Colorectal cancer(CRC)is a prevalent malignant tumor,with the global new cases reaching 1.9316 million and deaths reaching 935,200 in 2022.In China,therewere 555,500 new cases of CRC,with an age-standardized incidence...Colorectal cancer(CRC)is a prevalent malignant tumor,with the global new cases reaching 1.9316 million and deaths reaching 935,200 in 2022.In China,therewere 555,500 new cases of CRC,with an age-standardized incidence rate of 24.07 per 10million,and 286,200 deaths.China accounts for approximately 30%of new cases and deaths from CRC worldwide,with East Asia accounting for over 75%.Initially,CRC presents as local tumor growth,but it has the potential to spread to other body parts over time.Perineural infiltration(PNI)is a relatively less discussed route of diffusion,yet it plays a crucial role in the progression and prognosis of CRC.PNI often occurs alongside local lymph nodes and distant metastases,posing challenges for treatment and management.Clinical symptoms,radiographic findings,and histopathological examination can be used to diagnose PNI with skipmetastasis.Symptoms commonly include local pain,paresthesia,andmotor impairment.Imaging helps identify the mass’s location and relationship to nerves,whereas histopathological examination confirms the diagnosis.Treatment of PNI skipmetastases is similar to other CRC metastases,including surgical resection,chemotherapy,radiotherapy,and targeted therapy.Surgical resection is the primary therapeutic approach,but the wider range of metastasis in PNI skip transfer may limit its feasibility.In cases where surgical resection is not possible,chemotherapy,radiotherapy,and targeted therapy are used to control tumor metastasis.In conclusion,PNI skip metastases increase the risk of poor prognosis for CRC,requiring a comprehensive approach with multiple treatments to prevent disease progression.Early detection and treatment are vital to improving prognosis.展开更多
In contemporary society,film,as a significant form of cultural expression,bears profound ideological connotations and cultural significance.Religious films,as a distinct genre,serve as crucial avenues for humanity to ...In contemporary society,film,as a significant form of cultural expression,bears profound ideological connotations and cultural significance.Religious films,as a distinct genre,serve as crucial avenues for humanity to explore and contemplate religious beliefs,moral concepts,and the essence of existence.Plato’s philosophy,as a significant pillar of Western thought,exerted profound influence on the conception and depiction of religious films.This thesis aims to examine Plato’s philosophical impact on religious cinema,elucidating its significance and value via comprehensive analysis of his ideas and their manifestation in religious films.Platonic ideas transcend the realm of emotions,inciting moral conflicts and dilemmas in religious films,thereby probing the dynamics between good and evil,justice and injustice.Plato’s political concepts offer profound sociopolitical reflections within religious films,stimulating discourse on matters like authority,governance,and liberty.Additionally,it catalyzed inquiries into aesthetics and emotions.Plato’s appreciation and pursuit of beauty resonate extensively in religious films,guiding viewers into a transcendent aesthetic realm through depictions of beauty and emotion.This holds immense theoretical and practical significance in deepening individuals’comprehension of Plato’s philosophy,fostering cultural exchange and discourse,and augmenting the artistic merit and societal impact of religious films.展开更多
文摘Colorectal cancer(CRC)is a prevalent malignant tumor,with the global new cases reaching 1.9316 million and deaths reaching 935,200 in 2022.In China,therewere 555,500 new cases of CRC,with an age-standardized incidence rate of 24.07 per 10million,and 286,200 deaths.China accounts for approximately 30%of new cases and deaths from CRC worldwide,with East Asia accounting for over 75%.Initially,CRC presents as local tumor growth,but it has the potential to spread to other body parts over time.Perineural infiltration(PNI)is a relatively less discussed route of diffusion,yet it plays a crucial role in the progression and prognosis of CRC.PNI often occurs alongside local lymph nodes and distant metastases,posing challenges for treatment and management.Clinical symptoms,radiographic findings,and histopathological examination can be used to diagnose PNI with skipmetastasis.Symptoms commonly include local pain,paresthesia,andmotor impairment.Imaging helps identify the mass’s location and relationship to nerves,whereas histopathological examination confirms the diagnosis.Treatment of PNI skipmetastases is similar to other CRC metastases,including surgical resection,chemotherapy,radiotherapy,and targeted therapy.Surgical resection is the primary therapeutic approach,but the wider range of metastasis in PNI skip transfer may limit its feasibility.In cases where surgical resection is not possible,chemotherapy,radiotherapy,and targeted therapy are used to control tumor metastasis.In conclusion,PNI skip metastases increase the risk of poor prognosis for CRC,requiring a comprehensive approach with multiple treatments to prevent disease progression.Early detection and treatment are vital to improving prognosis.
文摘In contemporary society,film,as a significant form of cultural expression,bears profound ideological connotations and cultural significance.Religious films,as a distinct genre,serve as crucial avenues for humanity to explore and contemplate religious beliefs,moral concepts,and the essence of existence.Plato’s philosophy,as a significant pillar of Western thought,exerted profound influence on the conception and depiction of religious films.This thesis aims to examine Plato’s philosophical impact on religious cinema,elucidating its significance and value via comprehensive analysis of his ideas and their manifestation in religious films.Platonic ideas transcend the realm of emotions,inciting moral conflicts and dilemmas in religious films,thereby probing the dynamics between good and evil,justice and injustice.Plato’s political concepts offer profound sociopolitical reflections within religious films,stimulating discourse on matters like authority,governance,and liberty.Additionally,it catalyzed inquiries into aesthetics and emotions.Plato’s appreciation and pursuit of beauty resonate extensively in religious films,guiding viewers into a transcendent aesthetic realm through depictions of beauty and emotion.This holds immense theoretical and practical significance in deepening individuals’comprehension of Plato’s philosophy,fostering cultural exchange and discourse,and augmenting the artistic merit and societal impact of religious films.
