In an era dominated by artificial intelligence (AI), establishing customer confidence is crucial for the integration and acceptance of AI technologies. This interdisciplinary study examines factors influencing custome...In an era dominated by artificial intelligence (AI), establishing customer confidence is crucial for the integration and acceptance of AI technologies. This interdisciplinary study examines factors influencing customer trust in AI systems through a mixed-methods approach, blending quantitative analysis with qualitative insights to create a comprehensive conceptual framework. Quantitatively, the study analyzes responses from 1248 participants using structural equation modeling (SEM), exploring interactions between technological factors like perceived usefulness and transparency, psychological factors including perceived risk and domain expertise, and organizational factors such as leadership support and ethical accountability. The results confirm the model, showing significant impacts of these factors on consumer trust and AI adoption attitudes. Qualitatively, the study includes 35 semi-structured interviews and five case studies, providing deeper insight into the dynamics shaping trust. Key themes identified include the necessity of explainability, domain competence, corporate culture, and stakeholder engagement in fostering trust. The qualitative findings complement the quantitative data, highlighting the complex interplay between technology capabilities, human perceptions, and organizational practices in establishing trust in AI. By integrating these findings, the study proposes a novel conceptual model that elucidates how various elements collectively influence consumer trust in AI. This model not only advances theoretical understanding but also offers practical implications for businesses and policymakers. The research contributes to the discourse on trust creation and decision-making in technology, emphasizing the need for interdisciplinary efforts to address societal challenges associated with technological advancements. It lays the groundwork for future research, including longitudinal, cross-cultural, and industry-specific studies, to further explore consumer trust in AI.展开更多
Objective To evaluate the efficacy and safety of combination therapy of tamsulosin and solifenacin for benign prostatic hyperplasia ( BPH) with overactive bladder ( OAB) . Methods 82 patients with OAB and coexisting B...Objective To evaluate the efficacy and safety of combination therapy of tamsulosin and solifenacin for benign prostatic hyperplasia ( BPH) with overactive bladder ( OAB) . Methods 82 patients with OAB and coexisting BPH were randomly divided into tamsulosin group ( n展开更多
The problems of environmental geology refer to the geologic phenomena, incidents or accidents arising from action of environmental geology. The action is mainly the mutual influence between human activity and geologic...The problems of environmental geology refer to the geologic phenomena, incidents or accidents arising from action of environmental geology. The action is mainly the mutual influence between human activity and geologic environment. When human activity is uncoordinated with objective laws of the geologic environment, the problems of environmental geology or economic loss would occur.Therefore,the level and the changing orientation of geologic environmental quality are relative to the types of human activity,particularly relative to human intentional-activities of geologic environmental exploitation project. The geologic environment fitting to mining may not fit to urban construction,and fitting to water conservancy and hydroelectric projects may not fit to communication,and so on.Economy evaluation on the profit and loss of geologic environmental quality is exactly to depict the level of the profit and loss of geologic environmental quality about geologic environmental exploitation projects and the展开更多
AIM:To investigate efficacy and safety of vildagliptin compared to other oral antidiabetics in clinical practice in Germany.METHODS:In this prospective,open,observational study,patients with type 2 diabetes mellitus(T...AIM:To investigate efficacy and safety of vildagliptin compared to other oral antidiabetics in clinical practice in Germany.METHODS:In this prospective,open,observational study,patients with type 2 diabetes mellitus(T2DM) previously on oral monotherapy were selected by their treating physician to receive either vildagliptin addon to metformin(cohort 1),vildagliptin+metformin single-pill combination(SPC)(cohort 2)or another dual combination therapy with oral antidiabetic drugs(OADs)(cohort 3).According to routine clinical practice,interim examinations occurred every 3 mo:at baseline,after approximately 3 mo and after approximately 6 mo.Parameters documented in the study included demographic and diagnostic data,history of T2DM,data on diabetes control,vital signs,relevant prior and concomitant medication and disease history.Efficacy was assessed by changes in HbA1c and fasting plasma glucose(FPG)3 mo and 6 mo after initiation of dual combination therapy.Safety was assessed by adverseevent reporting and measurement of specific laboratory values(serum creatinine,total bilirubin,alanine aminotransferase,aspartate aminotransferase,creatine kinase).RESULTS:Between October 2009 and January 2011,a total of 3881 patients were enrolled in this study.Since 47 patients were withdrawn due to protocol violations,3834 patients were included in the statistical analysis.There were no relevant differences between the three cohorts concerning age,body weight and body mass index.Average diabetes duration was approximately 6 years and mean HbA1c was between 7.6%and 7.9% at baseline.Antidiabetic treatment was recorded in 3648 patients.Patients were treated with vildagliptin add-on to metformin(n=603),vildagliptin+metformin(SPC)(n =2198),and other oral OADs including combinations of metformin with sulfonylurea(n=370),with glitazones(n =123),other dipeptidyl peptidase-4 inhibitors(n=99).After 6 mo of treatment,the absolute decrease in HbA1c(mean±SE)was significantly more pronounced in patients receiving vildagliptin add-on to metformin(-0.9% ±0.04%)and vildagliptin+metformin(SPC)(-0.9%± 0.03%)than in patients receiving other OADs(-0.6% ±0.04%;P<0.0001).In addition,significant cohort differences were observed for the improvement in FPG after 6 mo treatment(vildagliptin add-on to metformin:-291 mg/L±18.3 mg/L;vildagliptin+metformin(SPC):-305 mg/L±9.6 mg/L;other antidiabetic drugs:-209 mg/L±14.0 mg/L for(P<0.0001).Moderate decreases in body weight(absolute difference between last control and baseline:mean±SE)were observed for patients in all cohorts(vildagliptin add-on to metformin:-1.4 kg ±0.17 kg;vildagliptin+metformin(SPC):-1.7 kg± 0.09 kg;other OADs:?0.8 kg±0.13 kg).No significant differences in adverse events(AEs)and other safety measures were observed between the cohorts.When performing an additional analysis by age(patients<65 years vs patients≥65 years),there was no relevant difference in the most common AEs between the two age groups and the AE profile was similar to that of the overall patient population.CONCLUSION:Clinical practice confirms that vildagliptin is an effective and well-tolerated treatment in combination with metformin in T2DM patients.展开更多
Background:Diarrhea remains a significant health threat to children under five years of age.The study aims to systematically elucidate the global burden of diarrhea in children,providing scientific insights for effect...Background:Diarrhea remains a significant health threat to children under five years of age.The study aims to systematically elucidate the global burden of diarrhea in children,providing scientific insights for effective prevention and control strategies.Methods:The data from the Global Burden of Disease(GBD)2021 study was analyzed to assess the trends in incidence,prevalence,mortality,and disability-adjusted life years(DALYs)of diarrhea in children under five years across the globe,21 geographical region,and 204 countries and territories,stratified by age group,sex,and socio-demographic index(SDI)levels.The trend of the disease burden for childhood diarrhea from 1990 to 2021 was described and estimated using the average annual percent change(AAPC),and a Bayesian age-period-cohort(BAPC)model was employed to predict the future burden of diarrhea in children.Results:From 1990 to 2021,there was a significant decline in the global burden of diarrhea among children under five years of age.The AAPC for incidence(-4092.18,95%confidence interval[CI]:-4224.60 to-3959.76),prevalence(-70.98,95%CI:-72.67 to-69.28),mortality(-6.89,95%CI:-6.95 to-6.83),and DALYs rate(-621.79,95%CI:-627.20 to-616.38)of diarrhea in children all showed a marked downward trend.Diarrheal incidence(r=-0.782,P<0.001),prevalence(r=-0.777,P<0.001),mortality(r=-0.908,P<0.001),and DALYs rate(r=-0.904,P<0.001)were negatively correlated with the SDI.Between 2022 and 2035,the global incidence,prevalence,and mortality rates of diarrhea in children under five years are projected to continue declining.The leading causes of diarrheal mortality in children include wasting,underweight,and non-exclusive breastfeeding.Rotavirus remains the predominant pathogen associated with diarrhea-related mortality rate and DALY rate.Conclusion:Although the global burden of diarrhea in children under five has steadily declined,it remains a significant health threat.Rotavirus is the leading pathogen,highlighting the importance of expanding rotavirus vaccination.Additionally,improving nutritional status,increasing exclusive breastfeeding rates,and enhancing access to sanitation and clean drinking water are crucial measures that,when widely implemented,can effectively reduce the health risks posed by diarrhea in children.展开更多
The pulse features of a bubble have a close connection with the boundary condition. When a bubble moves near a rigid wall, it will be attracted by the Bjerknes force of the wall, and a jet pointing at the wall will be...The pulse features of a bubble have a close connection with the boundary condition. When a bubble moves near a rigid wall, it will be attracted by the Bjerknes force of the wall, and a jet pointing at the wall will be generated. In real application, the bubble may move under the combined action of walls in different directions when it forms at the corner of a pipe or at the bottom of a dam. The motion of the bubble shows complex and nonlinear characteristics under these conditions. In order to investigate the bubble pulse features near complex walls, a horizontal wall and a vertical wall are put into the experimental water tank synchronously, and an electric circuit with 200 voltages is designed to generate discharge bubbles, and then experimental study on the bubble pulse features under the combined action of horizontal and vertical walls is carried out. The influences of the combined action of two walls on the bubble shape, pulse period, moving trace and inside jet are obtained by changing the distances from bubble center to the two walls. It aims at providing references for the relevant theoretical and numerical research.展开更多
The paper analyzes the environments confronted with academic libraries and the evolving characteristics of Shanghai Jiao Tong University that give shape to the conception and implementation of an IC2Culture Exploring ...The paper analyzes the environments confronted with academic libraries and the evolving characteristics of Shanghai Jiao Tong University that give shape to the conception and implementation of an IC2Culture Exploring Project. This innovative model of SJTU Library operation is not only in concert with the strategic goals of SJTU but also with two other conspicuous developmental trends in the larger academic library circle;namely, 1) a trend toward the deepening of library service support in academic arena on the one hand and 2) the trend of diversifying library outreach services on the other hand.Based on our first-hand involvement in all phases and aspects of this project and its subsequent review and analysis undertakings, this paper expatiates upon the IC2Culture Exploring Project of SJTU Library in terms of its vision, its specific mission objectives, its program design, its unique characteristics, its launching process, its salient case studies, its initial results and its strategies for a sustainable development in the future.展开更多
The purpose of this study is to investigate the disease distribution of tuberculosis in national regional project. 960 patients were selected from national tuberculosis control program who took treatments in the Fourt...The purpose of this study is to investigate the disease distribution of tuberculosis in national regional project. 960 patients were selected from national tuberculosis control program who took treatments in the Fourth People’s Hospital Clinical Laboratory in Nanning Guangxi from January to November in 2013. Then we observed all those patients’ disease distribution and analyzed all the lab test indexes. We analyzed the results according to gender and age distribution. From the age distribution, we found that the incidence was lower at the age of 40 or younger, while higher incidence occurred to patients over 40 years old. There is statistical significance comparing these two age groups. P is less than 0.001. Disease distribution: 731 patients were infected with TB;21 patients were co-infected with tuberculosis (TB) and HIV. 196 patients were co-infected with TB and fungal. 12 patients were co-infected with TB, HIV and fungal. From the laboratory testing, we know there were 87 patients whose liver function indexes were abnormal. There were 192 patients whose blood RT indexes were abnormal. The liver function and blood RT indexes of patients with co-infection were higher than those infected purely. There is statistical significance in comparison P < 0.05. The study indicates that patients with older age are more likely infected with tuberculosis. In addition, there are a high proportion of patients with co-infection among these patients in this study. Meanwhile, the liver functions and blood RT indexes of patients combining with infection are higher than those infected TB purely. Prompt clinical prevention and treatment should be under reasonable inspections. General analysis can enable us to investigate more effective treatment plan. Then the best treatment result will be obtained.展开更多
The development history of the project design of spaceflight launching site in China and the main forms used in these designs were introduced in this thesis, and it was pointed out that the spaceflight launch should n...The development history of the project design of spaceflight launching site in China and the main forms used in these designs were introduced in this thesis, and it was pointed out that the spaceflight launch should not use only one fixed model. According to its nation condition, China should design and build the launching project facility and device which correspond to the technology development of spacecraft and carrier rocket.展开更多
The purpose of this paper is to deliver a better perception of the project success,and how reporting system might increase the probability of project success in construction projects in UAE.Further,it aims at explorin...The purpose of this paper is to deliver a better perception of the project success,and how reporting system might increase the probability of project success in construction projects in UAE.Further,it aims at exploring the relationship between effective reporting system in terms of the characteristic of its outputs(mainly effectiveness of financial reporting system)and project success.Semi-structured interviews with a number of interior auditors,accountants,and chief financial officers(CFOs)from different corporations in construction sector in UAE in order to recognize how effective reporting system in terms of the characteristic of its outputs(broad scope,timeliness,aggregation,and integration)might contribute to increase the probability of project success.There are several success factors in construction projects in UAE,thus it is very hard to capture all these factors in one paper.Hence,this paper is not considering all project success factors rather it focuses on the characteristic of outputs of the reporting system generally and the financial reporting system particularly(broad scope,timeliness,aggregation,and integration),as most of the studies in the literature considered the reporting system as a key factor of project success.This paper adds to both project management and accounting research by evidencing results from an exploration how effective reporting might impact the project success,with valuable implications for standard officials,customers,investors,stakeholders,sponsors,shareholders,CFOs,project developer,consultants,internal auditors,and accounting academics.The effective reporting system in United Arab Emirates(UAE)construction projects enables possessors,customers,and contractors of projects to get timely information about the progress of project in a brief and significant format which in turn improve the decision-making process and contribute to project success.This paper implies a contribution for both project management literature and accounting research by investigative the effectiveness of reporting system in project successes from historical point of view and contemporary point of view.展开更多
On January 7, 2015 the project "Study on the technology formanufacture of high-spheroidicity FCC catalysts "undertakenby the SINOPEC Research Institute of Petroleum Processing(RIPP) has passed the technical apprai...On January 7, 2015 the project "Study on the technology formanufacture of high-spheroidicity FCC catalysts "undertakenby the SINOPEC Research Institute of Petroleum Processing(RIPP) has passed the technical appraisal organized by theScience and Technology Division of the Sinopec Corp.展开更多
LIRR's Priject of "Research on Spalling Mechanism Due to Rapid Heating-up of Dense Refractory Castables" declared by Wang Zhanmin,vice-president of LIRR,will gain the fund support from National Natural Science Foun...LIRR's Priject of "Research on Spalling Mechanism Due to Rapid Heating-up of Dense Refractory Castables" declared by Wang Zhanmin,vice-president of LIRR,will gain the fund support from National Natural Science Foundation of China in 2011.展开更多
The effect of the Chinese herbal compound (CHC) on solid sarcoma 180 (S180) in Swiss mice was studied either alone or in combination with 5-fluorouracil (5FU), cyclophosphamide (CYT) or mitomycin C (MMC). The prelimin...The effect of the Chinese herbal compound (CHC) on solid sarcoma 180 (S180) in Swiss mice was studied either alone or in combination with 5-fluorouracil (5FU), cyclophosphamide (CYT) or mitomycin C (MMC). The preliminary results indicated that combination treatment seemed to possess better antitumor activity than chemotherapy alone. The treatment with CHC alone however had neither an obvious antitumor effect in tumor bearing mice nor toxicity in normal mice. These results show that CHC may stimulate organs of the immune system such as the spleen to be im-munomodulators and enhance the antitumor activity of some chemotherapeutic agents.展开更多
Taking the process of treating coronavirus disease 2019(COVID-19)with Western medicine and traditional Chinese medicine(TCM)as the research object,this article compares the characteristics of Western medicine and TCM ...Taking the process of treating coronavirus disease 2019(COVID-19)with Western medicine and traditional Chinese medicine(TCM)as the research object,this article compares the characteristics of Western medicine and TCM from the perspectives of aetiology,pathogenesis,diagnosis,and treatment.Western medicine and TCM each has its own theoretical system.Each has its own exposition in explaining the etiology and pathogenesis of the disease,and each has its own characteristics and advantages in diagnosis and treatment.Integrating TCM and Western medicine can improve the effect of treatment by forming a coordinated traditional Chinese and Western medicine treatment method.展开更多
31 cases of atherosclerosis (AS) were treated with Jiang Zhi Tong Mai Fang ([symbol: see text], formula of JZTMF), and its effect was compared with 30 cases treated with lovastatin in the control group. Clinically, th...31 cases of atherosclerosis (AS) were treated with Jiang Zhi Tong Mai Fang ([symbol: see text], formula of JZTMF), and its effect was compared with 30 cases treated with lovastatin in the control group. Clinically, the JZTMF formula showed an effect of regulating blood lipids, and therefore it was antiatherosclerotic. The mechanism is, probably, restoration of the function of endothelial cells (EC) by increasing the synthesis of 6-keto-PGF1 alpha and decreasing the release of endothelin (ET) as evidenced in the experimental study.展开更多
The new double projecting neurons were found in the cat spinal dorsal horn by the double retrograde fluorescent tracing technique.Fast Blue(FB)was injected into unilateral dorsal column nucleus(DCN)of adult cats anest...The new double projecting neurons were found in the cat spinal dorsal horn by the double retrograde fluorescent tracing technique.Fast Blue(FB)was injected into unilateral dorsal column nucleus(DCN)of adult cats anesthetized with pentobarbital.Nuclear Yellow(NY)was injected ipsilaterally into the lateral cervical nucleus(LCN)8-9 days later.After an additional 18-30 hrs.展开更多
Objective To compare the effects of combined en bloc liver - pancreas transplantation ( LPT) with portal vein drainage and simultaneous combined kidney - pancreas transplantation ( KPT) with systemic venous drainage o...Objective To compare the effects of combined en bloc liver - pancreas transplantation ( LPT) with portal vein drainage and simultaneous combined kidney - pancreas transplantation ( KPT) with systemic venous drainage on the pancreatic endocrine function and related me-展开更多
Objective Evidence is lacking regarding the combined effects of smoking and obesity on mortality from coronary heart disease in male veterans.This study aimed to explore the combined effect of smoking and obesity on c...Objective Evidence is lacking regarding the combined effects of smoking and obesity on mortality from coronary heart disease in male veterans.This study aimed to explore the combined effect of smoking and obesity on coronary heart disease mortality in male veterans in China.Methods A cohort of 1,268 male veterans from 22 veteran centers in Xi’an(Shaanxi Province,China)were followed up once every 2 years from February 1,1987 to October 30,2016.The endpoint was death from any cause.The hazard ratio(HR)of each risk factor and the 95%confidence interval(CI)were calculated using a multivariate Cox proportional hazard model.Results The total follow-up was 24394.21 person-years;each subject was followed up for a mean duration of 19.24 years.By the end of the study,of the 1,268 veterans,889 had died,363 were alive,and 16 were lost to follow-up.Cox regression analysis results revealed that current smoking(HR:1.552,95%CI:1.074–2.243),obesity(HR:1.625,95%CI:1.024–2.581),and the combined effect of the two factors(HR:2.828,95%CI:1.520–5.262)were associated with coronary heart disease mortality.Conclusion Our results suggest that obese veterans who smoke might be an important target population for coronary heart disease mortality control.展开更多
文摘In an era dominated by artificial intelligence (AI), establishing customer confidence is crucial for the integration and acceptance of AI technologies. This interdisciplinary study examines factors influencing customer trust in AI systems through a mixed-methods approach, blending quantitative analysis with qualitative insights to create a comprehensive conceptual framework. Quantitatively, the study analyzes responses from 1248 participants using structural equation modeling (SEM), exploring interactions between technological factors like perceived usefulness and transparency, psychological factors including perceived risk and domain expertise, and organizational factors such as leadership support and ethical accountability. The results confirm the model, showing significant impacts of these factors on consumer trust and AI adoption attitudes. Qualitatively, the study includes 35 semi-structured interviews and five case studies, providing deeper insight into the dynamics shaping trust. Key themes identified include the necessity of explainability, domain competence, corporate culture, and stakeholder engagement in fostering trust. The qualitative findings complement the quantitative data, highlighting the complex interplay between technology capabilities, human perceptions, and organizational practices in establishing trust in AI. By integrating these findings, the study proposes a novel conceptual model that elucidates how various elements collectively influence consumer trust in AI. This model not only advances theoretical understanding but also offers practical implications for businesses and policymakers. The research contributes to the discourse on trust creation and decision-making in technology, emphasizing the need for interdisciplinary efforts to address societal challenges associated with technological advancements. It lays the groundwork for future research, including longitudinal, cross-cultural, and industry-specific studies, to further explore consumer trust in AI.
文摘Objective To evaluate the efficacy and safety of combination therapy of tamsulosin and solifenacin for benign prostatic hyperplasia ( BPH) with overactive bladder ( OAB) . Methods 82 patients with OAB and coexisting BPH were randomly divided into tamsulosin group ( n
文摘The problems of environmental geology refer to the geologic phenomena, incidents or accidents arising from action of environmental geology. The action is mainly the mutual influence between human activity and geologic environment. When human activity is uncoordinated with objective laws of the geologic environment, the problems of environmental geology or economic loss would occur.Therefore,the level and the changing orientation of geologic environmental quality are relative to the types of human activity,particularly relative to human intentional-activities of geologic environmental exploitation project. The geologic environment fitting to mining may not fit to urban construction,and fitting to water conservancy and hydroelectric projects may not fit to communication,and so on.Economy evaluation on the profit and loss of geologic environmental quality is exactly to depict the level of the profit and loss of geologic environmental quality about geologic environmental exploitation projects and the
文摘AIM:To investigate efficacy and safety of vildagliptin compared to other oral antidiabetics in clinical practice in Germany.METHODS:In this prospective,open,observational study,patients with type 2 diabetes mellitus(T2DM) previously on oral monotherapy were selected by their treating physician to receive either vildagliptin addon to metformin(cohort 1),vildagliptin+metformin single-pill combination(SPC)(cohort 2)or another dual combination therapy with oral antidiabetic drugs(OADs)(cohort 3).According to routine clinical practice,interim examinations occurred every 3 mo:at baseline,after approximately 3 mo and after approximately 6 mo.Parameters documented in the study included demographic and diagnostic data,history of T2DM,data on diabetes control,vital signs,relevant prior and concomitant medication and disease history.Efficacy was assessed by changes in HbA1c and fasting plasma glucose(FPG)3 mo and 6 mo after initiation of dual combination therapy.Safety was assessed by adverseevent reporting and measurement of specific laboratory values(serum creatinine,total bilirubin,alanine aminotransferase,aspartate aminotransferase,creatine kinase).RESULTS:Between October 2009 and January 2011,a total of 3881 patients were enrolled in this study.Since 47 patients were withdrawn due to protocol violations,3834 patients were included in the statistical analysis.There were no relevant differences between the three cohorts concerning age,body weight and body mass index.Average diabetes duration was approximately 6 years and mean HbA1c was between 7.6%and 7.9% at baseline.Antidiabetic treatment was recorded in 3648 patients.Patients were treated with vildagliptin add-on to metformin(n=603),vildagliptin+metformin(SPC)(n =2198),and other oral OADs including combinations of metformin with sulfonylurea(n=370),with glitazones(n =123),other dipeptidyl peptidase-4 inhibitors(n=99).After 6 mo of treatment,the absolute decrease in HbA1c(mean±SE)was significantly more pronounced in patients receiving vildagliptin add-on to metformin(-0.9% ±0.04%)and vildagliptin+metformin(SPC)(-0.9%± 0.03%)than in patients receiving other OADs(-0.6% ±0.04%;P<0.0001).In addition,significant cohort differences were observed for the improvement in FPG after 6 mo treatment(vildagliptin add-on to metformin:-291 mg/L±18.3 mg/L;vildagliptin+metformin(SPC):-305 mg/L±9.6 mg/L;other antidiabetic drugs:-209 mg/L±14.0 mg/L for(P<0.0001).Moderate decreases in body weight(absolute difference between last control and baseline:mean±SE)were observed for patients in all cohorts(vildagliptin add-on to metformin:-1.4 kg ±0.17 kg;vildagliptin+metformin(SPC):-1.7 kg± 0.09 kg;other OADs:?0.8 kg±0.13 kg).No significant differences in adverse events(AEs)and other safety measures were observed between the cohorts.When performing an additional analysis by age(patients<65 years vs patients≥65 years),there was no relevant difference in the most common AEs between the two age groups and the AE profile was similar to that of the overall patient population.CONCLUSION:Clinical practice confirms that vildagliptin is an effective and well-tolerated treatment in combination with metformin in T2DM patients.
基金supported by the fund of Shanghai Natural Science Foundation(grant number 23ZR1464000)the Talent Fund of Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine(grant number LH001.007)the Science and Technology Support Project of Taizhou city(SSF20210070).
文摘Background:Diarrhea remains a significant health threat to children under five years of age.The study aims to systematically elucidate the global burden of diarrhea in children,providing scientific insights for effective prevention and control strategies.Methods:The data from the Global Burden of Disease(GBD)2021 study was analyzed to assess the trends in incidence,prevalence,mortality,and disability-adjusted life years(DALYs)of diarrhea in children under five years across the globe,21 geographical region,and 204 countries and territories,stratified by age group,sex,and socio-demographic index(SDI)levels.The trend of the disease burden for childhood diarrhea from 1990 to 2021 was described and estimated using the average annual percent change(AAPC),and a Bayesian age-period-cohort(BAPC)model was employed to predict the future burden of diarrhea in children.Results:From 1990 to 2021,there was a significant decline in the global burden of diarrhea among children under five years of age.The AAPC for incidence(-4092.18,95%confidence interval[CI]:-4224.60 to-3959.76),prevalence(-70.98,95%CI:-72.67 to-69.28),mortality(-6.89,95%CI:-6.95 to-6.83),and DALYs rate(-621.79,95%CI:-627.20 to-616.38)of diarrhea in children all showed a marked downward trend.Diarrheal incidence(r=-0.782,P<0.001),prevalence(r=-0.777,P<0.001),mortality(r=-0.908,P<0.001),and DALYs rate(r=-0.904,P<0.001)were negatively correlated with the SDI.Between 2022 and 2035,the global incidence,prevalence,and mortality rates of diarrhea in children under five years are projected to continue declining.The leading causes of diarrheal mortality in children include wasting,underweight,and non-exclusive breastfeeding.Rotavirus remains the predominant pathogen associated with diarrhea-related mortality rate and DALY rate.Conclusion:Although the global burden of diarrhea in children under five has steadily declined,it remains a significant health threat.Rotavirus is the leading pathogen,highlighting the importance of expanding rotavirus vaccination.Additionally,improving nutritional status,increasing exclusive breastfeeding rates,and enhancing access to sanitation and clean drinking water are crucial measures that,when widely implemented,can effectively reduce the health risks posed by diarrhea in children.
基金financially supported by the China National Funds for Distinguished Young Scholars(Grant No.51222904)the National Natural Science Foundation of China(Grant No.51379039)
文摘The pulse features of a bubble have a close connection with the boundary condition. When a bubble moves near a rigid wall, it will be attracted by the Bjerknes force of the wall, and a jet pointing at the wall will be generated. In real application, the bubble may move under the combined action of walls in different directions when it forms at the corner of a pipe or at the bottom of a dam. The motion of the bubble shows complex and nonlinear characteristics under these conditions. In order to investigate the bubble pulse features near complex walls, a horizontal wall and a vertical wall are put into the experimental water tank synchronously, and an electric circuit with 200 voltages is designed to generate discharge bubbles, and then experimental study on the bubble pulse features under the combined action of horizontal and vertical walls is carried out. The influences of the combined action of two walls on the bubble shape, pulse period, moving trace and inside jet are obtained by changing the distances from bubble center to the two walls. It aims at providing references for the relevant theoretical and numerical research.
文摘The paper analyzes the environments confronted with academic libraries and the evolving characteristics of Shanghai Jiao Tong University that give shape to the conception and implementation of an IC2Culture Exploring Project. This innovative model of SJTU Library operation is not only in concert with the strategic goals of SJTU but also with two other conspicuous developmental trends in the larger academic library circle;namely, 1) a trend toward the deepening of library service support in academic arena on the one hand and 2) the trend of diversifying library outreach services on the other hand.Based on our first-hand involvement in all phases and aspects of this project and its subsequent review and analysis undertakings, this paper expatiates upon the IC2Culture Exploring Project of SJTU Library in terms of its vision, its specific mission objectives, its program design, its unique characteristics, its launching process, its salient case studies, its initial results and its strategies for a sustainable development in the future.
文摘The purpose of this study is to investigate the disease distribution of tuberculosis in national regional project. 960 patients were selected from national tuberculosis control program who took treatments in the Fourth People’s Hospital Clinical Laboratory in Nanning Guangxi from January to November in 2013. Then we observed all those patients’ disease distribution and analyzed all the lab test indexes. We analyzed the results according to gender and age distribution. From the age distribution, we found that the incidence was lower at the age of 40 or younger, while higher incidence occurred to patients over 40 years old. There is statistical significance comparing these two age groups. P is less than 0.001. Disease distribution: 731 patients were infected with TB;21 patients were co-infected with tuberculosis (TB) and HIV. 196 patients were co-infected with TB and fungal. 12 patients were co-infected with TB, HIV and fungal. From the laboratory testing, we know there were 87 patients whose liver function indexes were abnormal. There were 192 patients whose blood RT indexes were abnormal. The liver function and blood RT indexes of patients with co-infection were higher than those infected purely. There is statistical significance in comparison P < 0.05. The study indicates that patients with older age are more likely infected with tuberculosis. In addition, there are a high proportion of patients with co-infection among these patients in this study. Meanwhile, the liver functions and blood RT indexes of patients combining with infection are higher than those infected TB purely. Prompt clinical prevention and treatment should be under reasonable inspections. General analysis can enable us to investigate more effective treatment plan. Then the best treatment result will be obtained.
文摘The development history of the project design of spaceflight launching site in China and the main forms used in these designs were introduced in this thesis, and it was pointed out that the spaceflight launch should not use only one fixed model. According to its nation condition, China should design and build the launching project facility and device which correspond to the technology development of spacecraft and carrier rocket.
文摘The purpose of this paper is to deliver a better perception of the project success,and how reporting system might increase the probability of project success in construction projects in UAE.Further,it aims at exploring the relationship between effective reporting system in terms of the characteristic of its outputs(mainly effectiveness of financial reporting system)and project success.Semi-structured interviews with a number of interior auditors,accountants,and chief financial officers(CFOs)from different corporations in construction sector in UAE in order to recognize how effective reporting system in terms of the characteristic of its outputs(broad scope,timeliness,aggregation,and integration)might contribute to increase the probability of project success.There are several success factors in construction projects in UAE,thus it is very hard to capture all these factors in one paper.Hence,this paper is not considering all project success factors rather it focuses on the characteristic of outputs of the reporting system generally and the financial reporting system particularly(broad scope,timeliness,aggregation,and integration),as most of the studies in the literature considered the reporting system as a key factor of project success.This paper adds to both project management and accounting research by evidencing results from an exploration how effective reporting might impact the project success,with valuable implications for standard officials,customers,investors,stakeholders,sponsors,shareholders,CFOs,project developer,consultants,internal auditors,and accounting academics.The effective reporting system in United Arab Emirates(UAE)construction projects enables possessors,customers,and contractors of projects to get timely information about the progress of project in a brief and significant format which in turn improve the decision-making process and contribute to project success.This paper implies a contribution for both project management literature and accounting research by investigative the effectiveness of reporting system in project successes from historical point of view and contemporary point of view.
文摘On January 7, 2015 the project "Study on the technology formanufacture of high-spheroidicity FCC catalysts "undertakenby the SINOPEC Research Institute of Petroleum Processing(RIPP) has passed the technical appraisal organized by theScience and Technology Division of the Sinopec Corp.
文摘LIRR's Priject of "Research on Spalling Mechanism Due to Rapid Heating-up of Dense Refractory Castables" declared by Wang Zhanmin,vice-president of LIRR,will gain the fund support from National Natural Science Foundation of China in 2011.
文摘The effect of the Chinese herbal compound (CHC) on solid sarcoma 180 (S180) in Swiss mice was studied either alone or in combination with 5-fluorouracil (5FU), cyclophosphamide (CYT) or mitomycin C (MMC). The preliminary results indicated that combination treatment seemed to possess better antitumor activity than chemotherapy alone. The treatment with CHC alone however had neither an obvious antitumor effect in tumor bearing mice nor toxicity in normal mice. These results show that CHC may stimulate organs of the immune system such as the spleen to be im-munomodulators and enhance the antitumor activity of some chemotherapeutic agents.
基金2018 Shanghai Leading Talents Training ProgramShanghai Clinical Research Center for Acupuncture and Moxibustion Accelerating(No.20MC1920500)+1 种基金the Development of Chinese Medicine Three-Year Action Plan of Shanghai(No.ZY(2018-2020)-CCCX-2004-04)Clinical Key Specialty Construction Foundation of Shanghai(No.shslczdzk04701).
文摘Taking the process of treating coronavirus disease 2019(COVID-19)with Western medicine and traditional Chinese medicine(TCM)as the research object,this article compares the characteristics of Western medicine and TCM from the perspectives of aetiology,pathogenesis,diagnosis,and treatment.Western medicine and TCM each has its own theoretical system.Each has its own exposition in explaining the etiology and pathogenesis of the disease,and each has its own characteristics and advantages in diagnosis and treatment.Integrating TCM and Western medicine can improve the effect of treatment by forming a coordinated traditional Chinese and Western medicine treatment method.
文摘31 cases of atherosclerosis (AS) were treated with Jiang Zhi Tong Mai Fang ([symbol: see text], formula of JZTMF), and its effect was compared with 30 cases treated with lovastatin in the control group. Clinically, the JZTMF formula showed an effect of regulating blood lipids, and therefore it was antiatherosclerotic. The mechanism is, probably, restoration of the function of endothelial cells (EC) by increasing the synthesis of 6-keto-PGF1 alpha and decreasing the release of endothelin (ET) as evidenced in the experimental study.
文摘The new double projecting neurons were found in the cat spinal dorsal horn by the double retrograde fluorescent tracing technique.Fast Blue(FB)was injected into unilateral dorsal column nucleus(DCN)of adult cats anesthetized with pentobarbital.Nuclear Yellow(NY)was injected ipsilaterally into the lateral cervical nucleus(LCN)8-9 days later.After an additional 18-30 hrs.
文摘Objective To compare the effects of combined en bloc liver - pancreas transplantation ( LPT) with portal vein drainage and simultaneous combined kidney - pancreas transplantation ( KPT) with systemic venous drainage on the pancreatic endocrine function and related me-
基金supported by the Fund of the Military Medical Scientific Research[20BJZ46]the Special Project of Health Care from the Central Committee of Healthcare[W2013BJ32]。
文摘Objective Evidence is lacking regarding the combined effects of smoking and obesity on mortality from coronary heart disease in male veterans.This study aimed to explore the combined effect of smoking and obesity on coronary heart disease mortality in male veterans in China.Methods A cohort of 1,268 male veterans from 22 veteran centers in Xi’an(Shaanxi Province,China)were followed up once every 2 years from February 1,1987 to October 30,2016.The endpoint was death from any cause.The hazard ratio(HR)of each risk factor and the 95%confidence interval(CI)were calculated using a multivariate Cox proportional hazard model.Results The total follow-up was 24394.21 person-years;each subject was followed up for a mean duration of 19.24 years.By the end of the study,of the 1,268 veterans,889 had died,363 were alive,and 16 were lost to follow-up.Cox regression analysis results revealed that current smoking(HR:1.552,95%CI:1.074–2.243),obesity(HR:1.625,95%CI:1.024–2.581),and the combined effect of the two factors(HR:2.828,95%CI:1.520–5.262)were associated with coronary heart disease mortality.Conclusion Our results suggest that obese veterans who smoke might be an important target population for coronary heart disease mortality control.