Children’s creative art curriculum is a professional course supported by art materials and techniques and facilitated through creative activities,aiming at cultivating students’ability to organize creative art activ...Children’s creative art curriculum is a professional course supported by art materials and techniques and facilitated through creative activities,aiming at cultivating students’ability to organize creative art activities using various art materials and techniques.In light of the evolving focus in China’s colleges and universities from“what to know”to“how to apply,”the pivotal question for educators is how to maximize the value of children’s creative art curriculum.Based on this,this article takes“Sanquan education”as the starting point,combines factual and theoretical arguments,and analyzes the teaching optimization path of children’s creative art curriculum under the perspective of Sanquan education,to improve the quality and efficiency of teaching.展开更多
Inconsistent condom use among persons on antiretroviral treatment (ART) is a major public health concern because of the risk of HIV transmission. This study examined the association between socio-demographic variables...Inconsistent condom use among persons on antiretroviral treatment (ART) is a major public health concern because of the risk of HIV transmission. This study examined the association between socio-demographic variables and knowing partners’ HIV status, multiple sex partners, and consistent condom use among 400 HIV-infected adults who had received ART for at least six months in Johannesburg, South Africa. The study used a cross-sectional survey and a structured interviewer administered questionnaire. Over half (n = 225, 56.3%) of participants were on ART for more than two years. Two thirds (n = 234, 63.2%) were aware of partner’s HIV status. Over a third (n = 136, 34.0%) reported having more than one sex partners. Three quarters (n = 279, 75.8%) reported consistent condom use with regular partner. Discussing HIV testing (aOR = 2.28, CI: 1.31 -3.95), awareness of partner’s HIV status (aOR = 2.59, CI: 1.50 -4.46), level of education (aOR = 0.64, CI: 0.42 -0.98), and duration on ART (aOR = 0.71, CI: 1.31 -3.95) were predictors for consistent condom use. Awareness of partner’s HIV status was associated with multiple partnership (aOR = 0.38, CI: 0.21 -0.66), living with partner (aOR = 4.75, CI: 2.86 -7.91), discussing HIV testing (aOR = 2.43, CI: 1.48 -3.99), and duration on ART (aOR = 2.04, CI: 1.43 -2.92). While gender (aOR = 5.68, CI: 3.46 -9.34), marital status (aOR = 0.44, CI: 0.25 -0.77), and awareness of partner’s HIV status (aOR = 0.52, CI: 0.30 -0.89) were associated with multiple partnerships. Risky sexual behaviours occurred in all types of partners and knowing partner’s HIV status was a predictor for consistent condom use with all types of partners. It is essential that HIV prevention strategies create an enabling environment for disclosure and reductions of risky sexual behaviours by HIV-infected persons on ART.展开更多
He designed the national emblem of thePeople’s depublic of China, was a primary painterof the mural in the Beijing Capital Airport, ananimator of "Ne Zha Makes Havoc of the Sea", arenowned cartoonist, one o...He designed the national emblem of thePeople’s depublic of China, was a primary painterof the mural in the Beijing Capital Airport, ananimator of "Ne Zha Makes Havoc of the Sea", arenowned cartoonist, one of the founders of展开更多
The literature in 20th century is mainly characterized by irrationalism presented in modernism. Under the background, this paper aims to explore how Eliot attempts to use modern art techniques in The Waste Land to rev...The literature in 20th century is mainly characterized by irrationalism presented in modernism. Under the background, this paper aims to explore how Eliot attempts to use modern art techniques in The Waste Land to reveal a real life to readers.展开更多
Literary translation is the re-creation of the language art.To translate an English novel into Chinese one,translators need the skill of literature re-creation.Taking Zhang Guruo's translated version Tess of the D...Literary translation is the re-creation of the language art.To translate an English novel into Chinese one,translators need the skill of literature re-creation.Taking Zhang Guruo's translated version Tess of the D'urbervilles as an example,we perceive that translators have subjectivity and they should break the boundary between writing and translating.When a translator translates a piece of works,he must get rid of the constraint of the surface structures of the original works,and reproduces the flavor of the original novel.But the translators should try to show the original scenes in the original English novel to target readers.展开更多
Objective: To observe the adjuvant analgesic efficacy of Han's Acupoint Nerve Stimulator (HANS) in opioid tolerant patients with cancer pain. Methods: A prospective non-controlled study was conducted. Opioid tole...Objective: To observe the adjuvant analgesic efficacy of Han's Acupoint Nerve Stimulator (HANS) in opioid tolerant patients with cancer pain. Methods: A prospective non-controlled study was conducted. Opioid tolerant patients with cancer pain were enrolled and treated with both routinely analgesics and adjuvant HANS (2/100 Hz for 30 min/d, 5 d on and 2 d off for two weeks). Cancer pain, quality of life (QOL), anxiety and depression were assessed before enrollment and on d 8 and d 15 with the BPI-C, EORTC QLQ-C30, and self-rating anxiety scale (SAS)/ self-rating depression scale (SDS), respectively; the therapeutic frequency of breakthrough pain (BP) and daily opioid dose were also recorded. Results: Totally 47 patients meeting the inclusion criteria participated in this study; 43 patients completed the two-week treatment and assessment. The mean scores of patient's "worst" and "least" pain intensity assessed with BPI-C decreased significantly on d 8 and d 15; the therapeutic frequency of BP also significantly decreased; but the average daily dose of opioids did not change significantly. For the nine symptoms in EORTC QLQ-C30 assessment, the mean scores of pain, fatigue, constipation and insomnia were significantly lower on d 8 and d 15 compared with baseline; the mean scores of the overall health status, nausea/vomiting and the incidence rates of both anxiety and depression also decreased significantly on d 15. Conclusions: To opioid tolerant patients with cancer pain, adjuvant treatment with HANS could improve pain release and patients' QOL by decreasing the severity of pain, fatigue, constipation, insomnia and other concomitant symptoms; it could also decrease the incidence rates of anxiety and depression.展开更多
Ding's Manor is a Hakka's folk dwelling characterized by both Hakka's cultures on the Central Plain and also cultures of north Sichuan, and a typical Hakka's architecture in Sichuan Province. Design of...Ding's Manor is a Hakka's folk dwelling characterized by both Hakka's cultures on the Central Plain and also cultures of north Sichuan, and a typical Hakka's architecture in Sichuan Province. Design of the manor concentrates rich cultures, arts and beliefs of the Hakka, thus exploration of Ding's Manor, specifically, its site layout showing Fengshui doctrines of the Hakka, architectural style and watchtower with strict structures, and exquisite decorative arts, show architectural technology and wisdom of the Hakka, and also artistic characteristics of the Hakka's folk dwellings in a certain historical environment, which provides a favorable reference for the construction of modern folk dwellings.展开更多
AIM:To explore the association of single nucleotide polymorphisms(SNPs)in the IL33/IL1RL1 gene region with the susceptibility to Behcet’s disease(BD)in a Chinese Han population.METHODS:A total of eight SNPs in the ca...AIM:To explore the association of single nucleotide polymorphisms(SNPs)in the IL33/IL1RL1 gene region with the susceptibility to Behcet’s disease(BD)in a Chinese Han population.METHODS:A total of eight SNPs in the candidate gene region(rs11792633,rs7025417,rs10975519 and rs1048274 in IL33;rs2310220,rs12712142,rs13424006 and rs3821204 in IL1RL1)were genotyped in783 BD patients and 701 healthy controls by the Sequenom Mass Array i PLEX platform.RESULTS:A statistically significant association was observed between IL1RL1 rs12712142 and BD patients.The frequency of IL1RL1 rs12712142 variant allele A was significantly lower in BD patients than that in controls(OR=0.8,95%CI:0.69-0.94,Pc=0.039);the genotype distribution(Pc=0.043)and additive and dominant genetic model analyses(OR=0.8,95%CI:0.69-0.94,Pc=0.040 and OR=0.72,95%CI:0.58-0.88,Pc=0.011)also indicated a strong association between rs12712142 and BD patients.CONCLUSION:This is the first study to reveal the association between IL1RL1 rs12712142 variant allele A and the decreased risk of BD in the Chinese Han population,indicating a protective role of IL1RL1 in the pathogenesis of BD.展开更多
In a recent genome-wide association study, the SLC26A4 gene rs2072064 polymorphism was found to be associated with late-onset Alzheimer's disease in Caucasians. Here, we investigated this association in a large North...In a recent genome-wide association study, the SLC26A4 gene rs2072064 polymorphism was found to be associated with late-onset Alzheimer's disease in Caucasians. Here, we investigated this association in a large Northern Han Chinese cohort consisting of 599 sporadic late-onset Alzheimer's disease patients and 598 healthy controls matched for sex and age in a Northern Han Chinese population from Qingdao, China. Genotyping by the polymerase chain reaction-ligase detection reaction revealed that there were significant differences in the genotype (P = 0.017) and allele (P = 0.007) frequencies of the rs2072064 polymorphism between late-onset Alzheimer's disease patients and controls. The A allele of this polymorphism was significantly associated with a reduced risk of late-onset Alzheimer's disease (odds ratio (OR) = 0.792, 95% confidence interval (CI) = 0.670-0.937, P = 0.007). When the data were stratified by the apolipoprotein E E4 status, there was a significant difference only among apolipoprotein E E4 non-carriers (genotypic P = 0.001, allelic P = 0.001). Furthermore, the association between rs2072064 and late-onset Alzheimer's disease remained significant by logistic regression analysis after adjustment for age, gender, and the apolipoprotein E E4 carrier status (dominant model: OR = 0.787, 95% CI = 0.619-1.000, P = 0.050; recessive model: OR = 0.655, 95% CI = 0.448-0.959, P= 0.030; additive model: OR = 0.792, 95% CI = 0.661-0.950, P = 0.012). These findings suggest that SLC26A4 is a susceptibility gene for late-onset Alzheimer's disease in a Northern Han Chinese population from the Qingdao area.展开更多
BACKGROUND: Han's acupoint nerve stimulator (HANS) has been frequently used to relieve pain by promoting the central nerve system's release of endogenous opioid peptides through electric stimulation to the body s...BACKGROUND: Han's acupoint nerve stimulator (HANS) has been frequently used to relieve pain by promoting the central nerve system's release of endogenous opioid peptides through electric stimulation to the body surface. OBJECTIVE: To investigate the pain-relieving effects of HANS, combined with patient-controlled analgesia, following neurosurgery, and to observe adverse reactions and effects. DESIGN, TIME AND SETTING: A randomized control observation was performed at the Department of Neurology in the First Affiliated Hospital of Gannan Medical College (Ganzhou, Jiangxi Province, China) from January 2005 to February 2006. PARTICIPANTS: Forty patients, who were selected for craniotomy and required pain relief following surgery at the Department of Neurology in the First Affiliated Hospital of Gannan Medical College (China), were included in this study. METHODS: Forty patients underwent neurosurgery and were randomly divided into two groups: patient-controlled analgesia plus HANS (+HANS, n = 20) and patient-controlled analgesia (-HANS, n = 20). Both groups were well matched in baseline data. Automatic syringe infusion pump ZZB-150 was the product of Nantong Aipeng Medical Instruments Co., Ltd. (China). Patient-controlled analgesia consisted of 100 mL 0.02% lappaconitine/0.02% metoclopramide. LH-402 HANS instrument was produced in Beijing (China), with a serial number of 402183. The HANS instrumentation was used to stimulate the Hegu-Laogong acupoint on one side and Jiaogan, Shenmen penetrating Shen, Waifei, Naogan penetrating Pizhixia ear acupoints on the affected side for one hour, with 2-hour intervals. The disperse-dense wave was alternating, with a 2/100 Hz frequency of electrical stimulation. MAIN OUTCOME MEASURE: The scores of visual analogue scale and incidence of adverse reaction were observed in two groups following surgery. RESULTS: Compared with the HANS group, the visual analogue scale scores were remarkably lower in the +HANS group six hours after surgery (P 〈 0.01), and the incidence rate of adverse reactions, such as nausea and vomiting, was also decreased (P 〈 0.05).CONCLUSION: The application of HANS to induce body surface stimulation can enhance the effect of pain relief and reduce adverse reactions when used in combination with patient-controlled analgesia following neurosurgery. The effect of combined therapy is superior to patient-controlled analgesia alone.展开更多
A missense C/T polymorphism in exon 6 (the NCBI rslD is rs2227564) of the urokinase-type plasminogen activator gene has been identified as a possible hot spot for Alzheimer's disease risk. The present study analyze...A missense C/T polymorphism in exon 6 (the NCBI rslD is rs2227564) of the urokinase-type plasminogen activator gene has been identified as a possible hot spot for Alzheimer's disease risk. The present study analyzed urokinase-type plasminogen gene polymorphisms of rs2227564 with sporadic Alzheimer's disease by PCR-restriction fragment length polymorphism. Results showed that CC, CT and TT genotype distribution frequencies had significant differences between sporadic Aizheimer's disease patients and healthy controls, in-depth analysis of the association between urokinase-type plasminogen gene rs2227564 polymorphisms and sporadic Alzheimer's disease indicated that people with the C-positive genotype CC + CT were at a higher risk for developing sporadic Alzheimer's disease. These results support the contribution of the polymorphisms of rs2227564 in the urokinase-type plasminogen gene to the pathogenesis of sporadicAIzheimer's disease in the Han Chinese population.展开更多
On the basis of explaining goals of building temple gardens,Gu Dongyang’s Memorial Temple in Wuxi City was taken for example to analyze its gardening arts from the perspective of water layout,stone layout,building an...On the basis of explaining goals of building temple gardens,Gu Dongyang’s Memorial Temple in Wuxi City was taken for example to analyze its gardening arts from the perspective of water layout,stone layout,building and plant design,and elaborate its cultural connotations from decorative symbols of its architectural components.It was concluded that Gu Dongyang’s Memorial Temple,in spite of its small size and plain style,had profound historical background and high referential value for furthering the study on temple gardens in the south of the Yangtze River.展开更多
Qimin Yaoshu( Important Arts for the People's Welfare) made a detailed record of the diet and its production methods in the middle and lower reaches of the Yellow River during the Wei Dynasty.Hu foods are importan...Qimin Yaoshu( Important Arts for the People's Welfare) made a detailed record of the diet and its production methods in the middle and lower reaches of the Yellow River during the Wei Dynasty.Hu foods are important parts in the book.Hu foods recorded in Important Arts for the People's Welfare mainly include cheese products,cake products,and dish products.These contents not only reflect the exchange of diet culture between different nationalities in the middle and lower reaches of the Yellow River during this period,but also reflect the breadth and depth of ethnic exchanges and integration in this period.展开更多
文摘Children’s creative art curriculum is a professional course supported by art materials and techniques and facilitated through creative activities,aiming at cultivating students’ability to organize creative art activities using various art materials and techniques.In light of the evolving focus in China’s colleges and universities from“what to know”to“how to apply,”the pivotal question for educators is how to maximize the value of children’s creative art curriculum.Based on this,this article takes“Sanquan education”as the starting point,combines factual and theoretical arguments,and analyzes the teaching optimization path of children’s creative art curriculum under the perspective of Sanquan education,to improve the quality and efficiency of teaching.
文摘Inconsistent condom use among persons on antiretroviral treatment (ART) is a major public health concern because of the risk of HIV transmission. This study examined the association between socio-demographic variables and knowing partners’ HIV status, multiple sex partners, and consistent condom use among 400 HIV-infected adults who had received ART for at least six months in Johannesburg, South Africa. The study used a cross-sectional survey and a structured interviewer administered questionnaire. Over half (n = 225, 56.3%) of participants were on ART for more than two years. Two thirds (n = 234, 63.2%) were aware of partner’s HIV status. Over a third (n = 136, 34.0%) reported having more than one sex partners. Three quarters (n = 279, 75.8%) reported consistent condom use with regular partner. Discussing HIV testing (aOR = 2.28, CI: 1.31 -3.95), awareness of partner’s HIV status (aOR = 2.59, CI: 1.50 -4.46), level of education (aOR = 0.64, CI: 0.42 -0.98), and duration on ART (aOR = 0.71, CI: 1.31 -3.95) were predictors for consistent condom use. Awareness of partner’s HIV status was associated with multiple partnership (aOR = 0.38, CI: 0.21 -0.66), living with partner (aOR = 4.75, CI: 2.86 -7.91), discussing HIV testing (aOR = 2.43, CI: 1.48 -3.99), and duration on ART (aOR = 2.04, CI: 1.43 -2.92). While gender (aOR = 5.68, CI: 3.46 -9.34), marital status (aOR = 0.44, CI: 0.25 -0.77), and awareness of partner’s HIV status (aOR = 0.52, CI: 0.30 -0.89) were associated with multiple partnerships. Risky sexual behaviours occurred in all types of partners and knowing partner’s HIV status was a predictor for consistent condom use with all types of partners. It is essential that HIV prevention strategies create an enabling environment for disclosure and reductions of risky sexual behaviours by HIV-infected persons on ART.
文摘He designed the national emblem of thePeople’s depublic of China, was a primary painterof the mural in the Beijing Capital Airport, ananimator of "Ne Zha Makes Havoc of the Sea", arenowned cartoonist, one of the founders of
文摘The literature in 20th century is mainly characterized by irrationalism presented in modernism. Under the background, this paper aims to explore how Eliot attempts to use modern art techniques in The Waste Land to reveal a real life to readers.
文摘Literary translation is the re-creation of the language art.To translate an English novel into Chinese one,translators need the skill of literature re-creation.Taking Zhang Guruo's translated version Tess of the D'urbervilles as an example,we perceive that translators have subjectivity and they should break the boundary between writing and translating.When a translator translates a piece of works,he must get rid of the constraint of the surface structures of the original works,and reproduces the flavor of the original novel.But the translators should try to show the original scenes in the original English novel to target readers.
文摘Objective: To observe the adjuvant analgesic efficacy of Han's Acupoint Nerve Stimulator (HANS) in opioid tolerant patients with cancer pain. Methods: A prospective non-controlled study was conducted. Opioid tolerant patients with cancer pain were enrolled and treated with both routinely analgesics and adjuvant HANS (2/100 Hz for 30 min/d, 5 d on and 2 d off for two weeks). Cancer pain, quality of life (QOL), anxiety and depression were assessed before enrollment and on d 8 and d 15 with the BPI-C, EORTC QLQ-C30, and self-rating anxiety scale (SAS)/ self-rating depression scale (SDS), respectively; the therapeutic frequency of breakthrough pain (BP) and daily opioid dose were also recorded. Results: Totally 47 patients meeting the inclusion criteria participated in this study; 43 patients completed the two-week treatment and assessment. The mean scores of patient's "worst" and "least" pain intensity assessed with BPI-C decreased significantly on d 8 and d 15; the therapeutic frequency of BP also significantly decreased; but the average daily dose of opioids did not change significantly. For the nine symptoms in EORTC QLQ-C30 assessment, the mean scores of pain, fatigue, constipation and insomnia were significantly lower on d 8 and d 15 compared with baseline; the mean scores of the overall health status, nausea/vomiting and the incidence rates of both anxiety and depression also decreased significantly on d 15. Conclusions: To opioid tolerant patients with cancer pain, adjuvant treatment with HANS could improve pain release and patients' QOL by decreasing the severity of pain, fatigue, constipation, insomnia and other concomitant symptoms; it could also decrease the incidence rates of anxiety and depression.
文摘Ding's Manor is a Hakka's folk dwelling characterized by both Hakka's cultures on the Central Plain and also cultures of north Sichuan, and a typical Hakka's architecture in Sichuan Province. Design of the manor concentrates rich cultures, arts and beliefs of the Hakka, thus exploration of Ding's Manor, specifically, its site layout showing Fengshui doctrines of the Hakka, architectural style and watchtower with strict structures, and exquisite decorative arts, show architectural technology and wisdom of the Hakka, and also artistic characteristics of the Hakka's folk dwellings in a certain historical environment, which provides a favorable reference for the construction of modern folk dwellings.
基金the National Natural Science Foundation of China (No.81770917)。
文摘AIM:To explore the association of single nucleotide polymorphisms(SNPs)in the IL33/IL1RL1 gene region with the susceptibility to Behcet’s disease(BD)in a Chinese Han population.METHODS:A total of eight SNPs in the candidate gene region(rs11792633,rs7025417,rs10975519 and rs1048274 in IL33;rs2310220,rs12712142,rs13424006 and rs3821204 in IL1RL1)were genotyped in783 BD patients and 701 healthy controls by the Sequenom Mass Array i PLEX platform.RESULTS:A statistically significant association was observed between IL1RL1 rs12712142 and BD patients.The frequency of IL1RL1 rs12712142 variant allele A was significantly lower in BD patients than that in controls(OR=0.8,95%CI:0.69-0.94,Pc=0.039);the genotype distribution(Pc=0.043)and additive and dominant genetic model analyses(OR=0.8,95%CI:0.69-0.94,Pc=0.040 and OR=0.72,95%CI:0.58-0.88,Pc=0.011)also indicated a strong association between rs12712142 and BD patients.CONCLUSION:This is the first study to reveal the association between IL1RL1 rs12712142 variant allele A and the decreased risk of BD in the Chinese Han population,indicating a protective role of IL1RL1 in the pathogenesis of BD.
文摘In a recent genome-wide association study, the SLC26A4 gene rs2072064 polymorphism was found to be associated with late-onset Alzheimer's disease in Caucasians. Here, we investigated this association in a large Northern Han Chinese cohort consisting of 599 sporadic late-onset Alzheimer's disease patients and 598 healthy controls matched for sex and age in a Northern Han Chinese population from Qingdao, China. Genotyping by the polymerase chain reaction-ligase detection reaction revealed that there were significant differences in the genotype (P = 0.017) and allele (P = 0.007) frequencies of the rs2072064 polymorphism between late-onset Alzheimer's disease patients and controls. The A allele of this polymorphism was significantly associated with a reduced risk of late-onset Alzheimer's disease (odds ratio (OR) = 0.792, 95% confidence interval (CI) = 0.670-0.937, P = 0.007). When the data were stratified by the apolipoprotein E E4 status, there was a significant difference only among apolipoprotein E E4 non-carriers (genotypic P = 0.001, allelic P = 0.001). Furthermore, the association between rs2072064 and late-onset Alzheimer's disease remained significant by logistic regression analysis after adjustment for age, gender, and the apolipoprotein E E4 carrier status (dominant model: OR = 0.787, 95% CI = 0.619-1.000, P = 0.050; recessive model: OR = 0.655, 95% CI = 0.448-0.959, P= 0.030; additive model: OR = 0.792, 95% CI = 0.661-0.950, P = 0.012). These findings suggest that SLC26A4 is a susceptibility gene for late-onset Alzheimer's disease in a Northern Han Chinese population from the Qingdao area.
文摘BACKGROUND: Han's acupoint nerve stimulator (HANS) has been frequently used to relieve pain by promoting the central nerve system's release of endogenous opioid peptides through electric stimulation to the body surface. OBJECTIVE: To investigate the pain-relieving effects of HANS, combined with patient-controlled analgesia, following neurosurgery, and to observe adverse reactions and effects. DESIGN, TIME AND SETTING: A randomized control observation was performed at the Department of Neurology in the First Affiliated Hospital of Gannan Medical College (Ganzhou, Jiangxi Province, China) from January 2005 to February 2006. PARTICIPANTS: Forty patients, who were selected for craniotomy and required pain relief following surgery at the Department of Neurology in the First Affiliated Hospital of Gannan Medical College (China), were included in this study. METHODS: Forty patients underwent neurosurgery and were randomly divided into two groups: patient-controlled analgesia plus HANS (+HANS, n = 20) and patient-controlled analgesia (-HANS, n = 20). Both groups were well matched in baseline data. Automatic syringe infusion pump ZZB-150 was the product of Nantong Aipeng Medical Instruments Co., Ltd. (China). Patient-controlled analgesia consisted of 100 mL 0.02% lappaconitine/0.02% metoclopramide. LH-402 HANS instrument was produced in Beijing (China), with a serial number of 402183. The HANS instrumentation was used to stimulate the Hegu-Laogong acupoint on one side and Jiaogan, Shenmen penetrating Shen, Waifei, Naogan penetrating Pizhixia ear acupoints on the affected side for one hour, with 2-hour intervals. The disperse-dense wave was alternating, with a 2/100 Hz frequency of electrical stimulation. MAIN OUTCOME MEASURE: The scores of visual analogue scale and incidence of adverse reaction were observed in two groups following surgery. RESULTS: Compared with the HANS group, the visual analogue scale scores were remarkably lower in the +HANS group six hours after surgery (P 〈 0.01), and the incidence rate of adverse reactions, such as nausea and vomiting, was also decreased (P 〈 0.05).CONCLUSION: The application of HANS to induce body surface stimulation can enhance the effect of pain relief and reduce adverse reactions when used in combination with patient-controlled analgesia following neurosurgery. The effect of combined therapy is superior to patient-controlled analgesia alone.
基金supported by the National Natural Science Foundation of China, No. 30470615
文摘A missense C/T polymorphism in exon 6 (the NCBI rslD is rs2227564) of the urokinase-type plasminogen activator gene has been identified as a possible hot spot for Alzheimer's disease risk. The present study analyzed urokinase-type plasminogen gene polymorphisms of rs2227564 with sporadic Alzheimer's disease by PCR-restriction fragment length polymorphism. Results showed that CC, CT and TT genotype distribution frequencies had significant differences between sporadic Aizheimer's disease patients and healthy controls, in-depth analysis of the association between urokinase-type plasminogen gene rs2227564 polymorphisms and sporadic Alzheimer's disease indicated that people with the C-positive genotype CC + CT were at a higher risk for developing sporadic Alzheimer's disease. These results support the contribution of the polymorphisms of rs2227564 in the urokinase-type plasminogen gene to the pathogenesis of sporadicAIzheimer's disease in the Han Chinese population.
文摘On the basis of explaining goals of building temple gardens,Gu Dongyang’s Memorial Temple in Wuxi City was taken for example to analyze its gardening arts from the perspective of water layout,stone layout,building and plant design,and elaborate its cultural connotations from decorative symbols of its architectural components.It was concluded that Gu Dongyang’s Memorial Temple,in spite of its small size and plain style,had profound historical background and high referential value for furthering the study on temple gardens in the south of the Yangtze River.
文摘Qimin Yaoshu( Important Arts for the People's Welfare) made a detailed record of the diet and its production methods in the middle and lower reaches of the Yellow River during the Wei Dynasty.Hu foods are important parts in the book.Hu foods recorded in Important Arts for the People's Welfare mainly include cheese products,cake products,and dish products.These contents not only reflect the exchange of diet culture between different nationalities in the middle and lower reaches of the Yellow River during this period,but also reflect the breadth and depth of ethnic exchanges and integration in this period.