Previous studies have demonstrated that hand shadows may activate the motor cortex associated with the mirror neuron system in human brain. However, there is no evidence of activity of the human mirror neuron system d...Previous studies have demonstrated that hand shadows may activate the motor cortex associated with the mirror neuron system in human brain. However, there is no evidence of activity of the human mirror neuron system during the observation of intransitive movements by shadows and line drawings of hands. This study examined the suppression of electroencephalography mu waves （8-13 Hz） induced by observation of stimuli in 18 healthy students. Three stimuli were used： real hand actions, hand shadow actions and actions made by line drawings of hands. The results showed significant desynchronization of the mu rhythm （＂mu suppression＂） across the sensodmotor cortex （recorded at C3, Cz and C4）, the frontal cortex （recorded at F3, Fz and F4） and the central and right posterior parietal cortex （recorded at Pz and P4） under all three conditions. Our experimental findings suggest that the observation of ＂impoverished hand actions＂, such as intransitive movements of shadows and line drawings of hands, is able to activate widespread cortical areas related to the putative human mirror neuron system.展开更多
For many years, ruminant nutritionists and microbiologists have been interested in manipulating the microbial ecosystem of the rumen to improve production efficiency of different ruminant species. Removal and restrict...For many years, ruminant nutritionists and microbiologists have been interested in manipulating the microbial ecosystem of the rumen to improve production efficiency of different ruminant species. Removal and restriction of antibiotics subtherapeutic uses from ruminant diets has amplified interest in improving nutrient utilization and animal performance and search for more safe alternatives. Some bacterial and fungal microorganisms as a direct-fed microbial（DFM） can be the most suitable solutions. Microorganisms that are commonly used in DFM for ruminants may be classified mainly as lactic acid producing bacteria（LAB）, lactic acid utilizing bacteria（LUB）, or other microorganism＇s species like Lactobacillus, Bifidobacterium, Enterococcus, Streptococcus, Bacillus, Propionibacterium, Megasphaera elsdenii and Prevotellabryantii, in addition to some fungal species of yeast such as Saccharomyces and Aspergillus. A definitive mode of action for bacterial or fungal DFM has not been established; although a variety of mechanisms have been suggested. Bacterial DFM potentially moderate rumen conditions, and improve weight gain and feed efficiency. Fungal DFM may reduce harmful oxygen from the rumen, prevent excess lactate production, increase feed digestibility, and alter rumen fermentation patterns. DFM may also compete with and inhibit the growth of pathogens, immune system modulation, and modulate microbial balance in the gastrointestinal tract. Improved dry matter intake, milk yield, fat corrected milk yield and milk fat content were obtained with DFM administration. However, the response to DFM is not constant; depending on dosages, feeding times and frequencies, and strains of DFM. Nonetheless, recent studies have supported the positive effects of DFM on ruminant performance.展开更多
Insufficient insulin production or action in diabetic states is associated with growth retardation and impaired bone healing, while the underling mechanisms are unknown. In this study, we sought to define the role of ...Insufficient insulin production or action in diabetic states is associated with growth retardation and impaired bone healing, while the underling mechanisms are unknown. In this study, we sought to define the role of insulin signaling in the growth plate. Insulin treatment of embryonic metatarsal bones from wild-type mice increased chondrocyte proliferation. Mice lacking insulin receptor （IR） selectively in chondrocytes （CartIR-/-） had no discernable differences in total femoral length compared to control littermates. However, CartIR-/- mice exhibited an increase in chondrocyte numbers in the growth plate than that of the controls. Chondrocytes lacking IR had elevated insulin-like growth factor （IGF）-IR mRNA and protein levels. Subsequently, IGF-1 induced phosphorylafion of Akt and ERK was enhanced, while this action was eliminated when the cells were treated with IGF-1R inhibitor Picropodophyllin. Deletion of the IR impaired chondrogenic differentiation, and the effect could not be restored by treatment of insulin, but partially rescued by IGF-1 treatment. Intriguingly, the size of hypertrophic chondrocytes was smaller in CartIR-/- mice when compared with that of the control littermates, which was associated with upregnlation of tuberous sclerosis complex 2 （TSC2）. These results suggest that deletion of the IR in chondrocytes sensitizes IGF-1R signaling and action, IR and IGF-1R coordinate to regulate the proliferation, differentiation and hypertrophy of growth plate chondrocytes.展开更多
A mild-slope equation for combined refraction and diffraction of random waves in the independent time current is derived using Kirby equation(1984). In the derivation, the frequency of random waves is represented base...A mild-slope equation for combined refraction and diffraction of random waves in the independent time current is derived using Kirby equation(1984). In the derivation, the frequency of random waves is represented based on the time series concept, by a typical frequency and its deviation part. Numerical results, compared with those of laboratory experiments, demonstrate that new set of irregular mild slope equation with current is of good adaptability.展开更多
针对人体动作识别任务中特征值选取不当导致识别率低、使用多模态数据导致训练成本高等问题,提出一种轻量级人体动作识别方法。首先使用OpenPose、PoseNet提取出人体骨架信息,使用BWT69CL传感器提取姿势信息;其次对数据进行预处理、特...针对人体动作识别任务中特征值选取不当导致识别率低、使用多模态数据导致训练成本高等问题,提出一种轻量级人体动作识别方法。首先使用OpenPose、PoseNet提取出人体骨架信息,使用BWT69CL传感器提取姿势信息;其次对数据进行预处理、特征融合,对人体动作进行深度学习分类识别;最后,为验证此方法的有效性,在公开数据集WISDM、UCIHAR、HASC和自建的人体动作数据集上进行实验验证,并使用改进的目标引导注意力机制(target-guided attention,TGA)–长短期记忆(long short term memory,LSTM)网络输出最终的分类结果。实验结果表明,在自建数据集下融合姿势和骨架特征达到99.87%准确率,相比于只使用姿势信息特征,识别准确率提高了约5.31个百分点;相比于只使用人体骨架特征,识别准确率提高了约1.87个百分点;在识别时间上相比于只使用姿势信息,识别时间降低了约29.73 s;相比于只使用人体骨架数据,识别时间降低了约9 s。使用该方法能及时有效地反映人体的运动意图,有助于提高人体动作和行为的识别准确率和训练效率。展开更多
基金supported by the grants from the National Natural Science Foundation of China,No.60775019,60970062 and 61173116the Research Fund for the Doctoral Program of Higher Education of China,No.201100702110014
文摘Previous studies have demonstrated that hand shadows may activate the motor cortex associated with the mirror neuron system in human brain. However, there is no evidence of activity of the human mirror neuron system during the observation of intransitive movements by shadows and line drawings of hands. This study examined the suppression of electroencephalography mu waves （8-13 Hz） induced by observation of stimuli in 18 healthy students. Three stimuli were used： real hand actions, hand shadow actions and actions made by line drawings of hands. The results showed significant desynchronization of the mu rhythm （＂mu suppression＂） across the sensodmotor cortex （recorded at C3, Cz and C4）, the frontal cortex （recorded at F3, Fz and F4） and the central and right posterior parietal cortex （recorded at Pz and P4） under all three conditions. Our experimental findings suggest that the observation of ＂impoverished hand actions＂, such as intransitive movements of shadows and line drawings of hands, is able to activate widespread cortical areas related to the putative human mirror neuron system.
文摘For many years, ruminant nutritionists and microbiologists have been interested in manipulating the microbial ecosystem of the rumen to improve production efficiency of different ruminant species. Removal and restriction of antibiotics subtherapeutic uses from ruminant diets has amplified interest in improving nutrient utilization and animal performance and search for more safe alternatives. Some bacterial and fungal microorganisms as a direct-fed microbial（DFM） can be the most suitable solutions. Microorganisms that are commonly used in DFM for ruminants may be classified mainly as lactic acid producing bacteria（LAB）, lactic acid utilizing bacteria（LUB）, or other microorganism＇s species like Lactobacillus, Bifidobacterium, Enterococcus, Streptococcus, Bacillus, Propionibacterium, Megasphaera elsdenii and Prevotellabryantii, in addition to some fungal species of yeast such as Saccharomyces and Aspergillus. A definitive mode of action for bacterial or fungal DFM has not been established; although a variety of mechanisms have been suggested. Bacterial DFM potentially moderate rumen conditions, and improve weight gain and feed efficiency. Fungal DFM may reduce harmful oxygen from the rumen, prevent excess lactate production, increase feed digestibility, and alter rumen fermentation patterns. DFM may also compete with and inhibit the growth of pathogens, immune system modulation, and modulate microbial balance in the gastrointestinal tract. Improved dry matter intake, milk yield, fat corrected milk yield and milk fat content were obtained with DFM administration. However, the response to DFM is not constant; depending on dosages, feeding times and frequencies, and strains of DFM. Nonetheless, recent studies have supported the positive effects of DFM on ruminant performance.
基金supported by the Hong Kong Research Grant Council General Research Fund (RGC GRF 475311)National Natural Science Foundation of China (NSFC81171717, 81130034)+1 种基金Shenzhen Strategic Development Fund (GJHS20120702105445379)the Chinese University of Hong Kong Direct Grant 2041545 to CW
文摘Insufficient insulin production or action in diabetic states is associated with growth retardation and impaired bone healing, while the underling mechanisms are unknown. In this study, we sought to define the role of insulin signaling in the growth plate. Insulin treatment of embryonic metatarsal bones from wild-type mice increased chondrocyte proliferation. Mice lacking insulin receptor （IR） selectively in chondrocytes （CartIR-/-） had no discernable differences in total femoral length compared to control littermates. However, CartIR-/- mice exhibited an increase in chondrocyte numbers in the growth plate than that of the controls. Chondrocytes lacking IR had elevated insulin-like growth factor （IGF）-IR mRNA and protein levels. Subsequently, IGF-1 induced phosphorylafion of Akt and ERK was enhanced, while this action was eliminated when the cells were treated with IGF-1R inhibitor Picropodophyllin. Deletion of the IR impaired chondrogenic differentiation, and the effect could not be restored by treatment of insulin, but partially rescued by IGF-1 treatment. Intriguingly, the size of hypertrophic chondrocytes was smaller in CartIR-/- mice when compared with that of the control littermates, which was associated with upregnlation of tuberous sclerosis complex 2 （TSC2）. These results suggest that deletion of the IR in chondrocytes sensitizes IGF-1R signaling and action, IR and IGF-1R coordinate to regulate the proliferation, differentiation and hypertrophy of growth plate chondrocytes.
文摘A mild-slope equation for combined refraction and diffraction of random waves in the independent time current is derived using Kirby equation(1984). In the derivation, the frequency of random waves is represented based on the time series concept, by a typical frequency and its deviation part. Numerical results, compared with those of laboratory experiments, demonstrate that new set of irregular mild slope equation with current is of good adaptability.
文摘针对人体动作识别任务中特征值选取不当导致识别率低、使用多模态数据导致训练成本高等问题,提出一种轻量级人体动作识别方法。首先使用OpenPose、PoseNet提取出人体骨架信息,使用BWT69CL传感器提取姿势信息;其次对数据进行预处理、特征融合,对人体动作进行深度学习分类识别;最后,为验证此方法的有效性,在公开数据集WISDM、UCIHAR、HASC和自建的人体动作数据集上进行实验验证,并使用改进的目标引导注意力机制(target-guided attention,TGA)–长短期记忆(long short term memory,LSTM)网络输出最终的分类结果。实验结果表明,在自建数据集下融合姿势和骨架特征达到99.87%准确率,相比于只使用姿势信息特征,识别准确率提高了约5.31个百分点;相比于只使用人体骨架特征,识别准确率提高了约1.87个百分点;在识别时间上相比于只使用姿势信息,识别时间降低了约29.73 s;相比于只使用人体骨架数据,识别时间降低了约9 s。使用该方法能及时有效地反映人体的运动意图,有助于提高人体动作和行为的识别准确率和训练效率。
