Study on the relationship between syndrome characteristics degree and inflammatory factor and negative emotional scale in"double heart disease"patients with Qi stagnation blood stasis and heart gallbladder heat stagnation

Objective:To Discuss the correlation between Hypersensitivity C-reactive Protein(Hs-CRP),Total Cholesterol(TC),Triglyceride(TG),negative emotion scale and TCM syndrome scores in“Double Heart Disease”patients with Qi stagnation blood stasis and heart gallbladder heat stagnation.Method:Fifty-two patients in Western Medicine Diagnosis of Double Heart Disease,in TCM syndrome identified as Qi stagnation blood stasis Heart gallbladder heat stagnation syndrome,detects it Hs-CRP,TC,TG levels by ELISA,use TCM Syndromes Scale to evaluate TCM Syndrome,use the Pittsburgh Sleep Quality Index(PSQI)and Self-rating symptom scale(SCL-90)to assess anxiety and sleep levels,analyze the correlation between TCM syndrome scores and Hs-CRP,TC,TG level,PSQI index,SCL-90 index.Result:There was a significant positive correlation between Hs-CRP,TG level and TCM Syndrome scores(P<0.05);TC level was postively correlated with TCM Syndrome scores,but there was no statistical significance(P>0.05);There was a significant positive correlation between PSQI index,SCL-90 index and TCM Syndrome scores(P<0.05).Conclusion:In“Double Heart Disease”patients with Qi stagnation blood stasis and heart gallbladder heat stagnation,there have characteristic syndrome changes in terms of inflammatory factor level,blood lipid level and negative emotion score;Which the above indexes can reflect the severity of TCM syndromes to a certain extent and provide the basis for the effective intervention treatment of TCM.

Quantifying spatial scale of positive and negative terrains pattern at watershed-scale:Case in soil and water conservation region on Loess Plateau

The positive and negative terrains(P-N terrains) widely distributed across China's Loess Plateau constitute the dual structure characteristic of loess landforms. Analysis of loess P-N terrains at the watershed scale can serve to elucidate the structural characteristics and spatial patterns of P-N terrains, which benefits a better understanding of watershed evolution and suitable scales for loess landform research. The Two-Term Local Quadrat Variance Analysis(TTLQV) is calculated as the average of the square of the difference between the block totals of all possible adjacent pairs of block size, which can be used to detect both the scale and the intensity of landscape patches(e.g., plant/animal communities and gully networks). In this study, we determined the latitudinal and longitudinal spatial scale of P-N terrain patterns within 104 uniformly distributed watersheds in our target soil and water conservation region. The results showed that TTLQV is very effective for examining the scale of P-N terrain patterns. There were apparently three types of P-N terrain pattern in latitudinal direction(i.e., Loess Tableland type, Loess Hill type, and Transitional Form between Sand and Loess type), whereas there were both lower and higher values for P-N terrain pattern scales in all loess landforms in the longitudinal direction. The P-N terrain pattern alsoclearly presented anisotropy, suggesting that gully networks in the main direction were well-developed while others were relatively undeveloped. In addition, the relationships between the first scales and controlling factors(i.e., gully density, nibble degree, watershed area, mean watershed slope, NDVI, precipitation, loess thickness, and loess landforms) revealed that the first scales are primarily controlled by watershed area and loess landforms. This may indicate that the current spatial pattern of P-N terrains is characterized by internal force. In selecting suitable study areas in China' Loess Plateau, it is crucial to understand four control variables: the spatial scale of the P-N terrain pattern, the watershed area, the main direction of the watershed, and the loess landforms.

Forced Oscillation of Neutral Advanced Dynamic Equations with Positive and Negative Coeffcients on Time Scales

In this paper,we consider the forced neutral advanced dynamic equations with positive and negative coeffcients[x(t)-R(t)x(t+r)]+P(t)x(t+τ)△Q(t)x(t+δ)= f(t),t≥t0 on a time scale T.Several suffcient conditions are obtained for the oscillation of the dynamic equations.The main result is illustrated by an example.

Effect of psychological nursing interventions on effectiveness and quality of life in schizophrenia patients receiving modified electroconvulsive therapy

BACKGROUND Schizophrenia is a common and severe mental disorder characterized by severe thought disturbances,hallucinations,delusions,and emotional instability.For some patients,conventional treatment methods may not effectively alleviate symptoms,necessitating the use of alternative therapeutic approaches.Modified electroconvulsive therapy(MECT)is an effective treatment modality for schizophrenia,inducing anti-depressive and antipsychotic effects through the stimulation of brain electrical activity.AIM To explore the impact of psychological nursing intervention(PNI)before and after MECT on the efficacy and quality of life of patients with schizophrenia.METHODS Eighty patients with schizophrenia who received MECT treatment from 2021 to 2023 were randomly divided into two groups:The intervention group(n=40)and the control group(n=40).The intervention group received PNI before and after MECT,while the control group received routine nursing care.The efficacy of MECT was evaluated by the Positive and Negative Syndrome Scale(PANSS)and the Clinical Global Impression Scale(CGI)before and after the treatment.The quality of life was assessed by the Short Form 36 Health Survey(SF-36)after the treatment.RESUITS The intervention group had significantly lower scores of PANSS and CGI than the control group after the treatment(P<0.05).The intervention group also had significantly higher scores of SF-36 than the control group in all domains except physical functioning(P<0.05).CONCLUSION PNI before and after MECT can improve the efficacy and quality of life of patients with schizophrenia.It is suggested that nurses should provide individualized and comprehensive psychological care for patients undergoing MECT to enhance their recovery and well-being.

Correlation analyse between thyroid hormone levels and severity of schizophrenia symptoms

BACKGROUND The imbalance of hormone levels in the body is closely related to the occurrence and progression of schizophrenia,especially thyroid hormones.AIM To study the relationship between triiodothyronine(T3),thyroxine(T4),free T3(FT3),free T4(FT4),thyroid stimulating hormone(TSH)and schizophrenia.METHODS In this study,100 schizophrenia patients were selected from our hospital between April 2022 and April 2024.Their clinical data were analyzed retrospectively.Based on the Positive and Negative Syndrome Scale(PANSS)score,patients were divided into mild(1-3 points,n=39),moderate(4 points,n=45),and severe groups(5-7 points,n=16).Additionally,55 healthy individuals served as a control group.Venous blood samples were collected to measure T3,T4,FT3,FT4,TSH,and cortisol concentrations,analyzing their relationship with PANSS scores.RESULTS The serum levels of T3,FT3,FT4,TSH and cortisol in the schizophrenia group were lower than those in the control group(P<0.05).With the increase of the severity of the disease,the concentrations of T3 and T4 decreased,while the con-centrations of TSH and cortisol increased(P<0.05).The concentrations of TSH and cortisol were positively correlated with the PANSS score,while T3 and T4 were negatively correlated with the PANSS score(P<0.05).The receiver ope-rating characteristic curve results showed that T3,T4,TSH,and cortisol had good efficacy in the diagnosis of schizophrenia.Logistic results showed that decreased T3 level,decreased T4 level,decreased TSH level and increased cortisol level may be independent risk factors for schizophrenia.CONCLUSION Thyroid hormone levels are associated with the severity of schizophrenia symptoms,which can provide new solutions for the diagnosis and treatment of schizophrenia.

On the Cosmic Evolution of the Quantum Vacuum Using Two Variable G Models and Winterberg’s Thesis

We work within a Winterberg framework where space, i.e., the vacuum, consists of a two component superfluid/super-solid made up of a vast assembly (sea) of positive and negative mass Planck particles, called planckions. These material particles interact indirectly, and have very strong restoring forces keeping them a finite distance apart from each other within their respective species. Because of their mass compensating effect, the vacuum appears massless, charge-less, without pressure, net energy density or entropy. In addition, we consider two varying G models, where G, is Newton’s constant, and G-1, increases with an increase in cosmological time. We argue that there are at least two competing models for the quantum vacuum within such a framework. The first follows a strict extension of Winterberg’s model. This leads to nonsensible results, if G increases, going back in cosmological time, as the length scale inherent in such a model will not scale properly. The second model introduces a different length scale, which does scale properly, but keeps the mass of the Planck particle as, ± the Planck mass. Moreover we establish a connection between ordinary matter, dark matter, and dark energy, where all three mass densities within the Friedman equation must be interpreted as residual vacuum energies, which only surface, once aggregate matter has formed, at relatively low CMB temperatures. The symmetry of the vacuum will be shown to be broken, because of the different scaling laws, beginning with the formation of elementary particles. Much like waves on an ocean where positive and negative planckion mass densities effectively cancel each other out and form a zero vacuum energy density/zero vacuum pressure surface, these positive mass densities are very small perturbations (anomalies) about the mean. This greatly alleviates, i.e., minimizes the cosmological constant problem, a long standing problem associated with the vacuum.

Is the Current Diagnosis of Schizophrenia Useful or Harmful?

In recent decades, evidence has appeared in various scientific fields—genetic, psychopharmacological, neuro-psychological, etc.—which makes it difficult to maintain the positive and negative syndrome of schizophrenia under one and the same diagnosis. On the other hand, there are social and legal reasons recommending the conception of these two syndromes as different entities. In this paper, we conduct appropriate bibliographical researches to reveal these evidences. We discuss these findings and conclude proposing the split of positive and negative syndromes of schizophrenia in two different disorders.

不同首发年龄精神分裂症患者临床特征及影响因素

目的:探讨不同首发年龄精神分裂症患者的临床特征,以及社会人口学影响因素。方法:根据美国精神障碍诊断与统计手册第5版的精神分裂症诊断标准,选取15~70岁患者2016例,由精神科医生采用简明国际神经精神访谈、精神症状维度评定量表(CRDPSS)和阳性与阴性症状量表(PANSS)进行诊断和评估。以18岁和25岁作为精神分裂症早发、中发及晚发的分组界值。采用方差分析、多重相关分析和多重线性回归的方法进行统计分析。结果:早发型患者的PANSS量表总分(73.8±28.0)和CRDPSS量表总分(11.7±5.4)均为最高。女性、受教育程度高、汉族、首发年龄较早、起病形式较慢等特征与PANSS量表和CRDPSS量表总分及其各维度分数正关联(标化回归系数:0.04~0.47),收入水平和吸烟与PANSS量表和CRDPSS量表总分及其各维度分数负关联(标化回归系数:-0.04~-0.14)。结论:早发型精神分裂症患者的症状严重程度更高,女性、受教育水平高、早发病、慢性起病是精神分裂症患者症状严重的危险因素。

A New Interpretation of the Higgs Vacuum Potential Energy Based on a Planckion Composite Model for the Higgs

We present a new interpretation of the Higgs field as a composite particle made up of a positive, with, a negative mass Planck particle. According to the Winterberg hypothesis, space, i.e., the vacuum, consists of both positive and negative physical massive particles, which he called planckions, interacting through strong superfluid forces. In our composite model for the Higgs boson, there is an intrinsic length scale associated with the vacuum, different from the one introduced by Winterberg, where, when the vacuum is in a perfectly balanced state, the number density of positive Planck particles equals the number density of negative Planck particles. Due to the mass compensating effect, the vacuum thus appears massless, chargeless, without pressure, energy density, or entropy. However, a situation can arise where there is an effective mass density imbalance due to the two species of Planck particle not matching in terms of populations, within their respective excited energy states. This does not require the physical addition or removal of either positive or negative Planck particles, within a given region of space, as originally thought. Ordinary matter, dark matter, and dark energy can thus be given a new interpretation as residual vacuum energies within the context of a greater vacuum, where the populations of the positive and negative energy states exactly balance. In the present epoch, it is estimated that the dark energy number density imbalance amounts to, , per cubic meter, when cosmic distance scales in excess of, 100 Mpc, are considered. Compared to a strictly balanced vacuum, where we estimate that the positive, and the negative Planck number density, is of the order, 7.85E54 particles per cubic meter, the above is a very small perturbation. This slight imbalance, we argue, would dramatically alleviate, if not altogether eliminate, the long standing cosmological constant problem.

精神分裂症临床特征及影响因素

目的:探讨精神分裂症临床特征及其相关影响因素。方法:采用方便取样的方式招募铜陵市某二级甲等精神专科医院的精神分裂症患者630例,采用简明国际神经精神访谈(MINI)、精神症状维度评定量表(CRDPSS)和阳性与阴性症状量表(PANSS)进行诊断和评估,采用SAS 9.4进行方差分析、Pearson相关分析和多重线性回归等对数据进行统计分析。结果:不同病程特征的精神分裂症患者的CRDPSS(F=22.46,P<0.01)和PANSS(F=7.99,P<0.01)得分差异有统计学意义,其中持续恶化型患者的CRDPSS总分[(11.88±4.16)分]和PANSS总分[(75.63±23.95)分]均为最高。年龄、性别、受教育水平、家庭人口数、腰臀比、婚姻状况、工作状态、吸烟量、首次诊断年龄、首次治疗年龄、总发作次数、总住院次数、停药次数、起病形式和病程特征等因素与CRDPSS量表和PANSS量表总分及各维度得分有不同程度的关联。结论:持续恶化型精神分裂症患者的临床症状严重程度更高,腰臀比、平均每天吸烟量、停药次数、总住院次数、慢性起病是精神分裂症患者症状严重的危险因素。

持续正压通气与自动调压治疗对重症阻塞性睡眠呼吸暂停综合征睡眠的影响

目的:探究持续正压通气与自动调压治疗对重症阻塞性睡眠呼吸暂停综合征睡眠的影响。方法:选取2023年2月至2024年1月泉州市第一医院收治的重症阻塞性睡眠呼吸暂停综合征患者124例作为研究对象,按照随机数字表法分为对照组和观察组,每组62例。对照组采取自动调压治疗,观察组应用持续正压通气治疗。对比2组患者蒙特利尔认知评估量表(Montreal Cognitive Assessment,MoCA)评分、PSQI评分、PSG表现。结果:治疗后,2组患者的MoCA量表评分均有所上升,且观察组高于对照组,差异有统计学意义(P<0.05);对照组患者的PSQI评分高于观察组,差异有统计学意义(P<0.05);观察组患者PSG指标变化均优于对照组,差异有统计学意义(P<0.05)。结论:持续正压通气治疗重症阻塞性睡眠呼吸暂停综合征患者效果显示,可改善患者的认知功能和睡眠质量,改善患者睡眠效率,利于预后,值得推广采纳。

阳性和阴性症状量表(PANSS,中文版)的信、效度研究

目的 :以阳性和阴性症状量表 (PANSS)中文版为基础 ,进一步分析其心理测量特质 ,并简要介绍临床应用。方法 :选取 10 5例诊断符合国际疾病分类手册第 10版 (ICD -10 )中精神分裂症标准的患者进行PANSS评定 ,对原始评定结果进行因子分析、信度分析。结果 :因子分析提出 5个因子 ,分别是 :阴性症状、阳性症状、兴奋敌对、焦虑抑郁、认知缺损 ;信度分析显示量表的标准化Cronbachα值为 0 870 7,5个维度的Cronbachα值在 0 743 4-0 90 44间 ,项目间具有内在的一致性。结论 :PANSS中文版有较好的信、效度 ,适用于精神分裂症症状的量化评估。

导痰汤加减合并小剂量利培酮治疗慢性精神分裂症的临床观察

目的评价中药导痰汤合并小剂量利培酮和单独使用利培酮治疗痰湿内阻型慢性精神分裂症的临床疗效。方法对住院的65例患者随机分为两组,治疗组(34例)用利培酮每日(3．16±0．73)mg加中药导痰汤加减(常规剂量),每日1剂煎服;对照组(31例)单用利培酮每日(5．11±1．27)mg;疗程均为8周。以阳性与阴性症状量表(PANSS)作为主要疗效评价指标,以治疗时出现的症状量表(TESS)评定不良反应。结果两组总体疗效比较差异无显著性,治疗组阴性症状、激活性和一般精神病理方面的改善较对照组明显(P＜0．05),且治疗组药物不良反应出现频率较对照组低,而且轻微。结论中药合并小剂量抗精神病药物不失为治疗慢性精神分裂症的一种有效方法,且减少不良反应。

甲状腺激素水平与老年精神分裂症PANSS评分的相关性

目的探讨老年精神分裂症阳性与阴性症状量表(PANSS)评分与血清甲状腺激素水平的相关性。方法采用回顾性统计分析的方法,对西安市精神卫生中心2017年1月至2018年2月的门诊收治的45例(年龄≥65岁,病程≥2年)老年精神分裂症患者(疾病组)和西安市第九医院51例老年体检人群(健康对照组)的血清促甲状腺激素(TSH)、三碘甲状腺原氨酸(T3)、甲状腺素(T4)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)的化学发光检测结果进行分析,采用PANSS量表对疾病组老年患者的病情严重程度进行测定,并运用相关性分析的方法研究甲状腺激素与患者病情严重程度之间的关系。结果疾病组患者的T3、T4水平分别为(1.66±0.43)nmol/L、(103.76±18.17)nmol/L,明显低于对照组的(1.87±0.41)nmol/L、(113.23±17.03)nmol/L,差异均有统计学意义(P<0.05);疾病组不同性别患者的甲状腺激素水平比较差异无统计学意义(P>0.05);疾病组患者的阴性症状评分与TSH水平呈正相关(r=0.318,P<0.05),与T3、T4水平呈负相关(r=-0.337、-0.330,P<0.05)。结论老年精神分裂症患者的T3、T4水平偏低,但甲状腺激素水平无性别差异,阴性症状与TSH呈正相关,与T3、T4呈负相关。

社交技能训练治疗残留期精神分裂症的疗效观察

目的:探讨社交技能训练对残留期精神分裂症患者随访1年的疗效。方法:随机将57例残留期精神分裂症患者分为研究组29例和对照组28例,分别采用利培酮片+社交技能训练治疗及单用利培酮片治疗。采用前瞻性观察研究方法结合全病程管理模式对研究对象进行随访1年。采用阳性和阴性症状量表(PANSS)、日常生活能力量表(ADL)、社会功能缺陷量表(SDSS)分别评估患者的精神症状、日常生活能力及社会功能缺陷程度。结果:重复测量方差分析显示,研究组PANSS总分、阴性症状分、精神病理分、ADL总分、SDSS总分随时间变化呈线性下降趋势,且阴性症状分、ADL总分、SDSS总分变化趋势较对照组下降更显著(P<0.05,0.01)。与基线比较,研究组PANSS总分、阴性症状分、ADL及SDSS总分在治疗后3、6、9、12个月末均有明显下降(P<0.01)。组间比较,12个月末研究组PANSS总分低于对照组(P<0.05),9、12个月末PANSS阴性症状分低于对照组(P<0.01),训练后不同时点ADL、SDSS总分均明显低于对照组(P<0.05,0.01)。结论:系统而规范的社交技能训练不但能够在短期内改善残留期精神分裂症患者的总体病情、阴性症状及日常生活能力和社会功能,而且在长达1年的时间内仍然对患者有持续改善作用。

首发精神分裂症未治疗时间的变化及相关因素

目的探索首发精神分裂症患者的精神病未治疗时间(duration of unmedicted psychosis,DUP)的变化规律及其相关因素。方法对首都医科大学附属北京安定医院不同年份(1994、2004和2014年)首次发作的精神分裂症出院患者进行回顾性调查,描述DUP的变化。结果不同年份在首都医科大学附属北京安定医院就诊的精神分裂症首次发作的患者中,2014年就诊患者的DUP显著小于1994年和2004年,但后两者之间差异无统计学意义(P>0.05)。2014年精神分裂症患者的DUP与其阳性与阴性症状量表(Positive and Negative Syndrome Scale,PANSS)减分率呈负相关。结论精神分裂症患者从发病到开始治疗的疾病未治疗时间明显缩短,其中学生、未婚和高学历群体的比例呈增加趋势,显示了我国精神卫生事业的发展和进步。

nCPAP干预治疗对非急性期脑梗死合并OSAHS患者神经功能的影响

目的探讨经鼻持续气道正压通气(nCPAP)干预治疗对非急性期脑梗死(CI)合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者神经功能的影响。方法 68例患者经头颅CT或MRI确诊为CI且处于非急性期后,经多导睡眠图(PSG)诊断为OSAHS,将其分为观察组和对照组,对照组给予神经内科常规治疗,观察组在对照组基础上给予每晚大于4h的nCPAP呼吸机治疗,分别于治疗后1、3、6个月时根据美国国立卫生研究院卒中量表(NIHSS)对患者进行神经功能评分,爱泼沃斯嗜睡量表(ESS)进行嗜睡评分及用标准吞咽功能评定量表(SSA)进行吞咽功能评分。结果 nCPAP呼吸机治疗的观察组ESS评分下降,NIHSS评分上升,与对照组比较差异有统计学意义(P<0.05);而SSA评分与对照组比较差异无统计学意义(P>0.05)。结论nCPAP治疗可有效改善非急性期CI合并OSAHS患者症状,使其神经功能恢复,是临床一种药物以外的有效方法。

喹硫平与传统抗精神病药治疗精神分裂症临床效果比较研究

目的:比较研究喹碗平与传统抗精神病药治疗精神分裂症临床效果。方法:选择2007年5月～2010年1月在我科住院的精神分裂症患者96例作为研究对象。随机将其分为观察组和对照组各48例。对照组予以氯丙嗪口服,起始量为100mg/d,根据临床疗效和不良反应调整剂量,最高剂量可达1000 mg/d.;观察组予以喹硫平(英国Zencea公司生产),起始量为200mg/d,视临床疗效和不良反应调整剂量,最高剂量可达700 mg/d.。疗程均为8周。结果:两组治疗前后PANSS评分阳性症状、阴性症状、精神病理及总分比较均明显改善,差异均有统计学意义(P<0.01);治疗后,观察组PANSS评分阳性症状、阴性症状及总分与对照组比较,差异均有统计学意义(P<0.05),精神病理评分下降与对照组比较差异无统计学意义(P>0.05);观察组的总有效率为85.42%,对照组总有效率为66.67%,两组总有效率比较,经x^2检验,x^2=4.631,P>0.05,差异有统计学意义。说明观察组疗效优于对照组。结论:喹硫平替换传统抗精神病药治疗精神分裂症效果明显,有效率优于传统抗精神病药,值得推广使用。

首发未治疗精神分裂症患者的尾状核脑熵与PANSS阳性症状的相关性

目的探讨首发未治疗的精神分裂症患者静息态脑熵功能的异常模式,探索临床症状的潜在神经机制。方法本地招募49例(男性26例,女性23例)首发未治疗的精神分裂症患者为被试组及人口学相匹配的38例为健康对照组(男性21例,女性17例),经阳性和阴性综合征量表(PANSS)评估后使用GE Signa HDxt扫描仪采集静息态fMRI和T13D结构数据。MRI数据经dpabi预处理后计算各被试静息态全脑脑熵,并使用两样本t检验进行组间对比(P<0.05,GRF校正)。对被试组患者,提取差异区脑熵信号与PANSS阳性和阴性指标进行spearman偏相关分析(P<0.05为显著性),以年龄、教育程度为控制变量。结果相比对照组,被试组在右侧楔前叶脑熵显著增强、右侧尾状核脑熵显著降低(P<0.05,GRF校正);被试组右侧尾状核脑熵值与PANSS阳性症状总分存在显著的正相关(P=0.014,rho=0.36)。结论楔前叶与其它脑区的同步性受损影响其调控复杂和高度整合任务是精神分裂症的发病机制,而尾状核在病症中可能具有功能可塑性和代偿性,是潜在的治疗和缓解精神分裂症状的靶点。

持续气道正压通气治疗阻塞性睡眠呼吸暂停综合征患者的主观嗜睡程度和心理变化的Meta分析

目的评价持续气道正压通气(CPAP)治疗阻塞性睡眠呼吸暂停综合征(OSAS)患者的主观嗜睡程度和心理变化。方法计算机检索截止至2007年发表的文献(MEDLINE、EMBASE、CBMdisk等),分析符合条件的9项随机对照试验(RCT)中的Epworth嗜睡量表及有关心理评估量表的结果。由2名评价者独立对纳入文献进行质量评价,并提取资料,如有分歧,通过讨论解决。采用RevMan4.2进行Meta分析。结果9项RCT共纳入665例患者。Meta分析显示,CPAP治疗后的Epworth嗜睡量表评分分值降低[-2.94,95%CI(-4.68,-1.20),随机效应模型],一般健康状况量表-28的分值降低[-2.26,95%CI(-3.79,-0.72),固定效应模型],而合并分析医院焦虑抑郁量表的分值变化无统计学意义。结论依据现有的临床证据,应用CPAP后OSAS患者的日间主观嗜睡程度和整体的精神健康状况得以改善,但对缓解患者焦虑和抑郁情绪则无明显效果。