Fluorine-doped hydrogenated amorphous carbon (a-C:H:F) film was deposited on a flow-straightener, impeller and diffuser surface (SUS 304) of an enclosed-impeller type flow blood pump using the ionization deposition me...Fluorine-doped hydrogenated amorphous carbon (a-C:H:F) film was deposited on a flow-straightener, impeller and diffuser surface (SUS 304) of an enclosed-impeller type flow blood pump using the ionization deposition method with a source gas of C6F5H. The surface characteristics of the a-C:H:F film were examined using atomic force microscopy, X-ray photoelectron spectroscopy, and measurements of surface roughness, friction and surface potential. The a-C:H:F film tends to increase surface roughness and the negative surface charge. In addition, the surface energy and friction decrease with fluorine dopant in the a-C:H film. To estimate the hemolytic performance of a blood pump with the a-C:H:F film coating, the amount of hemolysis was measured using a mock circulatory system (in vitro test) with 500 mL of pig blood containing sodium citrate. In vitro test was conducted for 180 min with the blood flow and pump head maintained at 5 L/min and 100 mmHg, respectively. The a-C:H:F film coating reduced the amount of hemolysis and improved the hemolytic performance. Decreasing the surface energy and negative surface charge of the a-C:H:F film contributes to the improvement of the hemolytic performance. The a-C:H:F film coating is thus expected to be utilized in medical technology as a surface coating technology for artificial heart blood pumps.展开更多
目的 探讨老年原发性高血压(EH)患者心脏结构、泵血功能与动态血压变异性的关系。方法 选取2021年1月至2022年12月在郑州市中医院接受治疗的126例老年EH患者作为A组,其中79例H型高血压(HT)患者为H型HT组,47例非H型HT患者为非H型HT组。...目的 探讨老年原发性高血压(EH)患者心脏结构、泵血功能与动态血压变异性的关系。方法 选取2021年1月至2022年12月在郑州市中医院接受治疗的126例老年EH患者作为A组,其中79例H型高血压(HT)患者为H型HT组,47例非H型HT患者为非H型HT组。同期收治的130例非HT老年患者作为B组。比较A组和B组动态血压变异性指标、泵血功能、心脏结构,H型HT组和非H型HT组动态血压变异性指标、心脏结构、泵血功能,并采用Spearman相关性分析老年EH患者心脏结构、泵血功能与动态血压变异性指标的相关性。结果 A组夜间收缩压标准差(N-SSD)、24 h收缩压标准差(24 h SSD)、白天收缩压标准差(D-SSD)均高于B组(P<0.05)。A组每搏量、心排出量及室间隔厚度高于B组;A组左室射血分数(LVEF)及左心室后壁厚度低于B组(P<0.05)。相比于非H型HT组,H型HT组24 h SSD、N-SSD、D-SSD、每搏量、心排出量及室间隔厚度均更高;LVEF及左心室后壁厚度更低(P<0.05)。老年EH患者每搏量与24 h SSD、N-SSD、D-SSD呈正相关(r=0.548、0.508、0.487),心排出量与24 h SSD、N-SSD、D-SSD呈正相关(r=0.612、0.573、0.490);LVEF与24 h SSD、N-SSD、D-SSD呈负相关(r=-0.603、-0.489、-0.543);室间隔厚度与24 h SSD、N-SSD、D-SSD呈正相关(r=0.576、0.645、0.476);左心室后壁厚度与24 h SSD、N-SSD、D-SSD呈负相关(r=-0.524、-0.603、-0.498)(P<0.05)。结论 不同类型的老年EH患者动态血压变异性、心脏结构及泵血功能有所差异,患者24 h SSD、N-SSD、D-SSD与每搏量、心排出量、室间隔厚度呈正相关,与LVEF、左心室后壁厚度呈负相关。展开更多
This paper shows the blood flow control （FwC） performance to adjust rotational speed of an ICBP （implantable centrifugal blood pump） in order to provide an adequate flow to left ventricle in different patient cond...This paper shows the blood flow control （FwC） performance to adjust rotational speed of an ICBP （implantable centrifugal blood pump） in order to provide an adequate flow to left ventricle in different patient conditions. ICBP is a totally implantable LVAD （left ventricular assist device） with ceramic bearings developed for long term circulatory assistance. FwC uses PI （proportional-integral） control to adjust rotational speed in order to provide blood flow. FwC does not use sensor for feedback, as there is an estimation system to provide blood flow measurement. Control strategy has being studied in a HCS （hybrid cardiovascular simulator） as a tool that allows the physical connection of ICBP during evaluation. In addition, HCS allows changes of some cardiovascular parameters in order to simulate specific heart disease： ejection fraction （10-25%） and heart rate （50-110 bpm）. FwC was able to adjust blood flow with steady error less than 2%. Results demonstrated that FwC is adequate to LVAD control irL different left ventricle failure conditions.展开更多
文摘Fluorine-doped hydrogenated amorphous carbon (a-C:H:F) film was deposited on a flow-straightener, impeller and diffuser surface (SUS 304) of an enclosed-impeller type flow blood pump using the ionization deposition method with a source gas of C6F5H. The surface characteristics of the a-C:H:F film were examined using atomic force microscopy, X-ray photoelectron spectroscopy, and measurements of surface roughness, friction and surface potential. The a-C:H:F film tends to increase surface roughness and the negative surface charge. In addition, the surface energy and friction decrease with fluorine dopant in the a-C:H film. To estimate the hemolytic performance of a blood pump with the a-C:H:F film coating, the amount of hemolysis was measured using a mock circulatory system (in vitro test) with 500 mL of pig blood containing sodium citrate. In vitro test was conducted for 180 min with the blood flow and pump head maintained at 5 L/min and 100 mmHg, respectively. The a-C:H:F film coating reduced the amount of hemolysis and improved the hemolytic performance. Decreasing the surface energy and negative surface charge of the a-C:H:F film contributes to the improvement of the hemolytic performance. The a-C:H:F film coating is thus expected to be utilized in medical technology as a surface coating technology for artificial heart blood pumps.
文摘目的 探讨老年原发性高血压(EH)患者心脏结构、泵血功能与动态血压变异性的关系。方法 选取2021年1月至2022年12月在郑州市中医院接受治疗的126例老年EH患者作为A组,其中79例H型高血压(HT)患者为H型HT组,47例非H型HT患者为非H型HT组。同期收治的130例非HT老年患者作为B组。比较A组和B组动态血压变异性指标、泵血功能、心脏结构,H型HT组和非H型HT组动态血压变异性指标、心脏结构、泵血功能,并采用Spearman相关性分析老年EH患者心脏结构、泵血功能与动态血压变异性指标的相关性。结果 A组夜间收缩压标准差(N-SSD)、24 h收缩压标准差(24 h SSD)、白天收缩压标准差(D-SSD)均高于B组(P<0.05)。A组每搏量、心排出量及室间隔厚度高于B组;A组左室射血分数(LVEF)及左心室后壁厚度低于B组(P<0.05)。相比于非H型HT组,H型HT组24 h SSD、N-SSD、D-SSD、每搏量、心排出量及室间隔厚度均更高;LVEF及左心室后壁厚度更低(P<0.05)。老年EH患者每搏量与24 h SSD、N-SSD、D-SSD呈正相关(r=0.548、0.508、0.487),心排出量与24 h SSD、N-SSD、D-SSD呈正相关(r=0.612、0.573、0.490);LVEF与24 h SSD、N-SSD、D-SSD呈负相关(r=-0.603、-0.489、-0.543);室间隔厚度与24 h SSD、N-SSD、D-SSD呈正相关(r=0.576、0.645、0.476);左心室后壁厚度与24 h SSD、N-SSD、D-SSD呈负相关(r=-0.524、-0.603、-0.498)(P<0.05)。结论 不同类型的老年EH患者动态血压变异性、心脏结构及泵血功能有所差异,患者24 h SSD、N-SSD、D-SSD与每搏量、心排出量、室间隔厚度呈正相关,与LVEF、左心室后壁厚度呈负相关。
文摘This paper shows the blood flow control （FwC） performance to adjust rotational speed of an ICBP （implantable centrifugal blood pump） in order to provide an adequate flow to left ventricle in different patient conditions. ICBP is a totally implantable LVAD （left ventricular assist device） with ceramic bearings developed for long term circulatory assistance. FwC uses PI （proportional-integral） control to adjust rotational speed in order to provide blood flow. FwC does not use sensor for feedback, as there is an estimation system to provide blood flow measurement. Control strategy has being studied in a HCS （hybrid cardiovascular simulator） as a tool that allows the physical connection of ICBP during evaluation. In addition, HCS allows changes of some cardiovascular parameters in order to simulate specific heart disease： ejection fraction （10-25%） and heart rate （50-110 bpm）. FwC was able to adjust blood flow with steady error less than 2%. Results demonstrated that FwC is adequate to LVAD control irL different left ventricle failure conditions.
