Neurotrophic factor therapy for Parkinson's disease: past, present and future

One of the greatest unmet needs in the treatment of Parkinson’s disease（PD）is a disease-modifying therapy,which can halt the ongoing degeneration of dopaminergic neurons that is characteristic of this disorder.Current therapies focus on managing symptoms,rather than on addressing their cause.Promising candidates for disease-modifying therapies are the dopaminergic neurotrophic factors（NTFs）.

全面从严治党研究的前沿热点、演化趋势及未来展望——基于CiteSpace知识图谱的可视化分析

党的十八大以来,全面从严治党这一重大理念在学界和实务界引起广泛关注,迅速成为学术研究的热点。然而,目前对该研究尚缺乏基于文献计量的系统性分析。运用文献计量分析工具CiteSpace对2013—2023年中国知网(CNKI)收录的有关全面从严治党的728篇CSSCI来源期刊论文进行可视化分析,得到研究机构共现知识网络图谱、作者共现知识网络图谱、关键词共现图谱、关键词聚类图谱、关键词时间线图谱、关键词时区图谱、关键词突现图谱以及发文量表、热点关键词分析表等9个知识图谱和图表。根据这些图谱和图表可知,当前全面从严治党的研究成果已经较为丰富,呈现出主题主次分明、问题重点突出、结论达成基本共识的总体特点。着眼未来,推动全面从严治党研究的高质量发展,需要围绕学科交叉和团队合作进一步拓宽研究广度;围绕核心问题和长期跟踪进一步挖掘研究深度;围绕方法优化和范式拓展进一步提高研究精度。

Future Expectation for China’s Nuclear Power

China: the future of nuclear powerWang Yonggan: In terms of the highlighted issue ofenergy security, oil is of paramount importance, coal isthe foundation and electricity is the pivot according

Pediatric stricturing Crohn's disease

Crohn’s disease(CD)is a chronic inflammatory disease of the digestive tract.The incidence of pediatric CD is increasing and is currently 2.5-11.4 per 100000 world-wide.Notably,approximately 25%of children with CD develop stricturing CD(SCD)that requires intervention.Symptomatic stricturing diseases refractory to pharmacological management frequently require non-pharmacological interventions.Non-pharmacological therapeutic strategies include endoscopic balloon dilatation,stricturoplasty,and surgical resection of the strictured seg-ment.However,strictures tend to recur postoperatively regardless of treatment modality.The lifetime risk of surgery in patients with childhood SCD remains at 50%-90%.Thus,new and emerging strategies,advanced diagnostic tools,and minimally invasive approaches are under investigation to improve the outcomes and overall quality of life of pediatric patients with SCD.

Link between childhood obesity and gut microbiota

Childhood obesity is a critical global health concern with rising prevalence and significant long-term health implications.Recent studies have implicated gut microbiota in the development and progression of obesity.This editorial analyzes the research conducted by Li et al,who utilized 16S rRNA gene sequencing to compare the gut microbiome of overweight and healthy-weight children.The study found significant differences in microbial diversity and composition between the two groups,with potential implications for understanding and managing childhood obesity.We analyzed the study’s advantages and drawbacks,proposing potential areas for future research to better understand the connection between gut microbiota and obesity.

Fair Plan 8: Earth’s Climate Future—Pope Francis’ Population Mistake

Pope Francis wrote in his Encyclical Letter Laudato Si’: On Care for Our Common Home: “Instead of resolving the problems of the poor and thinking of how the world can be different, some can only propose a reduction in the birth rate.” … “To blame population growth instead of extreme and selective consumerism on the part of some is one way of refusing to face the issues.” Here, we test the hypothesis that population size does not matter. We do so in terms of the effect of the size of the human population on its emission of greenhouse gases. We find that the hypothesis is false = PO-PULATION MATTERS. Ceteris paribus, the larger the population of human beings on Planet Earth, the more difficult it will be to reduce, and finally eliminate, the emission of greenhouse gases by humanity and, thereby, constrain human-caused climate change = Anthropogenic Global Warming.

The Best Way for China's Future

Lu:The situation China will face in the future will become moreand more complicated.We have more and more tasks to do,just as theChinese poem goes“As one enters the circle of thousands of mountains,one faces another mountain after passing by one of them.”Lookingfrom the international scene,none of the two issues of peace and devel-opment has been solved.Economic security and military security

Bush' s China Policy and the Future of Sino-U.S.Relations

The past two years have witnessed great fluctuations ininternational oil prices,and diplomatic efforts,both above andunder the table,by major powers around this issue.The currenttension in the war-threatened Iraq has added more uncertainties to thefuture world oil situation.Will the world oil supply and demand change?What impact would this exert on big powers’ oil strategy choices,geopolitics as well as world economy?What should China do in such asituation?To find the answers to these questions,at the invitation of theeditor of the Contemporary International Relations,seven experts fromChina Institute of Contemporary International Relations gathered to have adiscussion in early February this year.Naturally,they have differentviews over many issues.Still,we hope our readers would find theirdiscussion interesting.Following is the list of participants.

Solar insiders upbeat on industry’s future

Solar industry insiders remain optimistic about the sector’s future, despite the recent challenges it has faced from a supply glut and weak demand, China Daily reported.

Climate Suitability of Schima superba in Subtropical Zone of China under Future Climate Scenario

[ Objective] The research aimed to study climate suitability of S. superba in subtropical zone of China under future climate scenario and response of its regional distribution on climate change. [ Metbed] Based on climate- vegetation related Kira model, Holdridge model and ecological suitability theory, climate suitability model of S. superba was established by using fuzzy mathematics. Based on the daily meteorological data at 246 stations of the subtropical zone from 1960 to 2005, by using spatial interpolation method, suitability of S. superba on temperature, precipitation, po- tential evapotranspiration rate was analyzed. According to Intergovernmental Panel on Climate Change （IPCC） Special Report on Emissions Sce- nario （SRES）, future scenario simulation result was used. Under IPCC A2 scenario, climate suitability of S. superba and its change were studied in subtropical zone of China under future climate scenario. Climate suitability of S. superba in future was classified. [ Result] Under future climate scenario, climate suitability of S. superba was stronger in most of areas in Hunan, north Guangdong, northeast Guangxi and east coast of Zhe- jiang. It was suitable for growth of S. superba in central Guangxi, east Guizhou, central Jiangxi and Fuzhou. Growth suitability of S. superba was still lower in the north of Gongshan - Weixi - Lijiang - Yuanjiang - Huize - Leibo - Emei - Neijiang - Nanchong - Bazhong - Zhongxiang - zaoyang - Xinyang -Lu＇an -Chuzhou -Gaoyou -Taitong. Climate suitability in west Yunnan and Sichuan had big change. Future climate suitability change of S. superba was greatly affected by temperature and potential evapotranspiration rate. [ Conclusion] Future climate suitability decreased toward west and north from Hunan. The climate suitability had a decline trend as time went by under future climate scenario. The research provided theoretical basis for studying geographic distribution of the vegetation population.

Expectations for Future China-U.S. Relations

The heads of state of China and the U.S. reached a consensus in Osaka at the end of June, agreeing to restart trade negotiations on the basis of equality and mutual respect. The U.S. side stated that it would no longer impose new tariffs on Chinese imports, sending a positive sign of the U.S.-China relationship to the international community. On July 3, the Washington Post published an open letter signed by 100 people from the academic, diplomatic, military, and business circles of the U.S. to President Trump and the U.S. Congress, affirming that the consensus is the intention of the two peoples and is in line with the expectations of the international community. The decline in U.S.- China relations is not in line with U.S. and global interests, and China is not an enemy of the U.S., nor does China pose a threat to U.S. national security.

Seeding the Future

SEEDS are the matrix of agriculture. The seed is to grain production what chips are to the technology industry. Sustainable development of the seed industry is vital to food safety.Since its founding in 1949, the People’s Republic of China (PRC) has paid particular attention to the seed industry in developing agriculture. Notably after the reform and opening-up policy was launched in 1978, China achieved marked progress in crop growing and grain production, feeding 22 percent of the world’s population with only seven percent of the total arable land.

An Important Forum for the Future of the World’s Rivers: The 8th International Riversymposium in Brisbane

The 8th Intemational Riversymposium was held in Brisbane, Australia on 6-9 September 2005. The Intemational Riversymposium is an integral part of Brisbane＇s annual broadbased cultural event. The Queensland Government is a foundation partner of the Intemational River Foundation, formed to secure the future of the Intemational and National Thiess Riverprize. The theme of symposium in this year is “Water and Food Security- Rivers in a Global Context” （ www.riversymposium.com ）. The Riversymposium provides a global forum which aims to make a difference to the declining state of rivers and waterways globally. Its strength lies in the breadth of its challenging program content of important keynote presentations and case studies of rivers in crisis, attracting a diverse range of national and intemational delegates. Some 450 scientists from 38 countries attended this conference, and about 100 papers were presented on the symposium in 2005.

NORTHEAST ASIA'S FUTURE AND CHINA'S ROLE

Since the end of the Cold War,the rest of the world has moved out of hypertension whereas Northeast Asia remains full of the Cold War atmosphere featuring of confrontation,especially marked by the tension of the Korean Peninsula,the Kuril Islands dispute between Russia and Japan。

China's Futures Market

Since the 1990s, futures trading with its particular economic form and functions, has interested domestic enterprises. To support the development of the futures market in a standard way, the State Council has authorized the State Supervisory and Administrative Commission for Securities Trading

MAY EARLIER MATURITY COME TO PEACE: THOUGHTS ON ASIA'S FUTURE

Huge historical progress has made up dire disasters for mankind in the 20th cen-tury. A number of dramatic turns characterize giant footsteps of Asian historyin the present century—from colonization to de-colonization, from feudalism tocapitalism or socialism, from agricultural to industrial civilization, from being terri-tories carved up among major foreign powers to a region for contention between thetwo superpowers, then to the current situation of multi-dimensional co-existence a-

Fair Plan 7: Earth’s Climate Future = Humanity’s Choice

Earth’s climate future is in the hands of humanity. If emissions of greenhouse gases remain unabated, Earth’s climate will return to the climate of the Late Eocene, 35 million years ago, when sea level was 73 meters (240 feet) higher than today. Should that occur, many coastal cities around the world would be inundated. Moreover the Global Warming of this unabated Reference case will be comparable to the Global Warming from the Last Glacial Maximum 21,000 years ago to the beginning of the Holocene interglacial climate 11,000 years ago. However, this human-caused Global Warming would occur 50 times faster than that caused by nature. Alternatively, humanity can mitigate greenhouse-gas emissions to keep Global Warming below the 2&#176C maximum adopted by the United Nations Framework Convention on Climate Change “to prevent dangerous anthropogenic interference with the climate system”. This mitigation can either be done rapidly, as in the “80/50” Plan to reduce greenhouse-gas emissions 80% by 2050, or much more slowly, from 2020 to 2100, as in the Fair Plan to Safeguard Earth’s Climate. The Fair Plan is a compromise between doing nothing, as in the Reference case, and rapidly reducing greenhouse-gas emissions, as in the 80/50 Plan. Regardless of the Plan chosen to reduce greenhouse-gas emissions to keep Global Warming below the UNFCCC limit of 2&#176C (3.6&#176F), it should not be tantamount to our saying to one of our planetary spacecraft, Bon Voyage, call us when you get to your planetary destination. Rather, as with our spacecraft, the chosen climate-change policy should be monitored throughout the 21st century and Midcourse Corrections made thereto as needed to keep our “Climate Spacecraft” on track to achieve its “Climate Target”.