Having faced increased clinical treatment failures with dihydroartemisinin-piperaquine(DHA-PPQ),Cambodia swapped the first line artemisinin-based combination therapy(ACT)from DHA-PPQ to artesunate-mefloquine given tha...Having faced increased clinical treatment failures with dihydroartemisinin-piperaquine(DHA-PPQ),Cambodia swapped the first line artemisinin-based combination therapy(ACT)from DHA-PPQ to artesunate-mefloquine given that parasites resistant to piperaquine are susceptible to mefloquine.However,triple mutants have now emerged,suggesting that drug rotations may not be adequate to keep resistance at bay.There is,therefore,an urgent need for alternative treatment strategies to tackle resistance and prevent its spread.A proper understanding of all contributors to artemisinin resistance may help us identify novel strategies to keep artemisinins effective until new drugs become available for their replacement.This review highlights the role of the key players in artemisinin resistance,the current strategies to deal with it and suggests ways of protecting future antimalarial drugs from bowing to resistance as their predecessors did.展开更多
This research is showing the effect of increasing an Fe extracting from the compression strength, tension and bending moment. The variations in this experiment are the increasing of Fe extracting 0.5%, 1% and 1.5% of ...This research is showing the effect of increasing an Fe extracting from the compression strength, tension and bending moment. The variations in this experiment are the increasing of Fe extracting 0.5%, 1% and 1.5% of concrete volume. Water Cement Ratio （WCR） variation of 0.48, 0.56 and 0.60. The result of increasing 1.5% Fe extracting causes the increasing of tension strength 44.028 kN/cm2, the increasing of slit tension strength 2.226 kN/cm2, the increasing of bending moment 14.81 kN/cm2 from normal concrete. 0.48 WCR produces tension strength, slit tension strength and bending moment more than 0.56 and 0.60 WCR. The increasing of Fe extracting with the distribution variation area and the spread concrete in the tension concrete area produce 3.705 kN/cm2 bending moment higher than the spread fiber in all of concrete area. The 4 cm fiber length produces the higher bending moment than the 2 cm fiber length. The difference is equally 5.185 kN/cm2. The combination result of the examined acting varieties by continuation statistic test gives the result to get the maximum tension and split tensile. It is a concrete combination of increasing 1.5% fiber percentage, 0.48 WCR, full spreading area and the 4 cm fiber length. The maximum bending moment is the increasing of 0.5% fiber percentage, 0.48 WCR, full spreading area and the 4 cm fiber length.展开更多
Background:In Nigeria,Artemisinin-based Combination Therapy(ACT)is the recommended first line antimalarial medicine for uncomplicated malaria.However,health care providers still continue the use of less efficacious me...Background:In Nigeria,Artemisinin-based Combination Therapy(ACT)is the recommended first line antimalarial medicine for uncomplicated malaria.However,health care providers still continue the use of less efficacious medicines such as Sulphadoxine-pyrimethamine and chloroquine.We therefore determined preference for ACT(PFA)and factors associated with PFA among healthcare providers(HCP)in Lokoja,North-Central Nigeria as well as assessed healthcare providers’knowledge of malaria case management.Methods:We conducted a cross-sectional study among physicians,nurses,pharmacists,community health officers(CHOs),community health extension workers(CHEWs)and,patent and proprietary medicine vendors(PPMVs).Interviewer-administered questionnaires were administered to collect data on respondents’characteristics,previously received malaria case management training and knowledge of malaria treatment.Knowledge scores≥3 were categorised as good,maximum obtainable being 5.Results:Of the 404 respondents,214(53.0%)were males.Overall,219(54.2%)respondents who received malaria case management training included PPMVs:79(65.8%),CHEWs:25(64.1%),CHOs:5(55.6%),nurses:72(48.7%),physicians:35(47.3%)and pharmacists:3(23.1%).Overall,202(50.0%)providers including physicians:69(93.2%),CHO:8(88.9%),CHEWs:33(84.6%),pharmacists:8(61.5%),nurses:64(43.2%)and PPMVs:20(16.5%),had good knowledge of malaria treatment guidelines.Overall,preference for ACT among healthcare providers was 39.6%.Physicians:50(67.6%),pharmacists:7(59.3%)CHOs:5(55.6%),CHEWS:16(41.0%),nurses:56(37.8%)and PPMV:24(19.8%)had PFA.Receiving malaria case management training(adjusted odds ratio[aOR])=2.3;CI=1.4-3.7)and having good knowledge of malaria treatment(aOR=4.0;CI=2.4-6.7)were associated with PFA.Conclusions:Overall preference for ACT use was low among health care providers in this study.Preference for ACTs and proportion of health workers with good knowledge of malaria case management were even lower among PPMVs who had highest proportion of those who received malaria case management training.We recommend evaluation of current training quality,enhanced targeted training,follow-up supportive supervision of PPMVs and behavior change communication on ACT use.展开更多
目的了解当前我国妇产科医生对不同种类复方短效口服避孕药(COC)服药方案及其雌激素剂量的认识和适应症应用情况,以期为临床个体化用药决策提供参考。方法2022年8月至12月在全国20个省、自治区、直辖市的155家医院邀请妇产科医生进行问...目的了解当前我国妇产科医生对不同种类复方短效口服避孕药(COC)服药方案及其雌激素剂量的认识和适应症应用情况,以期为临床个体化用药决策提供参考。方法2022年8月至12月在全国20个省、自治区、直辖市的155家医院邀请妇产科医生进行问卷调查,了解其对国内目前五种常用COC的雌激素剂量和服药方案的认知及适应症应用情况。采用卡方检验、Bonferroni法、Crame' s V系数、雷达图等方法对数据进行统计分析及归纳总结。结果向653名妇产科医生发放调查问卷,回收有效问卷650份,回收率99.54%。妇产科医生对国内目前五种常用COC的知晓率差别较大,其中以屈螺酮炔雌醇片(Ⅱ)(20μg/片,87.69%;24/4方案,84.77%)知晓率最高,去氧孕烯炔雌醇片(20μg/片,45.69%;21/7方案,83.54%)最低。对于治疗痤疮、经前焦虑障碍、易怒、抑郁、经前综合征、多毛症和多囊卵巢综合征,28.77%~31.69%的妇产科医生选择24/4方案,37.54%~47.85%的妇产科医生选择雌激素剂量20μg/片的COC;其中对改善易怒症状(χ^(2)=9.403,P=0.009)方面,硕士及以上妇产科医生选择选择24/4方案的比例高于本科及以下学历者,差异有统计学意义。在改善月经周期规律性、治疗月经过多、经期周期控制效果方面,49.38%~50.00%的妇产科医生选择两方案效果相似,44.46%~56.31%的妇产科医生选择两剂量效果相似;其中在改善月经周期规律性(χ^(2)=8.402,P=0.015)和治疗月经过多(χ^(2)=6.451,P=0.040)方面,选择两剂量相似的副主任医师及以上的比例高于主治医师及以下者,差异均有统计学意义。妇产科医生对不同雌激素剂量和服药方案的选择呈弱相关(0.2<Cramer's V<0.3,P<0.05)。结论国内妇产科医生对不同COC的知晓率参差不齐,普遍存在对COC的作用机制认知不足。鉴于COC应用的广泛性,建议对妇产科医生加强COC药物作用机制的相关培训,了解雌孕激素剂量、种类与服药方案的关系,准确掌握适应症,以期更好地提供个体化推荐用药。展开更多
The Hamiltonian of a quantum rod with an ellipsoidal boundary is given after a coordinate transformation which changes the ellipsoidal boundary into a spherical one.We then study the first internal excited state energ...The Hamiltonian of a quantum rod with an ellipsoidal boundary is given after a coordinate transformation which changes the ellipsoidal boundary into a spherical one.We then study the first internal excited state energy,the excitation energy and the frequency of the transition spectral line between the first internal excited state and the ground state of the strong-coupling polaron in a quantum rod.The effects of the electron-phonon coupling strength,the aspect ratio of the ellipsoid,the transverse radius of quantum rods and the transverse and longitudinal effective confinement length are taken into consideration by using a linear combination operator and the unitary transformation methods.It is found that the first internal excited state energy,the excitation energy and the frequency of the transition spectral line are increasing functions of the electron-phonon coupling strength,whereas they are decreasing ones of the transverse radius of quantum rods and the aspect ratio.The first internal excited state energy,the excitation energy and the frequency of the transition spectral line increase with decreasing transverse and longitudinal effective confinement length.展开更多
在国家"523"(防治疟疾新药项目代号)任务实施50周年之际,对广州中医药大学青蒿素抗疟研究科研团队采用青蒿素复方防治疟疾的历程与所取得的进展进行评述。广州中医药大学作为"523"项目研究小组之一,其青蒿素抗疟研...在国家"523"(防治疟疾新药项目代号)任务实施50周年之际,对广州中医药大学青蒿素抗疟研究科研团队采用青蒿素复方防治疟疾的历程与所取得的进展进行评述。广州中医药大学作为"523"项目研究小组之一,其青蒿素抗疟研究科研团队相继主持了采用青蒿素及其衍生物不同剂型、剂量、疗程治疗疟疾的临床研究(1974~1989)、青蒿素复方(Artekin及Artequick)治疗疟疾的临床研究(1984~2006),并于近10年中在东南亚地区及非洲全力推行快速消灭传染源清除疟疾(Fast Elimination of Malaria by Source Eradication,FEMSE)的抗疟项目。青蒿素抗疟研究科研团队所做的探索与获得的成就为青蒿素类药物走向世界做出了重要贡献,并为全球快速消灭疟疾创建了一种简单、易行、省钱的新方法。展开更多
文摘Having faced increased clinical treatment failures with dihydroartemisinin-piperaquine(DHA-PPQ),Cambodia swapped the first line artemisinin-based combination therapy(ACT)from DHA-PPQ to artesunate-mefloquine given that parasites resistant to piperaquine are susceptible to mefloquine.However,triple mutants have now emerged,suggesting that drug rotations may not be adequate to keep resistance at bay.There is,therefore,an urgent need for alternative treatment strategies to tackle resistance and prevent its spread.A proper understanding of all contributors to artemisinin resistance may help us identify novel strategies to keep artemisinins effective until new drugs become available for their replacement.This review highlights the role of the key players in artemisinin resistance,the current strategies to deal with it and suggests ways of protecting future antimalarial drugs from bowing to resistance as their predecessors did.
文摘This research is showing the effect of increasing an Fe extracting from the compression strength, tension and bending moment. The variations in this experiment are the increasing of Fe extracting 0.5%, 1% and 1.5% of concrete volume. Water Cement Ratio （WCR） variation of 0.48, 0.56 and 0.60. The result of increasing 1.5% Fe extracting causes the increasing of tension strength 44.028 kN/cm2, the increasing of slit tension strength 2.226 kN/cm2, the increasing of bending moment 14.81 kN/cm2 from normal concrete. 0.48 WCR produces tension strength, slit tension strength and bending moment more than 0.56 and 0.60 WCR. The increasing of Fe extracting with the distribution variation area and the spread concrete in the tension concrete area produce 3.705 kN/cm2 bending moment higher than the spread fiber in all of concrete area. The 4 cm fiber length produces the higher bending moment than the 2 cm fiber length. The difference is equally 5.185 kN/cm2. The combination result of the examined acting varieties by continuation statistic test gives the result to get the maximum tension and split tensile. It is a concrete combination of increasing 1.5% fiber percentage, 0.48 WCR, full spreading area and the 4 cm fiber length. The maximum bending moment is the increasing of 0.5% fiber percentage, 0.48 WCR, full spreading area and the 4 cm fiber length.
基金supported by cooperative agreement number U2R6H000046 funded by the Center for Disease Control and Prevention(CDC)through the Nigeria Field Epidemiology and Laboratory Training Programme。
文摘Background:In Nigeria,Artemisinin-based Combination Therapy(ACT)is the recommended first line antimalarial medicine for uncomplicated malaria.However,health care providers still continue the use of less efficacious medicines such as Sulphadoxine-pyrimethamine and chloroquine.We therefore determined preference for ACT(PFA)and factors associated with PFA among healthcare providers(HCP)in Lokoja,North-Central Nigeria as well as assessed healthcare providers’knowledge of malaria case management.Methods:We conducted a cross-sectional study among physicians,nurses,pharmacists,community health officers(CHOs),community health extension workers(CHEWs)and,patent and proprietary medicine vendors(PPMVs).Interviewer-administered questionnaires were administered to collect data on respondents’characteristics,previously received malaria case management training and knowledge of malaria treatment.Knowledge scores≥3 were categorised as good,maximum obtainable being 5.Results:Of the 404 respondents,214(53.0%)were males.Overall,219(54.2%)respondents who received malaria case management training included PPMVs:79(65.8%),CHEWs:25(64.1%),CHOs:5(55.6%),nurses:72(48.7%),physicians:35(47.3%)and pharmacists:3(23.1%).Overall,202(50.0%)providers including physicians:69(93.2%),CHO:8(88.9%),CHEWs:33(84.6%),pharmacists:8(61.5%),nurses:64(43.2%)and PPMVs:20(16.5%),had good knowledge of malaria treatment guidelines.Overall,preference for ACT among healthcare providers was 39.6%.Physicians:50(67.6%),pharmacists:7(59.3%)CHOs:5(55.6%),CHEWS:16(41.0%),nurses:56(37.8%)and PPMV:24(19.8%)had PFA.Receiving malaria case management training(adjusted odds ratio[aOR])=2.3;CI=1.4-3.7)and having good knowledge of malaria treatment(aOR=4.0;CI=2.4-6.7)were associated with PFA.Conclusions:Overall preference for ACT use was low among health care providers in this study.Preference for ACTs and proportion of health workers with good knowledge of malaria case management were even lower among PPMVs who had highest proportion of those who received malaria case management training.We recommend evaluation of current training quality,enhanced targeted training,follow-up supportive supervision of PPMVs and behavior change communication on ACT use.
文摘目的了解当前我国妇产科医生对不同种类复方短效口服避孕药(COC)服药方案及其雌激素剂量的认识和适应症应用情况,以期为临床个体化用药决策提供参考。方法2022年8月至12月在全国20个省、自治区、直辖市的155家医院邀请妇产科医生进行问卷调查,了解其对国内目前五种常用COC的雌激素剂量和服药方案的认知及适应症应用情况。采用卡方检验、Bonferroni法、Crame' s V系数、雷达图等方法对数据进行统计分析及归纳总结。结果向653名妇产科医生发放调查问卷,回收有效问卷650份,回收率99.54%。妇产科医生对国内目前五种常用COC的知晓率差别较大,其中以屈螺酮炔雌醇片(Ⅱ)(20μg/片,87.69%;24/4方案,84.77%)知晓率最高,去氧孕烯炔雌醇片(20μg/片,45.69%;21/7方案,83.54%)最低。对于治疗痤疮、经前焦虑障碍、易怒、抑郁、经前综合征、多毛症和多囊卵巢综合征,28.77%~31.69%的妇产科医生选择24/4方案,37.54%~47.85%的妇产科医生选择雌激素剂量20μg/片的COC;其中对改善易怒症状(χ^(2)=9.403,P=0.009)方面,硕士及以上妇产科医生选择选择24/4方案的比例高于本科及以下学历者,差异有统计学意义。在改善月经周期规律性、治疗月经过多、经期周期控制效果方面,49.38%~50.00%的妇产科医生选择两方案效果相似,44.46%~56.31%的妇产科医生选择两剂量效果相似;其中在改善月经周期规律性(χ^(2)=8.402,P=0.015)和治疗月经过多(χ^(2)=6.451,P=0.040)方面,选择两剂量相似的副主任医师及以上的比例高于主治医师及以下者,差异均有统计学意义。妇产科医生对不同雌激素剂量和服药方案的选择呈弱相关(0.2<Cramer's V<0.3,P<0.05)。结论国内妇产科医生对不同COC的知晓率参差不齐,普遍存在对COC的作用机制认知不足。鉴于COC应用的广泛性,建议对妇产科医生加强COC药物作用机制的相关培训,了解雌孕激素剂量、种类与服药方案的关系,准确掌握适应症,以期更好地提供个体化推荐用药。
基金supported by the National Natural Science Foundation of China(No.10747002)
文摘The Hamiltonian of a quantum rod with an ellipsoidal boundary is given after a coordinate transformation which changes the ellipsoidal boundary into a spherical one.We then study the first internal excited state energy,the excitation energy and the frequency of the transition spectral line between the first internal excited state and the ground state of the strong-coupling polaron in a quantum rod.The effects of the electron-phonon coupling strength,the aspect ratio of the ellipsoid,the transverse radius of quantum rods and the transverse and longitudinal effective confinement length are taken into consideration by using a linear combination operator and the unitary transformation methods.It is found that the first internal excited state energy,the excitation energy and the frequency of the transition spectral line are increasing functions of the electron-phonon coupling strength,whereas they are decreasing ones of the transverse radius of quantum rods and the aspect ratio.The first internal excited state energy,the excitation energy and the frequency of the transition spectral line increase with decreasing transverse and longitudinal effective confinement length.
文摘在国家"523"(防治疟疾新药项目代号)任务实施50周年之际,对广州中医药大学青蒿素抗疟研究科研团队采用青蒿素复方防治疟疾的历程与所取得的进展进行评述。广州中医药大学作为"523"项目研究小组之一,其青蒿素抗疟研究科研团队相继主持了采用青蒿素及其衍生物不同剂型、剂量、疗程治疗疟疾的临床研究(1974~1989)、青蒿素复方(Artekin及Artequick)治疗疟疾的临床研究(1984~2006),并于近10年中在东南亚地区及非洲全力推行快速消灭传染源清除疟疾(Fast Elimination of Malaria by Source Eradication,FEMSE)的抗疟项目。青蒿素抗疟研究科研团队所做的探索与获得的成就为青蒿素类药物走向世界做出了重要贡献,并为全球快速消灭疟疾创建了一种简单、易行、省钱的新方法。
