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Exome sequencing analysis identifies novel homozygous mutation in ABCA4 in a Chinese family with Stargardt disease 被引量:2
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作者 Xiao-Dan Hao Ying Liu +2 位作者 Bao-Wei Li Wei Wu Xiao-Wen Zhao 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2020年第4期671-676,共6页
AIM: To identify the disease-associated mutations in a Chinese Stargardt disease(STGD) family, extend the existing spectrum of disease-causing mutations and further define the genotype-phenotype correlations.METHODS: ... AIM: To identify the disease-associated mutations in a Chinese Stargardt disease(STGD) family, extend the existing spectrum of disease-causing mutations and further define the genotype-phenotype correlations.METHODS: A Chinese STGD family and 200 normal controls were collected. Whole exome sequencing(WES) and bioinformatics analysis were performed to find the pathogenic gene mutation. Physico-chemical parameters of mutant and wildtype proteins were computed by Prot Param tool. Domains analysis was performed by SMART online software. HOPE online software was used to analyze the structural effects of mutation. Immunofluorescence, quantitative real-time polymerase chain reaction and Western blotting were used for expression analysis.RESULTS: Using WES, a novel homozygous mutation(NM_000350: c.G3190 C, p.G1064 R) in ABCA4 gene was identified. This mutation showed co-segregation with phenotype in this family. It was not found in the 200 unrelated health controls and absent from any databases. It was considered "Deleterious" as predicted by five function prediction softwares, and was highly conserved during evolution. ABCA4 was expressed highly in the human eye and mouse retina. The p.G1064 R was located in AAA domain, may force the local backbone into an incorrect conformation, disturb the local structure, and reduce the activity of ATPase resulting in the disease pathology. CONCLUSION: We define a novel pathogenic mutation(c.G3190 C of ABCA4) of STGD. This extends the existing spectrum of disease-causing mutations and further defines the genotype-phenotype correlations. 展开更多
关键词 Stargardt disease whole-exome sequencing ABCA4 novel mutation RETINA
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First principles study on electronic structure and optical properties of novel Na-hP4 high pressure phase 被引量:1
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作者 施毅敏 叶绍龙 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2010年第6期1092-1096,共5页
The electronic structure and optical properties of novel Na-hP4 high pressure phase at different pressures(260,320,400 and 600 GPa)were investigated by the density functional theory(DFT)with the generalized gradient a... The electronic structure and optical properties of novel Na-hP4 high pressure phase at different pressures(260,320,400 and 600 GPa)were investigated by the density functional theory(DFT)with the generalized gradient approximation(GGA)for the exchange and correlation energy.The band structure along the higher symmetry axes in the Brillouin zone,the density of states(DOS) and the partial density of states(PDOS)were presented.The band gap increases and the energy band expands to some extent with the pressure increasing.The dielectric function,reflectivity,energy-loss function,optical absorption coefficient,optical conductivity, refractive index and extinction coefficient were calculated for discussing the optical properties of Na-hP4 high pressure phase at different pressures. 展开更多
关键词 first principles novel Na-hP4 phase high pressure phase density functional theory electronic structure optical properties
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Novel Reduction of Sodium Alkyl Thiosulfates to Disulfides with TiCl_4/Sm System 被引量:1
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作者 Hong Yun GUO You HUANG Yong Min ZHANG (Depatment of Chemistry, Hangzhou University, Hangzhou 310028) ( To whom correspondence should be addressed) 《Chinese Chemical Letters》 SCIE CAS CSCD 1997年第3期191-192,共2页
Sodium alkyl thiosulfates(Bunte salts) can be readily reduced to the corresponding disulfides with TiCl4/Sm system in good to excellent yields under mild conditions
关键词 SM Rev novel Reduction of Sodium Alkyl Thiosulfates to Disulfides with TiCl4/Sm System
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A Novel Real-Time State-of-Health and State-of-Charge Co-Estimation Method for LiFePO_4 Battery
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作者 乔荣学 张明建 +3 位作者 刘屹东 任文举 林原 潘锋 《Chinese Physics Letters》 SCIE CAS CSCD 2016年第7期182-185,共4页
The state of charge (SOC) and state of health (SOH) are two of the most important parameters of Li-ion batteries in industrial production and in practical applications. The real-time estimation for these two param... The state of charge (SOC) and state of health (SOH) are two of the most important parameters of Li-ion batteries in industrial production and in practical applications. The real-time estimation for these two parameters is crucial to realize a safe and reliable battery application. However, this is a great problem for LiFePO4 batteries due to the large constant potential plateau in the charge/discharge process. Here we propose a combined SOC and SOH co-estimation method based on the experimental test under the simulating electric vehicle working condition. A first-order resistance-capacitance equivalent circuit is used to model the battery cell, and three parameter values, ohmic resistance (Rs), parallel resistance (Rp) and parallel capacity (Cp), are identified from a real-time experimental test. Finally we find that Rp and Cp could be utilized to make a judgement on the SOIl. More importantly, the linear relationship between Cp and the SOC is established to make the estimation of the SOC for the first time. 展开更多
关键词 of in is on SOC A novel Real-Time State-of-Health and State-of-Charge Co-Estimation Method for LiFePO4 Battery SOH for
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SYNTHESIS AND CHARACTERIZATION OF A NOVEL BONDING TRINUCLEAR(Mo/Fe/Mo) COMPLEX (MoCl_4)_2·dppf
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作者 Zhen Feng XI Rui Na YANG +1 位作者 Dou Man JIN Jin Chun WU 《Chinese Chemical Letters》 SCIE CAS CSCD 1992年第10期809-810,共2页
By the reaction of bidentate ligand 1,1'-bis(diphenylphosphino)-ferrocene (dppf) with MoCl_4(CH_3CN)_2, a novel bonding type complex (MoCl_4)2_· (dppf) was synthesized and characterized by elemental analyses,... By the reaction of bidentate ligand 1,1'-bis(diphenylphosphino)-ferrocene (dppf) with MoCl_4(CH_3CN)_2, a novel bonding type complex (MoCl_4)2_· (dppf) was synthesized and characterized by elemental analyses, ^(31)p-NMR, IR and electronic spectra, TG and ICP-AES. Structure of the title complex was proposed. 展开更多
关键词 FE SYNTHESIS AND CHARACTERIZATION OF A novel BONDING TRINUCLEAR DPPF MoCl4 COMPLEX
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SYNTHESIS AND CHARACTERIZATION OF A SERIES OF NOVEL INORGANIC MICROPOROUS CRYSTALS,BePO_4-CIn(n=4-7).
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作者 Long YU Wenqin PANG (Department of Chemistry,Jilin University,Changchun,130021) 《Chinese Chemical Letters》 SCIE CAS CSCD 1991年第1期67-70,共4页
A series of novet beryllophosphate zeolites,named BePO_4-CIn(n=4-7), are synthesized hydrothermally and characterized with X-ray powder diffraction,IR spectra,SEM,thermat analysis and ion-exchange.
关键词 n=4-7 CJ SYNTHESIS AND CHARACTERIZATION OF A SERIES OF novel INORGANIC MICROPOROUS CRYSTALS BePO4-CIn N
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A Novel Calix[4]arene Having Long-Chain Monoalkenyl at The Upper Rim
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作者 Xue Ran LU Xing Hua TANG +1 位作者 Shu Ling GONG Yuan Yin CHEN(Department of Chemistry, Wuhan University, Wuhan, 430072) 《Chinese Chemical Letters》 SCIE CAS CSCD 1997年第7期579-582,共4页
5-1',1'-dimethylundecenyloxyphenylmethyl-11,17,23-tris-1 '',1 ''-dimethylethyl-25,26,27,28-tetrahydroxycalix[4] arene was synthesized from 1,1-dimethylundecenyoxylphenylmethylphenol (3) and bis... 5-1',1'-dimethylundecenyloxyphenylmethyl-11,17,23-tris-1 '',1 ''-dimethylethyl-25,26,27,28-tetrahydroxycalix[4] arene was synthesized from 1,1-dimethylundecenyoxylphenylmethylphenol (3) and bishydroxymethylated p-tert-butylphenol-formaldehyde trimer (7) (3-[3-[3-(Hydroxymethyl)-tert-butylsalicyl-5]-tert-butylsalicy]-5-tert-butyl-2-hydroxybenzyl Alcohol) by '1+3' fragment condensation in dioxane with TiCl4 as condensation agent in 28% yield. It is the first long-chain monoalkenyl substituted calix[4]arene in which the alkenyl was attached to the upper rim of calix[4]arene. 展开更多
关键词 LONG A novel arene Having Long-Chain Monoalkenyl at The Upper Rim CM
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T4SP: A Novel Tool and Database for Type IV Secretion Systems in Bacterial Genomes
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作者 ZHANG Wen YU Wei Wen +5 位作者 LIU Di LI Ming DU Peng Cheng WU Yi Lei George F. GAO CHEN Chen 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2013年第7期614-617,共4页
Secretion systems, macromolecules to pass which can mediate the across cellular membranes, are essential for virulent and genetic material exchange among bacterial species[1]. Type IV secretion system (T4SS) is one ... Secretion systems, macromolecules to pass which can mediate the across cellular membranes, are essential for virulent and genetic material exchange among bacterial species[1]. Type IV secretion system (T4SS) is one of the secretion systems and it usually consists of 12 genes: VirB1, VirB2 ...VirB11, and VirD4[2]. The structure and molecular mechanisms of these genes have been well analyzed in Gram-negative strains[3] and Gram-positive strains were once believed to be lack of T4SS. However, some recent studies revealed that one or more virB/D genes also exist in some kinds of Gram-positive bacteria and play similar role, and form a T4SS-like system[3]. The VirBl-like, VirB4, VirB6, and VirD4 genes were identified in the chromosome of Gram-positive bacterium Streptococcus suis in our previous studies and their role as important mobile elements for horizontal transfer to recipients in an 89 K pathogenicity island (PAl) was demonstrated[45]. However, their structure and molecular mechanisms in other strains, especially in Gram-positive strains, are remained unclear. 展开更多
关键词 T4SP A novel Tool and Database for Type IV Secretion Systems in Bacterial Genomes
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Cloning and characterization of a novel barley gene,HvORG4,induced by Fusarium graminearum infection
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作者 Theo Van-Der Lee 《湖南农业大学学报(自然科学版)》 CAS CSCD 北大核心 2007年第S1期212-,共1页
Barley Fusarium head blight(FHB),caused by species of the Fusarium fungus,is a devastating disease that is reemerging worldwide in recent years.In this study,a novel gene,HvORG4,was cloned from barley by using cDNA li... Barley Fusarium head blight(FHB),caused by species of the Fusarium fungus,is a devastating disease that is reemerging worldwide in recent years.In this study,a novel gene,HvORG4,was cloned from barley by using cDNA library and suppression subtractive hybridization(SSH) library strategies.The SSH library and cDNA library were constructed from the Chinese barley cultivar Jing02-461(resistance to FHB) infected by Fusarium graminearum isolate Huanggang-1.For the SSH analysis,more than 120 differentially expressed cDNAs were identified and sequenced.One of them showed high homology to the AtORG4 gene and was used as a probe to screen the cDNA library of Jing02-461.Six positive clones were identified and one of them contained a full-length cDNA,which was named HvORG4.Sequence analysis showed that HvORG4 encoded a deduced basic protein of 197 amino acids.Northern blotting analysis showed that HvORG4 was constitutively expressed in root and stalk,not in leaf or spike,and strongly induced in barley spikelets in response to infection with F.graminearum isolate Huanggang-1.Its homology and expression profile suggest that the HvORG4 might function as a transcription factor,playing an important role in signal transduction pathway for defense against FHB in barley. 展开更多
关键词 cDNA Cloning and characterization of a novel barley gene HvORG4 induced by Fusarium graminearum infection GENE
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Novel Reduction of Arylsulfonyl Chlorides and Sodium Alkyl Thiosulfates to Disulfides with TiCl_4/Zn System
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作者 Zhuang Pin ZHAN Hong Yun GUO and Yong Min ZHANG (Department of Chemistry. Hangzhou University,Hangzhou. 310028) 《Chinese Chemical Letters》 SCIE CAS CSCD 1997年第6期471-472,共2页
T1Cl4/Zn system reduces arylsulfonyl chlorides and sedium aldyl thiosulfates to corresponding disulfides in moderate to good yields
关键词 ZN novel Reduction of Arylsulfonyl Chlorides and Sodium Alkyl Thiosulfates to Disulfides with TiCl4/Zn System
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Novel in-frame deletion mutation c.177_179del TAC of neurofibromatosis type 1 in a Chinese 4-year-old boy with binocular blindness
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作者 Jie Peng Jia Zhang +2 位作者 Qi Zhang Pei-Quan Zhao Zhi-Rong Yao 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2015年第5期1078-1079,共2页
Dear editor,I am Dr.Jie Peng,from the Department of Ophthalmology,Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai,China.I write to present a case report of a novel in-frame del... Dear editor,I am Dr.Jie Peng,from the Department of Ophthalmology,Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai,China.I write to present a case report of a novel in-frame deletion mutation c.17779del TAC of neurofibromatosis type 1 in a Chinese boy with bilateral blindness.Neurofibromatosis type 1(NF1;OMIM#162200),an autosomal dominant disease,is caused by mutations in the NF1gene.The incidence of this disease is around 1 in 3500 展开更多
关键词 novel in-frame deletion mutation c.177179del TAC of neurofibromatosis type 1 in a Chinese 4-year-old boy with binocular blindness type
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PBO关键中间体4-氨基-6-硝基间苯二酚盐酸盐的合成 被引量:2
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作者 金宁人 刘斌 +2 位作者 胡建明 张建庭 赵德明 《化工进展》 EI CAS CSCD 北大核心 2010年第8期1547-1553,共7页
系统地研究了PBO关键中间体4-氨基-6-硝基间苯二酚盐酸盐(ANR.HCl)的合成新工艺及其优化条件,在初步探索实验的基础上,选用混合正交表L18(2×37)及5个影响因子,进行4,6-二硝基间苯二酚(DNR)选择还原、成盐合成ANR.HCl的正交优化实验... 系统地研究了PBO关键中间体4-氨基-6-硝基间苯二酚盐酸盐(ANR.HCl)的合成新工艺及其优化条件,在初步探索实验的基础上,选用混合正交表L18(2×37)及5个影响因子,进行4,6-二硝基间苯二酚(DNR)选择还原、成盐合成ANR.HCl的正交优化实验,并进行二次调优实验。结果表明:在95%高置信度时活性炭用量影响显著,在对其进行再次单独调优实验后,合成出收率90.73%、HPLC纯度94.05%的ANR.HCl产品,相应优化条件为:10.0gDNR以150mL乙醇为溶剂,在1.5gC/1.0gFeSO4.7H2O催化下用6.62g85%水合肼回流还原反应1h。精制后产品经FT-IR、1HNMR、13CNMR及MS等定性确认,具有产品的稳定性好、还原过程选择性高,污染低及操作方便等特点。 展开更多
关键词 4-氨基-6-硝基间苯二酚盐酸盐 PBO关键中间体 合成新工艺 4 6-二硝基间苯二酚 选择还原
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PBIO关键中间体5-氨基-2,4-二硝基苯酚的合成 被引量:2
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作者 金宁人 侯晓华 +3 位作者 毛连城 金婷婷 张建庭 赵德明 《化工进展》 EI CAS CSCD 北大核心 2010年第12期2379-2384,2394,共7页
系统地研究了以4,6-二硝基间二氯苯(DCDNB)为原料经单水解后氨解两步反应制备聚对亚苯基苯并咪口恶二唑(PBIO)的关键中间体5-氨基-2,4-二硝基苯酚(ADNP)的合成新路线及其优化条件。结果表明:采用NaOH在水溶剂中100℃回流下进行两个氯基... 系统地研究了以4,6-二硝基间二氯苯(DCDNB)为原料经单水解后氨解两步反应制备聚对亚苯基苯并咪口恶二唑(PBIO)的关键中间体5-氨基-2,4-二硝基苯酚(ADNP)的合成新路线及其优化条件。结果表明:采用NaOH在水溶剂中100℃回流下进行两个氯基的选择单水解反应,制得纯度98%以上的高收率5-氯-2,4-二硝基苯酚(CDNP);以1,4-二氧六环为溶剂,在150℃下使用氨水压力氨解另一个氯基合成ADNP,经精制后获得纯度98.5%以上、总收率达73.6%(以DCDNB计)的产品。产品经IR、1HNMR、13CNMR及MS等定性确认,合成过程已呈现有机污染少、操作方便、产品质量优异、经济性良好及易于产业化等特色,为进一步研发合成新型高性能材料PBIO及其新单体提供技术基础及中间体来源。 展开更多
关键词 5-氨基-2 4-二硝基苯酚 PBIO关键中间体 合成新方法 4 6-二硝基间二氯苯 单水解氨解
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手性4-膦酸二酯基-3-卤-2(5H)-呋喃酮的合成与结构 被引量:20
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作者 李学强 黄敏 陈庆华 《化学学报》 SCIE CAS CSCD 北大核心 2000年第3期363-367,共5页
手性呋喃酮1a~1b与亚磷酸三酯2a~2b通过串联的不对称Michael加成/分子内Michalis-Arbazov重排反应,得到了含磷官能团的新手性化合物,5-(S)-(l-孟氧基)-4-膦酸二酯基-3-卤素-2(5H)-呋喃酮4a~4d.该反应具有条件温和,产率高(86%~95%),... 手性呋喃酮1a~1b与亚磷酸三酯2a~2b通过串联的不对称Michael加成/分子内Michalis-Arbazov重排反应,得到了含磷官能团的新手性化合物,5-(S)-(l-孟氧基)-4-膦酸二酯基-3-卤素-2(5H)-呋喃酮4a~4d.该反应具有条件温和,产率高(86%~95%),光学纯度单一(d.e.≥98%)的特点.通过元素分析,IR,UV,~1HNMR,^(13)C NMR,MS,[α]_D^(20)波谱分析数据以及X射线四圆衍射数据确定了它们的化学结构和绝对构型. 展开更多
关键词 晶体结构 手性2(5H)-呋喃酮 合成 亚磷酸三酯
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基于DNA-AuNCs内滤效应诱导荧光猝灭灵敏检测4-硝基苯酚 被引量:1
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作者 王海波 陶贝贝 +2 位作者 吴宁宁 毛安丽 张红定 《信阳师范学院学报(自然科学版)》 CAS 北大核心 2022年第3期464-468,共5页
以A30 DNA作为合成模板,制备了荧光DNA模板金纳米簇(DNA-AuNCs),其最大激发波长为290 nm,最大发射波长为475 nm。当4-硝基苯酚(4-NP)存在时,其紫外吸收光谱与DNA-AuNCs的荧光激发光谱和发射光谱均有部分重叠,发生内滤效应,使DNA-AuNCs... 以A30 DNA作为合成模板,制备了荧光DNA模板金纳米簇(DNA-AuNCs),其最大激发波长为290 nm,最大发射波长为475 nm。当4-硝基苯酚(4-NP)存在时,其紫外吸收光谱与DNA-AuNCs的荧光激发光谱和发射光谱均有部分重叠,发生内滤效应,使DNA-AuNCs的荧光信号被显著地猝灭。基于内滤效应诱导DNA-AuNCs荧光信号猝灭,构建了一种灵敏检测4-NP的荧光分析方法。该方法对4-NP的线性检测范围为1~80μmol/L,检出限为0.3μmol/L(R_(SN)=3)。此外,该方法被成功应用于湖水样品中4-NP含量的测定。 展开更多
关键词 DNA模板金纳米簇 内滤效应 4-硝基苯酚检测 荧光传感新方法
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双酰胺类化合物引入环丙基制备新型杀虫剂的研究
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作者 高鹏 唐余 +1 位作者 陈诗桦 潘彤 《精细化工中间体》 CAS 2024年第4期10-12,16,共4页
在双酰胺类化合物中引入环丙基的结构改造,旨在通过结构改造,提升双酰胺类杀虫剂的杀虫广谱。以2-氟-3-胺基苯甲酸甲酯为原料制备新型双酰胺类化合物N-[2-溴-4-(1,1,1,2,3,3,3-七氟丙-2-基)-6-三氟甲氧基苯基]-3-[N-(环丙甲基)苯甲酰胺... 在双酰胺类化合物中引入环丙基的结构改造,旨在通过结构改造,提升双酰胺类杀虫剂的杀虫广谱。以2-氟-3-胺基苯甲酸甲酯为原料制备新型双酰胺类化合物N-[2-溴-4-(1,1,1,2,3,3,3-七氟丙-2-基)-6-三氟甲氧基苯基]-3-[N-(环丙甲基)苯甲酰胺基]-2-氟苯甲酰胺(BCPF)。有利于该化合物进一步杀虫药效、作用机制及高效杀虫剂的研究。 展开更多
关键词 环丙基双酰胺类化合物 2-氟-3-胺基苯甲酸甲酯 2-氟-3-[N-(环丙甲基)苯甲酰胺]苯甲酸 N-[2-溴-4-(1 1 1 2 3 3 3-七氟丙-2-基)-6-三氟甲氧基苯基]-3-[N-(环丙甲基)苯甲酰胺基]-2-氟苯甲酰胺
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新型抑制剂DLW-4用于鞍千公司混磁精反浮选 被引量:4
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作者 潘鹏飞 朱一民 +3 位作者 徐冬林 李伟 李艳军 韩跃新 《金属矿山》 CAS 北大核心 2015年第6期74-77,共4页
为检验东北大学自主合成的新型抑制剂DLW-4的性能及效果,对鞍钢集团鞍千矿业公司磁选混合精矿(MMC)进行了反浮选条件试验及1粗1精3扫、中矿顺序返回的反浮选闭路试验。结果表明,在浮选温度为40℃、粗选Na OH用量为800 g/t、抑制剂DLW-4... 为检验东北大学自主合成的新型抑制剂DLW-4的性能及效果,对鞍钢集团鞍千矿业公司磁选混合精矿(MMC)进行了反浮选条件试验及1粗1精3扫、中矿顺序返回的反浮选闭路试验。结果表明,在浮选温度为40℃、粗选Na OH用量为800 g/t、抑制剂DLW-4为342 g/t、活化剂Ca Cl2为600 g/t、捕收剂RA-715为480 g/t时选别指标最佳。对铁品位为47.74%的磁选混合精矿经1粗1精3扫闭路试验,获得了铁品位为68.08%、回收率为88.20%的铁精矿。与常规淀粉抑制剂相比,DLW-4可以以更少的药剂用量获得更好的反浮选指标,具有推广价值。 展开更多
关键词 新型抑制剂 DLW-4 磁选混合精矿 反浮选
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Facile synthesis of spinel LiNi_(0.5)Mn_(1.5)O_(4) as 5.0 V-class high-voltage cathode materials for Li-ion batteries 被引量:2
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作者 Xueyi Guo Chenlin Yang +3 位作者 Jinxiu Chen Qinghua Tian Hongmei Zhang Guoyong Huang 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2021年第11期247-254,共8页
LiNi_(0.5)Mn_(1.5)O_(4) and LiMn_(2)O_(4) with novel spinel morphology were synthesized by a hydrothermal and postcalcination process.The synthesized LiMn_(2)O_(4) particles(5–10 lm)are uniform hexahedron,while the L... LiNi_(0.5)Mn_(1.5)O_(4) and LiMn_(2)O_(4) with novel spinel morphology were synthesized by a hydrothermal and postcalcination process.The synthesized LiMn_(2)O_(4) particles(5–10 lm)are uniform hexahedron,while the LiNi_(0.5)Mn_(1.5)O_(4) has spindle-like morphology with the long axis 10–15 lm,short axis 5–8 lm.Both LiMn_(2)O_(4) and LiNi_(0.5)Mn_(1.5)O_(4) show high capacity when used as cathode materials for Li-ion batteries.In the voltage range of 2.5–5.5 V at room temperature,the LiNi_(0.5)Mn_(1.5)O_(4) has a high discharge capacity of 135.04 mA·h·g^(-1) at 20 mAg^(-1),which is close to 147 mA·h·g^(-1)(theoretical capacity of LiNi_(0.5)Mn_(1.5)O_(4)).The discharge capacity of LiMn_(2)O_(4) is 131.08 mA·h·g^(-1) at 20 mAg^(-1).Moreover,the LiNi_(0.5)Mn_(1.5)O_(4) shows a higher capacity retention(76%)compared to that of LiMn_(2)O_(4)(61%)after 50 cycles.The morphology and structure of LiMn_(2)O_(4) and LiNi_(0.5)Mn_(1.5)O_(4) are well kept even after cycling as demonstrated by SEM and XRD on cycled LiMn_(2)O_(4) and LiNi_(0.5)Mn_(1.5)O_(4) electrodes. 展开更多
关键词 LiMn_(2)O_(4) LiNi_(0.5)Mn_(1.5)O_(4) novel morphology Li-ion battery Electrochemistry Preparation Nanomaterials
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青年鸡混合感染血清4型禽腺病毒和传染性法氏囊病病毒新型变异株的鉴定与遗传进化分析 被引量:4
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作者 张燕 王威威 +6 位作者 陈果 李秋红 朱玮钰 乔远征 施俊 何秀苗 韦平 《中国家禽》 北大核心 2022年第5期38-46,共9页
为探究某青年鸡群临床突然发病死亡原因,试验通过病理剖检、实验室病原检测及序列测定进行可疑病原的鉴定与遗传进化分析。结果显示:病鸡心包有大量淡黄色清亮渗出液,肝脏肿胀,脾脏和肾脏肿大出血,胸肌出血和法氏囊萎缩;心肝病变组织FAd... 为探究某青年鸡群临床突然发病死亡原因,试验通过病理剖检、实验室病原检测及序列测定进行可疑病原的鉴定与遗传进化分析。结果显示:病鸡心包有大量淡黄色清亮渗出液,肝脏肿胀,脾脏和肾脏肿大出血,胸肌出血和法氏囊萎缩;心肝病变组织FAdV-4 hexon基因PCR检测结果呈阳性(命名为毒株FAdV-QZ191002);法氏囊组织IBDV vVP2、VP1-b基因RT-PCR检测结果呈阳性(命名为毒株GX-QZ191002);细菌及其它禽类常见病毒检测结果均为阴性;序列分析结果发现FAdV-QZ191002的hexon基因与SD1601、CH/GDYF/201706等近几年的FAdV-4中国流行毒株同处于FAdV-C这个分支,核苷酸相似性为100%,并且具有与SD1601、CH/GDYF/201706等中国高致病性分离株一致的氨基酸突变位点;GX-QZ191002的vVP2和VP1-b基因与我国最近新发的新型变异株(A2dB1b)的核苷酸相似性分别高达96.0%~98.5%和97.0%~97.8%,系统进化树处于同一分支。除具有与新型变异株一致的独特氨基酸位点外,GX-QZ191002在vVP2中还存在2个氨基酸突变(N251S、T321A),VP1-b存在1个氨基酸突变(D444N)。确定该青年鸡群突然发病死亡为FAdV-4和IBDV新型变异株混合感染所致,研究结果为我国今后开展FAdV-4和IBDV的监测和综合防控具有重要的指导意义。 展开更多
关键词 心包积液肝炎综合征 FAdV-4 IBDV 新型变异株 混合感染
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The role of histamine H4 receptors as a potential targets in allergic rhinitis and asthma 被引量:1
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作者 Eva Hanuskova Jana Plevkova 《Open Journal of Molecular and Integrative Physiology》 2013年第1期6-14,共9页
Histamine—the main product of mast cells plays critical role in the pathogenetic pathways of both allergic rhinitis and asthma. The novel concept of the unique airway diseases its only supported by the similarities w... Histamine—the main product of mast cells plays critical role in the pathogenetic pathways of both allergic rhinitis and asthma. The novel concept of the unique airway diseases its only supported by the similarities within pathogenetic process. Antagonists of H1 and H2 receptors are quite effective in allergic rhinitis, but not effective enough in asthma. In an era of corticosteroids, leucotriene antagonists and Anti-IgE treatment, there is still a challenge to search for more effective, more acurate and more safe treatment option. Antagonists (inversive agonists) of histamine receptors H4 seems to be one of the promising targets in the allergic rhinitis and asthma treatment. The first H4 antagonist entered to clinics and the results from a proof-of-concept Phase II clinical study is expected to be disclosed soon. This review article summarizes current knowledge on H4R that have been collected in various studies sharing evidences about efficacy of H4R as a reasonable target for diseases with histamine involved pathogenetic pathways. 展开更多
关键词 ALLERGIC Rhinits ASTHMA HISTAMINE H4R novel DRUG Target
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