Life values are people’s understanding and view on life.After the COVID-19 outbreak,China quickly adopted policies such as lockdown to control the epidemic,while the west could not adopt.One of the important reasons ...Life values are people’s understanding and view on life.After the COVID-19 outbreak,China quickly adopted policies such as lockdown to control the epidemic,while the west could not adopt.One of the important reasons is that Chinese and western life values are different.Through the comparative analysis on Chinese and western life values,it is found that Chinese traditional life values emphasize collective consciousness,while the west pays attention to individual value.Chinese traditional life values avoid death,while the west faces death directly.China emphasizes the present world,while the west pays attention to introspection.There are also similarities between Chinese and western life values.They both emphasize the realization of life values,desire to surpass life,and regard physical life as a natural process.The main reasons for their differences are different economic bases,different cultural influences,and different religious ideas.Therefore,the comparative analysis of Chinese and western life values has theoretical and practical value.展开更多
The value of a statistical life(VSL)is a crucial tool for monetizing health impacts.To explore the VSL in China,this study examines people’s willingness to pay(WTP)to reduce death risk from air pollution in six repre...The value of a statistical life(VSL)is a crucial tool for monetizing health impacts.To explore the VSL in China,this study examines people’s willingness to pay(WTP)to reduce death risk from air pollution in six representative cities in China based on face-to-face contingent valuation interviews(n=3936)from March 7,2019 to September 30,2019.The results reveal that the WTP varied from CNY 455 to 763 in 2019(USD 66-111),corresponding to a VSL range of CNY 3.79-6.36 million(USD 549395-921940).The VSL in China in 2019 is estimated to be CNY 4.76 million(USD 689659).The statistics indicate that monthly expenditure levels,environmental concerns,risk attitudes,and assumed market acceptance,which have seldom been dis‐cussed in previous studies,significantly impact WTP and VSL.These findings will serve as a reference for ana‐lyzing mortality risk reduction benefits in future research and for policymaking.展开更多
The view of life and death is the fundamental in human’s life, is a nation’s, or a country’s most intrinsic and most profound value about human life, it is also an important theme of ethics and philosophy. The cele...The view of life and death is the fundamental in human’s life, is a nation’s, or a country’s most intrinsic and most profound value about human life, it is also an important theme of ethics and philosophy. The celebration of life and for centuries, they all take life and death seriously, but they also have different views towards death and life. This article will center on major American poets such as Henry Wadsworth Longfellow Emily Dickinson, Robert Frost, Walt Whitman and so on. This article will try to have a discussion on the basis of ethical review and interpretation about the view of life and death, to reveal the similarities and differences about the view of life and death in different poets’ poems, to find a method for us to learn about how to adapt to the modern civilization on the basis of ethical review and interpretation, how to understand human life and death how to face life and death, how to survive beyond life and death how to live a wonderful life through understanding human life and death in a proper way.展开更多
The problem of "life and death" has been a confusing proposition of philosophy since long ago,for which philosophers both at home and abroad take great pains to pursue the answer.The problem of"life and...The problem of "life and death" has been a confusing proposition of philosophy since long ago,for which philosophers both at home and abroad take great pains to pursue the answer.The problem of"life and death"is also attractive for litterateurs.This paper attempts to scrutinize the works of Franz Kafka and based on comments of different critics,simply analyzing the theory of survival and the theory of death and exploring the aesthetic value.Through analysis,the author of this paper concludes that the theory of survival in the works of Kafka tends to express hating of not being favored by chances and the fright and anxiety of the time;on the contrary,the theory of death in his works tends to express worship and belief.Both life and death are expressed vividly in his works,showing the brave pursuit of senior artistic forms of Kafka and the essence of its aesthetic value.展开更多
What is success? How is success measured? Willa Cather provides us two sets of values.To some people, success is measured in terms of money. To some success means choosing one’s own life and realizing one’s own valu...What is success? How is success measured? Willa Cather provides us two sets of values.To some people, success is measured in terms of money. To some success means choosing one’s own life and realizing one’s own values. In the novel The Sculptor’s Funeral Cather portrays an artist, who breaks the bondage of the old environment, and becomes a successful sculptor. However, he is regarded as a failure by his local people because the values by which they judge success are not the same.展开更多
In this paper, we conduct research on the sphere of the infl uence of the core value of basic Confucianism under the perspective of life view and values. Value pluralism, as a kind of general phenomenon, the progress ...In this paper, we conduct research on the sphere of the infl uence of the core value of basic Confucianism under the perspective of life view and values. Value pluralism, as a kind of general phenomenon, the progress of the social values in the value of awakening diversifi ed value orientation, expanded the value choice and choice of the degrees of the freedom at the same time that caused the phenomenon such as value confl ict, value confl ict as make people in social life has a value lost and confused. Value is to reveal the external relationship between the signifi cance of the objective world to meet the needs of the people that serve as a specifi c attributes of the object to the subject needs. We integrate the Confucianism to introduce our understanding of the core value that will promote further development of the science and society management.展开更多
The "Tree of Death" is a metaphor I use to unlock my Christian assumptions on how the dead attain eternal existence in the afterlife state. The tree's unconcealedness, in this life and presumably the next, along wi...The "Tree of Death" is a metaphor I use to unlock my Christian assumptions on how the dead attain eternal existence in the afterlife state. The tree's unconcealedness, in this life and presumably the next, along with the moral habits an agent develops in this life explain the obstinacy of the dead, that is, how the agent's irrevocable decision to side with the God of Abraham, or not, is possible. For that to be the case, the existential relationships that generate personal identity in this life must accompany (individuate) the subject in the next life. In Christian philosophy, the person-making process mirrors the relationships of the Blessed Trinity. While Martin Heidegger is not a Christian philosopher, his view on truth and being's unconcealedness provides a useful piece of the argument to continue the Thomistic case for personal immortality. Heidegger is not a catholic philosopher, but the focus he places on being's unconcealedness is consonant with the focus Thomas Aquinas puts on the intelligibility of being. While Heidegger's discussion of being is rooted in Dasein's finitude, the Thomistic interpretation of being situates unconcealedness within the perspective of God's creative act. His vision resets the possibility of applying Heidegger's fundamental ontology beyond temporality. The paper develops through a discussion of the Tree's "branches, trunk, and roots" to conclude that the Christian perspective transforms Heidegger's view of death into "the ultimate possibility of possibility."展开更多
Movies have great power to shape the system of values in contemporary culture. In this paper, we deal with theological reflection of suicide and euthanasia and their presentation as free decisions of individuals shown...Movies have great power to shape the system of values in contemporary culture. In this paper, we deal with theological reflection of suicide and euthanasia and their presentation as free decisions of individuals shown in the movies Seven Pounds and The Sea Inside. Also, we shall present theological reflection on culture of life and culture of death aimed to find common ground for dialogue between two opposed points of view. In the first, introductory part, we will present two views of human freedom, and we will point out that just a theological speech about freedom includes the category of responsibility. On the other hand, what happens often is neglecting categories of resposibility and absolutisation or marginalization of free will. Then we will, as an introduction to the interpretation of films, present global statistics that justify global concerns when it comes to suicide and euthanasia. Next, we will show in central part the concept of quality of life, and we will interpret it through the two mentioned films. In the last section, We conclude, despite opposition between culture of life and death, to offer category of altruism as a starting point for dialogue between the two cultures.展开更多
Skopos Theory is the kernel part of functionalism, holding that the skopos rule is the top-ranking rule that justifies the overall translation process. This paper attempts to make an analysis of the C-E translation of...Skopos Theory is the kernel part of functionalism, holding that the skopos rule is the top-ranking rule that justifies the overall translation process. This paper attempts to make an analysis of the C-E translation of Life and Death Are Wearing Me Out from the perspectives of Skopos Theory, and intends to explore the impact of translating skopos on the translator's choice of translating skills as well as the possible reasons behind them.展开更多
John Keats, a good observer and interpreter of Mother Nature, makes a life-time quest for the beauty of nature and themeaning of life in his poems. Likewise, Tagore, a world-renowned Indian poet, is also a nature-wors...John Keats, a good observer and interpreter of Mother Nature, makes a life-time quest for the beauty of nature and themeaning of life in his poems. Likewise, Tagore, a world-renowned Indian poet, is also a nature-worshiper and writes under thedeep influence of European Romanticism.This paper is to explore the similarities and differences of the two poets' contemplationupon life and death in their view of nature, focusing on Ode to a Nightingale by Keats and Fruit-Gathering by Tagore, aiming tobetter understand the two great poet's poetics in a comparative dimension.展开更多
To investigate the immunogenic Cell Death gene’s potential mechanism and prognostic value in glioblastoma. Information on GBM samples from The Cancer Genome Atlas database was downloaded, ICD genes were obtained, gen...To investigate the immunogenic Cell Death gene’s potential mechanism and prognostic value in glioblastoma. Information on GBM samples from The Cancer Genome Atlas database was downloaded, ICD genes were obtained, genotyping, integrated bioinformatics to verify the prognostic value of genotyping, and finally, prognostic model construction. Two subtypes associated with the ICD gene were obtained by consensus clustering, and the high ICD subtype (risk) group was associated with poor prognosis, high mutations in the PTEN gene, high stromal score, and high immune score. We also constructed a new classification system for GBM based on ICD characteristics. This study is the first to use immunogenic cell death genes for genotyping and successfully build a prognostic model.展开更多
BACKGROUND Nonalcoholic fatty liver disease(NAFLD)has become the leading cause of cirrhosis and other chronic liver diseases(COCLDs).AIM To conduct a comprehensive and comparable updated analysis of the global,regiona...BACKGROUND Nonalcoholic fatty liver disease(NAFLD)has become the leading cause of cirrhosis and other chronic liver diseases(COCLDs).AIM To conduct a comprehensive and comparable updated analysis of the global,regional,and national burden of COCLDs due to NAFLD in 204 countries and territories from 1990 and 2019 by age,sex,and sociodemographic index.METHODS Data on COCLDs due to NAFLD were collected from the Global Burden of Diseases,Injuries,and Risk Factors Study 2019.Numbers and age-standardized prevalence,death,and disability-adjusted life years(DALYs)were estimated through a systematic analysis of modelled data from the Global Burden of Diseases,Injuries,and Risk Factors Study 2019.The estimated annual percentage change was used to determine the burden trend.RESULTS In 2019,the global age-standardized prevalence rate of COCLDs due to NAFLD was 15022.90 per 100000 population[95%uncertainty interval(UI):13493.19-16764.24],which increased by 24.51%(22.63%to 26.08%)from 1990,with an estimated annual percentage change of 0.78(95%confidence interval:0.74-0.82).In the same year,however,the age-standardized death rate and age-standardized DALYs per 100000 population were 1.66(95%UI:1.20-2.17)and 43.69(95%UI:31.28-58.38),respectively.North Africa and the Middle East had the highest prevalence rates of COCLDs due to NAFLD.The death rate increased with age up to the 95+age group for both sexes.Males had higher numbers of prevalence,death rate,and DALYs than females across all age groups before the 65-69 age group.The sociodemographic index was negatively correlated with the age-standardized DALYs.CONCLUSION Globally,the age-standardized prevalence rate has increased during the past three decades.However,the agestandardized death rate and age-standardized DALYs decreased.There is geographical variation in the burden of COCLDs due to NAFLD.It is strongly recommended to improve the data quality of COCLDs due to NAFLD across all countries and regions to facilitate better monitoring of the burden of COCLDs due to NAFLD.展开更多
Adenosine triphosphate(ATP)induced cell death(AICD)is a critical cellular process that has garnered substantial scientific interest for its profound relevance to cancer biology and to therapeutic interventions.This co...Adenosine triphosphate(ATP)induced cell death(AICD)is a critical cellular process that has garnered substantial scientific interest for its profound relevance to cancer biology and to therapeutic interventions.This comprehensive review unveils the intricate web of AICD mechanisms and their intricate connections with cancer biology.This review offers a comprehensive framework for comprehending the multifaceted role of AICD in the context of cancer.This is achieved by elucidating the dynamic interplay between systemic and cellular ATP homeostasis,deciphering the intricate mechanisms governing AICD,elucidating its intricate involvement in cancer signaling pathways,and scrutinizing validated key genes.Moreover,the exploration of AICD as a potential avenue for cancer treatment underscores its essential role in shaping the future landscape of cancer therapeutics.展开更多
Background: Value-Based Care is a program that was created by Professor Michael E. PORTER and Elizabeth O. TEISBERG which has been modified for implementation over the last seventeen years. This new program is paid by...Background: Value-Based Care is a program that was created by Professor Michael E. PORTER and Elizabeth O. TEISBERG which has been modified for implementation over the last seventeen years. This new program is paid by Commercial Health Insurers (Insurance Companies) and Centers for Medicare and Medicaid Services (Medicare). This program incorporates the patients, doctors, Life Sciences Companies, Insurance Companies, Holistic practice, traditional Chinese medicine, etc. with alternative traditional treatments and therapies for Real-World Evidence based and value-based treatment customized to patients’ needs and the patients benefit. Methods: The program was proposed to achieve value for patients and an improved healthcare system which is especially needed to provide treatment for patients in Serious or Life-threatening conditions or diseases. The program will accurately measure the outcomes of patients and provide a wider choice of treatments that matter to patients, also to measure the cost that successful alternative treatments provide which may lower the cost to Medicare and Insurance Companies. Conclusion: The proposed and now implemented program is to achieve value for patients. Golden Sunrise Nutraceutical (Golden Sunrise) provides a New Medical Innovation and treatment alternative to patients suffering from Serious or Life-threatening illnesses. By using Golden Sunrise Innovation and with the incorporation of Value-based Care patients will become the drivers or it could be said the patient Ambassadors of their own health. By incorporating Golden Sunrise Innovation, the doctors will have more diversity of treatments available for their patients. Payment should reflect value not volume, and the New Medical Innovation Golden Sunrise offers will help in reducing the costs to Insurance Companies accelerating the adoption of Value-Based Care.展开更多
Background: Anti-programmed death-1/programmed death-ligand 1(PD-1/PD-L1) immunotherapy has been proved to be effective on gastric cancer in ongoing clinical trials. However, the value of PD-L1 in predicting responses...Background: Anti-programmed death-1/programmed death-ligand 1(PD-1/PD-L1) immunotherapy has been proved to be effective on gastric cancer in ongoing clinical trials. However, the value of PD-L1 in predicting responses of patients with gastric cancer to anti-PD-1/PD-L1 immunotherapy is controversial. Some studies suggested that intra-and inter-tumoral heterogeneity of PD-L1 expression might explain the controversy.This study aimed to analyze the expression of PD-L1, PD-L2, and PD-1 as well as CD8(+) T-cell density in primary tumors and lymph nodes from patients with stage T1-4 N+M0 gastric adenocarcinoma to explore the heterogeneity of PD-1 signaling pathway molecules.Methods: In primary tumors and metastatic as well as non-metastatic lymph nodes from patients with stage T1-4 N+M0 gastric adenocarcinoma, we detected PD-L1 and PD-L2 expression with immunohistochemistry. CD8(+)T-cell density in primary tumors and PD-1 expression on CD8(+)T cells were detected with immunofluorescence. Univariate analysis was used to determine the prognostic values of them. Cox proportional hazard regression model was used to identify independent risk factors that affect patients' overall survival and disease-free survival.Results: Among 119 eligible patients who had undergone surgical resection, the positive rate of PD-L1 was higher in metastatic lymph nodes than in primary tumors(45.4% vs. 38.7%, P = 0.005); the positive rate of PD-1 on CD8(+)T cells was significantly higher in primary tumors and metastatic lymph nodes than in tumor-free lymph nodes(both P < 0.001). The intensity of PD-1 expression on CD8(+) T cells in primary tumors and in metastatic lymph nodes were stronger than that in tumor-free lymph nodes from the same patient. Beside, the positive rate of PD-L2 did not show any differences between primary tumors and metastatic lymph nodes. In multivariate analysis, PD-L1 expression,PD-L2 expression, a low density of CD8(+) T cells in primary tumors, and PD-1 expression on CD8(+) T cells in primary tumors were associated with poor prognosis.Conclusion: The expression of PD-L1 is heterogeneous in primary tumors and in metastatic lymph nodes from patients with stageT1-4 N+M0 gastric adenocarcinoma, which might explain the inconsistent results in assessing the prognostic value of PD-L1 expression in previous studies.展开更多
To expand the evidence base to inform future public policy aimed at accident prevention, we investigated the impact of different categories of injury on average life expectancy in China. We used data from the National...To expand the evidence base to inform future public policy aimed at accident prevention, we investigated the impact of different categories of injury on average life expectancy in China. We used data from the National Death Cause Registration Information System and National Maternity and Children Health Surveillance databases, as well as 2010 population data from the National Bureau of Statistics. We then calculated the average life expectancy of the Chinese population, in addition to life expectancy after eliminating injury-related mortality. The average life expectancy of the Chinese population in 2010 was 74.93 years. After eliminating deaths due to injuries, the fourth leading cause of mortality in China, average life expectancy increased by 1.36 years. When this was broken down by population sub-groups, these gains were 1.76 and 0.79 years in men and women, 0.94 and 1.56 years in urban and rural residents, and 1.11, 1.30, and 1.67 years for residents in the Eastern, Central and Western regions respectively. After eliminating all categories of injury, the average life expectancy of the Chinese population was found to increase by 1.36 years. This figure was higher for males and residents of rural areas and Western China.展开更多
Escherichia coli RecA has been considered traditionally a cellular protein with multiple vital functions working to ensure the maintenance of integrity of genome in each individual bacterial cell as well as promoting ...Escherichia coli RecA has been considered traditionally a cellular protein with multiple vital functions working to ensure the maintenance of integrity of genome in each individual bacterial cell as well as promoting swarming migration in collectivity. On the contrary, recently it has been described that RecA promotes cellular apoptotic-like death (ALD), a pathway of programmed cellular death (PCD). In fact, RecA has been dubbed as the major apoptotic executor in E. coli. From these studies, RecA emerges as a prototypical Gin/Gan protein that despite of their intrinsic vital and lethal anfi-funcionality becomes in a WISE factor: a Worker to Integrate Survival and Evolution in E. coli evolving populations living in community. Here, I provide a review of recent experimental and conceptual advances trying to understand these RecA’s antagonistic roles in appearance contradictory under a unified biological vision.展开更多
The 2012 Nobel Prize winner in Literature,Chinese writer Mo Yan,describes the 50 years history of Chinese countryside from 1950 to 2000 in his masterpiece Life and Death Are Wearing Me Out.By the six artistic images o...The 2012 Nobel Prize winner in Literature,Chinese writer Mo Yan,describes the 50 years history of Chinese countryside from 1950 to 2000 in his masterpiece Life and Death Are Wearing Me Out.By the six artistic images of the innocent killing landlord’s reincarnation as a donkey,an ox,a pig,a dog,a monkey,and a big head baby boy,it focuses on the topic of the land.It explains that all the relationships between the peasants and the land,and shows the changes in the life of Chinese peasants and their tenacious,optimistic and tough spirit since the foundation of the New China.By analyzing the unique plot of the six great divisions in the wheel of karma and the hero’s mental journey,it can be found that the theme of the novel is to reveal a global circular diaspora with the moon,rather than the sun as the center of the circle,which is quite different from the real world.展开更多
文摘Life values are people’s understanding and view on life.After the COVID-19 outbreak,China quickly adopted policies such as lockdown to control the epidemic,while the west could not adopt.One of the important reasons is that Chinese and western life values are different.Through the comparative analysis on Chinese and western life values,it is found that Chinese traditional life values emphasize collective consciousness,while the west pays attention to individual value.Chinese traditional life values avoid death,while the west faces death directly.China emphasizes the present world,while the west pays attention to introspection.There are also similarities between Chinese and western life values.They both emphasize the realization of life values,desire to surpass life,and regard physical life as a natural process.The main reasons for their differences are different economic bases,different cultural influences,and different religious ideas.Therefore,the comparative analysis of Chinese and western life values has theoretical and practical value.
基金supported by the National Natural Science Foun‐dation of China[Grant No.71773061].
文摘The value of a statistical life(VSL)is a crucial tool for monetizing health impacts.To explore the VSL in China,this study examines people’s willingness to pay(WTP)to reduce death risk from air pollution in six representative cities in China based on face-to-face contingent valuation interviews(n=3936)from March 7,2019 to September 30,2019.The results reveal that the WTP varied from CNY 455 to 763 in 2019(USD 66-111),corresponding to a VSL range of CNY 3.79-6.36 million(USD 549395-921940).The VSL in China in 2019 is estimated to be CNY 4.76 million(USD 689659).The statistics indicate that monthly expenditure levels,environmental concerns,risk attitudes,and assumed market acceptance,which have seldom been dis‐cussed in previous studies,significantly impact WTP and VSL.These findings will serve as a reference for ana‐lyzing mortality risk reduction benefits in future research and for policymaking.
文摘The view of life and death is the fundamental in human’s life, is a nation’s, or a country’s most intrinsic and most profound value about human life, it is also an important theme of ethics and philosophy. The celebration of life and for centuries, they all take life and death seriously, but they also have different views towards death and life. This article will center on major American poets such as Henry Wadsworth Longfellow Emily Dickinson, Robert Frost, Walt Whitman and so on. This article will try to have a discussion on the basis of ethical review and interpretation about the view of life and death, to reveal the similarities and differences about the view of life and death in different poets’ poems, to find a method for us to learn about how to adapt to the modern civilization on the basis of ethical review and interpretation, how to understand human life and death how to face life and death, how to survive beyond life and death how to live a wonderful life through understanding human life and death in a proper way.
文摘The problem of "life and death" has been a confusing proposition of philosophy since long ago,for which philosophers both at home and abroad take great pains to pursue the answer.The problem of"life and death"is also attractive for litterateurs.This paper attempts to scrutinize the works of Franz Kafka and based on comments of different critics,simply analyzing the theory of survival and the theory of death and exploring the aesthetic value.Through analysis,the author of this paper concludes that the theory of survival in the works of Kafka tends to express hating of not being favored by chances and the fright and anxiety of the time;on the contrary,the theory of death in his works tends to express worship and belief.Both life and death are expressed vividly in his works,showing the brave pursuit of senior artistic forms of Kafka and the essence of its aesthetic value.
文摘What is success? How is success measured? Willa Cather provides us two sets of values.To some people, success is measured in terms of money. To some success means choosing one’s own life and realizing one’s own values. In the novel The Sculptor’s Funeral Cather portrays an artist, who breaks the bondage of the old environment, and becomes a successful sculptor. However, he is regarded as a failure by his local people because the values by which they judge success are not the same.
文摘In this paper, we conduct research on the sphere of the infl uence of the core value of basic Confucianism under the perspective of life view and values. Value pluralism, as a kind of general phenomenon, the progress of the social values in the value of awakening diversifi ed value orientation, expanded the value choice and choice of the degrees of the freedom at the same time that caused the phenomenon such as value confl ict, value confl ict as make people in social life has a value lost and confused. Value is to reveal the external relationship between the signifi cance of the objective world to meet the needs of the people that serve as a specifi c attributes of the object to the subject needs. We integrate the Confucianism to introduce our understanding of the core value that will promote further development of the science and society management.
文摘The "Tree of Death" is a metaphor I use to unlock my Christian assumptions on how the dead attain eternal existence in the afterlife state. The tree's unconcealedness, in this life and presumably the next, along with the moral habits an agent develops in this life explain the obstinacy of the dead, that is, how the agent's irrevocable decision to side with the God of Abraham, or not, is possible. For that to be the case, the existential relationships that generate personal identity in this life must accompany (individuate) the subject in the next life. In Christian philosophy, the person-making process mirrors the relationships of the Blessed Trinity. While Martin Heidegger is not a Christian philosopher, his view on truth and being's unconcealedness provides a useful piece of the argument to continue the Thomistic case for personal immortality. Heidegger is not a catholic philosopher, but the focus he places on being's unconcealedness is consonant with the focus Thomas Aquinas puts on the intelligibility of being. While Heidegger's discussion of being is rooted in Dasein's finitude, the Thomistic interpretation of being situates unconcealedness within the perspective of God's creative act. His vision resets the possibility of applying Heidegger's fundamental ontology beyond temporality. The paper develops through a discussion of the Tree's "branches, trunk, and roots" to conclude that the Christian perspective transforms Heidegger's view of death into "the ultimate possibility of possibility."
文摘Movies have great power to shape the system of values in contemporary culture. In this paper, we deal with theological reflection of suicide and euthanasia and their presentation as free decisions of individuals shown in the movies Seven Pounds and The Sea Inside. Also, we shall present theological reflection on culture of life and culture of death aimed to find common ground for dialogue between two opposed points of view. In the first, introductory part, we will present two views of human freedom, and we will point out that just a theological speech about freedom includes the category of responsibility. On the other hand, what happens often is neglecting categories of resposibility and absolutisation or marginalization of free will. Then we will, as an introduction to the interpretation of films, present global statistics that justify global concerns when it comes to suicide and euthanasia. Next, we will show in central part the concept of quality of life, and we will interpret it through the two mentioned films. In the last section, We conclude, despite opposition between culture of life and death, to offer category of altruism as a starting point for dialogue between the two cultures.
文摘Skopos Theory is the kernel part of functionalism, holding that the skopos rule is the top-ranking rule that justifies the overall translation process. This paper attempts to make an analysis of the C-E translation of Life and Death Are Wearing Me Out from the perspectives of Skopos Theory, and intends to explore the impact of translating skopos on the translator's choice of translating skills as well as the possible reasons behind them.
文摘John Keats, a good observer and interpreter of Mother Nature, makes a life-time quest for the beauty of nature and themeaning of life in his poems. Likewise, Tagore, a world-renowned Indian poet, is also a nature-worshiper and writes under thedeep influence of European Romanticism.This paper is to explore the similarities and differences of the two poets' contemplationupon life and death in their view of nature, focusing on Ode to a Nightingale by Keats and Fruit-Gathering by Tagore, aiming tobetter understand the two great poet's poetics in a comparative dimension.
文摘To investigate the immunogenic Cell Death gene’s potential mechanism and prognostic value in glioblastoma. Information on GBM samples from The Cancer Genome Atlas database was downloaded, ICD genes were obtained, genotyping, integrated bioinformatics to verify the prognostic value of genotyping, and finally, prognostic model construction. Two subtypes associated with the ICD gene were obtained by consensus clustering, and the high ICD subtype (risk) group was associated with poor prognosis, high mutations in the PTEN gene, high stromal score, and high immune score. We also constructed a new classification system for GBM based on ICD characteristics. This study is the first to use immunogenic cell death genes for genotyping and successfully build a prognostic model.
基金National Key research and Development Program,No.2022YFE0131600National Natural Science Foundation of China,No.82160500+3 种基金Special Project of Central Government Guiding Local Science and Technology Development,No.ZY20198011Guangxi Science and Technology Base and Talent Project,No.GuikeAA21220002Natural Science Foundation of Guangxi,No.2022GXNSFAA035642The Liuzhou Science and Technology Plan Project,No.2021CB0101.
文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)has become the leading cause of cirrhosis and other chronic liver diseases(COCLDs).AIM To conduct a comprehensive and comparable updated analysis of the global,regional,and national burden of COCLDs due to NAFLD in 204 countries and territories from 1990 and 2019 by age,sex,and sociodemographic index.METHODS Data on COCLDs due to NAFLD were collected from the Global Burden of Diseases,Injuries,and Risk Factors Study 2019.Numbers and age-standardized prevalence,death,and disability-adjusted life years(DALYs)were estimated through a systematic analysis of modelled data from the Global Burden of Diseases,Injuries,and Risk Factors Study 2019.The estimated annual percentage change was used to determine the burden trend.RESULTS In 2019,the global age-standardized prevalence rate of COCLDs due to NAFLD was 15022.90 per 100000 population[95%uncertainty interval(UI):13493.19-16764.24],which increased by 24.51%(22.63%to 26.08%)from 1990,with an estimated annual percentage change of 0.78(95%confidence interval:0.74-0.82).In the same year,however,the age-standardized death rate and age-standardized DALYs per 100000 population were 1.66(95%UI:1.20-2.17)and 43.69(95%UI:31.28-58.38),respectively.North Africa and the Middle East had the highest prevalence rates of COCLDs due to NAFLD.The death rate increased with age up to the 95+age group for both sexes.Males had higher numbers of prevalence,death rate,and DALYs than females across all age groups before the 65-69 age group.The sociodemographic index was negatively correlated with the age-standardized DALYs.CONCLUSION Globally,the age-standardized prevalence rate has increased during the past three decades.However,the agestandardized death rate and age-standardized DALYs decreased.There is geographical variation in the burden of COCLDs due to NAFLD.It is strongly recommended to improve the data quality of COCLDs due to NAFLD across all countries and regions to facilitate better monitoring of the burden of COCLDs due to NAFLD.
基金Supported by National Natural Science Foundation of China,No.81960877University Innovation Fund of Gansu Province,No.2021A-076+4 种基金Gansu Province Science and Technology Plan(Innovation Base and Talent Plan),No.21JR7RA561Natural Science Foundation of Gansu Province,No.21JR1RA267 and No.22JR5RA582Education Technology Innovation Project of Gansu Province,No.2022A-067Innovation Fund of Higher Education of Gansu Province,No.2023A-088Gansu Province Science and Technology Plan International Cooperation Field Project,No.23YFWA0005.
文摘Adenosine triphosphate(ATP)induced cell death(AICD)is a critical cellular process that has garnered substantial scientific interest for its profound relevance to cancer biology and to therapeutic interventions.This comprehensive review unveils the intricate web of AICD mechanisms and their intricate connections with cancer biology.This review offers a comprehensive framework for comprehending the multifaceted role of AICD in the context of cancer.This is achieved by elucidating the dynamic interplay between systemic and cellular ATP homeostasis,deciphering the intricate mechanisms governing AICD,elucidating its intricate involvement in cancer signaling pathways,and scrutinizing validated key genes.Moreover,the exploration of AICD as a potential avenue for cancer treatment underscores its essential role in shaping the future landscape of cancer therapeutics.
文摘Background: Value-Based Care is a program that was created by Professor Michael E. PORTER and Elizabeth O. TEISBERG which has been modified for implementation over the last seventeen years. This new program is paid by Commercial Health Insurers (Insurance Companies) and Centers for Medicare and Medicaid Services (Medicare). This program incorporates the patients, doctors, Life Sciences Companies, Insurance Companies, Holistic practice, traditional Chinese medicine, etc. with alternative traditional treatments and therapies for Real-World Evidence based and value-based treatment customized to patients’ needs and the patients benefit. Methods: The program was proposed to achieve value for patients and an improved healthcare system which is especially needed to provide treatment for patients in Serious or Life-threatening conditions or diseases. The program will accurately measure the outcomes of patients and provide a wider choice of treatments that matter to patients, also to measure the cost that successful alternative treatments provide which may lower the cost to Medicare and Insurance Companies. Conclusion: The proposed and now implemented program is to achieve value for patients. Golden Sunrise Nutraceutical (Golden Sunrise) provides a New Medical Innovation and treatment alternative to patients suffering from Serious or Life-threatening illnesses. By using Golden Sunrise Innovation and with the incorporation of Value-based Care patients will become the drivers or it could be said the patient Ambassadors of their own health. By incorporating Golden Sunrise Innovation, the doctors will have more diversity of treatments available for their patients. Payment should reflect value not volume, and the New Medical Innovation Golden Sunrise offers will help in reducing the costs to Insurance Companies accelerating the adoption of Value-Based Care.
文摘Background: Anti-programmed death-1/programmed death-ligand 1(PD-1/PD-L1) immunotherapy has been proved to be effective on gastric cancer in ongoing clinical trials. However, the value of PD-L1 in predicting responses of patients with gastric cancer to anti-PD-1/PD-L1 immunotherapy is controversial. Some studies suggested that intra-and inter-tumoral heterogeneity of PD-L1 expression might explain the controversy.This study aimed to analyze the expression of PD-L1, PD-L2, and PD-1 as well as CD8(+) T-cell density in primary tumors and lymph nodes from patients with stage T1-4 N+M0 gastric adenocarcinoma to explore the heterogeneity of PD-1 signaling pathway molecules.Methods: In primary tumors and metastatic as well as non-metastatic lymph nodes from patients with stage T1-4 N+M0 gastric adenocarcinoma, we detected PD-L1 and PD-L2 expression with immunohistochemistry. CD8(+)T-cell density in primary tumors and PD-1 expression on CD8(+)T cells were detected with immunofluorescence. Univariate analysis was used to determine the prognostic values of them. Cox proportional hazard regression model was used to identify independent risk factors that affect patients' overall survival and disease-free survival.Results: Among 119 eligible patients who had undergone surgical resection, the positive rate of PD-L1 was higher in metastatic lymph nodes than in primary tumors(45.4% vs. 38.7%, P = 0.005); the positive rate of PD-1 on CD8(+)T cells was significantly higher in primary tumors and metastatic lymph nodes than in tumor-free lymph nodes(both P < 0.001). The intensity of PD-1 expression on CD8(+) T cells in primary tumors and in metastatic lymph nodes were stronger than that in tumor-free lymph nodes from the same patient. Beside, the positive rate of PD-L2 did not show any differences between primary tumors and metastatic lymph nodes. In multivariate analysis, PD-L1 expression,PD-L2 expression, a low density of CD8(+) T cells in primary tumors, and PD-1 expression on CD8(+) T cells in primary tumors were associated with poor prognosis.Conclusion: The expression of PD-L1 is heterogeneous in primary tumors and in metastatic lymph nodes from patients with stageT1-4 N+M0 gastric adenocarcinoma, which might explain the inconsistent results in assessing the prognostic value of PD-L1 expression in previous studies.
基金supported by the US Centers for Disease Control and Prevention, Atlanta, Georgia,USAThinkTank Research Center for Health Development, Beijing, China
文摘To expand the evidence base to inform future public policy aimed at accident prevention, we investigated the impact of different categories of injury on average life expectancy in China. We used data from the National Death Cause Registration Information System and National Maternity and Children Health Surveillance databases, as well as 2010 population data from the National Bureau of Statistics. We then calculated the average life expectancy of the Chinese population, in addition to life expectancy after eliminating injury-related mortality. The average life expectancy of the Chinese population in 2010 was 74.93 years. After eliminating deaths due to injuries, the fourth leading cause of mortality in China, average life expectancy increased by 1.36 years. When this was broken down by population sub-groups, these gains were 1.76 and 0.79 years in men and women, 0.94 and 1.56 years in urban and rural residents, and 1.11, 1.30, and 1.67 years for residents in the Eastern, Central and Western regions respectively. After eliminating all categories of injury, the average life expectancy of the Chinese population was found to increase by 1.36 years. This figure was higher for males and residents of rural areas and Western China.
文摘Escherichia coli RecA has been considered traditionally a cellular protein with multiple vital functions working to ensure the maintenance of integrity of genome in each individual bacterial cell as well as promoting swarming migration in collectivity. On the contrary, recently it has been described that RecA promotes cellular apoptotic-like death (ALD), a pathway of programmed cellular death (PCD). In fact, RecA has been dubbed as the major apoptotic executor in E. coli. From these studies, RecA emerges as a prototypical Gin/Gan protein that despite of their intrinsic vital and lethal anfi-funcionality becomes in a WISE factor: a Worker to Integrate Survival and Evolution in E. coli evolving populations living in community. Here, I provide a review of recent experimental and conceptual advances trying to understand these RecA’s antagonistic roles in appearance contradictory under a unified biological vision.
文摘The 2012 Nobel Prize winner in Literature,Chinese writer Mo Yan,describes the 50 years history of Chinese countryside from 1950 to 2000 in his masterpiece Life and Death Are Wearing Me Out.By the six artistic images of the innocent killing landlord’s reincarnation as a donkey,an ox,a pig,a dog,a monkey,and a big head baby boy,it focuses on the topic of the land.It explains that all the relationships between the peasants and the land,and shows the changes in the life of Chinese peasants and their tenacious,optimistic and tough spirit since the foundation of the New China.By analyzing the unique plot of the six great divisions in the wheel of karma and the hero’s mental journey,it can be found that the theme of the novel is to reveal a global circular diaspora with the moon,rather than the sun as the center of the circle,which is quite different from the real world.