographer, Shiono Nanami （1937-）. As a prominent transnational writer who has worked on the Italian Renaissance and the Roman antiquity for about 40 years, Shiono fictionalizes the political culture of 16th century Venice in the context of the Eastern Mediterranean history. Based on her The Tales of the Sea Capital （1981）, historiography par excellence, the novel portrays the political maneuver of the Republic of Venice from viewpoints of diplomacy. With this thematic approach to history, the novel centers on the life and death of Alvise Gritti （1480-1534）, an illegitimate son of famed Venetian Doge, Andrea Gritti. In the metaphorical/metafictional structure of historical crime fiction, the novel unveils the austerity of Venetian polity, while contrasting it with the liberalism fostered in Sultan Suleiman＇s Ottoman court. In conclusion, the author interprets that Alvise Gritti is a victim of the political intricacy with which Venice was wrestling, implying that the republic is the metaphorical murderer. Whereas Alvise＇s death commemorates a drastic step taken by Venice for political negotiation, Shiono＇s recent writings suggest that Japan should model the rigid pragmatism in Venetian politics, along with its effective use of intelligence in diplomacy