The study aimed to examine the applicability of carbon nanoparticles as a tracer for lymph node mapping and the related factors of lymph node and No.8p subgroup metastasis in patients with gastric cancer.Clinical data...The study aimed to examine the applicability of carbon nanoparticles as a tracer for lymph node mapping and the related factors of lymph node and No.8p subgroup metastasis in patients with gastric cancer.Clinical data of 50 patients with gastric cancer,who had not received treatment preoperatively and underwent gastrectomy in Department of Gastrointestinal Surgery,Wuhan Union Hospital,between October 2014 and August 2015,were retrospectively analyzed.These patients were found to have no distant metastasis preoperatively.Thirty-five out of 50 patients were subjected to lymphatic mapping technique using carbon nanoparticles as the tracer,and the rest 15 cases did not experience the lymphatic mapping and served as controls.The sensitivity,specificity,false positive rate and false negative rate were calculated according to the number of lymph nodes,and the staining and metastasis condition of lymph nodes.The diagnostic value of carbon nanoparticles on metastatic lymph nodes was evaluated.The relationship between the metastasis of lymph nodes or subgroup No.8p lymph nodes and clinicopathologic features was analyzed by χ^2-test or Fisher＇s exact test.All patients underwent D2 surgery（lymph node dissection including all the group 1 and group 2 nodes） plus the dissection of the subgroup No.8p lymph nodes.It was found that the average number of harvested lymph nodes in lymphatic mapping technique group（45.7±14.5） was greater than that in control group（39.2±11.7）,but the difference was not significantly different（P=0.138〉0.05）.The success rate,the accuracy,sensitivity,specificity and false negative rate was 97%,57%,28%,62% and 72% respectively.The metastasis of lymph nodes was correlated to the depth of cancer invasion（T stage）（P=0.004〈0.05）,and the metastasis of No.8p lymph nodes was correlated to the extent of lymph node involvement（N stage）（P=0.007〈0.05）.Six cases had lymph node metastasis in subgroup No.8p,and their TNM stages and clinical stages were as follows：T1N2M0 ⅡA,T3N3M0 ⅢB,T4 a N3M0 ⅢC,T4 a N3M0 ⅢC,T4 a N3M0 ⅢC,and T4 b N3M0 ⅢC.In conclusion,our study indicated that carbon nanoparticles failed to show good selectivity for metastatic lymph nodes;the result of lymphatic mapping does not achieve a satisfactory performance;the incidence of lymph node metastasis may increase,accompanying with the increase of the depth of cancer invasion;No.8p lymph node metastasis tends to occur for gastric carcinoma patients with the extent of lymph node metastasis over N2 stage.展开更多
The discovery and application of environment-sensitive genic male sterile(EGMS) rice germplasm provide an easy method for hybrid rice breeding and have made great contributions to hybrid rice production. Typically, th...The discovery and application of environment-sensitive genic male sterile(EGMS) rice germplasm provide an easy method for hybrid rice breeding and have made great contributions to hybrid rice production. Typically, the photoperiod-and thermosensitive GMS(P/TGMS) lines utilized in two-line hybrid systems are male sterile under long day or/and high temperature but fertile under short day or/and low temperature conditions. However, Yannong S(Yn S), a reverse TGMS(rTGMS) line, is sterile under low temperature(<29℃) and fertile under high temperature(>29.5℃). Here, we report a genetic study on the rTGMS trait in Yn S. Interestingly, the F1 plants of the cross between Yn S and a cultivar, L422, were male sterile at 22℃ and completely fertile at 27℃. Moreover, the segregation ratio of fertile and sterile individuals in Yn S/L422 F2 populations changed from 1:3.05 to 2.95:1 when the ambient temperature increased, showing that the rTGMS trait exhibits semidominance in Yn S. We further found a locus on chromosome 10, termed RTMS10, which controls the rTGMS trait in Yn S. We then finely mapped RTMS10 to a ~68 kb interval between markers ID13116 and ID1318 by Yn S/L422 BC6 F2 populations. A near iso-genic line(NIL) NL1 from the BC6 F3 generation was developed and the pollen of NL1 became abnormal from the meiosis stage under low temperature. In summary, we identified an rTGMS locus, RTMS10, and provided co-segregated markers, which could help to accelerate molecular breeding of rTGMS lines and better understand the rTGMS trait in rice.展开更多
In this note, we consider a holomorphic mapping f from the unit disk C in C to p-ball B^p = {z∈C^n;i=1∑n｜zi｜p〈1,1〈p〈＋∞. It is proved that for such f,｜ ｜ ｜f｜｜（z）｜≤1-｜｜f（z）｜｜^2/1-｜z｜^2,z∈D. Th...In this note, we consider a holomorphic mapping f from the unit disk C in C to p-ball B^p = {z∈C^n;i=1∑n｜zi｜p〈1,1〈p〈＋∞. It is proved that for such f,｜ ｜ ｜f｜｜（z）｜≤1-｜｜f（z）｜｜^2/1-｜z｜^2,z∈D. The extremal problem is also discussed when p is an even number. This result extends some related results on Schwarz lemma.展开更多
In this paper some theorems on fixed points of pair of asymptotically regularmappings in p-uniformly convex Banach space are proved For these mappings somefixed point theorems in a Hilbert space.in Lp spaces in Hardy ...In this paper some theorems on fixed points of pair of asymptotically regularmappings in p-uniformly convex Banach space are proved For these mappings somefixed point theorems in a Hilbert space.in Lp spaces in Hardy spaces Hp and in Sobolev spaces Hpk for 1<P<+∞ and K>0 are also established.Thus resultsof Gornicki Kruppel and others are extended.展开更多
E E. Browder and W. V. Petryshyn defined the topological degree for A- proper mappings and then W. V. Petryshyn studied a class of A-proper mappings, namely, P1-compact mappings and obtained a number of important fixe...E E. Browder and W. V. Petryshyn defined the topological degree for A- proper mappings and then W. V. Petryshyn studied a class of A-proper mappings, namely, P1-compact mappings and obtained a number of important fixed point theorems by virtue of the topological degree theory. In this paper, following W. V. Petryshyn, we continue to study P1-compact mappings and investigate the boundary condition, under which many new fixed point theorems of P1-compact mappings are obtained. On the other hand, this class of A-proper mappings with the boundedness property includes completely continuous operators and so, certain interesting new fixed point theorems for completely continuous operators are obtained immediately. As a result of it, our results generalize several famous theorems such as Leray-Schauder＇s theorem, Rothe＇s theorem, Altman＇s theorem, Petryshyn＇s theorem, etc.展开更多
In this paper, we present a necessary and suffcient condition that the perturbed monomial mapping is ergodic on a sphere S_(p-1)(1), which is in a combination with Anashin's earlier results about the perturbed mon...In this paper, we present a necessary and suffcient condition that the perturbed monomial mapping is ergodic on a sphere S_(p-1)(1), which is in a combination with Anashin's earlier results about the perturbed monomial ergodic mappings on a sphere S_(p-r)(1), r > 1, completely solve a problem posed by A. Khrennikov about the ergodicity of a perturbed monomial mapping on a sphere.展开更多
In this paper, we introduce an iterative sequence for finding a common element of the set of fixed points of a relatively nonexpansive mapping and the set of solutions of the variational inequality for an inverse-stro...In this paper, we introduce an iterative sequence for finding a common element of the set of fixed points of a relatively nonexpansive mapping and the set of solutions of the variational inequality for an inverse-strongly-monotone mapping in a Banach space. Then, we show that the sequence converges strongly to a common element of the two sets. Our results improve and extend the corresponding results reported by many others.展开更多
The existence of common fixed points for a pair of Lipschitzian mappings in Banach spaces is proved. By using this result, some common fixed point theorems are also established for these mappings in Hilbert spaces, in...The existence of common fixed points for a pair of Lipschitzian mappings in Banach spaces is proved. By using this result, some common fixed point theorems are also established for these mappings in Hilbert spaces, in L p spaces, in Hardy spaces H p, and in Sobolev spaces H r,p , for 1<p<+∞ and r≥0.展开更多
目的研究阿魏酸钠(sod ium feru late)对抗Aβ25-35致大鼠学习记忆障碍与白介素-1β(IL-1β)和丝裂原激活的蛋白激酶p38(M itogen-activated prote in k inase,p38MAPK)表达的相关性。方法大鼠脑室内一次性注射Aβ25-35制备AD动物模型,...目的研究阿魏酸钠(sod ium feru late)对抗Aβ25-35致大鼠学习记忆障碍与白介素-1β(IL-1β)和丝裂原激活的蛋白激酶p38(M itogen-activated prote in k inase,p38MAPK)表达的相关性。方法大鼠脑室内一次性注射Aβ25-35制备AD动物模型,通过大鼠行为学和海马CA1区的病理学改变观察阿魏酸钠的作用。W estern b lot和ELISA方法检测磷酸化p38MAPK和IL-1β蛋白表达量的变化。RT-PCR分析FasLmRNA表达水平。结果脑室内注射Aβ25-35可使大鼠出现明显的学习记忆障碍,即逃避潜伏期明显延长,原平台象限游泳时间占总游泳时间百分比明显降低。这些行为学的改变伴随有海马CA1区星形胶质细胞激活和浸润,IL-1β蛋白表达和FasL mRNA表达水平明显增加,海马CA1区锥体神经元损伤。另外,Aβ25-35也能引起磷酸化的p38MAPK蛋白表达明显增加。阿魏酸钠(50,100,250 mg.kg-1,连续应用4 wk)与阳性对照药布洛芬(15 mg.kg-1)均能明显对抗Aβ25-35所致大鼠学习记忆障碍,抑制Aβ25-35引起的IL-1β、磷酸化p38MAPK和FasL mRNA表达增加,海马CA1区锥体神经元的损伤和星形胶质细胞激活和浸润也被明显减轻。结论阿魏酸钠通过抑制Aβ25-35引起的海马炎症反应和p38MAPK活性,减轻大鼠海马锥体神经元的损伤,改善大鼠的学习记忆功能。展开更多
文摘The study aimed to examine the applicability of carbon nanoparticles as a tracer for lymph node mapping and the related factors of lymph node and No.8p subgroup metastasis in patients with gastric cancer.Clinical data of 50 patients with gastric cancer,who had not received treatment preoperatively and underwent gastrectomy in Department of Gastrointestinal Surgery,Wuhan Union Hospital,between October 2014 and August 2015,were retrospectively analyzed.These patients were found to have no distant metastasis preoperatively.Thirty-five out of 50 patients were subjected to lymphatic mapping technique using carbon nanoparticles as the tracer,and the rest 15 cases did not experience the lymphatic mapping and served as controls.The sensitivity,specificity,false positive rate and false negative rate were calculated according to the number of lymph nodes,and the staining and metastasis condition of lymph nodes.The diagnostic value of carbon nanoparticles on metastatic lymph nodes was evaluated.The relationship between the metastasis of lymph nodes or subgroup No.8p lymph nodes and clinicopathologic features was analyzed by χ^2-test or Fisher＇s exact test.All patients underwent D2 surgery（lymph node dissection including all the group 1 and group 2 nodes） plus the dissection of the subgroup No.8p lymph nodes.It was found that the average number of harvested lymph nodes in lymphatic mapping technique group（45.7±14.5） was greater than that in control group（39.2±11.7）,but the difference was not significantly different（P=0.138〉0.05）.The success rate,the accuracy,sensitivity,specificity and false negative rate was 97%,57%,28%,62% and 72% respectively.The metastasis of lymph nodes was correlated to the depth of cancer invasion（T stage）（P=0.004〈0.05）,and the metastasis of No.8p lymph nodes was correlated to the extent of lymph node involvement（N stage）（P=0.007〈0.05）.Six cases had lymph node metastasis in subgroup No.8p,and their TNM stages and clinical stages were as follows：T1N2M0 ⅡA,T3N3M0 ⅢB,T4 a N3M0 ⅢC,T4 a N3M0 ⅢC,T4 a N3M0 ⅢC,and T4 b N3M0 ⅢC.In conclusion,our study indicated that carbon nanoparticles failed to show good selectivity for metastatic lymph nodes;the result of lymphatic mapping does not achieve a satisfactory performance;the incidence of lymph node metastasis may increase,accompanying with the increase of the depth of cancer invasion;No.8p lymph node metastasis tends to occur for gastric carcinoma patients with the extent of lymph node metastasis over N2 stage.
基金funded by the Key Research and Development Program of Anhui Province,China(201904a06020016 and 202104g01020013)the National Natural Science Foundation of China(31101204)the Program of Rice Genetic Breeding Key Laboratory of Anhui Province,China(SDKF-201903)。
文摘The discovery and application of environment-sensitive genic male sterile(EGMS) rice germplasm provide an easy method for hybrid rice breeding and have made great contributions to hybrid rice production. Typically, the photoperiod-and thermosensitive GMS(P/TGMS) lines utilized in two-line hybrid systems are male sterile under long day or/and high temperature but fertile under short day or/and low temperature conditions. However, Yannong S(Yn S), a reverse TGMS(rTGMS) line, is sterile under low temperature(<29℃) and fertile under high temperature(>29.5℃). Here, we report a genetic study on the rTGMS trait in Yn S. Interestingly, the F1 plants of the cross between Yn S and a cultivar, L422, were male sterile at 22℃ and completely fertile at 27℃. Moreover, the segregation ratio of fertile and sterile individuals in Yn S/L422 F2 populations changed from 1:3.05 to 2.95:1 when the ambient temperature increased, showing that the rTGMS trait exhibits semidominance in Yn S. We further found a locus on chromosome 10, termed RTMS10, which controls the rTGMS trait in Yn S. We then finely mapped RTMS10 to a ~68 kb interval between markers ID13116 and ID1318 by Yn S/L422 BC6 F2 populations. A near iso-genic line(NIL) NL1 from the BC6 F3 generation was developed and the pollen of NL1 became abnormal from the meiosis stage under low temperature. In summary, we identified an rTGMS locus, RTMS10, and provided co-segregated markers, which could help to accelerate molecular breeding of rTGMS lines and better understand the rTGMS trait in rice.
基金supported by National Natural Science Foundations of China(11011373,11201199,11271333)Zhejiang Provincial Natural Science Foundation of China(LY14A010008)
文摘In this note, we consider a holomorphic mapping f from the unit disk C in C to p-ball B^p = {z∈C^n;i=1∑n｜zi｜p〈1,1〈p〈＋∞. It is proved that for such f,｜ ｜ ｜f｜｜（z）｜≤1-｜｜f（z）｜｜^2/1-｜z｜^2,z∈D. The extremal problem is also discussed when p is an even number. This result extends some related results on Schwarz lemma.
文摘In this paper some theorems on fixed points of pair of asymptotically regularmappings in p-uniformly convex Banach space are proved For these mappings somefixed point theorems in a Hilbert space.in Lp spaces in Hardy spaces Hp and in Sobolev spaces Hpk for 1<P<+∞ and K>0 are also established.Thus resultsof Gornicki Kruppel and others are extended.
基金Supported in part by Education Ministry,Anhui Province,China(No:2003kj047zd)
文摘E E. Browder and W. V. Petryshyn defined the topological degree for A- proper mappings and then W. V. Petryshyn studied a class of A-proper mappings, namely, P1-compact mappings and obtained a number of important fixed point theorems by virtue of the topological degree theory. In this paper, following W. V. Petryshyn, we continue to study P1-compact mappings and investigate the boundary condition, under which many new fixed point theorems of P1-compact mappings are obtained. On the other hand, this class of A-proper mappings with the boundedness property includes completely continuous operators and so, certain interesting new fixed point theorems for completely continuous operators are obtained immediately. As a result of it, our results generalize several famous theorems such as Leray-Schauder＇s theorem, Rothe＇s theorem, Altman＇s theorem, Petryshyn＇s theorem, etc.
基金Supported by the National Natural Science Foundation of China(10771075,11371379)
文摘In this paper, we present a necessary and suffcient condition that the perturbed monomial mapping is ergodic on a sphere S_(p-1)(1), which is in a combination with Anashin's earlier results about the perturbed monomial ergodic mappings on a sphere S_(p-r)(1), r > 1, completely solve a problem posed by A. Khrennikov about the ergodicity of a perturbed monomial mapping on a sphere.
文摘In this paper, we introduce an iterative sequence for finding a common element of the set of fixed points of a relatively nonexpansive mapping and the set of solutions of the variational inequality for an inverse-strongly-monotone mapping in a Banach space. Then, we show that the sequence converges strongly to a common element of the two sets. Our results improve and extend the corresponding results reported by many others.
文摘The existence of common fixed points for a pair of Lipschitzian mappings in Banach spaces is proved. By using this result, some common fixed point theorems are also established for these mappings in Hilbert spaces, in L p spaces, in Hardy spaces H p, and in Sobolev spaces H r,p , for 1<p<+∞ and r≥0.
