Building a Business and Strategic Intelligence Policy as a Strategy for Promoting Congolese Business Progress and Healthy Economic Development in Eastern DRC

The aim of this study was to verify the existence of business and strategic intelligence policies at the level of Congolese companies and at the state level, likely to foster progress and healthy development in the east of the DRC. The study was based on a mixed perspective consisting of objective analysis of quantitative data and interpretative analysis of qualitative data. The results showed that business and strategic intelligence policies have not been established at either company or state level, as this is an area of activity that is not known to the players in companies and public departments, and there are no units or offices in their organizational structures responsible for managing strategic information for competitiveness on the international market. In addition, there is a real need to establish strategic information management units within companies, upstream, and to set up a national strategic information management department or agency to help local companies compete in the marketplace, downstream. This reflects the importance and timeliness of building business and strategic intelligence policies to ensure economic progress and development in the eastern DRC. Business and strategic intelligence provides companies with an appropriate tool for researching, collecting, processing and disseminating information useful for decision-making among stakeholders, in order to cope with a crisis or competitive situation. The study suggests a number of key recommendations based on its findings. To the government, it is recommended to establish the national policy of business and strategic intelligence by setting up a national agency of strategic intelligence in favor of local companies;and to companies to establish business intelligence units in their organizational structures in favor of stakeholders to foster advantageous decision-making in the competitive market and achieve progress. Finally, the study suggests that studies be carried out to fully understand the opportunities and impact of business and strategic intelligence in African countries, particularly in the DRC.

New aspects of a small GTPase RAB35 in brain development and function

In eukaryotic cells,organelles in the secretory,lysosomal,and endocytic pathways actively exchange biological materials with each other through intracellular membrane trafficking,which is the process of transporting the cargo of proteins,lipids,and other molecules to appropriate compartments via transport vesicles or intermediates.These processes are strictly regulated by various small GTPases such as the RAS-like in rat brain(RAB)protein family,which is the largest subfamily of the RAS superfamily.Dysfunction of membrane trafficking affects tissue homeostasis and leads to a wide range of diseases,including neurological disorders and neurodegenerative diseases.Therefore,it is important to understand the physiological and pathological roles of RAB proteins in brain function.RAB35,a member of the RAB family,is an evolutionarily conserved protein in metazoans.A wide range of studies using cultured mammalian cells and model organisms have revealed that RAB35 mediates various processes such as cytokinesis,endocytic recycling,actin bundling,and cell migration.RAB35 is also involved in neurite outgrowth and turnover of synaptic vesicles.We generated brain-specific Rab35 knockout mice to study the physiological roles of RAB35 in brain development and function.These mice exhibited defects in anxiety-related behaviors and spatial memory.Strikingly,RAB35 is required for the precise positioning of pyramidal neurons during hippocampal development,and thereby for normal hippocampal lamination.In contrast,layer formation in the cerebral cortex occurred superficially,even in the absence of RAB35,suggesting a predominant role for RAB35 in hippocampal development rather than in cerebral cortex development.Recent studies have suggested an association between RAB35 and neurodegenerative diseases,including Parkinson's disease and Alzheimer's disease.In this review,we provide an overview of the current understanding of subcellular functions of RAB35.We also provide insights into the physiological role of RAB35 in mammalian brain development and function,and discuss the involvement of RAB35 dysfunction in neurodegenerative diseases.

Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins

Human brain development is a complex process,and animal models often have significant limitations.To address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and disease.To enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid culture.This involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid system.This cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology testing.As a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental toxins.Brain organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature differentiation.Cadmium exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic locations.The convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.

Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development

The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures.However,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development studies.Thus,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo retina.In this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in vivo.Initially,we used SOX2 and PAX6 immunostaining to identify retinal progenitor cells.We then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,respectively.Ki-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between groups.Additionally,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,respectively.The timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant retinas.Our study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina development.The findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.

Epigenetic regulation of targeted ferroptosis: A new strategy for drug development

Ferroptosis is a newly discovered form of cell death that is influenced by iron levels and is triggered by cellular metabolism and excessive lipid peroxidation.Epigenetic regulation plays a crucial role in the development and progression of diseases,making it essential to understand these mechanisms in order to identify potential targets for drug development and clinical treatment.The intersection of ferroptosis and epigenetics has opened up new avenues for research in drug development,offering innovative strategies for combating diseases.Recent studies have shown that epigenetic modifications can impact pathways related to ferroptosis,potentially leading to organ dysfunction.Despite the increasing focus on this relationship,the role of epigenetic regulation in drug development remains largely unexplored.This article explores current research on the interplay between epigenetic regulation and ferroptosis,delving into their regulatory mechanisms and discussing the effects of existing epigenetic modification regula-tors on diseases.Additionally,we highlight ongoing research on epigenetic factors involved in targeting ferroptosis in cancer,providing new insights for the development of cancer treatments.

Research on the Development Strategy of Smart Tourism in Hainan Under the Background of Big Data

Hainan is a major tourist province.It is urgent to promote the transformation and upgrading of Hainan’s tourism industry from a traditional service industry to a modern service industry by means of informatization.Smart tourism is a brand-new tourism form and operation mode of tourism transformation and upgrading.Integrating big data technology will make smart tourism more accurate in three aspects:tourism management,tourism service,and tourism marketing,and further enhance the satisfaction of the tourism experience.This paper studies the development status of smart tourism in Hainan,deeply summarizes its existing problems and causes,and puts forward the development strategy of smart tourism in Hainan to promote the healthy development of the tourism industry in Hainan.

Exploration of Teaching Development Strategies for Double-Qualified Teachers in University- Affiliated Hospitals Based on Role Conflict Theory

This study draws on the classic theories and research achievements of university teacher development,and from the perspective of role conflict in social psychology,proposes policy recommendations for the development of clinical teachers in medical colleges,including following different stages of teacher development and designing teaching development strategies at different levels;designing the content and form of teaching development activities to meet the temporal and spatial needs of clinical teachers;and building an academic community for clinical teachers to promote the creation of teaching development behaviors.

Interplay of Development and Governance in China's Modernization Strategy

High-quality development requires both development-oriented and government-oriented reforms.SINCE 1978,China's policy of reform and opening-up has been pivotal in propelling the nation toward big achievements.Its distinct and unique path of development has been a success due to a system and mechanisms that have been continually fine-tuned and strengthened through ongoing reforms.

Analysis of Innovative Paths for Enterprise Marketing Management Development Strategy under the Background of New Media

From the perspective of enterprise marketing strategy planning,innovative research should be conducted based on the current trends in new media.The findings should be applied to practical activities within enterprises to achieve innovation in marketing strategy decision-making in the new media environment.Enterprises should adopt advanced communication transmission technologies and big data processing capabilities to effectively leverage the hidden value and promotional planning advantages of network media platforms.This approach can enhance customer loyalty and increase demand for new products.Enterprises should integrate into the continuously evolving new media landscape,explore their potential business characteristics,and innovate promotional methods.By effectively combining product information with digital media content,companies can ultimately achieve significant increases in corporate interests.

A systematic review of climate change impacts,adaptation strategies,and policy development in West Africa

Climate change studies are diverse with no single study giving a comprehensive review of climate change impacts,adaptation strategies,and policy development in West Africa.The unavailability of an all-inclusive study to serve as a guide for practitioners affects the effectiveness of climate change adaptation strategies proposed and adopted in the West African sub-region.The purpose of this study was to review the impacts of climate change risks on the crop,fishery,and livestock sectors,as well as the climate change adaptation strategies and climate-related policies aimed at helping to build resilient agricultural production systems in West Africa.The review process followed a series of rigorous stages until the final selection of 56 articles published from 2009 to 2023.Generally,the results highlighted the adverse effects of climate change risks on food security.We found a continuous decline in food crop production.Additionally,the livestock sector experienced morbidity and mortality,as well as reduction in meat and milk production.The fishery sector recorded loss of fingerlings,reduction in fish stocks,and destruction of mariculture and aquaculture.In West Africa,climate-smart agriculture technologies,physical protection of fishing,and inclusion of gender perspectives in programs appear to be the major adaptation strategies.The study therefore recommends the inclusion of ecosystem and biodiversity restoration,weather insurance,replacement of unsafe vessels,and strengthening gender equality in all climate change mitigation programs,as these will help to secure enough food for present and future generations.

Development Strategy of Sichuan Sports Museum under the Background of Cultural and Tourism Integration

Through conducting a SWOT analysis of the Chengdu Sports Institute Museum,and utilizing the 4M management,5W display,and 4P marketing theoretical models,this study explores effective strategies suitable for Sichuan sports museums in terms of functionality,display,and marketing.

Food Security Problems and Solutions in China Based on the Strategy of Sustainable Agricultural Development

China attaches great importance to food security.With the strong promotion of the government,Chinas grain output has achieved a great feat from"shortage"to"surplus in bumper years"and then to"rising steadily",achieving a record"increase for the tenth consecutive year".From the current balance of food supply and demand in China,the food security situation can be guaranteed on the whole.However,if we analyze the food security in China from the perspective of agricultural sustainable development strategy,there are some difficulties,such as the reduction of cultivated land area,the decline of cultivated land quality,the fragility of agricultural ecological environment,and the transformation of residentsconsumption structure.This paper analyzes the difficulties faced by the development of food security in China under the strategy of sustainable agricultural development,and puts forward that to implement the strategy of sustainable agricultural development,it is necessary to realize the coordinated development of food security,science and technology,ecological environment,resources and society.

Career Development of Higher Education Teachers:Opportunities,Challenges,and Strategies for Success

Career development for higher education teachers plays a crucial role in enhancing both the quality of education and the professional satisfaction of academic staff.This essay explores the various stages of career development for educators,including entry into academia,professional growth,and leadership advancement.It examines the challenges these educators face-such as the balance between teaching,research,and service-and presents strategies that institutions and individuals can adopt to foster career growth.Key factors like mentorship,continuing education,and institutional support are discussed as critical to enabling sustainable career progression.The essay concludes by underscoring the importance of ongoing development to ensure teachers can meet evolving educational demands.

The Impact of Sustainable Development Strategies on Corporate Performance

Enterprises must develop and implement effective strategic measures to achieve sustainable development.This entails evaluating corporate performance,understanding the impact of sustainable development strategies on corporate performance,and implementing such strategies.The article proposes eight critical countermeasures to foster harmony and sustainable development among humanity,nature,the economy,and society:innovation-driven initiatives,green development practices,social responsibility initiatives,talent cultivation programs,collaborative cooperation efforts,sound financial management,brand-building endeavors,and effective information management.

Research on Creation Strategies of Picture Books for Children’s Cognitive and Imaginative Development

This paper discusses the creation strategies of picture books for children’s cognitive and imaginative development,and proposes that picture book creation should closely focus on the needs of children’s cognitive and imaginative development.Through analysis,this paper summarizes the effective strategies in the creation of picture books,aiming to provide theoretical reference and practical guidance for the design of children’s picture books,and further promote the comprehensive development of children’s cognitive and imaginative abilities.

Measurement and Strategy Research on the Green Development Level for the New Energy Vehicle Industry in Chongqing City

This article takes 2016-2022 as the inspection period to construct an evaluation index system for the green development level of the new energy vehicle industry.The entropy method and comprehensive index are used to measure the green development level of the new energy vehicle industry in Chongqing,and compared with neighboring provinces such as Yunnan,Guizhou,and Sichuan.Policy recommendations are proposed to promote the development of the new energy vehicle industry in Chongqing City.

Innovative Technologies for Large-Scale Water Production in Arid Regions: Strategies for Sustainable Development

Water scarcity in arid regions poses significant challenges to sustainable development and human well-being. This article explores both existing and innovative technologies and methods to produce large amounts of water to address these challenges effectively. Key approaches include atmospheric water generation, advanced desalination techniques, innovative water collection methods such as fog nets and dew harvesting, geothermal water extraction, and water recycling and reuse. Each method is evaluated for its feasibility with existing technology, potential time of implementation, required investments, and specific challenges. By leveraging these technologies and combining them into a multifaceted water management strategy, it is possible to enhance water security, support agricultural and industrial activities, and improve living conditions in arid regions. Collaborative efforts between governments, private sector entities, and research institutions are crucial to advancing these technologies and ensuring their sustainable implementation. The article provides a comprehensive overview of the current state of these technologies, their potential for large-scale application, and recommendations for future research and development.

Development Strategies for Urban Parks in Chongqing’s Main District:A New Paradigm for Urban Green Spaces

With the advent of the new concept of an“urban park”and the new paradigm of urban development,Chongqing Municipality has actively embraced this vision,integrating it with the city’s unique geographical and demographic conditions.The city has prioritized urban park construction as a key project for public welfare,aiming to address issues such as uneven geographical distribution,limited functionality,and mismatched supply and demand.This initiative seeks to optimize urban parks as vital public resources while protecting the ecological environment.Adhering to principles of functional priority,safety and comfort,shared development,and distinctive features,Chongqing has incorporated parks and other green open spaces into its basic urban planning.This approach aims to create beautiful,comfortable and age-friendly shared urban spaces.This study,grounded in the urban park development concept and the characteristics of a mountainous,multi-center city,constructs a model to measure urban park satisfaction in Chongqing’s main urban area.The model considers supply-demand matching and resident satisfaction.It aims to systematically review relevant policies,plans,and cutting-edge theories,analyze the urban park development in Chongqing,understand residents’needs,and address issues related to supply-demand matching,multifunctionality,and quality construction.The findings provide insights into the development and conservation of urban parks in Chongqing and beyond,aiming to continually meet the public’s growing desire for a better quality of life and support high-quality development.

Analysis and Innovative Strategies of Tax Preferential Policies to Promote the Sustainable Development of Small-Scale Individual Businesses

This study conducted an in-depth analysis of the current tax preferential policies for small-scale individual businesses and compared them with similar policies both domestically and internationally,aiming to reveal the advantages and disadvantages of the current system.After examining the impact of these tax preferential policies on the economic status of individual business owners and the broader social economy,this article proposes a set of innovative tax preferential strategies based on theoretical foundations.By developing these innovative strategies and clarifying their implementation paths,the aim is to promote the sustainable and healthy development of small-scale individual businesses,thereby fostering comprehensive socio-economic progress.The conclusion of this study not only summarizes policy recommendations with practical significance but also provides theoretical support for the optimization and innovation of future related systems.

Computational Strategy Research on the Development of Kiruna,in Sweden

In Kiruna,nearly all the residents support the migration plan in order to make LKAB able to continue the mining process.Based on current condition,a larger part of this town will be demolished by the sinking land caused by iron ore mining processing operated by LKAB.Since then,most of the buildings in the sinking district will be relocated in another district.However,the situation in Kiruna is not quite the same as when this kind of migration happens in another place.In other place,while migration happens,even if not most,a large part of the local residents will resist and fight for their house and properties.Concentrated on the ownership of different buildings and tried find the relationship between the public and private buildings to discover some issue that will help to work on the computational urban design.