BACKGROUND An inconclusive result from BRCA1/2 genetic testing indicates that a genetic variant of uncertain significance is detected.This case constitutes the majority of genetic test results,but studies specifically...BACKGROUND An inconclusive result from BRCA1/2 genetic testing indicates that a genetic variant of uncertain significance is detected.This case constitutes the majority of genetic test results,but studies specifically addressing the psychological adjustment of people with inconclusive results are scarce.AIM To examine psychological outcomes of receiving an uninformative BRCA1/2 test result.METHODS PubMed,PsychInfo,and Cochrane Central Register of Controlled Trials were screened for studies focusing on distress,anxiety,and depression levels in individuals with inconclusive genetic test results.This review is based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses method.RESULTS Studies on psychological outcomes of inconclusive BRCA1/2 focused on general and specific distress,anxiety,and depression.Overall,they produced mixed results.These inconsistent findings are probably due to the uncertainty caused by this type of result,that may also influence the decisions of individuals about surveillance and prophylactic options,reducing their compliance.In addition,this review highlights specific risk and protective factors that affect psychological adjustment in individuals with an inconclusive genetic testing result.CONCLUSION Individuals with inconclusive genetic test results need specific educational programs and support to better understand the meaning of their results in order to be able to make decisions about surveillance and prophylactic options.展开更多
Irrational beliefs play a central role in cognitive theory and therapy;they have been shown to be related to a variety of disorders such as depression and anxiety. Irrational beliefs, which can be assessed via clinica...Irrational beliefs play a central role in cognitive theory and therapy;they have been shown to be related to a variety of disorders such as depression and anxiety. Irrational beliefs, which can be assessed via clinical interviewing techniques, are frequently assessed by self-report measures, both clinically and for research purposes. Much of the research demonstrating the effect of irrational beliefs has utilized such measures. The present article reviews the empirical work on irrational beliefs assessment and identifies 25 scales and techniques. The measures are organized according to their theoretical affiliation (i.e., either the Ellis or Beck model), with the goal of providing investigators a source to identify the available tests, their shortcomings, and potential applications. The authors conclude with recommendations which would strengthen empirical cohesion and precision in the measurement of irrational beliefs.展开更多
文摘BACKGROUND An inconclusive result from BRCA1/2 genetic testing indicates that a genetic variant of uncertain significance is detected.This case constitutes the majority of genetic test results,but studies specifically addressing the psychological adjustment of people with inconclusive results are scarce.AIM To examine psychological outcomes of receiving an uninformative BRCA1/2 test result.METHODS PubMed,PsychInfo,and Cochrane Central Register of Controlled Trials were screened for studies focusing on distress,anxiety,and depression levels in individuals with inconclusive genetic test results.This review is based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses method.RESULTS Studies on psychological outcomes of inconclusive BRCA1/2 focused on general and specific distress,anxiety,and depression.Overall,they produced mixed results.These inconsistent findings are probably due to the uncertainty caused by this type of result,that may also influence the decisions of individuals about surveillance and prophylactic options,reducing their compliance.In addition,this review highlights specific risk and protective factors that affect psychological adjustment in individuals with an inconclusive genetic testing result.CONCLUSION Individuals with inconclusive genetic test results need specific educational programs and support to better understand the meaning of their results in order to be able to make decisions about surveillance and prophylactic options.
文摘Irrational beliefs play a central role in cognitive theory and therapy;they have been shown to be related to a variety of disorders such as depression and anxiety. Irrational beliefs, which can be assessed via clinical interviewing techniques, are frequently assessed by self-report measures, both clinically and for research purposes. Much of the research demonstrating the effect of irrational beliefs has utilized such measures. The present article reviews the empirical work on irrational beliefs assessment and identifies 25 scales and techniques. The measures are organized according to their theoretical affiliation (i.e., either the Ellis or Beck model), with the goal of providing investigators a source to identify the available tests, their shortcomings, and potential applications. The authors conclude with recommendations which would strengthen empirical cohesion and precision in the measurement of irrational beliefs.
