AIM To evaluate the reliability of pronator quadratus fat pad sign to detect distal radius fracture and to predict its severity.METHODS Retrospectively we identified 89 consecutive patients(41 female, mean age 49 ...AIM To evaluate the reliability of pronator quadratus fat pad sign to detect distal radius fracture and to predict its severity.METHODS Retrospectively we identified 89 consecutive patients(41 female, mean age 49 ± 18 years) who had X-ray(CR) and computed tomography(CT) within 24 h following distal forearm trauma. Thickness of pronator quadratus fat pad complex(PQC) was measured using lateral views(CR) and sagittal reconstructions(CT). Pearson's test was used to determine the correlation of the PQC thickness in CR and CT. A positive pronator quadratus sign(PQS) was defined as a PQC > 8.0 mm(female) or > 9.0 mm(male). Frykman classification was utilized to assess the severity of fractures.RESULTS Forty-four/89 patients(49%) had a distal radius fracture(Frykman Ⅰ n = 3, Ⅱ n = 0, Ⅲ n = 10, Ⅳ n = 5, Ⅴ n = 2, Ⅵ n = 2, Ⅶ n = 9, Ⅷ n = 13). Mean thickness of the PQC thickness can reliably be measured on X-ray views and was 7.5 ± 2.8 mm in lateral views(CR), respectively 9.4 ± 3.0 mm in sagittal reconstructions(CT), resulting in a significant correlation coefficientof 0.795. A positive PQS at CR was present in 21/44 patients(48%) with distal radius fracture and in 2/45 patients(4%) without distal radius fracture, resulting in a specificity of 96% and a sensitivity of 48% for the detection of distal radius fractures. There was no correlation between thickness of the PQC and severity of distal radius fractures.CONCLUSION A positive PQS shows high specificity but low sensitivity for detection of distal radius fractures. The PQC thickness cannot predict the severity of distal radius fractures.展开更多
目的采用非对称采集与迭代最小二乘估算法迭代水脂分离(iteraterative decomposition of water and fat with echo asymmetry and least-squares estimation quantitation,IDEAL-IQ)方法定量评估冈上肌腱损伤的严重程度与肩袖肌群脂肪...目的采用非对称采集与迭代最小二乘估算法迭代水脂分离(iteraterative decomposition of water and fat with echo asymmetry and least-squares estimation quantitation,IDEAL-IQ)方法定量评估冈上肌腱损伤的严重程度与肩袖肌群脂肪浸润程度及受试者特征之间的关系。材料与方法回顾性分析2022年8月至2024年6月本院经肩关节镜证实的33例冈上肌腱部分撕裂患者及89例完全撕裂患者,均进行了常规MRI扫描及IDEAL-IQ序列扫描。由两名放射科医生分别对所有受试者的MRI图像进行独立评估,根据常规MRI图像的冈上肌腱损伤表现,将完全撕裂组的冈上肌腱按照Patte分型分为Patte 1型(Ⅱ级)、Patte 2型(Ⅲ级)、Patte 3型(Ⅳ级),将部分撕裂组定义为Ⅰ级。同时在斜矢状位上进行Goutallier分级及Thomazeau萎缩分级,并通过GE ADW 4.7工作站后处理软件在IDEAL-IQ序列生成的脂肪分数图像上测量冈上肌、冈下肌、肩胛下肌及小圆肌脂肪分数(fat fraction,FF)。用组内相关系数(intra-class correlation coefficient,ICC)及Kappa一致性检验评估观察者间及观察者内的一致性。采用Kruskal-Wallis H检验、单因素ANOVA检验分析FF值在不同分组之间的差异,组间两两比较用Bonferroni检验。采用Pear_(s)on相关性分析肩袖肌肉FF值与年龄、症状持续时间的相关性(相关系数r),Spearman相关性分析冈上肌腱损伤分级与肩袖肌群FF值、Goutallier分级及Thomazeau萎缩分级之间的相关性(相关系数r_(s))。结果(1)冈上肌、冈下肌、肩胛下肌的FF值在冈上肌腱损伤Ⅳ级中显著高于Ⅲ级,高于Ⅱ级和Ⅰ级,差异有统计学意义(P值分别为<0.001、<0.001、0.005);小圆肌的FF值在不同分级之间差异无统计学意义(P=0.073)。组内比较Ⅰ级和Ⅱ级的冈上肌、冈下肌、肩胛下肌、小圆肌FF值差异无统计学意义(P值分别为0.026、0.102);Ⅲ级和Ⅳ级的FF值差异有统计学意义(P<0.001)。(2)冈上肌、冈下肌、小圆肌的FF值与年龄呈中等相关(r值分别为0.381、0.339、0.349,P均<0.001),肩胛下肌的FF值与年龄呈弱相关(r=0.216,P=0.017);冈上肌、冈下肌、肩胛下肌FF值与症状持续时间呈中等程度相关(r分别为0.442、0.412、0.314,P均<0.001),小圆肌的FF值与症状持续时间呈弱相关(r=0.277,P=0.002);冈上肌腱损伤程度与冈上肌FF值呈显著相关(r_(s)=0.740,P<0.001),与冈下肌的FF值呈强相关性(r_(s)=0.596,P<0.001),与肩胛下肌、小圆肌的FF值呈弱相关(r_(s)分别为0.257、0.212,P值分别为0.004、0.019);冈上肌损伤程度分级与Goutallier分级、Thomazeau分级之间呈显著正相关(r_(s)分别为0.757、0.737,P均<0.001),且冈上肌FF值在Goutallier和Thomazeau的分级中差异具有统计学意义(P均<0.001)。结论3.0 T MR IDEAL-IQ序列能量化和客观评估肩袖肌群脂肪浸润程度,肩袖肌群脂肪浸润程度与冈上肌腱损伤分级呈正相关,与年龄、症状持续时间呈正相关。展开更多
Objective: Aspirin resistance (AR) or poor response to aspirin is said to be high among subjects with diabetes and more so in patients with poor glycemic control. The aim of our study was to evaluate the prevalence of...Objective: Aspirin resistance (AR) or poor response to aspirin is said to be high among subjects with diabetes and more so in patients with poor glycemic control. The aim of our study was to evaluate the prevalence of AR among subjects with diabetes with moderate glycemic control and its association with inflammatory markers and cytokines. Design: This is a single-center open-label prospective clinical study. Methods: The study included 142 young male veterans (mean age of 49years) with Type 2 diabetes, with HbA1C of 7.7 ± 1.1. Urinary 11-dehydro-thromboxane beta-2 (11DhTx2) concentrations measured by immunoassay are the primary outcome measures. Results: Urinary 11DhTxB2 levels ≥ 1500 pg/mg of creatinine is considered as AR. Approximately 53% of subjects had AR. There are no significant differences in the clinical parameters, such as age, history of hypertension or BMI, waist to hip ratio;as well as biochemical parameters, such as HbA1C, lipid parameters or serum creatinine, between subjects with or without AR. Levels of 11DhTxB2 /cre correlated with history of CAD, abdominal fat content and IL-6 levels (p < 0.01) as well as abdominal fat content and IL-6 levels;duration of diabetes and history of CAD. Conclusions: Aspirin resistance is common in subjects with diabetes even with moderate control. Additional measures to improve aspirin response should be considered. Further studies with larger groups are needed to clarify the AR with various associated risk factors.展开更多
文摘AIM To evaluate the reliability of pronator quadratus fat pad sign to detect distal radius fracture and to predict its severity.METHODS Retrospectively we identified 89 consecutive patients(41 female, mean age 49 ± 18 years) who had X-ray(CR) and computed tomography(CT) within 24 h following distal forearm trauma. Thickness of pronator quadratus fat pad complex(PQC) was measured using lateral views(CR) and sagittal reconstructions(CT). Pearson's test was used to determine the correlation of the PQC thickness in CR and CT. A positive pronator quadratus sign(PQS) was defined as a PQC > 8.0 mm(female) or > 9.0 mm(male). Frykman classification was utilized to assess the severity of fractures.RESULTS Forty-four/89 patients(49%) had a distal radius fracture(Frykman Ⅰ n = 3, Ⅱ n = 0, Ⅲ n = 10, Ⅳ n = 5, Ⅴ n = 2, Ⅵ n = 2, Ⅶ n = 9, Ⅷ n = 13). Mean thickness of the PQC thickness can reliably be measured on X-ray views and was 7.5 ± 2.8 mm in lateral views(CR), respectively 9.4 ± 3.0 mm in sagittal reconstructions(CT), resulting in a significant correlation coefficientof 0.795. A positive PQS at CR was present in 21/44 patients(48%) with distal radius fracture and in 2/45 patients(4%) without distal radius fracture, resulting in a specificity of 96% and a sensitivity of 48% for the detection of distal radius fractures. There was no correlation between thickness of the PQC and severity of distal radius fractures.CONCLUSION A positive PQS shows high specificity but low sensitivity for detection of distal radius fractures. The PQC thickness cannot predict the severity of distal radius fractures.
文摘目的采用非对称采集与迭代最小二乘估算法迭代水脂分离(iteraterative decomposition of water and fat with echo asymmetry and least-squares estimation quantitation,IDEAL-IQ)方法定量评估冈上肌腱损伤的严重程度与肩袖肌群脂肪浸润程度及受试者特征之间的关系。材料与方法回顾性分析2022年8月至2024年6月本院经肩关节镜证实的33例冈上肌腱部分撕裂患者及89例完全撕裂患者,均进行了常规MRI扫描及IDEAL-IQ序列扫描。由两名放射科医生分别对所有受试者的MRI图像进行独立评估,根据常规MRI图像的冈上肌腱损伤表现,将完全撕裂组的冈上肌腱按照Patte分型分为Patte 1型(Ⅱ级)、Patte 2型(Ⅲ级)、Patte 3型(Ⅳ级),将部分撕裂组定义为Ⅰ级。同时在斜矢状位上进行Goutallier分级及Thomazeau萎缩分级,并通过GE ADW 4.7工作站后处理软件在IDEAL-IQ序列生成的脂肪分数图像上测量冈上肌、冈下肌、肩胛下肌及小圆肌脂肪分数(fat fraction,FF)。用组内相关系数(intra-class correlation coefficient,ICC)及Kappa一致性检验评估观察者间及观察者内的一致性。采用Kruskal-Wallis H检验、单因素ANOVA检验分析FF值在不同分组之间的差异,组间两两比较用Bonferroni检验。采用Pear_(s)on相关性分析肩袖肌肉FF值与年龄、症状持续时间的相关性(相关系数r),Spearman相关性分析冈上肌腱损伤分级与肩袖肌群FF值、Goutallier分级及Thomazeau萎缩分级之间的相关性(相关系数r_(s))。结果(1)冈上肌、冈下肌、肩胛下肌的FF值在冈上肌腱损伤Ⅳ级中显著高于Ⅲ级,高于Ⅱ级和Ⅰ级,差异有统计学意义(P值分别为<0.001、<0.001、0.005);小圆肌的FF值在不同分级之间差异无统计学意义(P=0.073)。组内比较Ⅰ级和Ⅱ级的冈上肌、冈下肌、肩胛下肌、小圆肌FF值差异无统计学意义(P值分别为0.026、0.102);Ⅲ级和Ⅳ级的FF值差异有统计学意义(P<0.001)。(2)冈上肌、冈下肌、小圆肌的FF值与年龄呈中等相关(r值分别为0.381、0.339、0.349,P均<0.001),肩胛下肌的FF值与年龄呈弱相关(r=0.216,P=0.017);冈上肌、冈下肌、肩胛下肌FF值与症状持续时间呈中等程度相关(r分别为0.442、0.412、0.314,P均<0.001),小圆肌的FF值与症状持续时间呈弱相关(r=0.277,P=0.002);冈上肌腱损伤程度与冈上肌FF值呈显著相关(r_(s)=0.740,P<0.001),与冈下肌的FF值呈强相关性(r_(s)=0.596,P<0.001),与肩胛下肌、小圆肌的FF值呈弱相关(r_(s)分别为0.257、0.212,P值分别为0.004、0.019);冈上肌损伤程度分级与Goutallier分级、Thomazeau分级之间呈显著正相关(r_(s)分别为0.757、0.737,P均<0.001),且冈上肌FF值在Goutallier和Thomazeau的分级中差异具有统计学意义(P均<0.001)。结论3.0 T MR IDEAL-IQ序列能量化和客观评估肩袖肌群脂肪浸润程度,肩袖肌群脂肪浸润程度与冈上肌腱损伤分级呈正相关,与年龄、症状持续时间呈正相关。
文摘Objective: Aspirin resistance (AR) or poor response to aspirin is said to be high among subjects with diabetes and more so in patients with poor glycemic control. The aim of our study was to evaluate the prevalence of AR among subjects with diabetes with moderate glycemic control and its association with inflammatory markers and cytokines. Design: This is a single-center open-label prospective clinical study. Methods: The study included 142 young male veterans (mean age of 49years) with Type 2 diabetes, with HbA1C of 7.7 ± 1.1. Urinary 11-dehydro-thromboxane beta-2 (11DhTx2) concentrations measured by immunoassay are the primary outcome measures. Results: Urinary 11DhTxB2 levels ≥ 1500 pg/mg of creatinine is considered as AR. Approximately 53% of subjects had AR. There are no significant differences in the clinical parameters, such as age, history of hypertension or BMI, waist to hip ratio;as well as biochemical parameters, such as HbA1C, lipid parameters or serum creatinine, between subjects with or without AR. Levels of 11DhTxB2 /cre correlated with history of CAD, abdominal fat content and IL-6 levels (p < 0.01) as well as abdominal fat content and IL-6 levels;duration of diabetes and history of CAD. Conclusions: Aspirin resistance is common in subjects with diabetes even with moderate control. Additional measures to improve aspirin response should be considered. Further studies with larger groups are needed to clarify the AR with various associated risk factors.
