Systematic and Theoretical Unfolding of Research on Xi Jinping’s Discourses on Respecting and Protecting Human Rights

Xi Jinping’s discourses on respecting and protect-ing human rights stand as a shining example of the sinicization and modernization of Marxist human rights theory,embodying profound theoretical,political,practical,and cultural logic.Existing research has conducted comprehensive and systematic theoretical analysis and academic extractions on the following contents:the core essence in-herent in these important discourses,including the“theory of human rights concepts,”the“theory of human rights paths,”the“theory of human rights practices,”the“theory of human rights protection,”and the“theory of human rights governance,”along with their profound theoretical significance,practical significance,and global signifi-cance.In the future,researchers should emphasize efforts on studying the original texts and understanding the original principles.While focusing on the precision of concepts,the scientific nature of the prop-ositions,the maturity of theoretical systems,and the rigor of internal logic related to Xi Jinping’s discourses on respecting and protecting human rights,researchers should also pay attention to constructing a discourse system on human rights from the dimensions of discourse power,discourse cluster,and discourse field.Researchers should be adept at drawing innovative insights into human rights theory from China’s vibrant human rights practices and the vast masses of people.This approach will facilitate the systematic unfolding,academic trans-formation,and innovative development of Xi Jinping’s discourses on respecting and protecting human rights.

Marx's Theory of Humanity and Nature

Marx's theory of humanity and nature is an indispensable part of Marx's theory of social development. The history of the development of human society is essentially a natural historical process. Human must start from certain natural premises and start from a combination of certain natural premises and human practices. This is the objective process and inevitable law of the development of human society. Grasping and understanding the scientific connotation of Marx's theory of humanity and nature has very important guiding significance for the development of human society.

Discussion on Action and Potential of Fenlong Megascience in the Symbiosis between Human and Nature

The fourth new farming model Fenlong is identified as megascience for the first time. Fenlong can be directly applied to farming of farmland, remoulding of mortar black soil and saline alkali land and development of degraded grassland. Deep loosening can create huge soil reservoirs, reduce fertilization, promote indi- rectly the improvement of river water fisheries and water sources and the upgrading of shaping and hydropower industry, thus making a new round of mobilization and pooling of natural resources. As a result, the nature is able to produce good food needed by human, the spatial dimension of the land is increased, the natural pre- cipitation storage is increased, the flood and drought disasters are reduced, the eco-environment is improved, and the economic benefits are increased. Fenlong is not restricted to global application by ecological region and crop variety and is not subject to the time-space constraints for a hundred thousand years. On the basis of utilizing the heaven and earth resources, it brings about a huge effect of mega- science. Compare with traditional farming, the depth under the mode of Fenlong is increased by 2-3 times, the contents of nutrient, water, oxygen and microorganism in the soil are increased by 10%-200%, the content of pale salt is increased by 20%-40%, the temperature is increased by 2-4 ~C, and the photosynthetic efficiency of crops is improved by 10%. Under the cultivation mode of Fenlong, the yield of crop applied with no fertilizers is increased by more than 10%, crop yield is still in- creased by more than 5% when the application amount of chemical fertilizer is re- duced by 10%-20%. Under the farming mode of Fenlong combined with no in- crease in fertilization, the crop yield, crop quality, farming efficiency, natural precipi- tation storage and air humidity are increased by 10%-50%, 5%, 15%, 100% and 5%, respectively, and the emissions of methane and other gases are reduced by more than 5%. Even in mortar black soil, saline alkali land and degraded grassland, the yield is still increased by 15%-50%. These improvement effects can last for many years, helping achieve the real harmonious coexistence between human and nature.

Study on the Epistemology Development of the Correlation between Human Beings and Nature

This study aimed to alert people that the harmony between human beings and nature has already become an urgent problem. All people are responsible for maintaining the harmony, which is the also the inexorable trend of historical development. Reviewing the evolution history of human kind, the relationship between human beings and nature from harmony to imbalance, from imbalance to a new harmony was analyzed from the macro perspective, and it was pointed out that the present society is in the transitional phase from imbalance to a new harmony and also a phase that people are consciously coordinating their relationship with nature. It was found through the study that a harmonious society relies on the harmony between human beings and nature, and the latter is a necessary condition for a real harmonious society, however, people always forget such a principle. The imbalanced relationship between human beings and nature has seriously influenced many aspects of social harmony, and become instable factors in China and international society, even threatened the development and survival of human beings. Thus, all people should make joint efforts in creating win-win conditions for the development between human beings and nature, and ensuring offspring a healthy and green earth.

Numerical Investigation of Combined Production of Natural Gas Hydrate and Conventional Gas

Natural gas hydrate(NGH)is generally produced and accumulated together with the underlying conventional gas.Therefore,optimizing the production technology of these two gases should be seen as a relevant way to effectively reduce the exploitation cost of the gas hydrate.In this study,three types of models accounting for the coexistence of these gases are considered.Type A considers the upper hydrate-bearing layer(HBL)adjacent to the lower conventional gas layer(CGL);with the Type B a permeable interlayer exists between the upper HBL and the lower CGL;with the type C there is an impermeable interlayer between the upper HBL and the lower CGL.The production performances associated with the above three models are calculated under different conditions,including only a depressurized HBL(only HBL DP);only a depressurized CGL(only CGL DP);and both the HBL and the CGL being depressurized(HBL+CGL DP).The results show that for Type A and Type B coexistence accumulation models,when only HBL or CGL is depressurized,the gas from the other layer will flow into the production layer due to the pressure difference between the two layers.In the coexistence accumulation model of type C,the cumulative gas production is much lower than that of Type A and Type B,regardless of whether only HBL DP,only CGL DP,or HBL+CGL DP are considered.This indicates that the impermeable interlayer restricts the cross-flow of gas between HBL and CGL.For three different coexistence accumulation models,CGL DP has the largest gas-to-water ratio.

Disinfection Byproducts and Their Precursors in Drinking Water Sources:Origins,Influencing Factors,and Environmental Insights

Tracing the contamination origins in water sources and identifying the impacts of natural and human processes are essential for ecological safety and public health.However,current analysis approaches are not ideal,as they tend to be laborious,time-consuming,or technically difficult.Disinfection byproducts(DBPs)are a family of well-known secondary pollutants formed by the reactions of chemical disinfectants with DBP precursors during water disinfection treatment.Since DBP precursors have various origins(e.g.,natural,domestic,industrial,and agricultural sources),and since the formation of DBPs from different precursors in the presence of specific disinfectants is distinctive,we argue that DBPs and DBP precursors can serve as alternative indicators to assess the contamination in water sources and identify pollution origins.After providing a retrospective of the origins of DBPs and DBP precursors,as well as the specific formation patterns of DBPs from different precursors,this article presents an overview of the impacts of various natural and anthropogenic factors on DBPs and DBP precursors in drinking water sources.In practice,the DBPs(i.e.,their concentration and speciation)originally present in source water and the DBP precursors determined using DBP formation potential tests—in which water samples are dosed with a stoichiometric excess of specific disinfectants in order to maximize DBP formation under certain reaction conditions—can be considered as alternative metrics.When jointly used with other water quality parameters(e.g.,dissolved organic carbon,dissolved organic nitrogen,fluorescence,and molecular weight distribution)and specific contaminants of emerging concern(e.g.,certain pharmaceuticals and personal care products),DBPs and DBP precursors in drinking water sources can provide a more comprehensive picture of water pollution for better managing water resources and ensuring human health.

Natural product-induced oxidative stress-synergistic anti-tumor effects of chemotherapeutic agents

Reactive oxygen species are closely related to tumor development.In recent years,reactive oxygen species has become a hot spot in tumor therapy,and many natural substances in nature contain compound components with anti-tumor effects.However,there is a lack of discussion on the synergistic anti-tumor effects of natural products in combination with chemotherapeutic drugs through reactive oxygen species.The terms“natural products”,“reactive oxygen species”,“anti-tumor”,and“chemotherapy”were used to identify the synergistic effects of natural products.We conducted a systematic literature search in PubMed and Web of Science databases for relevant research articles and reviews published in recent years.We systematically summarized the studies related to anti-tumor active ingredients in natural compounds in the field of reactive oxygen species in recent years.A total of 77 relevant literatures were included.Among them,45 literatures containing various natural products such as terpenoids,flavonoids,alkaloids,etc.exert anti-tumor effects by regulating reactive oxygen species levels,and 32 literatures regarding adjunctive role of natural products in anti-tumor therapy.In this study,we found that natural products exert anti-tumor effects by elevating reactive oxygen species levels.It provides strong theoretical support for future clinical studies.

From the Subjectivity of Human Rights to the Universality of Human Rights——A Preliminary Interpretation of the Theory on the Subjectivity of Human Rights

Universality is one of the essential characteristics of human rights, but there is a substantive difference between idealism and realism in understanding the concept of universality of human rights. The concepts of radical universality and strong universality based on the concept of natural human rights are too idealistic and thus have a high risk of being alienated into a tool of international re-pression in practice. On the contrary, the theory on the subjectivity of human rights can effectively defuse this risk brought about by radical universality and strong universality. Advocating a transition from the universality of human rights to the subjectivity of human rights not only keeps in line with the actual construction process of international human rights, but can also effectively interpret the practical difficul-ties in the realization process of international human rights. Therefore, it can be used as another alternative theory on human rights beyond the theory of natural human rights.

Investigation of Anthropogenic Activities along the Mamouwol River in the Urban Commune of Mamou (Republic of Guinea)

The monitoring of our watercourses for their preservation must be an imperative concern of the whole population.The aim of this study is to describe the main causes of degradation and destruction of the natural resources of the Mamouwol River in the Mamou commune.Data were collected using a survey method(questionnaire,interviews and observations).The study revealed that extensive agro-pastoral activities are the main socio-economic activity of the population,accounting for 78.5%-90%and 20.30%respectively.Fishing follows(1.2%).Related activities include handicrafts and petty trade;Other human activities:hunting(11%),charcoal burning(58%),brick making and firing(45.6%).Riverbanks and water resources in the vicinity of dwellings are damaged and polluted by socio-economic activities and the use of agricultural inputs.The absence of industrial units on the path for the data collection.

Disitamab vedotin combined with apatinib in gastric cancer: A case report and review of literature

BACKGROUND In patients with human epidermal growth factor receptor 2(HER2)-overex-pressing gastric cancer(GC),the combination of HER2 targeting and a standard first-line chemotherapy regimen has been demonstrated to significantly improve their prognosis.However,in a proportion of patients,cancer progresses within a short period of time,and there is currently no standard treatment after disease progression.CASE SUMMARY This study presents a case of a 51-year-old male with advanced GC who un-derwent radical resection(Billroth type II subtotal gastrectomy and gastrojejun-ostomy)and resection of liver metastases.Immunohistochemical staining revealed a HER2 score of 2+,a dMMR status,and a Ki67 proliferation index of 30%to 40%.The gene test results indicated the presence of ERBB2 amplification and a PD-L1 expression level of less than 5%.Since December 2021,the patient has experienced disease progression during both first-line(two cycles of KN026 combined with KN046)and second-line(five cycles of nivolumab combined with trastuzumab and SOX chemotherapy)treatment regimens.The patient's prognosis following the first and second lines of treatment was unfavorable,with pro-gression occurring in a relatively short time.For third-line therapy,disitamab vedotin(RC48)plus apatinib was used.At the time of this report,the patient had achieved a progression-free survival(PFS)of 25.8 months,which exceeded the median survival time for patients with advanced GC.CONCLUSION Despite the unfavorable prognosis associated with advanced GC,the imple-mentation of personalized treatment approaches may still prove beneficial for select patients.In patients with HER2-positive GC with extensive metastatic involvement,the use of the HER2-targeted combination with apatinib has demonstrated the potential to prolong both PFS and overall survival.

The Ecological Landscape with the Integration of Humanistic Culture and Nature Environment —A Case Study of Landscape Transformation in Baoyan Eco-Tourism Garden of Changshu City

Based on the landscape ecology theory,this paper analyzed the ecology concept and the existing misconceptions of landscape design from the perspective of ecology.The misconceptions included the excessive using of ecological concepts,undue emphasis on the natural features of ecology,and endowing landscape with human cultural blindly.Taking Baoyan eco-tourism garden landscape renovation as an example,this study analyzed the superior natural conditions of this garden,the negative status in the current development process which included the conservative development and construction,singleness of entertainment,cultural educational and the other activities,disorder of landscape structure,lack of cultural landscape,weakness of landscape features and the unremarkable competitive advantages.To construct an ecological landscape with integration of humanistic and nature features,this paper proposed "ecological gardens" as the theme,following the design concept which made full integration of creating cultural landscape with the improvement and protection of natural ecological environment.Finally,the author elaborated such kind of ecological landscape from the following 4 aspects,including the integration,protection,restoration,and creation of landscape.

Effects of combined spinal-epidural anesthesia on anxiety,labor analgesia and motor blocks in women during natural delivery

BACKGROUND The background of this study was analgesia in natural delivery.The combined spinal-epidural anesthesia has obvious analgesic effect on the parturients in natural labor,and combined spinal-epidural anesthesia has been widely used in anesthesia for various diseases.AIM To study the effects of combined spinal-epidural anesthesia on anxiety,labor analgesia,and motor blocks in parturients during natural delivery.METHODS A total of 120 women who gave birth at Changning District Maternal and Child Health Hospital between December 2021 to December 2022 were included;a random number table approach was employed to divide the women into a control group and a joint group,with each group consisting of 60 women.The control group was given epidural anesthesia,while the joint group was given combined spinal-epidural anesthesia.The visual analog scale(VAS)was used to evaluate the degree of maternal pain.Comparisons were made between the two groups’conditions of childbirth and the duration of labor.Apgar scores were used to evaluate the status of the newborns at birth;Self-rating Anxiety Scale(SAS)and General Self-Efficacy Scale(GSES)scores,umbilical artery blood gas analysis indices and stress indices were compared between the two groups;and the frequencies of motor block and postpartum complications were analyzed.RESULTS In comparison to the control group,in the joint group,the VAS scores for the first,second,and third stages of labor were lower(P<0.05).The rates of conversion to cesarean section and postpartum blood loss in the joint group were lower than those in the control group(P<0.05).No significant differences were observed in the Apgar score,the duration of the first stage of labor,or the total duration of labor between the two groups(P>0.05).The second and third stages of labor in the joint group were shorter than those in the control group(P<0.05).When compared to the control group,the postpartum SAS score of the joint group was lower,while the GSES score was greater(P<0.05).Between the control group and the joint group,the differences observed in pH,arterial carbon dioxide partial pressure,arterial oxygen partial pressure,or arterial hydrogen ion concentration were not significant(P>0.05).Nitric oxide,cortisol,and adrenaline levels were lower in the joint group than in the control group(P<0.05).There were no substantial differences in Bromage grade or rate of complications between the two groups(P>0.05).CONCLUSION For parturients during natural delivery,combined spinal-epidural anesthesia can reduce anxiety,provide labor analgesia,shorten labor time,and reduce postoperative stress levels but did not result in a motor block.

Assessing the dynamics of human activity intensity and its natural and socioeconomic determinants in Qinghai-Tibet Plateau

Investigating the spatiotemporal variation of human activity intensity and its determinants is a crucial basis for further revealing the mechanism of human-environment interaction and optimizing the human development mode.In this study,the human activity intensity on the Qinghai-Tibet Plateau(QTP)from 1990 to 2020 was measured based on the quantitative model of land use data and the actual regional background,and the under-lying natural and socioeconomic determinants were investigated using spatial econometric methods.The results demonstrate that(1)the human activity intensity in QTP has increased by 11.96%,and there are differences in different spatial scales;the areas with high human activity intensity are distributed in the Hehuang Valley where Xining City and its surrounding areas are located,as well as the One-River and Two-River Area where Lhasa City and surrounding areas are located.(2)Human activity intensity has significant positive spatial spillover,suggesting that local changes will cause changes in the same direction in adjacent areas.(3)The human activ-ity intensity in QTP is affected by various determinants.Concerning socioeconomic factors,the economic level has no significant impact on the human activity intensity in QTP,which differs from the general regional law.Both urbanization and traffic conditions have a significant positive effect,and the impact intensity continues to increase.Concerning natural factors,topographic relief has a significant positive effect;the impacts of temper-ature and vegetation coverage have changed from insignificant to a significant positive effect;the impacts of precipitation and river network density have not been verified;there is no linear relationship between altitude and human activity intensity in the entire QTP,while it exists in local regions.Finally,this study proposes three policy implications for the realization of a more harmonious human-environment relationship in QTP.

Exploring Green Development From the Perspective of Sociology:Logical Basis,Constraints,and Optimization Paths

With the advancement of ecological conservation in China,the concept of green development has gained extensive acceptance and recognition.Exploring green development from the perspectives of environmental protection and sociology holds great theoretical value and practical significance in studying the issues related to green development.Firstly,this paper examines green development in light of the objective needs of the economic and social transformation in the international community and China,and deconstructed its underlying social logic.Secondly,it further investigates the social factors that restrict green development,encompassing social structures,social concepts,social systems,and social behaviors.Finally,within the framework of the“green”discipline system in environmental sociology,this paper proposes specific measures such as restructuring social systems and transforming production modes,lifestyles,and consumption patterns to promote green development.

An Exploration of Human Nature and a Challenge Against Conventional Morality of American South——On the Theme ofThe Adventures of Huckleberry Finn

文章通过对马克.吐温名著《哈克贝利.芬历险记》主题的分析,深刻探讨了马克.吐温对人的本性的探索和对美国南方传统道德的挑战,并进而提出了与现今社会紧密联系的人文关怀问题。

Human Rights Connotations and Its Legal Protection in the Harmonious Coexistence between Humans and Nature

Promoting the unity of human nature and sociality in practice is a fundamental path dependence for achieving people's well-rounded development.Within the context of harmonious coexistence between humans and nature,the practice of the unity of human nature and sociality is allowed to be truly implemented,and people's well-rounded development moves from possibility to reality.Strengthening the protection of human rights for people's well-rounded development in the harmonious coexistence between humans and nature not only requires the expansion of the connotations of environmental rights from“the right to a healthy environment”to“the right to a beautiful environment”,but also necessitates the formation of a collaborative framework between environmental rights and development rights.For legal responses to the expansion of the connotations of environmental rights,it is necessary to implement such expansions in environmental legislation,enhance the underlying principles,and make progress in the development of systematic environmental legislation simultaneously.Regarding the legal promotion of the synergy between environmental rights and development rights,it is essential to follow the guidance of the“Two Mountains Theory,”take the coordinated functions of environmental and traditional legal departments as the basis,and build a legal mechanism for the realization of the value of ecological products and services.

The Thought of the Oneness Between Man and Nature in Walden

From the view of the ecological theory, this paper tries to analyze that Thoreau uses Chinese traditional philosophical thought--- the oneness of man and nature to deal with the relationship of human beings and the nature in Walden.

Effect of Environmental Gradients on the Quantity and Quality of Fallen Logs in Tsuga longibracteata Forest in Tianbaoyan National Nature Reserve, Fujian Province,China

We investigated the quantity and quality 0f fallen l0gs in different Tsuga l0ngibracteata f0rest c0mmunities in the Tianba0yan Nati0nal Nature Reserve. We used redundancy analysis t0 determine the spatial distributi0n 0f fallen l0gs in the different f0rest c0mmunities and t0 analyze the relati0nships am0ng stand structure, t0p0graphic fact0rs and human disturbance. The v0lume, c0vered area, mean l0g length and number 0f fallen l0gs differed significantly am0ng f0rest types （P 〈 0.05）, but mean diameter at breast height sh0wed n0 significant difference （P 〉 0.05）. The l0g v0lume and c0vered area in different f0rest types sh0wed the f0ll0wing trend： T. l0ngibracteata pure f0rest 〈 T. l0ngibracteata ＋ Olig0staehyum scabrifl0rur 〈 T. l0ngibraeteata ＋ hardw00d 〈 Rh0d0dendr0n simiarum ＋ T. l0ngibraeteata 〈 T. l0ngibraeteata ＋ Phyll0stachys heter0cycla pubescens. The spatial distributi0n patterns 0f l0gs quantity and quality indicated that l0g v0lume and c0vered area were str0ngly affected by envir0nmental fact0rs in the f0ll0wing 0rder： human disturbance 〉 elevati0n 〉 sl0pe p0siti0n 〉 b0le height 〉 tree height 〉 sl0pe aspect 〉 density 〉 basal area 〉 sl0pe gradient. The relative c0ntributi0n 0f envir0nmental variables 0n the t0tal variance was t0p0graphy （76%） 〉 disturbance （42%） 〉 stand structure （35%）. T0p0graphy and disturbance c0mbined explained 8.2% 0f the variance. Fallen l0~s auantitv and aualitvwere negatively related t0 elevati0n and sl0pe p0siti0n, and p0sitively ass0ciated t0 human disturbance. The l0g v0lume decreased fr0m n0rthern t0 s0uthern sl0pes. Envir0nmental fact0rs had the highest impact 0n class I （slightly decayed）, and l0west impact 0n class V （highly decayed）.

Long-term alpha interferon and lamivudine combination therapy in non-responder patients with anti-HBe-positive chronic hepatitis B:Results of an open,controlled trial

AIM: To investigate the safety and efficacy of long-term combination therapy with alpha interferon and lamivudine in non-responsive patients with anti-HBe-positive chronic hepatitis B.METHODS: 34 patients received combination treatment (1 month lamivudine, 12 month lamivudine+interferon, 6month lamivudine), 24 received lamivudine (12 months),24 received interferon (12 months). Interferon was administered at 6 MU tiw and lamivudine at 100 mg orally once daily. Patients were followed up for 6 months after treatment.RESULTS: At the end of treatment, HBV DNA negativity rates were 88 % with lamivudine+interferon, 99 % with lamivudine and 55 % with interferon, (P=0.004, combination therapy vs. interferon, and P=0.001 lamivudine vs.interferon), and serum transaminase normalization rates were 84 %, 91% and 53 % (P=0.01 combination therapy vs. interferon, and P=0.012 lamivudine vs. interferon). Six months later, HBV DNA negativity rates were 44 % with lamivudine+interferon, 33 % with lamivudine and 25 % with interferon, and serum transaminase normalization rates were 61%, 42 % and 45 %, respectively, without statistical significance. No YMDD variants were observed with lamivudine+interferon (vs. 12 % with lamivudine). The combination therapy appeared to be safe. CONCLUSION: Although viral clearance and transaminase normalization are slower with long-term lamivudine+interferon than that with lamivudine alone, the combination regimen seems to provide more lasting benefits and to protect against the appearance of YMDD variants. Studies with other regimens regarding sequence and duration are needed.

Therapeutic potential of thymoquinone in combination therapy against cancer and cancer stem cells

The long-term success of standard anticancer monotherapeutic strategies has been hampered by intolerable side effects,resistance to treatment and cancer relapse.These monotherapeutic strategies shrink the tumor bulk but do not effectively eliminate the population of self-renewing cancer stem cells(CSCs)that are normally present within the tumor.These surviving CSCs develop mechanisms of resistance to treatment and refuel the tumor,thus causing cancer relapse.To ensure durable tumor control,research has moved away from adopting the monotreatment paradigm towards developing and using combination therapy.Combining different therapeutic modalities has demonstrated significant therapeutic outcomes by strengthening the anti-tumor potential of monotreatment against cancer and cancer stem cells,mitigating their toxic adverse effects,and ultimately overcoming resistance.Recently,there has been growing interest in combining natural products from different sources or with clinically used chemotherapeutics to further improve treatment efficacy and tolerability.Thymoquinone(TQ),the main bioactive constituent of Nigella sativa,has gained great attention in combination therapy research after demonstrating its low toxicity to normal cells and remarkable anticancer efficacy in extensive preclinical studies in addition to its ability to target chemoresistant CSCs.Here,we provide an overview of the therapeutic responses resulting from combining TQ with conventional therapeutic agents such as alkylating agents,antimetabolites and antimicrotubules as well as with topoisomerase inhibitors and non-coding RNA.We also review data on anticancer effects of TQ when combined with ionizing radiation and several natural products such as vitamin D3,melatonin and other compounds derived from Chinese medicinal plants.The focus of this review is on two outcomes of TQ combination therapy,namely eradicating CSCs and treating various types of cancers.In conclusion,the ability of TQ to potentiate the anticancer activity of many chemotherapeutic agents and sensitize cancer cells to radiotherapy makes it a promising molecule that could be used in combination therapy to overcome resistance to standard chemotherapeutic agents and reduce their associated toxicities.