A retention prediction system(RPS)of seven O-ethyl N-isopropyl phosphoro(thioureido)- thioates in reversed phase HPLC was investigated.The system is based on the solvent selectivity triangle concept.Three molecular st...A retention prediction system(RPS)of seven O-ethyl N-isopropyl phosphoro(thioureido)- thioates in reversed phase HPLC was investigated.The system is based on the solvent selectivity triangle concept.Three molecular structure parameters(hydrophobicity Ⅱ,substituent length L, and substituent maximum width B_5)were used to describe the quantitative structure-retention relation- ships.With these quantitative relationships,the retention behaviours of other eight homologs for different mobile phase composition were predicted.The predicted values were consistent with the measured values within relative error of 10%,which means that it is possible to apply the reported method to predict retention values for qualitative purposes for different mobile phase compositions.展开更多
文摘A retention prediction system(RPS)of seven O-ethyl N-isopropyl phosphoro(thioureido)- thioates in reversed phase HPLC was investigated.The system is based on the solvent selectivity triangle concept.Three molecular structure parameters(hydrophobicity Ⅱ,substituent length L, and substituent maximum width B_5)were used to describe the quantitative structure-retention relation- ships.With these quantitative relationships,the retention behaviours of other eight homologs for different mobile phase composition were predicted.The predicted values were consistent with the measured values within relative error of 10%,which means that it is possible to apply the reported method to predict retention values for qualitative purposes for different mobile phase compositions.
