This paper described T cell proliferative response by an alternative pathway in normal subjects and In patients with malignant diseases. Two McAbs, Anti-CCTl and Lo-CD2-act recognizing two distinct epitopes on E-recep...This paper described T cell proliferative response by an alternative pathway in normal subjects and In patients with malignant diseases. Two McAbs, Anti-CCTl and Lo-CD2-act recognizing two distinct epitopes on E-receptor (CD2) were used to costimulate PBMC. Proliferative responsiveness was measured by 3H-thymidine incorporation. It was found that 82% of 72 nonnal subjects gave proliferative response whereas only 23% of the 93 patients did. The average cpm±SD in patients with bladder cancer (118±2314), kidney cancer (1619±2719) or lymphoma (2518±4057) was significantly lower than that in normal subjects (4935±2314), (P<0.001). These results indicate that T cell proliferation through the alternative pathway was significantly depressed in patients with cancer, and this can be used as a new parameter to monitor the immune status of cancer patients.展开更多
Subject Code:C05With the support by the National Natural Science Foundation of China,the research team led by Prof.Gao Ning(高宁)at the Ministry of Education Key Laboratory of Protein Sciences,Beijing Advanced Innovat...Subject Code:C05With the support by the National Natural Science Foundation of China,the research team led by Prof.Gao Ning(高宁)at the Ministry of Education Key Laboratory of Protein Sciences,Beijing Advanced Innovation Center for Structural Biology,School of Life Sciences,Tsinghua University,Beijing,recently reported how bacteria make use of a small protein called ArfA to rescue ribosomes stalled on defective messager RNAs,in Nature(2017,541:550—553).展开更多
In this paper, the theorem of the alternative based on separation functions in ordered locally convex topological vector spaces has been established by using the concept on set valued mappings. The optimality con...In this paper, the theorem of the alternative based on separation functions in ordered locally convex topological vector spaces has been established by using the concept on set valued mappings. The optimality conditions in ref. for D convex function have been generalized to ordered locally convex topological vector space and the similarly optimality conditions for D subconvexlike functions, such as the necessary and sufficient conditions of nondominated solutions, the generalized saddle point theorems and the lagrange duality theorems, have been obtained.展开更多
文摘This paper described T cell proliferative response by an alternative pathway in normal subjects and In patients with malignant diseases. Two McAbs, Anti-CCTl and Lo-CD2-act recognizing two distinct epitopes on E-receptor (CD2) were used to costimulate PBMC. Proliferative responsiveness was measured by 3H-thymidine incorporation. It was found that 82% of 72 nonnal subjects gave proliferative response whereas only 23% of the 93 patients did. The average cpm±SD in patients with bladder cancer (118±2314), kidney cancer (1619±2719) or lymphoma (2518±4057) was significantly lower than that in normal subjects (4935±2314), (P<0.001). These results indicate that T cell proliferation through the alternative pathway was significantly depressed in patients with cancer, and this can be used as a new parameter to monitor the immune status of cancer patients.
文摘Subject Code:C05With the support by the National Natural Science Foundation of China,the research team led by Prof.Gao Ning(高宁)at the Ministry of Education Key Laboratory of Protein Sciences,Beijing Advanced Innovation Center for Structural Biology,School of Life Sciences,Tsinghua University,Beijing,recently reported how bacteria make use of a small protein called ArfA to rescue ribosomes stalled on defective messager RNAs,in Nature(2017,541:550—553).
文摘In this paper, the theorem of the alternative based on separation functions in ordered locally convex topological vector spaces has been established by using the concept on set valued mappings. The optimality conditions in ref. for D convex function have been generalized to ordered locally convex topological vector space and the similarly optimality conditions for D subconvexlike functions, such as the necessary and sufficient conditions of nondominated solutions, the generalized saddle point theorems and the lagrange duality theorems, have been obtained.
