A Leaking-Proof Theranostic Nanoplatform for Tumor-Targeted and Dual-Modality Imaging-Guided Photodynamic Therapy

Objective:A protein-based leaking-proof theranostic nanoplatform for dual-modality imaging-guided tumor photodynamic therapy(PDT)has been designed.Impact Statement:A site-specific conjugation of chlorin e6(Ce6)to ferrimagnetic ferritin(MFtn-Ce6)has been constructed to address the challenge of unexpected leakage that often occurs during small-molecule drug delivery.Introduction:PDT is one of the most promising approaches for tumor treatment,while a delivery system is typically required for hydrophobic photosensitizers.However,the nonspecific distribution and leakage of photosensitizers could lead to insufficient drug accumulation in tumor sites.Methods:An engineered ferritin was generated for site-specific conjugation of Ce6 to obtain a leaking-proof delivery system,and a ferrimagnetic core was biomineralized in the cavity of ferritin,resulting in a fluorescent ferrimagnetic ferritin nanoplatform(MFtn-Ce6).The distribution and tumor targeting of MFtn-Ce6 can be detected by magnetic resonance imaging(MRI)and fluorescence imaging(FLI).Results:MFtn-Ce6 showed effective dual-modality MRI and FLI.A prolonged in vivo circulation and increased tumor accumulation and retention of photosensitizer was observed.The time-dependent distribution of MFtn-Ce6 can be precisely tracked in real time to find the optimal time window for PDT treatment.The colocalization of ferritin and the iron oxide core confirms the high stability of the nanoplatform in vivo.The results showed that mice treated with MFtn-Ce6 exhibited marked tumor-suppressive activity after laser irradiation.Conclusion:The ferritin-based leaking-proof nanoplatform can be used for the efficient delivery of the photosensitizer to achieve an enhanced therapeutic effect.This method established a general approach for the dual-modality imagingguided tumor delivery of PDT agents.

DPM-CFD simulation of powder motion in the burden distribution process of COREX shaft furnace

Single off-gas outlet devised by one-step COREX shaft furnace will ultimately lead gas distribution to segregate,furthermore the distribution of powder on charge level is non-uniformity.DPM-CFD model was employed to simulate the pellet minus sieve powder motion in the burden distribution process,in order to quantitative description the non-uniformity distribution.The results showed that,the non-uniformity distribution is increasing with the melting rate increased.The powder segregates to the fourth quadrant where off-gas outlet lies is 2.4 or 2.5 fold of any other quadrant,while the melting rate is 130 t/h or 180 t/h.The best method to resolved the problem adds an symmetry off-gas outlet.

Mathematical simulation of burden distribution in COREX 3000 shaft by discrete element method

The distribution of reducing gas in a shaft furnace dominates the temperature profile,gas utilization ratio,metallization degree and is the overwhelming factor for stable,high productivities and low-energy-consumption operation.At the same time,the distribution of gas flow is mainly determined by the position of gas inlet,the packed bed porosity distribution as well as its change due to the difference on the mode of top charge and bottom discharge.When injecting position of the process is fixed,the charge mode is the only means for regulating the gas flow distribution.In this paper,a numerical simulation model of burden distribution in the shaft furnace of COREX 3000 has been developed to analyze the porosity distribution under the different charge modes by means of Discrete Element Method(DEM).The effects of the particle size and its distribution under conditions of different charge batches,chute angle,stoke line on the burden surface shape and burden bed particle size distribution and segregation were investigated,and then the porosity distribution in the shaft of corresponding charging pattern was quantitatively accessed.Therefore,the results can be used to optimize the charge patterns base on required gas distribution.

Improve the System of Medical Damage Identification to Balance the Burden of Proof between Medical Institutions and Patients

With the development of the theory of identification "duality" in medical tort lawsuit,the burden distribution system of proof of medical tort also gradually developed.So-called links are universal,state institutions are often"one change makes all change".In medical tort cases,the judges replace the trial results with expert opinion let alone tend to rely on expert opinion to determine the truth while he can't verify the case facts.The another thing,after the newly revised Civil Procedure Law revised in 2012,it defined the parties of basic rights or interests protected in the case of the cross-examination of medical damage expert opinion.But due to patient lack of medical expertise and expert refuse to appear in court,no right of cross examination could happen.A part of the medical cases are used in expert auxiliary system to solve the above difficulties,but procedures of expert assistant system have not been unified.Many problems and doubts are still in implementation for judges,lawyers,parties concerned.Analyzing the disadvantages of the present the appraisal system of medical lawsuits and working on the improvement of expert assistant system,and expect to the analysis and explanation for the medical tort lawsuit contribute to subsequent researchers and juridical practice.

Empirical study of the dilemma regarding preliminary proof of causality and methods used by victims in China's environmental health litigation

Environmental health incidents have occurred frequently in recent years;in China,however,litigation has not been effective in protecting the rights and interests of victims due to their heavy burden of proof.In order to mitigate the burden of proof for victims,the environmental judicature in China introduced the rule of inversion of burden of proof;this means that the victim only assumes the preliminary burden of proof,but in practice it has not been sufficient.Victims in environmental health litigation still face many difficulties in proving causality.Based on the statistical analysis of judicial big data,this paper demonstrates three dilemmas faced by victims.First,the preliminary burden of proof of causality has a high standard.Second,the victim's ability to produce evidence is low.Third,the casual relationship between pollution behaviors and health damage is difficult to identify.When examining the possible legal instruments,there are three aspects to the causes of these dilemmas:theory,judicial practice,and society.The theoretical aspect manifests as the differences between the rule of inversion of burden of proof and the presumption of causality;the practical aspect manifests as the lack of an identification system for personal injury;and the social aspect manifests as the victim's lack of economic,scientific,technological,and information resources,as well as the absence of assistance from government sectors and social organizations.Combining Chinese law with judicial practice,this paper proposes a solution to the dilemma of victims needing to prove causality in environmental health litigation.On the basis of clarifying the theoretical differences between the inversion of burden of proof and the presumption of causality,China should adhere to the rule of inversion of burden of proof,establish an identification system for personal injuries caused by environmental pollution,and use methods such as epidemiological causality,indirect counterevidence,and prima facie bewies.Furthermore,the full functions of the government and social organizations must be brought into play.This will not only help victims demonstrate causality,it can also help victims achieve equitable relief.

Proof of Security of a Semi-Device-Independent Quantum Key Distribution Protocol

Semi-device-independent quantum key distribution （SDI-QKD） has been proposed by applying the quantum dimension correlation, and the security relies on the violation of quantum dimension witness inequalities. We prove the security of the SDI-QKD protocol under the depolarization channel by considering the quantum dimension witness inequalities and minimum entropy and the specific process of the QKD protocol, combining with a four- quantum-state preparation and three measurement bases. We also provide the relationship between the dimension witness value, the error rate and the security key rate by the numerical simulation.

Improving mathematical model of burden distribution and correcting chute angle to cope with fluctuation of stock line

Accurate evaluations of the burden distribution are of critical importance to stabilize the operation of blast furnace.The mathematical model and discrete element method(DEM)are two attractive methods for predicting burden distribution.Based on DEM,the initial velocities of the pellet,sinter,and coke were calculated,and the velocity attenuations of the above three particles between the burden and the chute were analyzed.The initial velocity and velocity attenuation were applied to a mathematical model for improving the accuracy.Additionally,based on the improved model,a scheme for rectifying the chute angles was proposed to address the fluctuation of the stock line and maintain a stable burden distribution.The validity of the scheme was confirmed via a stable burden distribution under different stock lines.The mathematical model has been successfully applied to evaluate the online burden distribution and cope with the fluctuation of the stock line.

A Simple Security Proof for Entanglement-Based Quantum Key Distribution

Quantum cryptography exploits the quantum mechanical properties of communication lines to enhance the security of the so-called key distribution. In this work, we explain the role played by quantum mechanics in cryptographic tasks and also investigate how secure is quantum cryptography. More importantly, we show by a simple security proof that for any state sent by the sender, the eavesdropper can only guess the output state with a probability that will allow her not to learn more than half of the classical Shannon information shared between the legitimate parties. This implies that with high probability, the shared key is secure.

Rethinking the Method and Function of Proportionality Test in the European Court of Human Rights

Strasbourg’s application of proportionality test has some unique features.Due to the Court inherent subsidiary role,it hardly transplants the formulas and criteria adopted by the German Constitutional Court or Court of Justice European Union(CJEU) in the complete sense.Consequently,the Strasbourg application of the proportionality has been depicted as a "mysterious house" for the reason that it lacks of certainty.Therefore,some scholars often worry the application of the proportionality test will threaten the predictability and the Strasbourg rule of law.Generally,the proportionality test has two internal functions for the Strasbourg judges:(1) strike fair balance between/among the competing interests;(2) testing on the reasonableness and appropriateness between the measures employed and aim pursued.In the first category,the primary task of the Court is to protect the scope of "essence" of the Convention rights from the interference of collective goods relying on the interest-based rights theory.Beyond this scope,the Court would have to balance the interests explicitly incorporated into the Convention rights as well as the external collective goods claimed by the state authorities.In some sensitive judgments,the Strasbourg Court tends to impose the onerous responsibility of "burden of proof" to the State authorities,or strategically defers to the domestic decisions unless they will be found "manifestly unreasonable".Secondly,the Court must take a scrutiny towards the appropriateness between the means employed and ends pursued,and then it has to decide whether a less intrusive alternative existed or will possibly be found or not.Sometimes,the Court might impose state authorities an obligation looking for a new alternation.However,due to subsidiarity characteristic of the Strasbourg Court,the task of the assessments sometimes is complicated and time-consuming,so the Court are not capable of evaluations in all occasions.Finally,the Court could strike down the "chilling consequence" caused by some few of the legitimate measures which may highly potentially threaten the individual rights in the National legal order.

Mathematical model of burden distribution in bell-less top blast furnace

The burden distribution in the shaft of blast furnace is known to affect the gas distribution,heat transfer,and chemical reactions inside the furnace.However,the internal layer structure of burden in the shaft cannot be directly measured.Hence,a mathematical model for evaluating burden profile and layer structure was established.A sensitivity analysis based on the model was implemented to elucidate the effect of some factors on the burden distribution,including the stockline height and the mass of central coke.The results show that the width of funnel zone widens with the increase in stockline height,and the mass percentage of ore to coke in this zone slightly increases.Besides,the mass of central coke shows a significant influence on the width of coke channel,and 2%of batch mass of coke is recommended to implement central coke charging operation.The model has been indirectly verified by the gas temperature in operating blast furnace and successfully applied to online evaluate burden distribution.

Burden Distribution for Bell-Less Top With Two Parallel Hoppers

The circumferential burden distribution of bell-less top with two parallel hoppers was analyzed to obtain the expressions of burden flux and uneven ratio. The four-batch feeding spirally with two parallel hoppers was proposed to realize even burden distribution by uneven flux, ensuring reasonable distribution of BF gas and effective usage of heat energy and chemical energy of gas as well as stable BF production with higher quality and lower consumption.

A Modeling Study of Seasonal Variation of Atmospheric Aerosols over East Asia

In this study, a regional air quality model system （RAQMS） was applied to investigate the spatial distributions and seasonal variations of atmospheric aerosols in 2006 over East Asia. Model validations demonstrated that RAQMS was able to reproduce the evolution processes of aerosol components reasonably well. Ground-level PM10 （particles with aerodynamic diameter ≤10 μm） concentrations were highest in spring and lowest in summer and were characterized by three maximum centers： the Taklimakan Desert （-1000 μg m^-3）, the Gobi Desert （-400 μg m^-3）, and the Huabei Plain （- 300 μg m^-3） of China. Vertically, high PM10 concentrations ranging from 100 μg m-3 to 250 μg m-3 occurred from the surface to an altitude of 6000 m at 30°-45°N in spring. In winter, the vertical gradient was so large that most aerosols were restricted in the boundary layer. Both sulfate and ammonium reached their highest concentrations in autumn, while nitrate reached its maximum level in winter. Black carbon and organic carbon aerosol concentrations reached maximums in winter. Soil dust were strongest in spring, whereas sea salt exerted the strongest influence on the coastal regions of eastern China in summer. The estimated burden of anthropogenic aerosols was largest in winter （1621 Gg） and smallest in summer （1040 Gg）. The sulfate burden accounted for -42% of the total anthropogenic aerosol burden. The dust burden was about twice the anthropogenic aerosol burden, implying the potentially important impacts of the natural aerosols on air quality and climate over East Asia.

Multi-Model Based PSO Method for Burden Distribution Matrix Optimization With Expected Burden Distribution Output Behaviors

Burden distribution is one of the most important operations, and also an important upper regulation in blast furnace(BF) iron-making process. Burden distribution output behaviors(BDOB) at the throat of BF is a 3-dimensional spatial distribution produced by burden distribution matrix(BDM),including burden surface output shape(BSOS) and material layer initial thickness distribution(MLITD). Due to the lack of effective model to describe the complex input-output relations,BDM optimization and adjustment is carried out by experienced foremen. Focusing on this practical challenge, this work studies complex burden distribution input-output relations, and gives a description of expected MLITD under specific integral constraint on the basis of engineering practice. Furthermore, according to the decision variables in different number fields, this work studies optimization of BDM with expected MLITD, and proposes a multi-mode based particle swarm optimization(PSO) procedure for optimization of decision variables. Finally, experiments using industrial data show that the proposed model is effective, and optimized BDM calculated by this multi-model based PSO method can be used for expected distribution tracking.

Strategic Perspectives on China's New Round of Tax Reform

China's current tax structure is seriously out of balance.It is dominated by indirect tax primarily paid by firms,and the share of direct tax is limited and the share of direct tax paid by households and individuals is still more limited.In order to achieve a more equitable distribution of the tax burden,the tax reform initiated by the Third Plenum of the 18 th CPC Central Committee mandated increasing the direct tax and reducing the indirect tax as key priorities to improve China's tax structure.

论环境民事公益诉讼中因果关系要件的证明

当前,环境民事公益诉讼中因果关系要件的证明责任如何分配及其证明标准如何设定,对此理论界和实务界仍有很大争议。在证明责任分配问题上,解决路径在于参照适用《民法典》第一千二百三十条的规定,由被告承担环境民事公益诉讼中因果关系要件的客观证明责任。与此同时,原告需提供能够证明关联性事实的初步证据。这一规则应当理解为因果关系的法律推定。将因果关系法律推定规则引入环境民事公益诉讼中具有合理性基础,如纠正人们对环境侵权因果关系要件“证明责任倒置”的错误认识、防止原告滥用诉权、平衡原被告双方的举证负担。在证明标准问题上,环境民事公益诉讼中因果关系要件的证明标准应因事后救济性环境民事公益诉讼和预防性环境民事公益诉讼的类型划分而有所区别,且受关联性事实认定标准的影响。

医疗损害责任过错要件证明之困境及其破解

司法实务中,大量医疗损害责任之过错要件的证明责任分配存在混乱、医疗“违法违规”认定泛化和机械适用《民法典》第1222条第2款及第3款来推定过错,致对医疗损害责任过错要件的证明面临困境;进一步探究其因,是人类的技术与认知局限无法查明诊疗过错的事实、主观心理状态与客观证据的关联性弱,以及过错事实证明标准不统一而致法官自由裁量权过大,故需在厘清与细化《民法典》第1222条过错推定规则的基础上,建立重大医疗瑕疵规则、强化医疗机构事案解明义务、合理适用证明妨碍规则。

Mathematical Simulation of Burden Distribution in COREX Melter Gasifier by Discrete Element Method

COREX process is one of the earliest industrialized smelting reduction ironmaking technology.A numerical simulation model based on discrete element method ( DEM ) has been developed to analyze the burden distribution in the melter gasifier of COREX process.The DEM considering the collisions between particles can directly reproduce the charging process.The burden trajectory , the location and the burden surface profile are analyzed in melter gasifier with a mixing charging of coal and direct reduction iron ( DRI ) at the same time.Considering the porosity of packed bed has an important effect on the gas flow distribution of melter gasifier , a method to calculate porosity has been proposed.The distribution of DRI and coal and the porosity in the radial direction are given under different charging patterns , which is necessary to judge the gas flow distribution and provide base data for further researching the melter gasifier for the next work in the future.The research results can be used to guide the operation of adjusting charging and provide important basis for optimizing the charging patterns in order to obtain the reasonable gas distribution.

表见代理证明责任分配论略

《民诉法解释》第91条以规范说为蓝本确立了我国证明责任分配的基本原则,而规范说旨在对实体规范进行分类的基础上确立证明责任的分配。《民法典》第172条规定了表见代理下相对人请求被代理人履行合同内容的请求权基础,奠定了表见代理证明责任分配的基准,但相关司法解释的规定存在不完善及矛盾之处。从实现制度设立的意旨出发,立足于相关实体规范所内含的风险分配,并基于体系化解释,应将被代理人可归责性作为表见代理的构成要件之一;对于可归责性与善意且无过失的证明责任分配,应遵循规范说的分配路径,明确可归责性属于权利妨碍规范、善意且无过失属于权利发生规范,分别由被代理人与相对人承担证明责任。

基于改进T分布烟花-粒子群算法的AUV全局路径规划

针对传统粒子群算法在处理自主水下机器人(Autonomous Underwater Vehicle,AUV)全局路径规划时面临的寻优时间长、能耗高的问题,本文提出一种改进的T分布烟花-粒子群算法(T-distribution Fireworks-Particle Swarm Optimization Algorithm,TFWA-PSO),该算法融合了烟花算法的高效全局搜索能力和粒子群算法的快速局部寻优特性.在变异阶段,提出自适应T分布变异来扩大搜索范围,并在理论上证明了该变异方式能够使个体在局部最优解附近增强搜索能力.在选择阶段提出了适应度选择策略,淘汰适应度差的个体,解决了传统烟花算法易丢失优秀个体的问题,并对改进的T分布烟花算法与传统烟花算法的收敛速度进行对比.将改进算法的爆炸操作、变异操作和选择策略融合到粒子群算法中,对粒子群算法的速度更新公式进行了改进,同时从理论上对所改进的算法进行了收敛性证明.仿真实验结果表明,TFWA-PSO能够有效规划出一条最短路径,同时与给定的智能优化算法相比,TFWA-PSO在寻找最优路径的时间上平均降低了24.72%,能耗平均降低了17.33%,路径长度平均降低了16.96%.

商业秘密侵权案件“接触加相同”举证规则之反思

“接触加相同”举证规则是基于商业秘密侵权行为的特殊性而对原、被告举证证明义务的一种新探索,目的在于减轻商业秘密权利人的举证负担。当前,该规则虽已为我国《反不正当竞争法》第32条所明确规定,但在适用过程中仍面临本质定位不清、判断标准不明、内部逻辑混乱及过分加重涉嫌侵权人举证负担等问题。为此,要正确适用“接触加相同”举证规则,应厘清其本质定位、明确其判断标准、理顺其内部关系,科学利用司法技术对“接触加相同”举证规则进行修正,以实现对原、被告双方程序利益与实体利益的平等保护。