Risk factors for secondary infection after liver failure and effect of comprehensive nursing intervention

BACKGROUND In patients with liver failure(LF),the high rate of secondary infections,which are associated with poor prognosis,highlights the clinical significance of understanding the underlying risk factors and implementing targeted intervention programs.AIM To investigate risk factors for secondary infections in patients with LF and evaluate the effectiveness of comprehensive nursing interventions.METHODS This retrospective study included 64 patients with LF,including 32 with and 32 without secondary infections.A questionnaire was used to collect data on age;laboratory parameters,including total and direct bilirubin,prothrombin time,blood ammonia,and other biochemical parameters;invasive procedures;and complications.Patients with secondary infections received comprehensive nursing intervention in addition to routine nursing care,whereas those without secondary infections received only routine nursing care to compare the effect of nursing intervention on outcomes.RESULTS The infection rate,which was not associated with age or complications,was significantly associated with biochemical parameters and invasive procedures(P<0.05).The infection rate was 61.6%in patients who had undergone invasive procedures and 32.1%in those who had not undergone invasive procedures during the hospital stay.The infection rate was also significantly associated with the type of LF(P<0.05),with the lowest rate observed in patients with acute LF and the highest rate observed in those with subacute LF.The nursing satisfaction rate was 58.3%in the uninfected group and 91.7%in the infected group,indicating significantly higher satisfaction in the infected group(P<0.05).CONCLUSION In patients with LF,the rate of secondary infections was high and associated with biochemical parameters and type of LF.Comprehensive nursing intervention can improve patient satisfaction.

Bending Strength of Glass Materials under Strong Dynamic Impact and Its Strain Rate Effects

Based on the structural characteristics of the high-speed loading tester,a four-point bending test device was designed to carry out the four-point bending strength test of glass under the action of static load and different impact velocities,and the formulae for calculating the maximum dynamic stress and strain rate of glass specimens under the action of impact loads were derived.The experimental results show that the bending strength values of the glass under dynamic impact loading are all higher than those under static loading.With the increase of impact speed,the bending strength value of glass specimens generally tends to increase,and the bending strength value increases more obviously when the impact speed exceeds 0.5 m/s or higher.By increasing the impact velocity,higher tensile strain rate of glass specimens can be obtained because the load action time becomes shorter.The bending strength of the glass material increases with its tensile strain rate,and when the tensile strain rate is between 0 and 2 s^(-1),the bending strength of the glass specimen grows more obviously with the strain rate,indicating that the glass bending strength is particularly sensitive to the tensile strain rate in this interval.As the strain rate increases,the number of cracks formed after glass breakage increases significantly,thus requiring more energy to drive the crack formation and expansion,and showing the strain rate effect of bending strength at the macroscopic level.The results of the study can provide a reference for the load bearing and structural design of glass materials under dynamic loading.

Risk factors for recurrence of common bile duct stones after surgical treatment and effect of ursodeoxycholic acid intervention

BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP)is an accurate diagnostic method for choledocholithiasis and treatment option for stone removal.Additionally,ursodeoxycholic acid(UDCA)can dissolve cholesterol stones and prevent their development and reappearance by lowering the cholesterol concen-tration in bile.Despite these treatment options,there are still patients who experience stone recurrence.The clinical data of 100 patients with choledochal stones who were hospitalized at the Yixing People’s Hospital and underwent ERCP for successful stone extraction between June 2020 and December 2022 were retrospectively collected.According to the post-ERCP treatment plan,100 patients were classified into UDCA(n=47)and control(n=53)groups.We aimed to assess the clinical efficacy and rate of relapse in the two patient populations.We then collected information(basic demographic data,clinical characteristics,and serum biochemical indicators)and determined the factors contributing to relapse using logistic regression analysis.Our secondary goal was to determine the effects of UDCA on liver function after ERCP.Compared to the control group,the UDCA group demonstrated a higher clinical effectiveness rate of 92.45%vs 78.72%(P<0.05).No significant differences were observed in liver function indices,including total bilirubin,direct bilirubin,gamma-glutamyl transpeptidase,alanine aminotransferase,alkaline phosphatase,and aspartate aminotransferase,between the two groups before treatment.After treatment,all liver function indices were significantly reduced.Comparing the control vs UDCA groups,the UDCA group exhibited significantly lower levels of all indices(55.39±6.53 vs 77.31±8.52,32.10±4.62 vs 45.39±5.69,142.32±14.21 vs 189.63±16.87,112.52±14.25 vs 149.36±15.36,122.61±16.00 vs 171.33±22.09,96.98±10.44 vs 121.35±11.57,respectively,all P<0.05).The stone recurrence rate was lower in the UDCA group(13.21%)in contrast with the control group(44.68%).Periampullary diverticula(OR:6.00,95%CI:1.69-21.30),maximum stone diameter(OR:1.69,95%CI:1.01-2.85),stone quantity>3(OR:4.23,95%CI:1.17-15.26),and positive bile culture(OR:7.61,95%CI:2.07-27.91)were independent factors that influenced the relapse of common bile duct stones after ERCP(P<0.05).Furthermore,postoperative UDCA was identified as a preventive factor(OR:0.07;95%CI:0.08-0.09).CONCLUSION The intervention effect of UDCA after ERCP for common bile duct stones is adequate,providing new research directions and references for the prevention and treatment of stone recurrence.

Research on large-scale cascading failure of power systems using synergistic effect

This paper discusses the primary causes from the point of synergistic effects to improve power system vulnerability in the power system planning and safety operation. Based on the vulnerability conception in the complex network theory the vulnerability of the power system can be evaluated by the minimum load loss rate when considering power supply ability.Consequently according to the synergistic effect theory the critical line of the power system is defined by its influence on failure set vulnerability in N-k contingencies.The cascading failure modes are proposed based on the criterion whether the acceptable load curtailment level is below a preset value.Significant conclusions are revealed by results of IEEE 39 case analysis weak points of power networks and heavy load condition are the main causes of large-scale cascading failures damaging synergistic effects can result in partial failure developed into large-scale cascading failures vulnerable lines of power systems can directly lead the partial failure to deteriorate into a large blackout while less vulnerable lines can cause a large-scale cascading failure.

Effect of montmorillonite on hydrate-based methane separation from mine gas

Three types of mine gas samples were used in the solutions of tetrahydrofuran(THF),sodium dodecyl sulfate(SDS)and THF-SDS with/without MMT respectively to investigate the effect of montmorillonite(MMT)on separation characteristics of methane recovered from mine gas based on hydrate method.The partition coefficient,separation factor and recovery rate were used to evaluate the effects of MMT,and the selection factor was primarily proposed to define the selectivity of mine gas hydrate in the relative target gases.The experimental results indicate that MMT could improve the following factors including hydration separation factor,the selection factor,the partition coefficient,and the recovery rate.Furthermore,the effect of SDS on the function of MMT is analyzed in the process of hydration separation.Finally,due to the results of the experiment,it is concluded that MMT hydration mechanism explores the effect of MMT enrichment methane from mine gas.

Mechanical properties of deep sandstones under loading rate effect

The advance speed of the working face in coal mines can significantly affect the fluctuation frequency of abutment pressure in front of the coal body.Moreover,it has a certain correlation with the change of axial loading rate in coal and rock mechanics test.Therefore,uniaxial compression tests under various loading rates of 0.05,0.1,0.15,0.25,0.5 MPa/s were conducted using 2000 kN triaxial testing machine and PCI-2 acoustic emission test system to study the loading rate effect on the mechanical properties of deep sandstones.The results show that 1)the peak strength and elastic modulus of the deep sandstone increase with the loading rate increasing;2)with the loading rate increasing,the deep sandstone transforms from plastic-elastic-plastic to plastic-elastic and moreover,the failure mode gradually transfers from type I to type III;3)With the loading rate increasing,the total input strain energy,elastic strain energy,and dissipated strain energy generally increase;4)the damage variable presents the evolution characteristics of inverted“S”shape with time,and with the loading rate increasing,the damage degree of the deep sandstone is aggravated.The conclusion obtained can provide the theoretical basis for the stability control of the surrounding rock in deep engineering.

Experimental investigation of rigid confinement effects of radial strain on dynamic mechanical properties and failure modes of concrete

In this study,to confirm the effect of confining pressure on dynamic mechanical behavior and failure modes of concrete,a split Hopkinson pressure bar dynamic loading device was utilized to perform dynamic compressive experiments under confined and unconfined conditions.The confining pressure was achieved by applying a lateral metal sleeve on the testing specimen which was loaded in the axial direction.The experimental results prove that dynamic peak axial stress,dynamic peak lateral stress,and peak axial strain of concrete are strongly sensitive to the strain rate under confined conditions.Moreover,the failure patterns are significantly affected by the stress-loading rate and confining pressure.Concrete shows stronger strain rate effects under an unconfined condition than that under a confined condition.More cracks are created in concrete subjected to uniaxial dynamic compression at a higher strain rate,which can be explained by a thermal-activated mechanism.By contrast,crack generation is prevented by confinement.Fitting formulas of the dynamic peak stress and dynamic peak axial strain are established by considering strain rate effects(50–250 s-1)as well as the dynamic confining increase factor(DIFc).

Numerical Derivation of Strain Rate Effects on Material Properties of Masonry with Solid Clay Bricks

In this paper, numerical method is used als. A typical unit of masonry is selected to serve merical model of RVE is established with detailed to study the strain rate effect on masonry materias a representative volume element （RVE）. Nudistinctive modeling of brick and mortar with their respective dynamic material properties obtained from laboratory tests. The behavior of brick and mortar are characterized by a dynamic damage model that accounts for rate-sensitive and pressuredependent properties of masonry materials. Dynamic loads of different loading rates are applied to RVE. The equivalent homogenized uniaxial compressive strength, threshold strain and elastic modulus in three directions of the masonry are derived from the simulated responses of the RVE. The strain rate effect on the masonry material with clay brick and mortar, such as the dynamic increase factor （DIF） of the ultimate strength and elastic modulus as a function of strain rate are derived from the numerical results.

Clinical Study on Respiratory Medicine Treatment of Chronic Obstructive Pulmonary Disease Combined with Respiratory Failure

Objective:To explore the respiratory medicine treatment methods for treating chronic obstructive pulmonary disease(COPD)combined with respiratory failure.Methods:70 cases of COPD patients with combined respiratory failure admitted to our hospital from January 2021 to January 2023 were selected as the study subjects,and randomly divided into the control group and the experimental group,each with 35 cases.The control group received only conventional treatment,and the experimental group received non-invasive positive pressure ventilation,and the treatment effects and changes in the levels of IL-18,hs-CRP,and CES2 inflammatory factors were observed and evaluated in the two groups.Results:There was no significant difference between the general data of the two groups(P>0.05);after treatment,the total effective rate of clinical efficacy of the observation group(91.43%)was significantly higher than that of the control group(71.43%),and the difference showed a significant correlation(P<0.05);after treatment,the level of inflammatory factor of the observation group was significantly reduced compared with that of the control group,and the difference showed a highly significant correlation(P<0.001).Conclusion:The non-invasive positive pressure ventilation treatment program significantly improves the therapeutic effect,effectively controls the level of inflammatory factors,and improves the health status of patients when dealing with patients with chronic obstructive pulmonary disease accompanied by respiratory failure,showing a good clinical application prospect.

Reliability analysis of k-out-of-n system with load-sharing and failure propagation effect

In complex systems,functional dependency and physical dependency may have a coupling effect.In this paper,the reliability of a k-out-of-n system is analyzed considering load-sharing effect and failure mechanism(FM)propagation.Three types of FMs are considered and an accumulative damage model is proposed to illustrate the system behavior of the k-out-of-n system and the coupling effect between load-sharing effect and FM propagation effect.A combinational algorithm based on Binary decision diagram(BDD)and Monte-Carlo simulation is presented to evaluate the complex system behavior and reliability of the k-out-of-n system.A current stabilizing system that consists of a 3-out-of-6 subsystem with FM propagation effect is presented as a case to illustrate the complex behavior and to verify the applicability of the proposed method.Due to the coupling effect change,the main mechanism and failure mode will be changed,and the system lifetime is shortened.Reasons are analyzed and results show that different sensitivity factors of three different FMs lead to the change of the development rate,thus changing the failure scenario.Neglecting the coupling effect may lead to an incomplete and ineffective measuring and monitoring plan.Design strategies must be adopted to make the FM propagation insensitive to load-sharing effect.

Laser-assisted Simulation of Dose Rate Effects of Wide Band Gap Semiconductor Devices

Laser-assisted simulation technique has played a crucial role in the investigation of dose rate effects of silicon-based devices and integrated circuits,due to its exceptional advantages in terms of flexibility,safety,convenience,and precision.In recent years,wide band gap materials,known for their strong bonding and high ionization energy,have gained increasing attention from researchers and hold significant promise for extensive applications in specialized environments.Consequently,there is a growing need for comprehensive research on the dose rate effects of wide band gap materials.In response to this need,the use of laser-assisted simulation technology has emerged as a promising approach,offering an effective means to assess the efficacy of investigating these materials and devices.This paper focused on investigating the feasibility of laser-assisted simulation to study the dose rate effects of wide band gap semiconductor devices.Theoretical conversion factors for laser-assisted simulation of dose rate effects of GaN-based and SiC-based devices were been provided.Moreover,to validate the accuracy of the conversion factors,pulsed laser and dose rate experiments were conducted on GaN-based and SiC-based PIN diodes.The results demonstrate that pulsed laser radiation andγ-ray radiation can produce highly similar photocurrent responses in GaN-based and SiC-based PIN diodes,with correlation coefficients of 0.98 and 0.974,respectively.This finding reaffirms the effectiveness of laser-assisted simulation technology,making it a valuable complement in studying the dose rate effects of wide band gap semiconductor devices.

CONTRACEPTIVE PREVALENCE AND USE－EFFECTIVENESS OF MARRIED WOMEN OF REPRODUCTIVE AGE IN THE RURAL AREAS OF SHAANXI PROVINCE

In order to study women's fertility and behavior in shaanxi Province, we used PPS method to sample Weinan, Nanzheng and Yan'an counties which represent the centre, south and north of Shaanxi respectively from February to March in 1990. 3253 qualified married women of reproductive age were available. Because contraception is one of the most imPOrtant proximate determinants in inhibiting fertility, we just measured contraceptive prevalence and use-effectiveness among different subgroups in this dissertation. The results indicated that the prevalence rate of contraception was 75. 9 %, prevalence of different contraceptive methods varied widely: it was 43. 5% in IUD, 27. 7% in women'sterilization, 2. 0% in pill, 1.9% in men's sterilization, 0. 2% in condom and 0. 7 % in other methods, The average use-effectiveness of three methods was 0. 9965 for sterilization,0. 8792 for IUD and 0. 8520 for other methods and total average use-effectiveness was 0. 9251.

The Optimization of Preventive Maintenance Scheduling for Production Machine of Production System in Finite Time Horizon

The recursion relation of preventive maintenance (PM) cycle is built up concerning the concept of effective age and age setback factor proposed in this paper, which illustrates the dynamic relationship between failure rate and preventive maintenance activity. And the nonlinear optimal PM policy model satisfying the reliability constraints in finite time horizon following Weibull distribution is proposed. The model built in this paper avoids the shortcoming of steady analytical PM model in infinite time horizon and can be used to aid scheduling the maintenance plan and providing decision supporting for job shop scheduling.

An assessment of Charter airline benefits for Port Elizabeth and the Eastern Cape

Tourism is becoming a vital component for economic development in South Africa. The income generated by the tourism industry is about 6% of the GDP, which is significant but still falls short of the goal set by the White Paper on Tourism in 2000. In the light of South Africa hosting the 2010 Football World Cup, it is important to identify ways of sustainable tourism development that would continue to increase the benefits to the economy long after the event＇s over. The main objective of the research was to explore an idea for increasing the level of tourist income generated in the Port Elizabeth （Eastern Cape） area. The idea was researched by means of conducting a cost-benefit analysis of two tourist related projects. These projects would introduce Charter airline services between Europe and Port Elizabeth. A second objective was to identify constraints on the project or market failures which would prevent their implementation. The economic theory behind the operation of an airline showed that lease costs and aeroplane operating costs are the two most important factors determine Charter airline＇s profitability. In order to offset these costs, airlines must achieve high passenger load factors. Charter airlines have the advantage over scheduled airlines, in that they will only fly if a minimum level of people has pre-booked seats. Two aeroplanes were chosen for comparison purpose： an Airbus A 340-300 and a Boeing 767-300ER. The private benefits calculated were based on load factors between 80 and 95 percent for ticket prices of USD 667 and USD 773. In addition, to private costs and benefits, social benefits were also estimated in the form of additional secondary revenue generated. With the introduction of net social benefits, both projects become profitable. A 50 percent substitution of revenue generated by the Charter tourists reduces the profits for the both projects drastically. A project based on a Boeing 767-300ER is the most efficient project as it has the highest NPV and BCR values. A reduction in the lease cost of the Airbus 340-300 could make projects based on it more competitive. A few constraints on the establishment of a Charter airline operator based in Port Elizabeth are： the lack of adequate runway for the landing of the long-haul carriers and the need of a larger liberalisation of the aviation policy by eliminating protectionism. The cost benefit analysis undertaken in this research does not take into account social costs and benefits to the economy of establishing a Charter airline based in Port Elizabeth, such as an employment, infrastructure development and poverty alleviation. Nevertheless the analysis does suggest that there are strong private and social benefits warranting the establishment of an airline business between Europe and Port Elizabeth. The economic benefits of the tourism industry and its link to airline travel are outlined in section 3. It is shown that the growth of the airline industry is a major component and contributor to tourism growth.

Study on Multi-effect Time Parameters of Ergonomic Validity Index in Low-carbon Residential Kitchen

In the study on functional low-carbon ergonomic validity in buildings,ergonomic validity is different from resource validity which is easy for quantitative analysis. To eliminate the complexity and uncertainty impacts of human factors on quantitative study,it proposes a method of building a parameter of ergonomic validity—multi-effect time by using cardiotachometer to record heart rate change,being used to evaluate the functional low-carbon ergonomic validity targeting at the ontological characteristics of kitchen. This method is used to determine the physical consumption intensity( multi-effect) through heart rate incremental relation based on the principles of physiology and ergonomics,and to confirm the ergonomic validity of environmental factors by the time to complete standard work as well as multi-effect quantitative analysis. The test results show that,under the kitchen operating conditions,the multi-effect( ME) can properly reflect the real-time status of the operator and is easily operated; the parameters obtained are not significantly related to the physiological status of the operator,and multi-effect time( MT) is sensitive to the physical consumption brought about to the operator due to kitchen environmental factors; thus,it can be taken as an objective index,which is simple and easy to operate in residential kitchen functional low-carbon evaluation.

连续r-with-k-out-of-n冲击模型的可靠性

考虑一个电子系统,由于遭受冲击而引起失效,而且这个系统的寿命依赖于遭受的连续的致命冲击数,且系统承受的致命冲击数是有限的.本文提出了一个连续的r-with-k-out-of-n冲击系统,当且仅当有连续的k次有效冲击中有r次是致命的冲击发生会直接导致系统失效.利用马尔科夫嵌入法得到系统的寿命分布.最后,用一个数值算例来描述文章所获得的结果.

Application of fiberoptic bronchscopy in patients with acute exacerbations of chronic obstructive pulmonary disease during sequential weaning of invasive-noninvasive mechanical ventilation

BACKGROUND:Early withdrawal of invasive mechanical ventilation(IMV) followed by noninvasive MV(NIMV) is a new strategy for changing modes of treatment in patients with acute exacerbations of chronic obstructive pulmonary disease(AECOPD) with acute respiratory failure(ARF).Using pulmonary infection control window(PIC window) as the switch point for transferring from invasive to noninvasive MV,the time for early extubation can be more accurately judged,and therapy efficacy can be improved.This study aimed to prospectively investigate the clinical effectiveness of fiberoptic bronchscopy(FOB) in patients with AECOPD during sequential weaning of invasive-noninvasive MV.METHODS:Since July 2006 to January 2011,106 AECOPD patients with ARF were treated with comprehensive medication and IMV after hospitalization.Patients were randomly divided into two groups according to whether fiberoptic bronchoscope is used(group A,n=54) or not(group B,n=52) during sequential weaning from invasive to noninvasive MV.In group A,for sputum suction and bronchoalveolar lavage(BAL),a fiberoptic bronchoscope was put into the airway from the outside of an endotracheal tube,which was accompanied with uninterrupted use of a ventilator.After achieving PIC window,patients of both groups changed to NIMV mode,and weaned from ventilation.The following listed indices were used to compare between the groups after treatment:1) the occurrence time of PIC,the duration of MV,the length of ICU stay,the success rate of weaning from MV for the first time,the rate of reventilatJon and the occurrence rate of ventilator-associated pneumonia(VAP);2) the convenience and safety of FOB manipulation.The results were compared using Student's f test and the Chi-square test.RESULTS:The occurrence time of PIC was(5.01 ±1.49) d,(5.87±1.87) d in groups A and B,respectively(P<0.05);the duration of MV was(6.98±1.84) d,(8.69±2.41) d in groups A and B,respectively(P<0.01);the length of ICU stay was(9.25±1.84) d,(11.10±2.63) d in groups A and B,respectively(P<0.01);the success rate of weaning for the first time was 96.30%,76.92%in groups A and B,respectively(P<0.01);the rate of reventilation was 5.56%,19.23%in groups A and B,respectively(P<0.05);and the occurrence rate of VAP was 3.70%,23.07%in groups A and B,respectively(P<0.01).Moreover,it was easy and safe to manipulate FOB,and no side effect was observed.CONCLUSIONS:The application of FOB in patients with AECOPD during sequential weaning of invasive-noninvasive MV is effective in ICU.It can decrease the duration of MV and the length of ICU stay,increase the success rate from weaning MV for the first time,reduce the rate of reventilation and the occurrence rate of VAP.In addition,such a method is convenient and safe in patients of this kind.

Hill slope instability of Nainital City,Kumaun Lesser Himalaya,Uttarakhand,India

Nainital City of Kumaun Lesser Himalaya is prone to mass wasting processes during monsoon season,which mischievously triggers the hill slope instability in this region. Slate, dolomitic limestone, silty sandstone and rhythmite of the Krol Formation are the main rock types. The present study focuses on the investigation of slope stability in the region in terms of potential seismicity and landslide. Geological and geotechnical mapping indicates that the major portion of the area is characterized by slope wash materials and buildings. The combination of 3-4 joint sets with one random joint is the main structure at outcrops.The major geological structures of this area are Nainital lake fault passing from the center of the lake, Main Boundary Thrust at SW, and Khuriya Fault passing from the SE direction of Nainital City. This work finds that different types of discontinuities(e.g. joints and faults), overburden due to unplanned civil structures,and neotectonic activity in the vicinity of this ara affect the stability of the city. The slate forms the base of the city, dipping slightly towards the lake side along the NW direction, thus accelerating the instability of this area. Rock mass rating(RMR), slope mass rating, factor of safety(FOS) and graphical analysis of the discontinuity for slope kinematics indicate that the study area is a landslide-prone zone. This study can facilitate reducing the risk of human life, and contribute to the ongoing construction works in the area.

Numerical study on dynamic properties of rubberised concrete with different rubber contents

As a green environmentally-friendly material,rubberised concrete(Ru C),which has the characteristics of low elastic modulus,large deformation capacity,high damping,good energy dissipation and good crack resistance,has attracted extensive attention and research in the civil engineering discipline.However,most of existing studies are based on experimental tests on Ru C material properties,and there has been no numerical study based on meso-scale modelling of Ru C yet.To more comprehensively investigate the Ru C dynamic material properties without conducting intensive experimental tests,this study developed a high-fidelity meso-scale model considering coarse and fine aggregates and rubber crumbs to numerically investigate the mechanical properties of rubberised concrete under different strain rates.The meso-scale model was verified against both quasi-static compressive testing data and Split Hopkinson Pressure Bar(SHPB)dynamic testing data.Using the verified numerical model,the dynamic properties of rubberised concrete with various rubber content(0%-30%)under different strain rates were studied.The numerical results show that the developed meso-scale model can use to predict the static and dynamic properties of rubberised concrete with high accuracy.The dynamic compressive strength of the rubberised concrete increases with the increment of the strain rate,and the strain rate sensitivity increases with the rubber content ranging from 0 to 30%.Based on intensive numerical simulation data,empirical DIFs is used as a function of strain rate and rubber content to predict the dynamic strength of rubberised concrete.

医疗失效模式与效应分析在新生儿医院感染防控中的应用

目的研究医疗失效模式与效应分析(healthcare failure mode and effect analysis,HFMEA)在新生儿医院感染防控中的应用效果。方法选取揭阳市人民医院新生儿中心2020年7月—2021年6月住院患儿1150例为对照组,2021年7月—2022年6月住院患儿1353例为观察组。对照组应用常规感染防控管理模式,观察组应用HFMEA管理模式进行医院感染防控干预。比较2组新生儿医院感染例次发病率、工作人员(医护、保洁)医院感染知识知晓率、手卫生依从率和正确率。结果观察组新生儿医院感染例次发病率为3.92%,低于对照组的5.65%,差异有统计学意义(P<0.05)。观察组医护人员医院感染知识知晓率、手卫生依从率、手卫生正确率为93.25%、90.25%、88.98%,高于对照组的51.84%、80.64%、79.94%,差异有统计学意义(P<0.05)。观察组保洁人员医院感染知识知晓率、手卫生依从率、手卫生正确率为91.15%、76.71%、75.71%,高于对照组的65.31%、60.65%、62.50%,差异有统计学意义(P<0.05)。结论应用HFMEA对新生儿中心进行科学管理,可有效指导新生儿医院感染防控,提升医院感染管理水平。