Automation 5.0: The Key to Systems Intelligence and Industry 5.0

AUTOMATION has come a long way since the early days of mechanization,i.e.,the process of working exclusively by hand or using animals to work with machinery.The rise of steam engines and water wheels represented the first generation of industry,which is now called Industry Citation:L.Vlacic,H.Huang,M.Dotoli,Y.Wang,P.Ioanno,L.Fan,X.Wang,R.Carli,C.Lv,L.Li,X.Na,Q.-L.Han,and F.-Y.Wang,“Automation 5.0:The key to systems intelligence and Industry 5.0,”IEEE/CAA J.Autom.Sinica,vol.11,no.8,pp.1723-1727,Aug.2024.

Advances in Polysaccharide-Based Microneedle Systems for the Treatment of Ocular Diseases

The eye,a complex organ isolated from the systemic circulation,presents significant drug delivery challenges owing to its protective mechanisms,such as the blood-retinal barrier and corneal impermeability.Conventional drug administration methods often fail to sustain therapeutic levels and may compromise patient safety and compliance.Polysaccharidebased microneedles(PSMNs)have emerged as a transformative solution for ophthalmic drug delivery.However,a comprehensive review of PSMNs in ophthalmology has not been published to date.In this review,we critically examine the synergy between polysaccharide chemistry and microneedle technology for enhancing ocular drug delivery.We provide a thorough analysis of PSMNs,summarizing the design principles,fabrication processes,and challenges addressed during fabrication,including improving patient comfort and compliance.We also describe recent advances and the performance of various PSMNs in both research and clinical scenarios.Finally,we review the current regulatory frameworks and market barriers that are relevant to the clinical and commercial advancement of PSMNs and provide a final perspective on this research area.

Clinical validation of the early embryo viability assessment system: Analysis for the blastocyst morphology and pregnancy outcomes

Objective:To determine the relationship between the early embryo viability assessment(EEVA)and blastocyst morphological parameters and pregnancy outcomes.Methods:This retrospective cohort study was conducted on 291 intracytoplasmic sperm injection cycles including 2522 embryos with indications of prolonging embryo culture to the blastocyst stage in the Genea embryo review incubator,and 511 single vitrified-warmed blastocyst transfer cycles from January 2020 to June 2023.The EEVA system produced an EEVA score from E1(best)to E5(worse)for the potential of blastocyst formation.Blastocyst morphology was evaluated.The association between the EEVA score and each type of blastocyst morphology,implantation rate,clinical pregnancy,and ongoing pregnancy were assessed using generalized estimating equations.Results:The inner cell mass A(ICM A),trophectoderm A(TE A),blastocoele expansion degree of 3,4,5,6,7 rates were higher with lower the EEVA score.The adjusted odd ratio(aOR)(E5 vs E1)was 0.3 for ICM A,0.174 for TE A and 0.210 for BL3,4,5,6,7(all P<0.001),suggesting a significant association between lower EEVA scores and improved embryo quality.The implantation,clinical pregnancy,and ongoing pregnancy rate were also higher with lower the EEVA score.The aOR of E5 vs E1 was 0.245 for implantation,0.185 for clinical pregnancy and 0.200 for ongoing pregnancy rate(P<0.001).Conclusions:There were associations between blastocyst morphology,pregnancy outcome and EEVA scores.The good blastocyst morphology and pregnancy outcomes are higher with lower the EEVA score.

A Home Automation Control System Based on LabVIEW

The objective of this project is to explore the possibility of using X-10 and LabVIEW to control the device in the house. Based on the serial port communication of LabVIEW, the X-10 module can be programmed by using the X-10 commands. Through the power line, all the devices connected to the socket will be controlled. Without replacing the existing wire, it must be an easy control system for the user who has no experience in electronics or communication engineering. Actually, this is a quite practical X-10 home automation system.

Instrument Automation Control System Faults and Maintenance

This article explores the topic of fault diagnosis and maintenance strategies for instrument automation control systems,analyzing them through specific cases.The aim of this research is to improve the stability and reliability of the system by conducting a thorough investigation of faults and maintenance in instrument automation control systems.By doing so,this research hopes to provide a strong guarantee for the smooth progress of industrial production.

Teaching Mode Reform of the Electrical Automation Control Course

Under the background of the new era,higher requirements are put forward for colleges and universities to carry out teaching reform.Teachers of electrical automation control courses should update their teaching ideas regularly,innovate teaching methods,and take novel and effective measures to carry out related work.Because electrical automation control courses tend to be technology-oriented,teachers can help students consolidate basic knowledge.They should also focus on developing practical skills so students can easily adapt to future job positions.However,there are many problems in the actual teaching process,which hampers the improvement of the teaching quality to a certain extent.In view of this,this paper presents an in-depth exploration based on theories and practical experiences.It starts with an analysis of the current teaching status of electrical automation control courses in colleges and universities,followed by suggestions to improve them based on their characteristics and students’needs.

The ChatGPT After: Building Knowledge Factories for Knowledge Workers with Knowledge Automation

Briefing: This perspective introduces the concept and framework of knowledge factories with knowledge machines for knowledge workers to achieve knowledge automation for Industry 5.0 and intelligent industries.Introduction The big hit of Chat GPT makes it imperative to contemplate the practical applications of big or foundation models [1]-[5]. However, as compared to conventional models, there is now an increasingly urgent need for foundation intelligence of foundation models for real-world industrial applications.

Intranasal administration of stem cell-derived exosomes for central nervous system diseases

Exosomes,lipid bilayer-enclosed small cellular vesicles,are actively secreted by various cells and play crucial roles in intercellular communication.These nanosized vesicles transport internalized proteins,mRNA,miRNA,and other bioactive molecules.Recent findings have provided compelling evidence that exosomes derived from stem cells hold great promise as a therapeutic modality for central nervous system disorders.These exosomes exhibit multifaceted properties including antiapoptotic,anti-inflammatory,neurogenic,and vasculogenic effects.Furthermore,exosomes offer several advantages over stem cell therapy,such as high preservation capacity,low immunogenicity,the ability to traverse the blood-brain barrier,and the potential for drug encapsulation.Consequently,researchers have turned their attention to exosomes as a novel therapeutic avenue.Nonetheless,akin to the limitations of stem cell treatment,the limited accumulation of exosomes in the injured brain poses a challenge to their clinical application.To overcome this hurdle,intranasal administration has emerged as a non-invasive and efficacious route for delivering drugs to the central nervous system.By exploiting the olfactory and trigeminal nerve axons,this approach enables the direct transport of therapeutics to the brain while bypassing the blood-brain barrier.Notably,exosomes,owing to their small size,can readily access the nerve pathways using this method.As a result,intranasal administration has gained increasing recognition as an optimal therapeutic strategy for exosomebased treatments.In this comprehensive review,we aim to provide an overview of both basic and clinical research studies investigating the intranasal administration of exosomes for the treatment of central nervous system diseases.Furthermore,we elucidate the underlying therapeutic mechanisms and offer insights into the prospect of this approach.

The DAO to MetaControl for MetaSystems in Metaverses:The System of Parallel Control Systems for Knowledge Automation and Control Intelligence in CPSS

An investigation and outline of MetaControl and DeControl in Metaverses for control intelligence and knowledge automation are presented.Prescriptive control with prescriptive knowledge and parallel philosophy is proposed as the starting point for the new control philosophy and technology,especially for computational control of metasystems in cyberphysical-social systems.We argue that circular causality,the generalized feedback mechanism for complex and purposive systems,should be adapted as the fundamental principle for control and management of metasystems with metacomplexity in metaverses.Particularly,an interdisciplinary approach is suggested for MetaControl and DeControl as a new form of intelligent control based on five control metaverses:MetaVerses,MultiVerses,InterVerses,TransVerse,and DeepVerses.

Efficient and Secure IoT Based Smart Home Automation Using Multi-Model Learning and Blockchain Technology

The concept of smart houses has grown in prominence in recent years.Major challenges linked to smart homes are identification theft,data safety,automated decision-making for IoT-based devices,and the security of the device itself.Current home automation systems try to address these issues but there is still an urgent need for a dependable and secure smart home solution that includes automatic decision-making systems and methodical features.This paper proposes a smart home system based on ensemble learning of random forest(RF)and convolutional neural networks(CNN)for programmed decision-making tasks,such as categorizing gadgets as“OFF”or“ON”based on their normal routine in homes.We have integrated emerging blockchain technology to provide secure,decentralized,and trustworthy authentication and recognition of IoT devices.Our system consists of a 5V relay circuit,various sensors,and a Raspberry Pi server and database for managing devices.We have also developed an Android app that communicates with the server interface through an HTTP web interface and an Apache server.The feasibility and efficacy of the proposed smart home automation system have been evaluated in both laboratory and real-time settings.It is essential to use inexpensive,scalable,and readily available components and technologies in smart home automation systems.Additionally,we must incorporate a comprehensive security and privacy-centric design that emphasizes risk assessments,such as cyberattacks,hardware security,and other cyber threats.The trial results support the proposed system and demonstrate its potential for use in everyday life.

Design and Research of High-throughput Automation System for Food Testing Laboratory

In the process of food testing,human operation is an important variable affecting the experimental results.In order to reasonably avoid the influence of human subjective operation behavior on the accuracy of detection results,the laboratory information management system was used as the information platform to design a high-throughput laboratory automation pre-treatment system based on the deep integration of mechanical principles,visual analysis,high-speed conduction,intelligent storage and other technical systems.The experimental results showed that the system could shorten the sample circulation cycle,effectively improve the laboratory biosafety,and meet the requirements of high-throughput processing of samples.

Hypothalamic circuits and aging:keeping the circadian clock updated

Over the past century,age-related diseases,such as cancer,type-2 diabetes,obesity,and mental illness,have shown a significant increase,negatively impacting overall quality of life.Studies on aged animal models have unveiled a progressive discoordination at multiple regulatory levels,including transcriptional,translational,and post-translational processes,resulting from cellular stress and circadian derangements.The circadian clock emerges as a key regulator,sustaining physiological homeostasis and promoting healthy aging through timely molecular coordination of pivotal cellular processes,such as stem-cell function,cellular stress responses,and inter-tissue communication,which become disrupted during aging.Given the crucial role of hypothalamic circuits in regulating organismal physiology,metabolic control,sleep homeostasis,and circadian rhythms,and their dependence on these processes,strategies aimed at enhancing hypothalamic and circadian function,including pharmacological and non-pharmacological approaches,offer systemic benefits for healthy aging.Intranasal brain-directed drug administration represents a promising avenue for effectively targeting specific brain regions,like the hypothalamus,while reducing side effects associated with systemic drug delivery,thereby presenting new therapeutic possibilities for diverse age-related conditions.

Design of Traditional Chinese Medicine Extraction Workshop Process and Automation System

Objective: This paper takes the example of a Panax notoginseng extraction workshop and designs an automated production workshop with advanced domestic capabilities. Methods: 1) Based on the small-scale Panax notoginseng extraction process, the feasibility of the workshop production process is demonstrated. 2) The workshop process design for Panax Notoginseng saponin extraction is completed, including production organization plans and the selection of key equipment. 3) For the Panax notoginseng extraction workshop process, an automated production control system is designed. Conclusion: Through optimized design of the production process and automation system, continuous and automated production of traditional Chinese medicine extraction is achieved, leading to improvements in drug quality and production efficiency.

The Configuration and Communication of Integrated Substation Automation Systems

Based on a discussion of the feature of a substation, the paper presents the concept that a substation is composed of basic units (BC). The hardware structure of the IED of a BC is described. Next, the paper discusses the communication mode of the current Integrated Substation Automation Systems(ISA) and describes the hardware structre and the functions of the ISA with fieldbus. At last the paper presents trends in the development of ISA.

Maximizing the Efficiency of Automation Solutions with Automation 360: Approaches for Developing Subtasks and Retry Framework

I present a solution that explores the use of A360 subtasks as a comparable concept to functions in programming. By leveraging subtasks as reusable and maintainable functions, users can efficiently develop customized high-quality automation solutions. Additionally, the paper introduces the retry framework, which allows for the automatic retrying of subtasks in the event of system or unknown exceptions. This framework enhances efficiency and reduces the manual effort required to retrigger bots. The A360 Subtask and Retry Framework templates provide valuable assistance to both professional and citizen developers, improving code quality, maintainability, and the overall efficiency and resiliency of automation solutions.

The Age of Automation China has been the world’s largest consumer of industrial robots for nine consecutive years

In the latest Chinese science fiction film The Wandering Earth II,viewers can see a broad variety of robots,from the super robot with artificial intelligence to the four-legged bionic robot.Many of the robots portrayed in the movie are actual robots that are being used in manufacturing,commerce,logistics,and healthcare,rather than being special effects,which are the creation of Youibot,a hi-tech company based in Shenzhen,south China’s Guangdong Province.

Implementation of Embedded Ethernet Based on Hardware Protocol Stack in Substation Automation System

Embedded Ethernet technology has been utilized increasingly widely as the communication mode in the substation automation system(SAS).This paper introduces the current applying situation about embedded Ethernet in SAS First.After analyzing the protocol levels used in SAS based on embedded Ethernet and the differences between the TCP and UDP,UDP/IP is selected as the communication protocol between the station-level and bay-level devices for its real-time characteristic.Then a new kind of implementation of the embedded Ethernet is presented based on hardware protocol stack.The designed scheme can be implemented easily,reduce cost significantly and shorten developing cycle.

Prospects of Using Low-Code in the Creation of Automated Systems

Ever-changing market conditions and a rapidly changing IT landscape call for fast and cheap ways to meet software demands. In order to tackle these problems, low-code development platforms (LCDPs) have emerged. These platforms are designed with the idea to limit recurring traditional hand-coding and programming. This article provides a theoretical overview of low-code solutions. The advantages and disadvantages of using LCDP in the creation of automated systems are considered. In conclusion, a conclusion is formulated about the prospects of using low-code technology.

Optimization and Construction of Collaborative Office under the Background of Smart Campus in Universities

At present, with the continuous development of technologies such as the Internet, big data, and artificial intelligence, smart campuses in universities are being rapidly constructed. Improving the informatization level of administrative management work is also an important content. The collaborative office work in multiple departments requires more standardized, convenient, intelligent, and secure office systems. In response to this issue, this article analyzes the optimization and construction process of collaborative office systems based on the development of university informatization, summarizes the operational results, and explores the prospects of smart office.

Goal-Oriented Control Systems(GOCS):From HOW to WHAT

Brief:New control theory is required to underpin safe design and deployment of future highly automated systems to deal with uncertain environments and complicated tasks,enabled by AI and other advanced technologies.Goal-Oriented Control Systems offer potential to transform the control system design from currently instructing a control system how to perform a task to specifying what is to be achieved.