The Road Not Taken is one of the best known poems by Robert Frost.Simple and beautiful in form,it is profound in meaning.It reflects the tragedy of human beings as a whole and also the personal tragedy of the poet him...The Road Not Taken is one of the best known poems by Robert Frost.Simple and beautiful in form,it is profound in meaning.It reflects the tragedy of human beings as a whole and also the personal tragedy of the poet himself,and as a consequence,it is tinted with an exotic sense of tragic beauty.展开更多
The TEEOF method that expands temporally is used to conduct a diagnostic study of the variation patterns of 1, 3, 6 and 10 years with regard to mean air temperature over the globe and Southern and Northern Hemispheres...The TEEOF method that expands temporally is used to conduct a diagnostic study of the variation patterns of 1, 3, 6 and 10 years with regard to mean air temperature over the globe and Southern and Northern Hemispheres over the course of 100 years. The results show that the first mode of TEEOF takes up more than 50% in the total variance, with each of the first mode in the interannual oscillations generally standing for annually varying patterns which are related with climate and reflecting long-term tendency of change in air temperature. It is particularly true for the first mode on the 10-year scale, which shows an obvious ascending trend concerning the temperature in winter and consistently the primary component of time goes in a way that is very close to the sequence of actual temperature. Apart from the first mode of all time sections of TEEOF for the globe and the two hemispheres and the second mode of the 1-year TEEOF, interannual variation described by other characteristic vectors are showing various patterns, with corresponding primary components having relation with long-term variability of specific interannual quasi-periodic oscillation structures. A 2T test applied to the annual variation pattern shows that the abrupt changes for the Southern Hemisphere and the globe come closer to the result of a uni-element t test for mean temperature than those for the Northern Hemisphere do. It indicates that the 2Ttest, when carried out with patterns of multiple variables, seems more reasonable than the t test with single elements.展开更多
The adoptive transfer of T cells is a promising approach to treat cancers. Primary human T cells can be modified using viral and non-viral vectors to promote the specific targeting of cancer cells via the introduction...The adoptive transfer of T cells is a promising approach to treat cancers. Primary human T cells can be modified using viral and non-viral vectors to promote the specific targeting of cancer cells via the introduction of exogenous T-cell receptors(TCRs) or chimeric antigen receptors(CARs). This gene transfer displays the potential to increase the specificity and potency of the anticancer response while decreasing the systemic adverse effects that arise from conventional treatments that target both cancerous and healthy cells. This review highlights the generation of clinical-grade T cells expressing CARs for immunotherapy, the use of these cells to target B-cell malignancies and, particularly, the first clinical trials deploying the Sleeping Beauty gene transfer system, which engineers T cells to target CD19+ leukemia and non-Hodgkin's lymphoma.展开更多
It is difficult to measure the online values of biochemical oxygen demand(BOD) due to the characteristics of nonlinear dynamics, large lag and uncertainty in wastewater treatment process. In this paper, based on the k...It is difficult to measure the online values of biochemical oxygen demand(BOD) due to the characteristics of nonlinear dynamics, large lag and uncertainty in wastewater treatment process. In this paper, based on the knowledge representation ability and learning capability, an improved T–S fuzzy neural network(TSFNN) is introduced to predict BOD values by the soft computing method. In this improved TSFNN, a K-means clustering is used to initialize the structure of TSFNN, including the number of fuzzy rules and parameters of membership function. For training TSFNN, a gradient descent method with the momentum item is used to adjust antecedent parameters and consequent parameters. This improved TSFNN is applied to predict the BOD values in effluent of the wastewater treatment process. The simulation results show that the TSFNN with K-means clustering algorithm can measure the BOD values accurately. The algorithm presents better approximation performance than some other methods.展开更多
Generalized linear mixed models (GLMMs) are typically constructed by incorporating random effects into the linear predictor. The random effects are usually assumed to be normally distributed with mean zero and varianc...Generalized linear mixed models (GLMMs) are typically constructed by incorporating random effects into the linear predictor. The random effects are usually assumed to be normally distributed with mean zero and variance-covariance identity matrix. In this paper, we propose to release random effects to non-normal distributions and discuss how to model the mean and covariance structures in GLMMs simultaneously. Parameter estimation is solved by using Quasi-Monte Carlo (QMC) method through iterative Newton-Raphson (NR) algorithm very well in terms of accuracy and stabilization, which is demonstrated by real binary salamander mating data analysis and simulation studies.展开更多
认知语法框架下的构式搭配分析通过参照一般认知能力描写情景编码的语义结构,并从认知加工的角度探究搭配的典型性和多样性,进而弥补认知构式语法在结果阐释阶段的不足。以让步构式Just Because X Doesn't Mean Y(JBX-DMY)为例,从...认知语法框架下的构式搭配分析通过参照一般认知能力描写情景编码的语义结构,并从认知加工的角度探究搭配的典型性和多样性,进而弥补认知构式语法在结果阐释阶段的不足。以让步构式Just Because X Doesn't Mean Y(JBX-DMY)为例,从侧显和视角两个维度对其代词共现词位进行阐释,并提出经验性和概念性理据的区分。展开更多
In the present paper, an attempt is made to obtain the degree of approximation of conjugate of functions (signals) belonging to the generalized weighted W(LP, ξ(t)), (p ≥ 1)-class, by using lower triangular matrix o...In the present paper, an attempt is made to obtain the degree of approximation of conjugate of functions (signals) belonging to the generalized weighted W(LP, ξ(t)), (p ≥ 1)-class, by using lower triangular matrix operator of conjugate series of its Fourier series.展开更多
文摘The Road Not Taken is one of the best known poems by Robert Frost.Simple and beautiful in form,it is profound in meaning.It reflects the tragedy of human beings as a whole and also the personal tragedy of the poet himself,and as a consequence,it is tinted with an exotic sense of tragic beauty.
文摘The TEEOF method that expands temporally is used to conduct a diagnostic study of the variation patterns of 1, 3, 6 and 10 years with regard to mean air temperature over the globe and Southern and Northern Hemispheres over the course of 100 years. The results show that the first mode of TEEOF takes up more than 50% in the total variance, with each of the first mode in the interannual oscillations generally standing for annually varying patterns which are related with climate and reflecting long-term tendency of change in air temperature. It is particularly true for the first mode on the 10-year scale, which shows an obvious ascending trend concerning the temperature in winter and consistently the primary component of time goes in a way that is very close to the sequence of actual temperature. Apart from the first mode of all time sections of TEEOF for the globe and the two hemispheres and the second mode of the 1-year TEEOF, interannual variation described by other characteristic vectors are showing various patterns, with corresponding primary components having relation with long-term variability of specific interannual quasi-periodic oscillation structures. A 2T test applied to the annual variation pattern shows that the abrupt changes for the Southern Hemisphere and the globe come closer to the result of a uni-element t test for mean temperature than those for the Northern Hemisphere do. It indicates that the 2Ttest, when carried out with patterns of multiple variables, seems more reasonable than the t test with single elements.
文摘The adoptive transfer of T cells is a promising approach to treat cancers. Primary human T cells can be modified using viral and non-viral vectors to promote the specific targeting of cancer cells via the introduction of exogenous T-cell receptors(TCRs) or chimeric antigen receptors(CARs). This gene transfer displays the potential to increase the specificity and potency of the anticancer response while decreasing the systemic adverse effects that arise from conventional treatments that target both cancerous and healthy cells. This review highlights the generation of clinical-grade T cells expressing CARs for immunotherapy, the use of these cells to target B-cell malignancies and, particularly, the first clinical trials deploying the Sleeping Beauty gene transfer system, which engineers T cells to target CD19+ leukemia and non-Hodgkin's lymphoma.
基金Supported by the National Natural Science Foundation of China(61203099,61034008,61225016)Beijing Science and Technology Project(Z141100001414005)+3 种基金Beijing Science and Technology Special Project(Z141101004414058)Ph.D.Program Foundation from Ministry of Chinese Education(20121103120020)Beijing Nova Program(Z131104000413007)Hong Kong Scholar Program(XJ2013018)
文摘It is difficult to measure the online values of biochemical oxygen demand(BOD) due to the characteristics of nonlinear dynamics, large lag and uncertainty in wastewater treatment process. In this paper, based on the knowledge representation ability and learning capability, an improved T–S fuzzy neural network(TSFNN) is introduced to predict BOD values by the soft computing method. In this improved TSFNN, a K-means clustering is used to initialize the structure of TSFNN, including the number of fuzzy rules and parameters of membership function. For training TSFNN, a gradient descent method with the momentum item is used to adjust antecedent parameters and consequent parameters. This improved TSFNN is applied to predict the BOD values in effluent of the wastewater treatment process. The simulation results show that the TSFNN with K-means clustering algorithm can measure the BOD values accurately. The algorithm presents better approximation performance than some other methods.
文摘Generalized linear mixed models (GLMMs) are typically constructed by incorporating random effects into the linear predictor. The random effects are usually assumed to be normally distributed with mean zero and variance-covariance identity matrix. In this paper, we propose to release random effects to non-normal distributions and discuss how to model the mean and covariance structures in GLMMs simultaneously. Parameter estimation is solved by using Quasi-Monte Carlo (QMC) method through iterative Newton-Raphson (NR) algorithm very well in terms of accuracy and stabilization, which is demonstrated by real binary salamander mating data analysis and simulation studies.
文摘认知语法框架下的构式搭配分析通过参照一般认知能力描写情景编码的语义结构,并从认知加工的角度探究搭配的典型性和多样性,进而弥补认知构式语法在结果阐释阶段的不足。以让步构式Just Because X Doesn't Mean Y(JBX-DMY)为例,从侧显和视角两个维度对其代词共现词位进行阐释,并提出经验性和概念性理据的区分。
文摘In the present paper, an attempt is made to obtain the degree of approximation of conjugate of functions (signals) belonging to the generalized weighted W(LP, ξ(t)), (p ≥ 1)-class, by using lower triangular matrix operator of conjugate series of its Fourier series.
