Based on network pharmacology and molecular docking technology to explore the mechanism of Panax notoginseng in the treatment of membranous nephropathy

Objective:Based on network pharmacology and molecular docking technology to explore the mechanism of Professor Cao Enze's application of Panax notoginseng in the treatment of membranous nephropathy.Methods:TCMSP database was used to obtain the effective components and corresponding target information of Panax notoginseng,and Gene Cards database was used to obtain the disease target genes of membranous nephropathy.The intersection targets of the two were taken and the Venn diagram was drawn.The STRING database was used to obtain the protein interaction relationship,and the PPI network diagram was constructed by Cytoscape 3.9.1 software to screen out the core targets of Panax notoginseng in the treatment of membranous nephropathy.GO function and KEGG pathway enrichment analysis were performed using the David database to obtain the potential pathway of Panax notoginseng in the treatment of membranous nephropathy.Finally,Autodock software was used to verify the molecular docking of the main active components of the drug with the core targets.Results:A total of 7 effective components such as quercetin,ginsenoside rh2,Mandenol and Stigmasterol were retrieved,and 127 potential targets of Panax notoginseng in the treatment of membranous nephropathy were screened out.By PPI network topology analysis,23 core targets such as JUN,TP53,RELA,AKT1 and MAPK1 were screened out.GO functional enrichment analysis contained 703 biological processes,55 cell components and 121 molecular functions,and KEGG signal pathway enrichment analysis enriched 171 signal pathways.The results of molecular docking showed that there was a strong binding ability between the main core targets and the main components of Panax notoginseng.Conclusion:Through network pharmacology,it is concluded that Panax notoginseng treats membranous nephropathy through multiple targets and multiple pathways,which provides a theoretical basis for subsequent basic research.

Doctor Song Fuyin's Experience in Treating Hashimoto's Thyroiditis Based on Qi,Blood Essence and Spirit Syndrome Differentiation Stage Classification

The paper systematically summarizes the experience of Director Song Fuyin in treating Hashimoto's thyroiditis which is a typical emotional disease that causes obvious changes in organ morphology and endocrine and body fluid metabolism.It belongs to the category of psychosomatic diseases,and is the embodiment of a series of pathogenesis processes of qi disease,blood disease,essence disease and deformation in TCM theory.The whole course of the disease is dominated by the dialectical relationship of mutual influence,mutual control,mutual root and mutual use among the deity disease,qi disease,blood disease,essence and spiritual disease.Therefore,the treatment emphasizes the dialectical relationship based on qi,blood,essence and spirit.At the beginning,the treatment focuses on regulating qi and clearing heat and eliminating phlegm;at the middle stage,the treatment focuses on replenishing essence and promoting yang and eliminating wind and calming the deity;at the late stage,the treatment focuses on replenishing qi and eliminating phlegm and promoting collages.Flexible use of calming the spirits,regulating qi,dispersing essence,eliminating phlegm,promoting blood and other methods of stage classification treatment,can be targeted,improve the cure rate of the disease.This article aims to clarify the experience of Director Song Fuyin in treating Hashimoto's thyroiditis based on syndrome differentiation of qi,blood essence and spirit.

Professor LUO Zhijuan's experience in the treatment of infertility in elderly women

With the national second child policy, old-age fertility problem increasingly prominent, female fertility decline by the increase of age, so the incidence of infertility also will increase from the understanding of disease dialectical trichotomy therapy to summarize professor LUO Zhi-juan clinical experience infertility think the disease occurs mainly in kidney empty as this, liver and spleen viscera dysfunction to heart, wet phlegm and blood stasis as the main pathological product of common cause kidney - menstruation - ran ren - cell palace reproductive axis dysfunction and infertility.

Experience of the national-level old Chinese medicine expert Wu Zhengshi on syndrome differentiation and treatment of anaphylactoid purpura

This paper introduced and summarized the experience of the national-level old Chinese medicine expert Wu Zhengshi on syndrome differentiation and treatment of anaphylactoid purpura.Wu Zhengshi believes that blood-heat is the main cause of anaphylactoid purpura.When Qi is weak,the human body is attacked by external heat,resulting in the damage of the blood system,which lead to the anaphylactoid purpura.The blood is thermalized poison,which enters the vessel quickly and forces the blood to overflow the vessel,which develops for the purpura.According to the ancient book of Chinese medicine Jie Wei Yuan Sou(1550 C.E.),Wu Zhengshi put forward the treatment of relieving blood detoxification,heat and cooling blood,which achieved significant curative effects.

The experiences of Zheng-ping Bai in treating gastric cancer based on qi,phlegm,and stasis

This paper will introduce the clinical experiences of Professor Zheng-pingBai in treating gastric cancer.In his diagnosis and treatment of this disease,Professor Bai advocates the integration of disease,symptom,and syndrome differentiation,pointing out that gastric cancer is caused by the accumulation of phlegm-dampness and blood stasis in the stomach due to qi stagnation.Therefore,the basic pathogenic mechanism involves the loss of harmonious descent in the stomach.This implies that treatment should prioritize qi activity by calming the stomach and suppressing the abnormal ascent of qi,as well as emphasizing the elimination of phlegm and stasis,and this has achieved significant therapeutic efficacy.

Professor Cheng Lan's Experience in Treating Endometriosis

Endometriosis is one of the refractory and common disease in gynaecology, which the main manifestations are dysmenorrhea and infertility. Professor Cheng considers it's the deficiency-excess mixing illness whose pathological base is blood stasis and root is the deficiency of Yin and Yang, Qi and blood. So in terms of treatment, Professor Cheng praises highly the way of strengthening the body resistance to eliminate pathogenic factors. Strengthening the body resistance and expelling evil at the same time can achieve the purpose of treatment. In the adjustment of Yin and Yang ,Qi and blood, Professor Cheng attaches importance to treating middle burner. On the treatment of dysmenorrhea, Professor Cheng is able to capture xuefu zhuyu decoction and bazhen decoction and pays attention to menstrual cycle therapy. In addition, Professor Cheng often uses jingui wenjing decoction for infertility and re-understands the decoction by meridians theory and circular motion theory. Furthermore, Professor Cheng's treatment in reserving follicle, promoting ovulation and developing follicle is distinctive by traditional Chinese medicine.

Professor Yanping Bai’s experience in treating alopecia areata

To summarize and analyze Professor Bai Yanping’s clinical experience in treating alopecia areata.Prof.Bai thinks the etiology of alopecia areata is a combination of liver-kidney depletion,qi and blood deficiency,qi stagnation and blood stasis,always along with wind-heat,damp-heat,blood heat and insomnia.It is indispensable to enrich and nourish the liver and kidney,supplement and nourish the qi and blood,invigorate blood and dissolve stasis,and at the same time,the usage of messenger drug and plum-blossom needle is important and formula has to vary from person to person on the basis of commonality.

Brief Analysis of Treatment of Postpartum Body Pain by Professor Zhang Xiaofeng from the Viewpoint of “Liver Vital Deficiency and Yang Stagnation”

Postpartum body pain is a common gynecological disease in clinical setting.Its symptoms are complex and is difficult to treat.It is often treated in many ways but with poor results,which bring great pain to patients and their families.Professor Zhang Xiaofeng can effectively improve clinical treatment of this disease from the point of view of“liver vital deficiency and yang stagnation”.This paper mainly introduces the professional experience of Professor Zhang Xiaofeng in treating postpartum body pain.A clinical case was attached for reference as proof.

Professor Pei Ruixia's ExperienAce in Treating Diabetes with the"Harmony Method"

This paper introduces professor Pei Ruixia's experience in the treatment of diabetes with the"harmony method." Professor Pei believes that the pathogenic factors of diabetes are mainly divided into emotional and dietary factors,and the essence of diabetes are not in harmony of the human body.Thus,its treatment is to"make it harmonious."It is good to use the method of"clearing and harmonizing,"appropriately using Xiaochaihu decoction,paying attention to the compatibility of drugs,and taking care of spleen and stomach,as well as Qi.

Summary on SHANG Hong-tao's Experience in Treating Alopecia of Spleen Deficiency with Shengyang Sanhuo Decoction (升阳散火汤)

Alopecia is a common but difficult miscellaneous disease in dermatology.Director SHANG Hong-tao believes that alopecia is often caused by exogenous cold or heat in daily life,internal damage of emotions and improper diet,leading to injury of spleen and stomach.So it can be treated with LI Dongyuan's Shengyang Sanhuo Decoction(升阳散火汤),which protects spleen and stomach.Here are 3 proved cases as evidence.

Multi-target therapy for autoimmune hemolytic anemia under the guidance of traditional Chinese medicine pharmacology

Autoimmune hemolytic anemia(AIHA)is a rare and refractory acquired autoimmune disease.At present,western medicine treatment has obvious side effects,low drug sensitivity,easy to relapse and other problems.Multi-target treatment of autoimmune hemolytic anemia through the study of pharmacology of traditional Chinese medicine can effectively improve the clinical efficacy of autoimmune hemolytic anemia,and the price is low,worthy of promotion.This paper discusses the effects of traditional Chinese medicine on maintaining acid-base balance,alleviating liver and kidney function damage and immune collapse.

基于“伏毒”理论探析颈动脉粥样硬化斑块发病机制与中医治疗

总结郑关毅教授基于“伏毒”理论辨析颈动脉粥样硬化斑块(颈动脉斑块)发病机制与中医治疗经验。通过分析伏毒与颈动脉斑块在致病危险因素、病因病机、病理基础、临床特点方面的相关性,认为脏腑功能亏虚或邪气蕴结不解,酿生痰、湿、浊、瘀、热等伏毒藏于机体,日久致脉络损伤而发为本病,具有隐伏、缠绵、暗耗、暴戾、杂合、多变等病理特性,发作时具有毒性猛烈、病情危重,或迁延反复难祛等临床特点。“伏毒损脉”是本病的根本原因与核心病机所在,病位在“脉”,并可累及“脑”。正虚毒聚-伏毒损脉-毒蚀脑窍3个阶段与颈动脉斑块的发生、发展过程具有一致性。提出扶正祛毒的总体治则,具体包括化痰、活血、养阴、清热、行气、导滞、通络、息风等治法,审证求因,荡涤伏毒。临证特别注重调补脾肾,通过益气健脾恢复中焦运化功能,以绝生痰之源;补肾填精以充五脏气血化生。常以香砂六君子汤、半夏白术天麻汤、血府逐瘀汤等为基础方加减,喜佐以红景天、红曲以健脾益气、消痰化瘀。若热毒炽盛,配伍清热解毒兼有活血功效的药物,如牡丹皮、赤芍、大血藤等;病久入络者,投以藤类或虫类通络化瘀之品,如鸡血藤、僵蚕、地龙、路路通等搜剔络脉伏毒。

高彦彬教授从络病论治慢性肾衰经验

慢性肾衰是各类进展性肾脏疾病的最终结局,病机错综复杂,中医对其治疗具有较好疗效。高彦彬教授学术思想师承国医大师吕仁和教授,临证四十载,认为此病属于“络病”范畴,并针对慢性肾衰提出肾元虚衰、肾络瘀结、浊毒内停的基本病机和益气固肾、解毒通络的基本治法。临床上以虚定型,以实定候进行辨证论治,并基于治未病理论,提出慢性肾病三级预防策略。

Professor Zhang Jun's four methods for treating Children with purpuric nephritis

Based on the theory of children's TCM constitution"children are Zhi yang wei chong,and Zhi yin wei zhang",combined with the etiology and pathogenesis of TCM in children with purpuric nephritis,Professor Zhang Jun uses The four methods of"Clearing heat,dampness,tonicity,and stasis"are used to treat children with purpuric nephritis,and it is advocated that the method of"resolving blood stasis"runs through the entire treatment process,and the clinical results are quite good.

Professor LIU Huilin’s experience in treating cluster headache with acupuncture-moxibustion

This paper introduces chief physician LIU Huilin’s empirical characteristics in treating cluster headache based on holism and pattern-identification-based treatment,with spirit-regulating filiform needling,filiform fire needle pricking,and collateral-pricking for bloodletting sequential therapy,which inherits the academic thoughts of“acupuncture-moxibustion for treating spirit”from Professor ZHOU De’an and“three-unblocking acupuncture therapy”from HE Puren,thus providing a reference for treating cluster headache with acupuncture-moxibustion therapy.

Professor Zhang Yu-zhen's medication rule in treating metrorrhagia and bleeding based on data mining

Objective:To explore the medication rules of Professor Zhang Yuzhen in treating the bleeding period of metrorrhagia and metrostaxisthe,and to explore the treatment of the disease.Methods:Collected 520 prescriptions of Professor Zhang Yuzhen in the treatment of patients with the bleeding period of metrorrhagia and metrostaxis,and analyzed the regularity of medication by using"TCM inheritance assist platform(V2.5)".Results:According to the analysis,the top 30 most frequently used herbs for treating the bleeding period of metrorrhagia and metrostaxisthe were Codonopsis pilosula,Trogopterus dung,Cattail pollen,Motherwort,Cornus,Ophiopogon japonicas,Schisandra,Tortoiseshell,Panax notoginseng,Radix Paeoniae Alba,etc.Core combination 35 In the group,the core prescription has 1 hemostasis,followed by 2 hemostasis,and evolves to get 3 new prescriptions.Conclusion:Professor Zhang Yuzhen's medication for the treatment of metrorrhagia and metrostaxisthe is mostly Gan Wen's product.The treatment is based on the three organs of the liver,spleen,and kidney,and the disease is treated with"tonifying the kidney and benefiting qi,reducing blood stasis and stopping bleeding".

Feasibility Analysis of the Value of Q Method in the Classification and Understanding of Expert Experience

The Q method, combining qualitative and quantitative methods, refers to the qualitative analysis of Q-sorts based on quantitative techniques. It is used to research individual subjective experience, analyzing consensus and divergence to identify and categorize subjects＇ viewpoints. The sorting process is completely performed by the subjects, independent of study researchers. The Q method in medical research has been applied in many fields, including nursing care, clinical studies, doctor and patient＇s perceptions, health evaluation and decision making. The authors used the Q method to research Chinese medicine （CM） group decision making, exploring its practical feasibility in this important field. Four primary domains are addressed： （1） integration of expert opinion; （2） expert classification; （3） ascertaining the entire viewpoint orientation of a certain type of expert; and （4） comparison of expert opinion using an additional perspective. The essence of the Q method caters to the CM thinking model and should be introduced into CM and explored more deeply.

Experience of professor JIA Chun-sheng in rapid analgesia by subcutaneous penetration needling of auricular acupuncture

To introduce the experience of professor JIA Chun-sheng in rapid analgesia and motor function rehabilitation by subcutaneous penetration needling of auricular acupuncture.Subcutaneous penetration needling of auricular acupuncture plays a role in rapid analgesia and motor function rehabilitation in treatment of pain in limbs and trunk and/or limb dysfunction caused by migraine,cervical spondylosis,acute lumbar sprain,soft tissue injury,scapulohumeral periarthritis,lumbar disc herniation,sciatica,stroke or cerebral trauma,and it is worthy of being widely promoted and applied clinically.

名老中医经验传承研究模式探索

目的:总结既往名老中医传承研究模式,认为以往研究存在信息量少、时限短、受研究者素质影响较大、缺乏横向比较、缺少验证性研究及机理探讨等缺点。解决问题的方法是基于临床,规范采集临床信息;利用数据挖掘技术,实现知识的迅速发现,采用人机结合,以人为主的方法解析结果,总结经验;同时对挖掘总结的结果进行验证与评价,进一步阐明其作用机理及临床有效的原因。名老中医经验传承研究,应当遵循"临床信息采集-挖掘提取经验-临床应用验证-机理机制研究-理论指导临床"的模式,建立有关的技术平台,从临床中来,再到临床中去,反复总结,不断提升。结果:该模式对促进名老中医经验的继承发扬,推动中医药事业发展具有重大意义。

谈名老中医经验传承的3个层次和方法

思考中医经验继承的内涵,提出中医经验继承存在3个层次:1)传承医术,2)传承医学,3)传承医道。师傅和徒弟都是传承的载体和研究对象,指出不同层次传承的传承方法和验证方法。