Huntington＇s disease （HD） is the most common dominantly inherited neurodegenerative disorder, mainly characterized by the progressive striatal and cortical neurodegeneration and as- sociated motor, cognitive and be...Huntington＇s disease （HD） is the most common dominantly inherited neurodegenerative disorder, mainly characterized by the progressive striatal and cortical neurodegeneration and as- sociated motor, cognitive and behavioural disturbances （Zuccato et al., 2010）. The disease-causing mutation is an expansion of a GAG trinucleotide repeat （〉 36 repeats） encoding a polygluta- mine stretch in the N-terminal region ofhuntingtin （Htt） （Zuc- cato et al., 2010）, a ubiquitous protein whose function is still unclear （Zuccato et al., 2010）. Expansion of the polyQ stretch endows mutant Htt （mHtt） with toxic properties, and results in the development of a broad array of undesirable effects in both neuronal and non-neuronal cells （Zuccato et al., 2010）. Among all cellular dysfunctions and biochemical imbalances classically associated with HD, perturbed metabolism of （glyco） sphingolipids appears to play a crucial role in the pathogenesis of the disease. Over the last years, we and other have extensively contributed to these findings （Desplats et al., 2007;展开更多
New Criticism is an approach to literature which was developed by a group of American critics,most of whom taught at southern universities during the years following the First World War.The New Critics wanted to avoid...New Criticism is an approach to literature which was developed by a group of American critics,most of whom taught at southern universities during the years following the First World War.The New Critics wanted to avoid impressionistic criticism,which risked being shallow and arbitrary,and social/historical approaches which might easily be subsumed by other disciplines.Thus,they attempted to systematize the study of literature,to develop an approach which was centered on the rigorous study of the text itself.They were given their name by John Crowe Ransom,who describes the new American formalists in The New Criticism(1941).展开更多
With the deepening of the reform process of the new college entrance examination,the enrollment of Independent Colleges in the new period is facing greater difficulties and challenges.Meanwhile,with the novel coronavi...With the deepening of the reform process of the new college entrance examination,the enrollment of Independent Colleges in the new period is facing greater difficulties and challenges.Meanwhile,with the novel coronavirus pneumonia epidemic spreading in 2020 and the urgent demand of Independent Colleges'transformation work,enrollment is full of uncertainty.Based on this,the purpose of this study is to deeply analyze the plight,current situation and related research deficiencies of independent college enrollment work in the new period,and put forward the ways and direction of improvement,hoping to provide some reference for the enrollment work in the transition of independent college.展开更多
基金supported by"Fondazione Neuromed"funded by Italian Ministry of Health"Ricerca Corrente"funding program
文摘Huntington＇s disease （HD） is the most common dominantly inherited neurodegenerative disorder, mainly characterized by the progressive striatal and cortical neurodegeneration and as- sociated motor, cognitive and behavioural disturbances （Zuccato et al., 2010）. The disease-causing mutation is an expansion of a GAG trinucleotide repeat （〉 36 repeats） encoding a polygluta- mine stretch in the N-terminal region ofhuntingtin （Htt） （Zuc- cato et al., 2010）, a ubiquitous protein whose function is still unclear （Zuccato et al., 2010）. Expansion of the polyQ stretch endows mutant Htt （mHtt） with toxic properties, and results in the development of a broad array of undesirable effects in both neuronal and non-neuronal cells （Zuccato et al., 2010）. Among all cellular dysfunctions and biochemical imbalances classically associated with HD, perturbed metabolism of （glyco） sphingolipids appears to play a crucial role in the pathogenesis of the disease. Over the last years, we and other have extensively contributed to these findings （Desplats et al., 2007;
文摘New Criticism is an approach to literature which was developed by a group of American critics,most of whom taught at southern universities during the years following the First World War.The New Critics wanted to avoid impressionistic criticism,which risked being shallow and arbitrary,and social/historical approaches which might easily be subsumed by other disciplines.Thus,they attempted to systematize the study of literature,to develop an approach which was centered on the rigorous study of the text itself.They were given their name by John Crowe Ransom,who describes the new American formalists in The New Criticism(1941).
文摘With the deepening of the reform process of the new college entrance examination,the enrollment of Independent Colleges in the new period is facing greater difficulties and challenges.Meanwhile,with the novel coronavirus pneumonia epidemic spreading in 2020 and the urgent demand of Independent Colleges'transformation work,enrollment is full of uncertainty.Based on this,the purpose of this study is to deeply analyze the plight,current situation and related research deficiencies of independent college enrollment work in the new period,and put forward the ways and direction of improvement,hoping to provide some reference for the enrollment work in the transition of independent college.
