Yin Yang 1(YY1) is a multi-functional transcription factor that regulates gene expression in a range of cell types,including neurons.It controls neuronal differentiation,as well as neuronal specification and migration...Yin Yang 1(YY1) is a multi-functional transcription factor that regulates gene expression in a range of cell types,including neurons.It controls neuronal differentiation,as well as neuronal specification and migration during the development of the mammalian nervous system.Besides,YY1 also mediates the transcription of genes that are required for neuronal survival.An impairment of the transcriptional function of YY1 causes neuronal death.This review summarizes recent research findings that unveil the dysfunction of YY1 in multiple neurodegenerative disorders.The expression of disease proteins perturbs the function of YY1 via distinct molecular mechanisms,including recruitment to protein aggregates,protein degradation and aberrant nuclear/cytoplasmic shuttling.Understanding the pathogenic roles of YY1 will further broaden our knowledge of the disease mechanisms in distinct neurodegenerative disorders.展开更多
Asthma is characterized by paroxysmaldyspnea,rales in the throat,difficulty in breathing,and inability to lie horizontally.It is commonly seenin children with a weak body constitution,and tendsto be intractable,thus b...Asthma is characterized by paroxysmaldyspnea,rales in the throat,difficulty in breathing,and inability to lie horizontally.It is commonly seenin children with a weak body constitution,and tendsto be intractable,thus being harmful to the展开更多
This paper seeks to examine the image and text relationship in TANG Yin's scroll of poetry and painting from three aspects: The first aspect focuses upon the schema type of its image and text relationship in physica...This paper seeks to examine the image and text relationship in TANG Yin's scroll of poetry and painting from three aspects: The first aspect focuses upon the schema type of its image and text relationship in physical form; the second aspect, explores the text's/poetry's functions of anchorage and relay while appreciating those images/paintings; the third aspect, traces the semiosis process of image, exploring how image and text as cultural products in the epistemological world mediates with the phenomenological world展开更多
为了解决微波无线输能系统中微波源的小型化和高效率需求,提出了一种高效谐波调谐功率振荡器的设计方法,振荡器由晶体管、谐波控制网络、反馈网络和负载网络组成。首先,通过调谐晶体管谐波阻抗以减少漏极电压与电流波形的重叠,从而提高...为了解决微波无线输能系统中微波源的小型化和高效率需求,提出了一种高效谐波调谐功率振荡器的设计方法,振荡器由晶体管、谐波控制网络、反馈网络和负载网络组成。首先,通过调谐晶体管谐波阻抗以减少漏极电压与电流波形的重叠,从而提高其效率;其次,反馈网络与负载网络使用仿真获得的数据合成,两者可独立设计,避免了反馈回路对振荡器输出效率的影响。使用Cree CGH40010F GaN HEMT设计并制作了一款工作在S波段的高效功率振荡器,测试结果表明振荡器在2.445 GHz下成功实现了41.7 dBm的输出功率和79.9%的直流到射频(direct current to radio frequency,DC-RF)转化效率,在偏移载波1 MHz处,相位噪声低至-136 dBc/Hz。该功率振荡器性能优越,在微波无线能量传输系统中具有良好的应用前景。展开更多
We report 10 Gb/s data transmissions using a packaged two-section InGaAsP/InP distributed Bragg reflector(DBR)laser.The tunable DBR laser has a wavelength tuning range of 12.12 nm.The DBR laser has greater than 10.84 ...We report 10 Gb/s data transmissions using a packaged two-section InGaAsP/InP distributed Bragg reflector(DBR)laser.The tunable DBR laser has a wavelength tuning range of 12.12 nm.The DBR laser has greater than 10.84 GHz 3-dB direct modulation bandwidth within the wavelength tuning range.The 10 Gb/s data transmissions are performed at up to a distance of 30-km.展开更多
基金supported by the General Research Fund(14100714)of the Hong Kong Research Grants Council(to HYEC)The Chinese University of Hong Kong Vice-Chancellor’s One-Off Discretionary Fund(VCF2014011)(to HYEC)+5 种基金The Chinese University of Hong Kong One-of Funding for Joint Lab/Research Collaboration(3132980)(to HYEC)The Chinese University of Hong Kong Faculty of Science Strategic Development Fund(FACULTY-P17173)(to HYEC)The Chinese University of Hong Kong Gerald Choa Neuroscience Centre(7105306)(to HYEC)donations from Chow Tai Fook Charity Foundation(6903898)(to HYEC)Hong Kong Spinocerebellar Ataxia Association(6903291)(to HYEC)supported by the Postdoctoral Fellowship in Clinical Neurosciences of The Chinese University of Hong Kong,China
文摘Yin Yang 1(YY1) is a multi-functional transcription factor that regulates gene expression in a range of cell types,including neurons.It controls neuronal differentiation,as well as neuronal specification and migration during the development of the mammalian nervous system.Besides,YY1 also mediates the transcription of genes that are required for neuronal survival.An impairment of the transcriptional function of YY1 causes neuronal death.This review summarizes recent research findings that unveil the dysfunction of YY1 in multiple neurodegenerative disorders.The expression of disease proteins perturbs the function of YY1 via distinct molecular mechanisms,including recruitment to protein aggregates,protein degradation and aberrant nuclear/cytoplasmic shuttling.Understanding the pathogenic roles of YY1 will further broaden our knowledge of the disease mechanisms in distinct neurodegenerative disorders.
文摘Asthma is characterized by paroxysmaldyspnea,rales in the throat,difficulty in breathing,and inability to lie horizontally.It is commonly seenin children with a weak body constitution,and tendsto be intractable,thus being harmful to the
文摘This paper seeks to examine the image and text relationship in TANG Yin's scroll of poetry and painting from three aspects: The first aspect focuses upon the schema type of its image and text relationship in physical form; the second aspect, explores the text's/poetry's functions of anchorage and relay while appreciating those images/paintings; the third aspect, traces the semiosis process of image, exploring how image and text as cultural products in the epistemological world mediates with the phenomenological world
文摘为了解决微波无线输能系统中微波源的小型化和高效率需求,提出了一种高效谐波调谐功率振荡器的设计方法,振荡器由晶体管、谐波控制网络、反馈网络和负载网络组成。首先,通过调谐晶体管谐波阻抗以减少漏极电压与电流波形的重叠,从而提高其效率;其次,反馈网络与负载网络使用仿真获得的数据合成,两者可独立设计,避免了反馈回路对振荡器输出效率的影响。使用Cree CGH40010F GaN HEMT设计并制作了一款工作在S波段的高效功率振荡器,测试结果表明振荡器在2.445 GHz下成功实现了41.7 dBm的输出功率和79.9%的直流到射频(direct current to radio frequency,DC-RF)转化效率,在偏移载波1 MHz处,相位噪声低至-136 dBc/Hz。该功率振荡器性能优越,在微波无线能量传输系统中具有良好的应用前景。
基金Supported by the National Key Research and Development Program of China(Grant Nos.2017YFF0206103,2016YFB0402301,2018YFB2200801)the National Natural Science Foundation of China(Grant Nos.61635010,61320106013,61474112,and 61574137)。
文摘We report 10 Gb/s data transmissions using a packaged two-section InGaAsP/InP distributed Bragg reflector(DBR)laser.The tunable DBR laser has a wavelength tuning range of 12.12 nm.The DBR laser has greater than 10.84 GHz 3-dB direct modulation bandwidth within the wavelength tuning range.The 10 Gb/s data transmissions are performed at up to a distance of 30-km.