Genome-wide and candidate gene association studies identify BnPAP17 as conferring the utilization of organic phosphorus in oilseed rape

Phosphorus(P)is essential for living plants,and P deficiency is one of the key factors limiting the yield in rapeseed production worldwide.As the most important organ for plants,root morphology traits(RMTs)play a key role in P absorption.To investigate the genetic variability of RMT under low P availability,we dissected the genetic structure of RMTs by genome-wide association studies(GWAS),linkage mapping and candidate gene association studies(CGAS).A total of 52 suggestive loci were associated with RMTs under P stress conditions in 405 oilseed rape accessions.The purple acid phosphatase gene BnPAP17 was found to control the lateral root number(LRN)and root dry weight(RDW)under low P stress.The expression of BnPAP17 was increased in shoot tissue in P-efficient cultivars compared to root tissue and P-inefficient cultivars in response to low P stress.Moreover,the haplotype of BnPAP17^(Hap3)was detected for the selective breeding of P efficiency in oilseed rape.Over-expression of the BnPAP17^(Hap3)could promote the shoot and root growth with enhanced tolerance to low P stress and organic phosphorus(Po)utilization in oilseed rape.Collectively,these findings increase our understanding of the mechanisms underlying BnPAP17-mediated low P stress tolerance in oilseed rape.

Genome-Wide Association Study for Certain Carcass Traits and Organ Weights in a Large White×Minzhu Intercross Porcine Population

Porcine carcass traits and organ weights have important economic roles in the swine industry. A total of 576 animals from a Large White×Minzhu intercross population were genotyped using the Illumina PorcineSNP60K Beadchip and were phenotyped for 10 traits, speciifcally, backfat thickness （6-7 libs）, carcass length, carcass weight, foot weight, head weight, heart weight, leaf fat weight, liver weight, lung weight and slaughter body weight. The genome-wide association study （GWAS） was assessed by Genome Wide Rapid Association using the mixed model and regression-genomic control approach. A total of 31 single nucleotide polymorphisms （SNPs） （with the most signiifcant SNP being MARC0033464, P value=6.80×10-13） were located in a 9.76-Mb （31.24-41.00 Mb） region on SSC7 and were found to be signiifcantly associated with one or more carcass traits and organ weights. High percentage of phenotypic variance explanation was observed for each trait ranging from 31.21 to 67.42%. Linkage analysis revealed one haplotype block of 495 kb, in which the most signiifcant SNP being MARC0033464 was contained, on SSC7 at complete linkage disequilibrium. Annotation of the pig reference genome suggested 6 genes （GRM4, HMGA1, NUDT3, RPS10, SPDEF and PACSIN1） in this candidate linkage disequilibrium （LD） interval. Functional analysis indicated that the HMGA1 gene presents the prime biological candidate for carcass traits and organ weights in pig, with potential application in breeding programs.

Simple approach for the histomolecular diagnosis of central nervous system gliomas based on 2021 World Health Organization Classification

The classification of central nervous system(CNS)glioma went through a sequence of developments,between 2006 and 2021,started with only histological approach then has been aided with a major emphasis on molecular signatures in the 4^(th) and 5^(th) editions of the World Health Organization(WHO).The recent reformation in the 5th edition of the WHO classification has focused more on the molecularly defined entities with better characterized natural histories as well as new tumor types and subtypes in the adult and pediatric populations.These new subclassified entities have been incorporated in the 5^(th) edition after the continuous exploration of new genomic,epigenomic and transcriptomic discovery.Indeed,the current guidelines of 2021 WHO classification of CNS tumors and European Association of Neuro-Oncology(EANO)exploited the molecular signatures in the diagnostic approach of CNS gliomas.Our current review presents a practical diagnostic approach for diffuse CNS gliomas and circumscribed astrocytomas using histomolecular criteria adopted by the recent WHO classification.We also describe the treatment strategies for these tumors based on EANO guidelines.

The Architecture of Value Thinking and Pneuma in Housing Associations

Housing associations make too small a contribution to society, the government has to step in too frequently because of maladministration, and the associations＇ executives are often unaware of the far-reaching impact of their decisions. These are the conclusions of new academic research conducted by Jan Veuger of Rotterdam School of Management, Erasmus University （RSM）. In the author＇s dissertation, he asserts that in numerous cases, there is no correlation between social and financial objectives. The Dutch House of Representatives debated the results of the report Ver van huis from the Parliamentary Committee of Inquiry on Housing Associations in early December, 2014. The research that is being carried out at the moment is constructed in a manner that if we understand something about value thinking and what underlying motivation is, an approach can be deducted that will allow us to control them. After the introduction, an explanation of the theme of the research will be given and the choice for a four-phase model with a deepening as to what value（s） is （and are）. From the perspective of the four-phase model, the emphasis will be put on the socialization and thinking capacities, and parallels will be drawn between the values within the four-phase model, the examined values, and in specific, public housing corporations.

Chinese Anti-Cancer Association as a non-governmental organization undertakes systematic cancer prevention work in China

Cancer has become the first leading cause of death in the world, particularly in low- and middle-income countries. Facing the increasing trend of cancer incidence and mortality, China issued and implemented ＂three-early（early prevention, early diagnosis and early treatment）＂ national cancer prevention plan. As the main body and dependence of social governance, non-governmental organizations（NGOs） take over the role of government in the field of cancer prevention and treatment. American Cancer Society（ACS） made a research on cancer NGOs and civil society in cancer control and found that cancer NGOs in developing countries mobilize civil society to work together and advocate governments in their countries to develop policies to address the growing cancer burden. Union for International Cancer Control（UICC）, Cancer Council Australia（CCA）, and Malaysian cancer NGOs are the representatives of cancer NGOs in promoting cancer control. Selecting Chinese Anti-Cancer Association（CACA） as an example in China, this article is to investigate how NGOs undertake systematic cancer prevention work in China. By conducting real case study, we found that, as a NGO, CACA plays a significant role in intensifying the leading role of government in cancer control, optimizing cancer outcomes, decreasing cancer incidence and mortality rates and improving public health.

Determining knots by optimizing the bending and stretching energies

For a given set of data points in the plane, a new method is presented for computing a parameter value（knot） for each data point. Associated with each data point, a quadratic polynomial curve passing through three adjacent consecutive data points is constructed. The curve has one degree of freedom which can be used to optimize the shape of the curve. To obtain a better shape of the curve, the degree of freedom is determined by optimizing the bending and stretching energies of the curve so that variation of the curve is as small as possible. Between each pair of adjacent data points, two local knot intervals are constructed, and the final knot interval corresponding to these two points is determined by a combination of the two local knot intervals. Experiments show that the curves constructed using the knots by the new method generally have better interpolation precision than the ones constructed using the knots by the existing local methods.

Viscoelastic rheological property of different types of polymer solutions for enhanced oil recovery

The capability of hydrophobic association polymer(HAPAM) to displace oil is different from that of hydrolyzed polyacrylamide(HPAM) because they have different rheological properties.The viscoelasticity of five polymers was measured using Physica MCR301 rheometer and was compared.The five polymers include three HAPAMs with relative molecular mass of 1 248×104(TypeⅠ),750×104(TypeⅡ),and 571×104(Type Ⅲ) separately and two HPAMs with relative molecular mass of 1 200×104 and 3 800×104 respectively.The experiment results indicate that the viscoelasticity of HAPAM is better than that of HPAM.The storage modulus G' and the loss modulus G″ for HAPAM solutions are also larger than those for HPAM.Comparing the rheological curves of different HAPAM types,it is found that the viscosity of typeⅡ and type Ⅲ is almost same at different shear rates while the viscosity of type I is the lower than that of Types Ⅱ and Ⅲ.The storage modulus G' and the loss modulus G″ for three types of HAPAM were measured in low oscillation frequency range,and the results show that G' is greater than G″ for all three different types of HAPAM,but their loss modulus is almost same,and the G' is in the order of type Ⅱ>type Ⅲ>type I.In addition,the G' and G″ increase with aging time for all three HAPAM solutions were stayed at different days.The viscoelasticity of type Ⅰ reaches the highest value when aging time is 9 d at 45 ℃,but it is 7 d for type Ⅱ and type Ⅲ.The different viscoelasticity properties can be attributed to self-organization supermolecule networks which is formed by hydrophobic association of HAPAM molecular and molecular chain entanglement.

Rural Cooperative Economic Organized United Association: A Case Study of Baoding City of Hebei Province

Taking its development in Baoding City as an example, we introduced service fields of rural cooperative economic organized united association. It mainly includes setting up service platform and providing scientific and technological services; organizing economic and trade negotiation and exchange, and promoting farmer-supermarket partnership; providing financial services and solving fund-raising problems. In line with these fields, we analyzed existing problems: (i) regional development is unbalanced and organization lacks internal connection; (ii) the development in some counties (cities) is to be improved, and the promotion effect is not significant; (iii) there is shortage of talent and the innovation strength is not enough; and (iv) it lacks system and management lacks restriction mechanism. Finally, we put forward countermeasures and recommendations: strengthen propaganda and cultivate farmers' cooperative awareness; incorporate rural cooperative economic organized united association into formal system arrangement, and absorb professional talents; innovate upon organization system of rural cooperative economic organized united association and improve service methods; improve internal operating mechanism and innovate upon working contents of rural cooperative economic organized united association at new development background.

Research on Role Definition of Industry Association and Administrative Organ

Industry association is an important part of China＇s economic and social life, which plays an important role in these areas. However, due to various reasons, there exist some objective difficulties and problems for industry associations. In March 2013, Chinese government requires to clear relationship between govemment~ market and society, actively yet prudently carry forward the work of canceling the subordinate relations between industry associations and administrative organs, speed up the construction of modem social organizational system that is independent of government, and with well defined rights and responsibilities and self-governing by law. In such a background, it is especially necessary to deeply analyze the role definition of industry association and administrative organ, discuss how to clarify the role relationship between industry association and administrative organ, and consider how to promote the better and faster development of industry association. This paper has briefly introduced the development status and existing problems of industry association, and put forward relevant measures and suggestions to solve the problems.

Minerogenetic Mechanism of the Songxi Silver Antimony Deposit of Northeastern Guangdong-Ore-Controlling Role of Organic Matter

Organic geochemistry and comparisons of characteristics of the organic matter in wall rocks of the ore\|controlling strata and ores of the Lower Jurassic Songling black shale formation and the related Songxi silver\|antimony deposit of northeastern Guangdong have been studied in this paper. The results show that the Lower Jurassic Songling shale formation is a suite of biologic\|rich and organic\|rich ore\|bearing marine sedimentary rocks. Micro\|components of the organic matter in the Songling black shale formation consists primarily of algae, amorphous marine kerogen, solid bitumen, and pyrobitumen. The thermal evolution of organic matter is at the over\|maturity stage. There is a general positive correlation between total organic carbon (TOC) and metallogenetic elements such as Ag and Sb in the black shale formation. Organic matter in the host rocks in the Songxi ore deposit played a role in controlling the silver\|antimony depositing environment during the forming process of the black shale ore\|bearing formation. In the absence of vitrinite, the relative level of thermal maturity calculated by solid bitumen reflectance indicates that the ore\|forming temperature of the Songxi silver\|antimony deposit was about 150-170℃, which was considered as an epithermally reworked ore deposit. The roles of organic matter in the formation of the Songxi ore deposit are a primitive accumulation of the metallogenetic elements (Ag, Sb) in the sea\|water cycle system for ore source and a concentration of metals by ion exchange or chelation as well as reduction of the oxidized metals.

The Diagnostic and Prognostic Value of Serum Procalcitonin among Ventilator Associated Pneumonia Patients

Ventilator-associated pneumonia (VAP) is a complication in as many as 28% of patients who receive mechanical ventilation. Studies have consistently shown that a delay in diagnosis and treatment increases the mortality risk. The aim of this work was to clarify the role of the serum procalcitonin (PCT) in the diagnosis and the prognosis of ventilator associated pneumonia. Methods: Forty two VAP patients, 20 non VAP-ICU (on mechanical ventilation) admitted patients and 20 healthy control subjects of similar age and sex were included in the study. PCT levels in serum samples were measured in all subjects. Results: There was a highly statistically significant difference (p value 0.001) between VAP patients on one side and non VAP-ICU patients and healthy control subjects on the other side regarding the mean values of PCT. Also, the mean values of PCT were statistically significantly higher (p 0.001) among died VAP group than the survivor VAP group. There was a statistically positive correlation (p = 0.449), CRIP (R = 0.403) and SOFA (R = 0.437)) and initial PCT serum levels. Conclusions: This study found that the increased PCT serum level is an important diagnostic tool for VAP and the PCT serum levels can predict the outcome of VAP patients. We recommend other larger studies to augment our findings.

鱼类鼻黏膜相关淋巴组织的研究进展

鱼类黏膜相关淋巴组织是抵御病原入侵的第一道防线。其中,鱼类鼻黏膜相关淋巴组织(nasal-associated lymphoid tissue,NALT)近年来被国内外学者所关注,并被证明是嗅觉器官中抗原识别和启动黏膜免疫应答的重要场所,在细菌、病毒和寄生虫感染后可发挥快速的局部免疫响应。以NALT为靶点,对鱼类开展疫苗鼻内接种可起到良好的免疫保护效果。但目前,对NALT中复杂的免疫细胞与分子网络及其互作机制知之甚少。本文对鱼类嗅觉器官结构与功能、NALT的细胞与分子网络及免疫应答、鼻内接种的应答及免疫保护效果等方面的最新研究进展进行综述,旨在阐明鱼类NALT在黏膜局部发挥的免疫防御机制,以期为新型黏膜疫苗的设计与研发提供参考。

外源内生型社会组织参与农村社会治理何以可能?

社会组织参与农村社会治理有助于提升社会治理效能,契合了国家推动社会组织积极参与乡村振兴的要求。与外源型和内生型社会组织不同,外源内生型社会组织主要由村庄外部主体动员成立,由村内精英运行,具有参与农村社会治理的优势,但因缺乏外部资源的持续性输入,导致很多外源内生型社会组织运行困难。本文以运行较好的一个外源内生型社会组织陕西省T村老年协会为个案,探讨外源内生型社会组织参与农村社会治理的机理。研究发现,通过一定的组织行为,外源内生型社会组织可以形成参与农村社会治理的各项机制,如与其他治理组织互相嵌入的组织机制,政府资助、社会捐赠与用者付费相结合的多元化筹资机制,定期活动串联重塑村庄节奏的链接机制,规范活动程序与采取预防措施的风险防范机制,以声誉、信任和互惠为关键因素巩固集体行动领导力的领导机制,从而保障外源内生型社会组织有效参与农村社会治理,助力乡村振兴。

知识流动视角下数字人文产业联盟构建研究

[目的/意义]探究数字人文产业联盟构建策略,规划其未来发展路径,拓宽数字人文领域研究思路,加快数字人文领域迈向规模化、市场化、产业化步伐,加强数字人文领域内从数字人文知识到生产力再到经济效益的转化效率。[方法/过程]从知识流动视角出发,明晰数字人文产业概念,探析数字人文产业知识流动路径,探究数字人文产业联盟构建策略与发展路径。[结论/结果]界定数字人文产品、数字人文产业概念,分析数字人文产业知识流动路径,构建知识流动视角下数字人文产业联盟模型,提出以企业、高等院校与科研机构、政府与行业协会/组织等知识主体要素的构建策略,并规划“放眼未来”“着力当下”“弯道超车”三步走的发展路径。

知识关联视角下标准文档的多粒度知识组织方法研究

传统的文档组织方式无法应对标准数字化发展形势,有必要充分发掘标准文档中的多粒度知识单元及其语义关联,探索能够高效运用标准知识的新型组织方法,为优化标准供给提供参考。从知识关联视角出发,提出一种面向标准文档的多粒度、富语义的通用知识组织方法。首先,基于知识粒度理论,依据标准文档的知识内容和需求特征进行多粒度的知识划分与描述;其次,从知识层级、文档特征、文本逻辑、时空演化等方面认知和发现标准多粒度知识间的语义关联模式与类型;最后,采用本体构建方法实现标准文档的多粒度知识组织,并通过知识实例的添加来实现本体验证与价值阐述。多粒度知识关联的标准组织方法能够完整揭示标准文档中的多粒度知识单元,形成联通广泛的知识层次与关联,有助于标准知识在多种服务场景中被有效获取、共享与重用,既推进了适应数智时代的标准资源建设,又丰富了多粒度知识驱动的文档内容挖掘与利用。

老年人社会参与组织化发展的三个突出问题——基于老年协会的视角

组织化是老年人参与社会发展的重要形式。老年协会作为老年人参与社会发展的自组织平台,不仅是老年群体有序参与社会发展的重要组织形式,而且是推动我国老龄工作尤其是城乡社区老龄工作的重要组织载体。改革开放至今,在党和国家一系列政策的推动与支持下,我国老年协会在整合老年人资源、参与基层治理等方面发挥了重要作用。然而,与深度老龄化的时代背景相比,老年协会的发展现状还远远不能满足党中央对其提出的新要求。当前,我国老年协会存在合法性困境、管理体制困境、内部治理困境三大突出问题,它们已成为阻碍老年协会规范化、专业化发展的重要樊篱。

联合检测外周血TIRAP、FOXO3a、HBP预测脓毒症患者近期预后的价值及意义

目的探讨联合检测外周血TOLL/白介素-1受体相关蛋白(TIRAP)、叉头蛋白转录因子3a(FOXO3a)、肝素结合蛋白(HBP)对脓毒症患者近期预后的预测价值。方法回顾性收集2020年1月—2022年12月本院205例脓毒症患者的临床资料,根据28 d生存情况分为生存组157例、死亡组48例。统计两组外周血TIRAP、FOXO3a、HBP及急性生理功能和慢性健康状况评分系统Ⅱ(APACHEⅡ)、序贯器官衰竭评估(SOFA)评分。分析TIRAP、FOXO3a、HBP与APACHEⅡ、SOFA评分的相关性。采用Logistic回归方程分析TIRAP、FOXO3a、HBP交互作用对脓毒症近期预后的影响。评价TIRAP、FOXO3a、HBP联合预测脓毒症近期预后的价值。结果死亡组入院第1、3、7天外周血TIRAP、HBP水平及APACHEⅡ、SOFA评分高于生存组,FOXO3a水平低于生存组(P<0.05);入院第1天,脓毒症死亡患者TIRAP、HBP水平与APACHEⅡ、SOFA评分呈正相关,FOXO3a与APACHEⅡ、SOFA评分呈负相关(P<0.05);TIRAP×FOXO3a×HBP在脓毒症近期预后中存在交互作用(P<0.05);入院第1天外周血TIRAP+FOXO3a+HBP联合预测预后的曲线下面积(AUC)大于TIRAP+FOXO3a、TIRAP+HBP、FOXO3a+HBP,预测效能更佳(P<0.05)。结论脓毒症预后不良患者外周血TIRAP、HBP水平升高,FOXO3a水平降低,其水平变化与病情严重程度、近期预后有关,联合检测其水平可提高近期预后的预测效能。

关于高质量推进“双一流”高校科协工作的思考

本文深入剖析“双一流”高校科协在实际工作中存在的问题,提出推动高校科协工作高质量发展的若干建议,重点聚焦科协在日常工作中的组织建设、系统能力提升和重点工作开展等方面,旨在提升高校科协组织的工作成效,使高校科协更好地发挥服务学校“双一流”建设、服务国家科技战略实施和服务经济社会发展的作用。

林龄对刺槐人工林土壤团聚体、有机碳和细菌群落的影响

探究刺槐人工林土壤团聚体、有机碳及细菌群落的变化特征,可为提升土壤质量与功能提供理论依据。以黄土高原沟壑区不同林龄刺槐人工林(8年生、18年生和30年生)和刚撂荒的农耕地(CK)为研究对象,利用最适湿度筛分法获得不同粒径团聚体,测定其有机碳含量和细菌群落结构特征。结果表明:(1)各林龄土壤团聚体均以>0.25 mm粒径为主,含量为92.74%—95.78%。土壤团聚体稳定性随着林龄的增加显著提高,以30年生林地最高,团聚体平均重量直径(MWD)、几何平均直径(GMD)分别较CK显著增加48.19%和91.38%(P<0.05)。(2)各林龄均以<0.25 mm粒径有机碳含量最高。土壤有机碳含量和>2 mm粒径团聚体有机碳含量均随着林龄的增长而显著增加。(3)团聚体细菌群落主要由变形菌门(Proteobacteria)、放线菌门(Actinobacteria)和酸杆菌门(Acidobacteria)组成。随着林龄的增加,各粒径团聚体中放线菌门相对丰度先降低后增加,18年生林地最低。酸杆菌门变化趋势与放线菌门相反。变形菌门无明显变化。土壤有机碳、pH、全氮和全磷是影响团聚体细菌群落的主要因素。(4)>2 mm和2—0.25 mm粒径团聚体中,己科河菌门(Rokubacteria)对团聚体稳定性影响最大,既对团聚体稳定性产生直接正效应,又通过增加有机碳的含量间接提高团聚体稳定性。在<0.25 mm粒径团聚体中,有机碳含量对其稳定性的影响最大,有机碳含量越高,团聚体稳定性越强。综上,营造刺槐人工林有利于提高土壤团聚体稳定性,促进土壤有机碳的积累,可作为该区域生态恢复的有效措施。在生长发育过程中,人工林可通过改变土壤团聚体细菌群落和有机碳含量从而影响团聚体的稳定性。