Rip Van Winkle is one of the most enduring stories of Washington Irving. It is a fantasy tale about a man who somehow "stepped outside of the mainstream of life" (Chang Yao-xin, 1991: 62). Rip Van Winkle liv...Rip Van Winkle is one of the most enduring stories of Washington Irving. It is a fantasy tale about a man who somehow "stepped outside of the mainstream of life" (Chang Yao-xin, 1991: 62). Rip Van Winkle lived in a village near the Hudson River north of New York City. He was a simple, good-natured man; he was, moreover, a kind neighbor and an obedient hen-pecked husband. Yet Rip was lazy and this kept him in constant trouble with his wife. His two favorite past-times were sitting in front of the inn, chatting with his friends, and wandering through the mountains with his dog, Wolf. On one of these trips he met a strange dwarf who invited him to join him and other strange-looking dwarfs in a drinking party and a game called nine-pins, in a remote valley. Rip drank too much of beverage and fell asleep. When he woke up, he found that during just one night, twenty years had vanished and strangers were everywhere. His scolding wife had died, and his son, every bit his counterpart in appearance and personality had grown up to replace him. At last he was reunited with a married daughter and began to live a life the same as before.展开更多
We find that a conserved mutation residue Glu to residue Asp （E303D）, which both have the same polar and charged properties, makes Kit2.1 protein lose its function. To understand the mechanism, we identify three int...We find that a conserved mutation residue Glu to residue Asp （E303D）, which both have the same polar and charged properties, makes Kit2.1 protein lose its function. To understand the mechanism, we identify three interactions which control the conformation change and maintain the function of the Kit2.1 protein by combining homology modeling and molecular dynamics with targeted molecular dynamics. We find that the E303D mutation weakens these interactions and results in the loss of the related function. Our data indicate that not only the amino residues but also the interactions determine the function of proteins.展开更多
Gold Medals in Summer Qlympics Measures A 1) Program to develop junior athletes to top level 2) National Training Center 3) National Coach Academy B 1) Sports medicine and sciences(JISS) 2) Anti-doping 3) To hold inte...Gold Medals in Summer Qlympics Measures A 1) Program to develop junior athletes to top level 2) National Training Center 3) National Coach Academy B 1) Sports medicine and sciences(JISS) 2) Anti-doping 3) To hold international展开更多
Response of mucous cells, in the epidermis of the catfish Clarias batrachus, to a sublethal concentration of sodium dodecyl sulfate was studied and correlated with the alteration in the status of their secretory activ...Response of mucous cells, in the epidermis of the catfish Clarias batrachus, to a sublethal concentration of sodium dodecyl sulfate was studied and correlated with the alteration in the status of their secretory activity after different durations of the treatment. At 4h, 8h, 24h,48h and 72h of the detergent treatment, most mucous cells attained voluminous dimensions and appeared closely approximating to or even overlapping the adjacent ones. At 12h, 36h, and 60h, in contrast, the mucous cells appeared small and slender, and seemed to be located at greater intervals. These changes in dimensions were responsible for the apparent increase or decrease in the density of mucous cells after different durations of detergent treatment. Statistically, however, no significant change was observed in the total number of the mucous cells throughout the experiment.The mucous cells appeared enlarged towards the end of the experiment signifying increased mucus production. This is considered as an adaptation, for protection, assisting the fish to adjust to the changed environment.A shift in the histochemical nature of the secretory contents at the middle and basal parts of the mucous cells, from a mixture of neutral and acid glycoproteins to neutral glycoproteins, during the early stages of the treatment suggests that acid moities could not simultaneously be synthesized as an immediate response to enhanced mucous secretion. The apical parts of the mucous cells, however, showed no histochemical change throughout the experiment.展开更多
Mr.Jiang Zcmin,Gencral-Seerctary of the Cen-tral Committee of the Chincse Communist Party and.Chairman of the People's Republic of China,in a rC-ccnt spcech cm phasized that the family planning pro-gramme should b...Mr.Jiang Zcmin,Gencral-Seerctary of the Cen-tral Committee of the Chincse Communist Party and.Chairman of the People's Republic of China,in a rC-ccnt spcech cm phasized that the family planning pro-gramme should be strictly and effectively im plemented in 1994,a year of crucial importance for promoting re-form and opening and thc drive lowards.modernization.To makc continucd contributions to the sociocconomic development in the country,we must fulfil the plan for controlling population growth..The spcech was delivcred at the anua!National Fo-rum on Family Planning Work convened jointly by the Party's Central Committcc and the Statc Council.展开更多
Results of analytical studies of the physical properties of the function and number of empirical macrohardness based on the standard experimental force diagram of kinetic macroindentation by a sphere.An analytical com...Results of analytical studies of the physical properties of the function and number of empirical macrohardness based on the standard experimental force diagram of kinetic macroindentation by a sphere.An analytical comparison method and a criterion for the similarity of the physical and empirical macrohardness of a material are proposed.The physical properties of the hardness measurement process using the Calvert-Johnson method are shown.The physical reasons for the size effect when measuring macrohardness are considered.The universal physical unit and standard of macrohardness of kinetic macroindentation by a sphere is substantiated.展开更多
The paper took the human-land relations as a basic point, and the theories of tourism industry system and sustainable development as the guidance, with Gannan Tibetan Autonomous Prefecture （Gannan） as the case study...The paper took the human-land relations as a basic point, and the theories of tourism industry system and sustainable development as the guidance, with Gannan Tibetan Autonomous Prefecture （Gannan） as the case study area. From microcosmic and macroscopic viewpoints, the author carded out function orientation and evaluation to the tourism industry development, and research on the comprehensive tourism industry development pattern of Gannan. Results show that the fragile ecological environment and the traditional economic growth pattern have restricted regional sustainable development, and made Gannan to become a representative of the periphery minority areas in Northwest China. Tourism development of Gannan is at the primary phase, with the characteristics of short industry chain and low economic efficiency. It is an inevitable choice to transform the way of regional economic growth and the development pattern of tourism industry from the traditional pattern to the pattern of sustainable development. Simultaneously, Gannan＇s natural, national and religious culture makes Gannan a broad prospect on the comprehensive tourism development. Gannan should choose the comprehensive tourism industry as its scientific pattern to realize sustainable development, promote harmonious social, economic and ecological development, alleviate the human-land contradictory, and realize dual goals in terms of ecology construction and economical development. For Gannan and the similar areas in China, studies on the sustainable development pattern of tourism have extremely important strategic sense with respect to tourism development and the sustainable development of regional economy.展开更多
Based on Investigation and Assessment on Rational Exploitation and Utilization of Groundwater Resources in Typical Areas of the Hexi Corridor, the thesis studies on groundwater and environmental problems arising from ...Based on Investigation and Assessment on Rational Exploitation and Utilization of Groundwater Resources in Typical Areas of the Hexi Corridor, the thesis studies on groundwater and environmental problems arising from the large-scale agricultural development projects in Shule River Basin. The thesis analyzes problems in exploiting and utilizing water resources, defines the function zoning of groundwater resources in key areas and evaluates them. Finally, the thesis uses three-dimensional unsteady flow simulation and regional social and economic development plan to study on the allocation of groundwater in Shule River Basin. A proposal for rational allocation of Shule River Basin water resources has been put forward.展开更多
Genomics is a biology term appeared ten years ago, used todescribe the researches of genomic mapping, sequencing,and structure analysis, etc. Genomics, the first journal forpublishing papers on genomics research was b...Genomics is a biology term appeared ten years ago, used todescribe the researches of genomic mapping, sequencing,and structure analysis, etc. Genomics, the first journal forpublishing papers on genomics research was born in 1986.In the past decade, the concept of genomics has beenwidely accepted by scientists who are engaging in biologyresearch. Meanwhile, the research scope of genomics hasbeen extended continuously, from simple gene mappingand sequencing to function genomics study. To reflect thechange, genomics is divided into two parts now, thestructure genomics and the function genomics.Structure genomics retains the primary research con-tent of genomics, such as constructing high density genetic展开更多
The magnetic properties of as quenched and annealed Fe 73.5 Ag 1Nb 3Si 13.5 B 9 alloys were investigated. X ray diffraction was used to monitor the structure changes of the samples under different anneali...The magnetic properties of as quenched and annealed Fe 73.5 Ag 1Nb 3Si 13.5 B 9 alloys were investigated. X ray diffraction was used to monitor the structure changes of the samples under different annealing temperatures. It was found that by Cu addition, the crystallization temperature T x1 of Fe Nb Si B alloy is decreased, whereas by Ag addition, the T x1 is increased. A small amount of α Fe and Ag were obtained after the sample was annealed at 500℃ for 1 h. With increasing the annealing temperature, Fe 23 B 6、 Fe 2B、 Fe 3B were separated out and magnetic properties of the samples were impaired quickly. A mostly single nanocrystalline grain of α Fe phase could not be obtained in the annealed samples.展开更多
In the past two decades, extensive studies have focused on a group of so-called polarity proteins that play conserved and essential functions in establishing and maintaining cell polarity in epithelial cells. Among th...In the past two decades, extensive studies have focused on a group of so-called polarity proteins that play conserved and essential functions in establishing and maintaining cell polarity in epithelial cells. Among them, Crumbs （Crb） is the only trans- membrane polarity protein characterized to date （Tepass et al.,展开更多
Objective: To investigate the immune regulation of flavonoid of Astragalus membranaceus′ s stem and leaves (FAM). Methods: Changes of total T cell count and subsets in mice were determined by monoclonal antibody a...Objective: To investigate the immune regulation of flavonoid of Astragalus membranaceus′ s stem and leaves (FAM). Methods: Changes of total T cell count and subsets in mice were determined by monoclonal antibody assay before and after treatment with FAM, and the lymphokine activated killer(LAK) activity was tested simultaneously by isotope technique. Results: FAM could promote the proliferation of lymphocytes induced by ConA, raise the T cell count and regulate the T cell subsets disorder, elevate the LAK activity induced by IL 2. Conclusion: FAM possesses the effect of immune stimulation and immune regulation in treating immunosuppressive mice. This study provides the experimental basis for clinical application of FAM.展开更多
The stress field in granular soils heap(including piled coal) will have a non-negligible impact on the settlement of the underlying soils. It is usually obtained by measurements and numerical simulations.Because the f...The stress field in granular soils heap(including piled coal) will have a non-negligible impact on the settlement of the underlying soils. It is usually obtained by measurements and numerical simulations.Because the former method is not reliable as pressure cells instrumented on the interface between piled coal and the underlying soft soil do not work well, results from numerical methods alone are necessary to be doubly checked with one more method before they are extended to more complex cases. The generalized stress field in granular soils heap is analyzed with Rayleighe Ritz method. The problem is divided into two cases: case A without horizontal constraint on the base and case B with horizontal constraint on the base. In both cases, the displacement functions u(x, y) and v(x, y) are assumed to be cubic polynomials with 12 undetermined parameters, which will satisfy the Cauchy’s partial differential equations, generalized Hooke’s law and boundary equations. A function is built with the Rayleighe Ritz method according to the principle of minimum potential energy, and the problem is converted into solving two undetermined parameters through the variation of the function, while the other parameters are expressed in terms of these two parameters. By comparison of results from the Rayleighe Ritz method and numerical simulations, it is demonstrated that the Rayleighe Ritz method is feasible to study the generalized stress field in granular soils heap. Solutions from numerical methods are verified before being extended to more complicated cases.展开更多
The domain of linear function f(x)=ax+b(a≠0) is R, its range is R. The domain of inverse proportion function f(x)=(k/x)(k≠0) is {x|x≠0}, its range is B ={y|y≠0}. The domain of quadratic function, f(x)=ax^2 +bx+c(a...The domain of linear function f(x)=ax+b(a≠0) is R, its range is R. The domain of inverse proportion function f(x)=(k/x)(k≠0) is {x|x≠0}, its range is B ={y|y≠0}. The domain of quadratic function, f(x)=ax^2 +bx+c(a≠0)is R, its range is B. B={y|y≥(4ac-b^2)/4a},when a>0;B={y|y≤(4ac-b^2/4a)},展开更多
A new method of investigating the kinetic parameters and mechanism functions of a solid phase reaction is pre-sented. This method is to analyze the data based on the use of these data at the same temperature and the s...A new method of investigating the kinetic parameters and mechanism functions of a solid phase reaction is pre-sented. This method is to analyze the data based on the use of these data at the same temperature and the same de-gree of conversion on a series of TA curves with different heating rates, so that the kinetic tripletthe activation energy E, the pre-exponential factor A and the analytical form of the function of conversion f(a) can be obtained. The main advantage of this method is that the values of E and f(a) are obtained respectively, and the determination of f(a) is not under the influence of the value of E and the calculation of the value of E is not influenced by the f(a) either.展开更多
文摘Rip Van Winkle is one of the most enduring stories of Washington Irving. It is a fantasy tale about a man who somehow "stepped outside of the mainstream of life" (Chang Yao-xin, 1991: 62). Rip Van Winkle lived in a village near the Hudson River north of New York City. He was a simple, good-natured man; he was, moreover, a kind neighbor and an obedient hen-pecked husband. Yet Rip was lazy and this kept him in constant trouble with his wife. His two favorite past-times were sitting in front of the inn, chatting with his friends, and wandering through the mountains with his dog, Wolf. On one of these trips he met a strange dwarf who invited him to join him and other strange-looking dwarfs in a drinking party and a game called nine-pins, in a remote valley. Rip drank too much of beverage and fell asleep. When he woke up, he found that during just one night, twenty years had vanished and strangers were everywhere. His scolding wife had died, and his son, every bit his counterpart in appearance and personality had grown up to replace him. At last he was reunited with a married daughter and began to live a life the same as before.
基金Supported by the National Natural Science Foundation of China under Grant Nos 11247010,11175055,11475053 and 11347017the Natural Science Foundation of Hebei Province under Grant Nos C2012202079 and C201400305
文摘We find that a conserved mutation residue Glu to residue Asp （E303D）, which both have the same polar and charged properties, makes Kit2.1 protein lose its function. To understand the mechanism, we identify three interactions which control the conformation change and maintain the function of the Kit2.1 protein by combining homology modeling and molecular dynamics with targeted molecular dynamics. We find that the E303D mutation weakens these interactions and results in the loss of the related function. Our data indicate that not only the amino residues but also the interactions determine the function of proteins.
文摘Gold Medals in Summer Qlympics Measures A 1) Program to develop junior athletes to top level 2) National Training Center 3) National Coach Academy B 1) Sports medicine and sciences(JISS) 2) Anti-doping 3) To hold international
文摘Response of mucous cells, in the epidermis of the catfish Clarias batrachus, to a sublethal concentration of sodium dodecyl sulfate was studied and correlated with the alteration in the status of their secretory activity after different durations of the treatment. At 4h, 8h, 24h,48h and 72h of the detergent treatment, most mucous cells attained voluminous dimensions and appeared closely approximating to or even overlapping the adjacent ones. At 12h, 36h, and 60h, in contrast, the mucous cells appeared small and slender, and seemed to be located at greater intervals. These changes in dimensions were responsible for the apparent increase or decrease in the density of mucous cells after different durations of detergent treatment. Statistically, however, no significant change was observed in the total number of the mucous cells throughout the experiment.The mucous cells appeared enlarged towards the end of the experiment signifying increased mucus production. This is considered as an adaptation, for protection, assisting the fish to adjust to the changed environment.A shift in the histochemical nature of the secretory contents at the middle and basal parts of the mucous cells, from a mixture of neutral and acid glycoproteins to neutral glycoproteins, during the early stages of the treatment suggests that acid moities could not simultaneously be synthesized as an immediate response to enhanced mucous secretion. The apical parts of the mucous cells, however, showed no histochemical change throughout the experiment.
文摘Mr.Jiang Zcmin,Gencral-Seerctary of the Cen-tral Committee of the Chincse Communist Party and.Chairman of the People's Republic of China,in a rC-ccnt spcech cm phasized that the family planning pro-gramme should be strictly and effectively im plemented in 1994,a year of crucial importance for promoting re-form and opening and thc drive lowards.modernization.To makc continucd contributions to the sociocconomic development in the country,we must fulfil the plan for controlling population growth..The spcech was delivcred at the anua!National Fo-rum on Family Planning Work convened jointly by the Party's Central Committcc and the Statc Council.
文摘Results of analytical studies of the physical properties of the function and number of empirical macrohardness based on the standard experimental force diagram of kinetic macroindentation by a sphere.An analytical comparison method and a criterion for the similarity of the physical and empirical macrohardness of a material are proposed.The physical properties of the hardness measurement process using the Calvert-Johnson method are shown.The physical reasons for the size effect when measuring macrohardness are considered.The universal physical unit and standard of macrohardness of kinetic macroindentation by a sphere is substantiated.
文摘The paper took the human-land relations as a basic point, and the theories of tourism industry system and sustainable development as the guidance, with Gannan Tibetan Autonomous Prefecture （Gannan） as the case study area. From microcosmic and macroscopic viewpoints, the author carded out function orientation and evaluation to the tourism industry development, and research on the comprehensive tourism industry development pattern of Gannan. Results show that the fragile ecological environment and the traditional economic growth pattern have restricted regional sustainable development, and made Gannan to become a representative of the periphery minority areas in Northwest China. Tourism development of Gannan is at the primary phase, with the characteristics of short industry chain and low economic efficiency. It is an inevitable choice to transform the way of regional economic growth and the development pattern of tourism industry from the traditional pattern to the pattern of sustainable development. Simultaneously, Gannan＇s natural, national and religious culture makes Gannan a broad prospect on the comprehensive tourism development. Gannan should choose the comprehensive tourism industry as its scientific pattern to realize sustainable development, promote harmonious social, economic and ecological development, alleviate the human-land contradictory, and realize dual goals in terms of ecology construction and economical development. For Gannan and the similar areas in China, studies on the sustainable development pattern of tourism have extremely important strategic sense with respect to tourism development and the sustainable development of regional economy.
基金the project Survey and Assessment of Water Resources Exploitation and Utilization in Characteristic Areas of the Hexi Corridor
文摘Based on Investigation and Assessment on Rational Exploitation and Utilization of Groundwater Resources in Typical Areas of the Hexi Corridor, the thesis studies on groundwater and environmental problems arising from the large-scale agricultural development projects in Shule River Basin. The thesis analyzes problems in exploiting and utilizing water resources, defines the function zoning of groundwater resources in key areas and evaluates them. Finally, the thesis uses three-dimensional unsteady flow simulation and regional social and economic development plan to study on the allocation of groundwater in Shule River Basin. A proposal for rational allocation of Shule River Basin water resources has been put forward.
文摘Genomics is a biology term appeared ten years ago, used todescribe the researches of genomic mapping, sequencing,and structure analysis, etc. Genomics, the first journal forpublishing papers on genomics research was born in 1986.In the past decade, the concept of genomics has beenwidely accepted by scientists who are engaging in biologyresearch. Meanwhile, the research scope of genomics hasbeen extended continuously, from simple gene mappingand sequencing to function genomics study. To reflect thechange, genomics is divided into two parts now, thestructure genomics and the function genomics.Structure genomics retains the primary research con-tent of genomics, such as constructing high density genetic
文摘The magnetic properties of as quenched and annealed Fe 73.5 Ag 1Nb 3Si 13.5 B 9 alloys were investigated. X ray diffraction was used to monitor the structure changes of the samples under different annealing temperatures. It was found that by Cu addition, the crystallization temperature T x1 of Fe Nb Si B alloy is decreased, whereas by Ag addition, the T x1 is increased. A small amount of α Fe and Ag were obtained after the sample was annealed at 500℃ for 1 h. With increasing the annealing temperature, Fe 23 B 6、 Fe 2B、 Fe 3B were separated out and magnetic properties of the samples were impaired quickly. A mostly single nanocrystalline grain of α Fe phase could not be obtained in the annealed samples.
基金supported by the grants from the National Institutes of Health of USA(NCRR R21RR024869, NIGMS RO1GM086423 and RO1GM121534 to Y.H.)the Start-up Foundation from Nanjing Medical University (2012RC04 to J.H.)University of Pittsburgh Medical School Center for Biologic Imaging was supported by the grant 1S100D019973-01 from NIH, USA
文摘In the past two decades, extensive studies have focused on a group of so-called polarity proteins that play conserved and essential functions in establishing and maintaining cell polarity in epithelial cells. Among them, Crumbs （Crb） is the only trans- membrane polarity protein characterized to date （Tepass et al.,
文摘Objective: To investigate the immune regulation of flavonoid of Astragalus membranaceus′ s stem and leaves (FAM). Methods: Changes of total T cell count and subsets in mice were determined by monoclonal antibody assay before and after treatment with FAM, and the lymphokine activated killer(LAK) activity was tested simultaneously by isotope technique. Results: FAM could promote the proliferation of lymphocytes induced by ConA, raise the T cell count and regulate the T cell subsets disorder, elevate the LAK activity induced by IL 2. Conclusion: FAM possesses the effect of immune stimulation and immune regulation in treating immunosuppressive mice. This study provides the experimental basis for clinical application of FAM.
文摘The stress field in granular soils heap(including piled coal) will have a non-negligible impact on the settlement of the underlying soils. It is usually obtained by measurements and numerical simulations.Because the former method is not reliable as pressure cells instrumented on the interface between piled coal and the underlying soft soil do not work well, results from numerical methods alone are necessary to be doubly checked with one more method before they are extended to more complex cases. The generalized stress field in granular soils heap is analyzed with Rayleighe Ritz method. The problem is divided into two cases: case A without horizontal constraint on the base and case B with horizontal constraint on the base. In both cases, the displacement functions u(x, y) and v(x, y) are assumed to be cubic polynomials with 12 undetermined parameters, which will satisfy the Cauchy’s partial differential equations, generalized Hooke’s law and boundary equations. A function is built with the Rayleighe Ritz method according to the principle of minimum potential energy, and the problem is converted into solving two undetermined parameters through the variation of the function, while the other parameters are expressed in terms of these two parameters. By comparison of results from the Rayleighe Ritz method and numerical simulations, it is demonstrated that the Rayleighe Ritz method is feasible to study the generalized stress field in granular soils heap. Solutions from numerical methods are verified before being extended to more complicated cases.
文摘The domain of linear function f(x)=ax+b(a≠0) is R, its range is R. The domain of inverse proportion function f(x)=(k/x)(k≠0) is {x|x≠0}, its range is B ={y|y≠0}. The domain of quadratic function, f(x)=ax^2 +bx+c(a≠0)is R, its range is B. B={y|y≥(4ac-b^2)/4a},when a>0;B={y|y≤(4ac-b^2/4a)},
基金Project supported by the Natural Science Foundation of Hebei Province (No. 202140).
文摘A new method of investigating the kinetic parameters and mechanism functions of a solid phase reaction is pre-sented. This method is to analyze the data based on the use of these data at the same temperature and the same de-gree of conversion on a series of TA curves with different heating rates, so that the kinetic tripletthe activation energy E, the pre-exponential factor A and the analytical form of the function of conversion f(a) can be obtained. The main advantage of this method is that the values of E and f(a) are obtained respectively, and the determination of f(a) is not under the influence of the value of E and the calculation of the value of E is not influenced by the f(a) either.
