Based on Yan Fu’s translation norms of“faithfulness,expressiveness,and elegance”and Liu Miqing’s concept of aesthetic representation in translation,the present study employed a combined method of qualitative and q...Based on Yan Fu’s translation norms of“faithfulness,expressiveness,and elegance”and Liu Miqing’s concept of aesthetic representation in translation,the present study employed a combined method of qualitative and quantitative analysis to investigate the linguistic styles employed by Zhu Ziqing in his renowned prose Beiying.Then,using relevant corpora and self-designed Python software,we investigated whether Zhang Peiji,as a translator,has successfully reproduced the simplistic,emotional,and realistic linguistic characteristics in Zhu Ziqing’s prose from the perspectives of“faithfulness,expressiveness,and elegance.”The findings of the research indicate that by employing a dynamic imitative translation approach,Zhang Peiji has successfully enhanced the linguistic aesthetic qualities of the source text,striving to reflect the distinctive linguistic style of Zhu Ziqing.展开更多
Qaidam basin is located at northeast Qinghai—Xizang (Tibet) plateau, and surrounded by east Kunlun, south Qilian and Altun mountain systems. The purpose of this paper is to study the Cenozoic basin evolutionary stage...Qaidam basin is located at northeast Qinghai—Xizang (Tibet) plateau, and surrounded by east Kunlun, south Qilian and Altun mountain systems. The purpose of this paper is to study the Cenozoic basin evolutionary stages, structural styles of the Qaidam, and the denudation in adjacent mountain systems through seismic profile interpretation and complemented by field observation. The Qaidam basin has experienced two tectonic stages of Paleogene—early Miocene (65~12Ma) and late Miocene—present (12~0Ma). The former is characterized by differential uplift of the mountains and subsidence of the basin, and the latter by intense compression, wrench, thrusting and folding. The compressional structural styles are mainly distributed in the Circle Hero—Range Depression of southwest Qaidam, such as Nanyishan, Youquanzi, Younan, Youshashan anticline belts and thrust faults. The wrench structural styles of the northern Qaidam include en echelon uplifts (fault—block outcrops) such as Seshitengshan, Luliangshan, Xitieshan and Eimnikshan, which are mainly composed of pre\|Sinian and Paleozoic rocks; en echelon anticlines such as Lenghu—Nanbaxian belts; and en echelon depressions such as Kunteyi, Senan and Yibei depressions, which are mainly composed of Mesozoic and Cenozoic rocks.展开更多
Based on the studies of geology and geochemistry, A’nymaque—Mianlue limited oceanic basin is comparable to the Paleo\|Tethys on time, sedimentary, biocoenosis, and the type of ophiolite (Coleman, 1984; Deng, 1984; X...Based on the studies of geology and geochemistry, A’nymaque—Mianlue limited oceanic basin is comparable to the Paleo\|Tethys on time, sedimentary, biocoenosis, and the type of ophiolite (Coleman, 1984; Deng, 1984; Xu, 1996;Chenliang, 1999). The A’nyemaqen—Mianlue oceanic basin was one of a northeast branches of Paleo\|Tethys (Zhang Guowei, 1995; 1996) .Our researches on deformations reveal that tectonic styles of the Southwest Qinling orogenic belt is obviously influenced by the dynamics of Qinghai—Tibet plateau.Structural deformation analysis suggested that the southwest part of Qinling have undergone 3 major deformation stages in Mesozoic and Cenozoic. Firstly, rock folding at deep\|middle tectonic level and progressively thrusting shearing characterized the deformation of collision. The thrust tectonics are south\|directed, such as A’nymaque, Wenxian—Kangxian and Mianlue thrusting systems, and the deformations took place in T\-2—T\-3. Secondly, the middle\|tectonic level thrusting and sinistral strike\|slip formed at early intracontinental period (J—K), the thrust tectonics was south\|directed and the regional penetrative left\|lateral slips were NW or NWW. Finally, the east\|west extensional deformations which occurred in late Mesozoic and Cenozoic, a series of north\|south directing basins came into being in this stage, Huixian—Chengxian basin and Lixian basin for example, which overlapped the former deformation styles.展开更多
The Northeastern margin of Qinghai—Tibet plateau,here refers to the region bounded by Western Qinling fault zone and Longshoushan—Liupanshan tectonic zone, where obliquely compression deformation occurred with the N...The Northeastern margin of Qinghai—Tibet plateau,here refers to the region bounded by Western Qinling fault zone and Longshoushan—Liupanshan tectonic zone, where obliquely compression deformation occurred with the NE\|trending maximum principle axis of stress, with Ordos Massif to the east, Alaxa Block to the north, and Qinghai—Tibet plateau to the southwest. The main structure in this region is Haiyuan—Gulang transpression zone. It consists of a series of active faults: the Haiyuan fault zone, the Tianjingshan fault zone, the Yantongshan fault zone and the Niushoushan—Luoshan fault zone.展开更多
Diaolou style building is an important residential building of Qiang people. In recent years, Qiang people’s own cultural identities and behavioral awareness have transformed. Due to the lack of attention to the inhe...Diaolou style building is an important residential building of Qiang people. In recent years, Qiang people’s own cultural identities and behavioral awareness have transformed. Due to the lack of attention to the inheritance of original architectural style and the absence of a detailed scientific protection of the landscape, the architectural style of Diaolou style building gradually loses its vitality. It is difficult to control and guide it effectively. And tourism economy which enjoys a direct link with the architecture has been confined to further development. From the perspective of behavioral science, this study innovatively analyzes the Diaolou style building of Qiang people by combining the methodology of Lew in metal of behavior and Analytic Hierarchy Process. Firstly, 32 symbols are chosen as Diaolou architectural style factors from the selection of more than 100 Diaolou architectural decorative symbols. Then by measuring their weight coefficients through the Analytic Hierarchy Process, eight main style factors have been screened out. After field research, we analyze the actual use of the style factors of the six typical villages such as Gina. On this basis, this paper analyzes the behavioral factors of Diaolou style building of Qiang people, deconstructs its use and puts forward a concept which takes style control as a guidance and behavior guidance as a strategy to protect and develop Diaolou style building of Qiang people. It is also proposed that a control and guidance strategy of inheritance and development of Qiang Diaolou architectural style, including master the influencing factors as a whole, follow the principle of people-oriented, compound function, dynamic development and highlighting national aesthetics, based on its style system, and grasp the trend of architectural style, etc. The study provides an effective guarantee for the further development of rural tourism, and a necessary theoretical and technical guidance for the government to adopt targeted steps.展开更多
This paper proposes an artificial intelligence-based robust information hiding algorithm to address the issue of confidential information being susceptible to noise attacks during transmission.The algorithm we designe...This paper proposes an artificial intelligence-based robust information hiding algorithm to address the issue of confidential information being susceptible to noise attacks during transmission.The algorithm we designed aims to mitigate the impact of various noise attacks on the integrity of secret information during transmission.The method we propose involves encoding secret images into stylized encrypted images and applies adversarial transfer to both the style and content features of the original and embedded data.This process effectively enhances the concealment and imperceptibility of confidential information,thereby improving the security of such information during transmission and reducing security risks.Furthermore,we have designed a specialized attack layer to simulate real-world attacks and common noise scenarios encountered in practical environments.Through adversarial training,the algorithm is strengthened to enhance its resilience against attacks and overall robustness,ensuring better protection against potential threats.Experimental results demonstrate that our proposed algorithm successfully enhances the concealment and unknowability of secret information while maintaining embedding capacity.Additionally,it ensures the quality and fidelity of the stego image.The method we propose not only improves the security and robustness of information hiding technology but also holds practical application value in protecting sensitive data and ensuring the invisibility of confidential information.展开更多
In this editorial,I comment on the article“Association of preschool children behavior and emotional problems with the parenting behavior of both parents”which was published in the latest issue of“World Journal of C...In this editorial,I comment on the article“Association of preschool children behavior and emotional problems with the parenting behavior of both parents”which was published in the latest issue of“World Journal of Clinical Cases”that demonstrates the prevalence of behavioral disorders in preschool children.Therefore I am focused on parenting which is the most effective factor shown to affect the development and continuity of these behaviors.The management of child behavior problems is crucial.Children in early ages,especially preschoolers who are in the first 5 years of life,are influenced by dramatic changes in various aspects of development,such as social,emotional,and physical.Also,children experience many changes linked to different developmental tasks,such as discovering themselves,getting new friendships,and adapting to a new environment.In this period,parents have a critical role in supporting child development.If parents do not manage and overcome their child’s misbehavior,it could be transformed into psychosocial problems in adulthood.Parenting is the most powerful predictor in the social development of preschool children.Several studies have shown that to reduce the child’s emotional and behavioral problems,a warm relationship between parents and children is needed.In addition,recent studies have demonstrated significant relationships between family regulation factors and parenting,as well as with child behaviors.展开更多
This paper is a contrastive study of two translated versions of an essay which are very different in language and register style. It comes to the conclusion that the translator has to follow the fundamental translatio...This paper is a contrastive study of two translated versions of an essay which are very different in language and register style. It comes to the conclusion that the translator has to follow the fundamental translation principle of functional equivalence, that is, to faithfully reproduce the linguistic and stylistic features of the original, while retaining the verbal beauty of the original as much as possible. Through contrastive analysis, this paper also argues that stylistic features should be consistent with the choice of word, syntactic structures, rhetorical devices, and overall textual layout.展开更多
As Taijiquan is going global,the culture embodied in this traditional physical practice is gaining wider attention and interest among the people around the world。
Two questions in the research of animal personality—whether there is a correlation between a personality trait and individual reproductive success,and what is the genetic basis underlying a personality trait—remain ...Two questions in the research of animal personality—whether there is a correlation between a personality trait and individual reproductive success,and what is the genetic basis underlying a personality trait—remain unresolved.We addressed these two questions in three shrub-nesting birds,the Azure-winged Magpie(Cyanopica cyanus,AM),White-collared Blackbird(Turdus albocinctus,WB),and Brown-cheeked Laughingthrush(Trochalopteron henrici,BL).The personality type of an individual was first identified according to its response to a territorial intruder.Then,we compared the fleeing distance,breeding parameters,and differential expressed genes(DEGs) in the brain transcriptome between bold and shy breeders.In the three species,bold breeders exhibited more aggressiveness towards an intruder of their territory than did shy breeders.The reproductive success of bold breeders was significantly higher than that of shy breeders in AM but not in WB and BL.The three species shared one DEG,crabp1,which was up-regulated in bold relative to in shy individuals.By regulating the expression of corticotropin-releasing hormone,higher crabp1 gene expression can decrease cellular response to retinoic acid.Therefore,bold individuals are insensitive to external stresses and able to exhibit more aggressiveness to intruders than their shier counterparts.Aggressiveness is beneficial to bold individuals in AM but not in WB and BL because the former could evoke neighbors to make the same response of defending against intruders but the latter could not.Although a personality trait may have the same genetic basis across species,its correlation with reproductive success depends largely on the life history style of a species.展开更多
The Makran accretionary wedge has the smallest subduction angle among any accretionary prism in the world. The factors controlling the spacing and morphological development of its deep thrust faults, as well as the fo...The Makran accretionary wedge has the smallest subduction angle among any accretionary prism in the world. The factors controlling the spacing and morphological development of its deep thrust faults, as well as the formation mechanism of shallow normal faults, remain unclear. Meanwhile, the factors affecting the continuity of plane faults must be comprehensively discussed. Clarifying the development characteristics and deformation mechanisms of the Makran accretionary wedge is crucial to effectively guide the exploration of gas hydrate deposits in the area. This study aims to interpret seismic data to identify typical structures in the Makran accretionary wedge, including deep imbricate thrust faults, shallow and small normal faults, wedge-shaped piggyback basins, mud diapirs with fuzzy and disorderly characteristics of reflection, décollements with a northward tilt of 1° – 2°, and large seamounts. Physical simulation-based experiments are performed to comprehensively analyze the results of the plane, section, and slices of the wedge. Results reveal that the distances between and shapes of thrust faults in the deep parts of the Makran accretionary wedge are controlled by the bottom décollement. The uplift of the thrust fault-related folds and the upwelling of the mud diapirs primarily contribute to the formation of small normal faults in the shallow part of the area. The mud diapirs originate from plastic material at the bottom, while those that have developed in the area near the trench are larger. Seamounts and mud diapirs break the continuity of fault plane distribution.展开更多
The concept of Zheng Qi in traditional Chinese medicine (TCM) refers to the vital energy produced by the interaction of Yin and Yang forces in the body. Zheng Qi performs two main functions: Wei Qi (defensive Qi), whi...The concept of Zheng Qi in traditional Chinese medicine (TCM) refers to the vital energy produced by the interaction of Yin and Yang forces in the body. Zheng Qi performs two main functions: Wei Qi (defensive Qi), which shields the body from external pathogens, and Ying Qi (nutritive Qi), which sustains the internal organs and enhances their functionality. In TCM, Chinese tonifying herbs can help restore the balance of Yin/Yang and Qi/Blood function in visceral organs (i.e., optimal physiological functions), thereby fostering the efficient production of Zheng Qi and enhancing health. To ensure the quality of Chinese herbal products, functional assays to measure Yin/Yang, Qi/Blood functions, and Zheng Qi production should be implemented. The efficacy of Yang and Qi herbs can be evaluated by their ability to increase mitochondrial ATP in cultured mouse cardiomyocytes, while Yin and Blood herbs are tested through their immunostimulatory effects on antigen-induced T/B cell proliferation in mouse splenocytes and the production of erythropoietin/nitric oxide in hepatocytes/vascular endothelial cells, respectively. Additionally, Zheng Qi’s effect can be gauged by examining natural killer cell activity and antigen-induced T/B cell proliferation in mice ex vivo. These assays act as biomarkers for assessing the quality and effectiveness of herbal health products within TCM theory.展开更多
Objective:To elucidate the biological basis of the heart qi deficiency(HQD)pattern,an in-depth understanding of which is essential for improving clinical herbal therapy.Methods: We predicted and characterized HQD patt...Objective:To elucidate the biological basis of the heart qi deficiency(HQD)pattern,an in-depth understanding of which is essential for improving clinical herbal therapy.Methods: We predicted and characterized HQD pattern genes using the new strategy,TCM-HIN2Vec,which involves heterogeneous network embedding and transcriptomic experiments.First,a heterogeneous network of traditional Chinese medicine(TCM)patterns was constructed using public databases.Next,we predicted HQD pattern genes using a heterogeneous network-embedding algorithm.We then analyzed the functional characteristics of HQD pattern genes using gene enrichment analysis and examined gene expression levels using RNA-seq.Finally,we identified TCM herbs that demonstrated enriched interactions with HQD pattern genes via herbal enrichment analysis.Results: Our TCM-HIN2Vec strategy revealed that candidate genes associated with HQD pattern were significantly enriched in energy metabolism,signal transduction pathways,and immune processes.Moreover,we found that these candidate genes were significantly differentially expressed in the transcriptional profile of mice model with heart failure with a qi deficiency pattern.Furthermore,herbal enrichment analysis identified TCM herbs that demonstrated enriched interactions with the top 10 candidate genes and could potentially serve as drug candidates for treating HQD.Conclusion: Our results suggested that TCM-HIN2Vec is capable of not only accurately identifying HQD pattern genes,but also deciphering the basis of HQD pattern.Furthermore our finding indicated that TCM-HIN2Vec may be further expanded to develop other patterns,leading to a new approach aimed at elucidating general TCM patterns and developing precision medicine.展开更多
文摘Based on Yan Fu’s translation norms of“faithfulness,expressiveness,and elegance”and Liu Miqing’s concept of aesthetic representation in translation,the present study employed a combined method of qualitative and quantitative analysis to investigate the linguistic styles employed by Zhu Ziqing in his renowned prose Beiying.Then,using relevant corpora and self-designed Python software,we investigated whether Zhang Peiji,as a translator,has successfully reproduced the simplistic,emotional,and realistic linguistic characteristics in Zhu Ziqing’s prose from the perspectives of“faithfulness,expressiveness,and elegance.”The findings of the research indicate that by employing a dynamic imitative translation approach,Zhang Peiji has successfully enhanced the linguistic aesthetic qualities of the source text,striving to reflect the distinctive linguistic style of Zhu Ziqing.
文摘Qaidam basin is located at northeast Qinghai—Xizang (Tibet) plateau, and surrounded by east Kunlun, south Qilian and Altun mountain systems. The purpose of this paper is to study the Cenozoic basin evolutionary stages, structural styles of the Qaidam, and the denudation in adjacent mountain systems through seismic profile interpretation and complemented by field observation. The Qaidam basin has experienced two tectonic stages of Paleogene—early Miocene (65~12Ma) and late Miocene—present (12~0Ma). The former is characterized by differential uplift of the mountains and subsidence of the basin, and the latter by intense compression, wrench, thrusting and folding. The compressional structural styles are mainly distributed in the Circle Hero—Range Depression of southwest Qaidam, such as Nanyishan, Youquanzi, Younan, Youshashan anticline belts and thrust faults. The wrench structural styles of the northern Qaidam include en echelon uplifts (fault—block outcrops) such as Seshitengshan, Luliangshan, Xitieshan and Eimnikshan, which are mainly composed of pre\|Sinian and Paleozoic rocks; en echelon anticlines such as Lenghu—Nanbaxian belts; and en echelon depressions such as Kunteyi, Senan and Yibei depressions, which are mainly composed of Mesozoic and Cenozoic rocks.
文摘Based on the studies of geology and geochemistry, A’nymaque—Mianlue limited oceanic basin is comparable to the Paleo\|Tethys on time, sedimentary, biocoenosis, and the type of ophiolite (Coleman, 1984; Deng, 1984; Xu, 1996;Chenliang, 1999). The A’nyemaqen—Mianlue oceanic basin was one of a northeast branches of Paleo\|Tethys (Zhang Guowei, 1995; 1996) .Our researches on deformations reveal that tectonic styles of the Southwest Qinling orogenic belt is obviously influenced by the dynamics of Qinghai—Tibet plateau.Structural deformation analysis suggested that the southwest part of Qinling have undergone 3 major deformation stages in Mesozoic and Cenozoic. Firstly, rock folding at deep\|middle tectonic level and progressively thrusting shearing characterized the deformation of collision. The thrust tectonics are south\|directed, such as A’nymaque, Wenxian—Kangxian and Mianlue thrusting systems, and the deformations took place in T\-2—T\-3. Secondly, the middle\|tectonic level thrusting and sinistral strike\|slip formed at early intracontinental period (J—K), the thrust tectonics was south\|directed and the regional penetrative left\|lateral slips were NW or NWW. Finally, the east\|west extensional deformations which occurred in late Mesozoic and Cenozoic, a series of north\|south directing basins came into being in this stage, Huixian—Chengxian basin and Lixian basin for example, which overlapped the former deformation styles.
文摘The Northeastern margin of Qinghai—Tibet plateau,here refers to the region bounded by Western Qinling fault zone and Longshoushan—Liupanshan tectonic zone, where obliquely compression deformation occurred with the NE\|trending maximum principle axis of stress, with Ordos Massif to the east, Alaxa Block to the north, and Qinghai—Tibet plateau to the southwest. The main structure in this region is Haiyuan—Gulang transpression zone. It consists of a series of active faults: the Haiyuan fault zone, the Tianjingshan fault zone, the Yantongshan fault zone and the Niushoushan—Luoshan fault zone.
文摘Diaolou style building is an important residential building of Qiang people. In recent years, Qiang people’s own cultural identities and behavioral awareness have transformed. Due to the lack of attention to the inheritance of original architectural style and the absence of a detailed scientific protection of the landscape, the architectural style of Diaolou style building gradually loses its vitality. It is difficult to control and guide it effectively. And tourism economy which enjoys a direct link with the architecture has been confined to further development. From the perspective of behavioral science, this study innovatively analyzes the Diaolou style building of Qiang people by combining the methodology of Lew in metal of behavior and Analytic Hierarchy Process. Firstly, 32 symbols are chosen as Diaolou architectural style factors from the selection of more than 100 Diaolou architectural decorative symbols. Then by measuring their weight coefficients through the Analytic Hierarchy Process, eight main style factors have been screened out. After field research, we analyze the actual use of the style factors of the six typical villages such as Gina. On this basis, this paper analyzes the behavioral factors of Diaolou style building of Qiang people, deconstructs its use and puts forward a concept which takes style control as a guidance and behavior guidance as a strategy to protect and develop Diaolou style building of Qiang people. It is also proposed that a control and guidance strategy of inheritance and development of Qiang Diaolou architectural style, including master the influencing factors as a whole, follow the principle of people-oriented, compound function, dynamic development and highlighting national aesthetics, based on its style system, and grasp the trend of architectural style, etc. The study provides an effective guarantee for the further development of rural tourism, and a necessary theoretical and technical guidance for the government to adopt targeted steps.
基金the National Natural Science Foundation of China(Nos.62272478,61872384)Natural Science Foundation of Shanxi Province(No.2023-JC-YB-584)+1 种基金National Natural Science Foundation of China(No.62172436)Engineering University of PAP’s Funding for Scientific Research Innovation Team,Engineering University of PAP’s Funding for Key Researcher(No.KYGG202011).
文摘This paper proposes an artificial intelligence-based robust information hiding algorithm to address the issue of confidential information being susceptible to noise attacks during transmission.The algorithm we designed aims to mitigate the impact of various noise attacks on the integrity of secret information during transmission.The method we propose involves encoding secret images into stylized encrypted images and applies adversarial transfer to both the style and content features of the original and embedded data.This process effectively enhances the concealment and imperceptibility of confidential information,thereby improving the security of such information during transmission and reducing security risks.Furthermore,we have designed a specialized attack layer to simulate real-world attacks and common noise scenarios encountered in practical environments.Through adversarial training,the algorithm is strengthened to enhance its resilience against attacks and overall robustness,ensuring better protection against potential threats.Experimental results demonstrate that our proposed algorithm successfully enhances the concealment and unknowability of secret information while maintaining embedding capacity.Additionally,it ensures the quality and fidelity of the stego image.The method we propose not only improves the security and robustness of information hiding technology but also holds practical application value in protecting sensitive data and ensuring the invisibility of confidential information.
基金the main study who are focused on parenting style and preschoolers'behavioral problems and give an opportunity to me to comment on this issue.
文摘In this editorial,I comment on the article“Association of preschool children behavior and emotional problems with the parenting behavior of both parents”which was published in the latest issue of“World Journal of Clinical Cases”that demonstrates the prevalence of behavioral disorders in preschool children.Therefore I am focused on parenting which is the most effective factor shown to affect the development and continuity of these behaviors.The management of child behavior problems is crucial.Children in early ages,especially preschoolers who are in the first 5 years of life,are influenced by dramatic changes in various aspects of development,such as social,emotional,and physical.Also,children experience many changes linked to different developmental tasks,such as discovering themselves,getting new friendships,and adapting to a new environment.In this period,parents have a critical role in supporting child development.If parents do not manage and overcome their child’s misbehavior,it could be transformed into psychosocial problems in adulthood.Parenting is the most powerful predictor in the social development of preschool children.Several studies have shown that to reduce the child’s emotional and behavioral problems,a warm relationship between parents and children is needed.In addition,recent studies have demonstrated significant relationships between family regulation factors and parenting,as well as with child behaviors.
文摘This paper is a contrastive study of two translated versions of an essay which are very different in language and register style. It comes to the conclusion that the translator has to follow the fundamental translation principle of functional equivalence, that is, to faithfully reproduce the linguistic and stylistic features of the original, while retaining the verbal beauty of the original as much as possible. Through contrastive analysis, this paper also argues that stylistic features should be consistent with the choice of word, syntactic structures, rhetorical devices, and overall textual layout.
文摘As Taijiquan is going global,the culture embodied in this traditional physical practice is gaining wider attention and interest among the people around the world。
基金provided by the National Natural Science Foundation of China (Grant 32071491, 31772465, 31672299, 31572271, and 32260128)the Natural Sciences Foundation of the Tibetan (XZ202101ZR0051G)。
文摘Two questions in the research of animal personality—whether there is a correlation between a personality trait and individual reproductive success,and what is the genetic basis underlying a personality trait—remain unresolved.We addressed these two questions in three shrub-nesting birds,the Azure-winged Magpie(Cyanopica cyanus,AM),White-collared Blackbird(Turdus albocinctus,WB),and Brown-cheeked Laughingthrush(Trochalopteron henrici,BL).The personality type of an individual was first identified according to its response to a territorial intruder.Then,we compared the fleeing distance,breeding parameters,and differential expressed genes(DEGs) in the brain transcriptome between bold and shy breeders.In the three species,bold breeders exhibited more aggressiveness towards an intruder of their territory than did shy breeders.The reproductive success of bold breeders was significantly higher than that of shy breeders in AM but not in WB and BL.The three species shared one DEG,crabp1,which was up-regulated in bold relative to in shy individuals.By regulating the expression of corticotropin-releasing hormone,higher crabp1 gene expression can decrease cellular response to retinoic acid.Therefore,bold individuals are insensitive to external stresses and able to exhibit more aggressiveness to intruders than their shier counterparts.Aggressiveness is beneficial to bold individuals in AM but not in WB and BL because the former could evoke neighbors to make the same response of defending against intruders but the latter could not.Although a personality trait may have the same genetic basis across species,its correlation with reproductive success depends largely on the life history style of a species.
基金funded by the National Natural Science Foundation of China(No.42076069).
文摘The Makran accretionary wedge has the smallest subduction angle among any accretionary prism in the world. The factors controlling the spacing and morphological development of its deep thrust faults, as well as the formation mechanism of shallow normal faults, remain unclear. Meanwhile, the factors affecting the continuity of plane faults must be comprehensively discussed. Clarifying the development characteristics and deformation mechanisms of the Makran accretionary wedge is crucial to effectively guide the exploration of gas hydrate deposits in the area. This study aims to interpret seismic data to identify typical structures in the Makran accretionary wedge, including deep imbricate thrust faults, shallow and small normal faults, wedge-shaped piggyback basins, mud diapirs with fuzzy and disorderly characteristics of reflection, décollements with a northward tilt of 1° – 2°, and large seamounts. Physical simulation-based experiments are performed to comprehensively analyze the results of the plane, section, and slices of the wedge. Results reveal that the distances between and shapes of thrust faults in the deep parts of the Makran accretionary wedge are controlled by the bottom décollement. The uplift of the thrust fault-related folds and the upwelling of the mud diapirs primarily contribute to the formation of small normal faults in the shallow part of the area. The mud diapirs originate from plastic material at the bottom, while those that have developed in the area near the trench are larger. Seamounts and mud diapirs break the continuity of fault plane distribution.
文摘The concept of Zheng Qi in traditional Chinese medicine (TCM) refers to the vital energy produced by the interaction of Yin and Yang forces in the body. Zheng Qi performs two main functions: Wei Qi (defensive Qi), which shields the body from external pathogens, and Ying Qi (nutritive Qi), which sustains the internal organs and enhances their functionality. In TCM, Chinese tonifying herbs can help restore the balance of Yin/Yang and Qi/Blood function in visceral organs (i.e., optimal physiological functions), thereby fostering the efficient production of Zheng Qi and enhancing health. To ensure the quality of Chinese herbal products, functional assays to measure Yin/Yang, Qi/Blood functions, and Zheng Qi production should be implemented. The efficacy of Yang and Qi herbs can be evaluated by their ability to increase mitochondrial ATP in cultured mouse cardiomyocytes, while Yin and Blood herbs are tested through their immunostimulatory effects on antigen-induced T/B cell proliferation in mouse splenocytes and the production of erythropoietin/nitric oxide in hepatocytes/vascular endothelial cells, respectively. Additionally, Zheng Qi’s effect can be gauged by examining natural killer cell activity and antigen-induced T/B cell proliferation in mice ex vivo. These assays act as biomarkers for assessing the quality and effectiveness of herbal health products within TCM theory.
基金supported by the National Natural Science Foundation of China(32088101)National key Research and Development Program of China(2017YFC1700105,2021YFA1301603).
文摘Objective:To elucidate the biological basis of the heart qi deficiency(HQD)pattern,an in-depth understanding of which is essential for improving clinical herbal therapy.Methods: We predicted and characterized HQD pattern genes using the new strategy,TCM-HIN2Vec,which involves heterogeneous network embedding and transcriptomic experiments.First,a heterogeneous network of traditional Chinese medicine(TCM)patterns was constructed using public databases.Next,we predicted HQD pattern genes using a heterogeneous network-embedding algorithm.We then analyzed the functional characteristics of HQD pattern genes using gene enrichment analysis and examined gene expression levels using RNA-seq.Finally,we identified TCM herbs that demonstrated enriched interactions with HQD pattern genes via herbal enrichment analysis.Results: Our TCM-HIN2Vec strategy revealed that candidate genes associated with HQD pattern were significantly enriched in energy metabolism,signal transduction pathways,and immune processes.Moreover,we found that these candidate genes were significantly differentially expressed in the transcriptional profile of mice model with heart failure with a qi deficiency pattern.Furthermore,herbal enrichment analysis identified TCM herbs that demonstrated enriched interactions with the top 10 candidate genes and could potentially serve as drug candidates for treating HQD.Conclusion: Our results suggested that TCM-HIN2Vec is capable of not only accurately identifying HQD pattern genes,but also deciphering the basis of HQD pattern.Furthermore our finding indicated that TCM-HIN2Vec may be further expanded to develop other patterns,leading to a new approach aimed at elucidating general TCM patterns and developing precision medicine.