BACKGROUND Acute kidney injury(AKI)after liver transplantation(LT)is a frequent and multifactorial event related to increased morbidity and mortality.Risk factors for AKI after LT still need to be clarified.AIM To ide...BACKGROUND Acute kidney injury(AKI)after liver transplantation(LT)is a frequent and multifactorial event related to increased morbidity and mortality.Risk factors for AKI after LT still need to be clarified.AIM To identify the predictors of acute kidney injury after liver transplantation.METHODS The frequency and pre-and intraoperative predictors of AKI within the first 7 d after LT were evaluated in adult liver transplant candidates in a single LT center in Croatia.AKI was defined according to the Kidney Disease:Improving Global Outcomes criteria.RESULTS Out of 205 patients(mean age 57±10 years;73.7%males,52.7%with alcoholrelated liver disease)93(45.36%)developed AKI,and the majority of them(58.06%)had stage 1.Only 5.38%of patients required renal replacement therapy after LT.The majority of patients(82.8%)developed AKI within the first two days after the procedure.Multivariate logistic regression identified pre-LT body mass index(OR=1.1,95%CI:1.05-1.24)and red blood cell transfusion(OR=1.66,95%CI:1.09-2.53)as independent predictors of early post-LT AKI occurrence.30-d survival after LT was significantly better for patients without AKI(P=0.01).CONCLUSION Early AKI after LT is a frequent event that negatively impacts short-term survival.The pathogenesis of AKI is multifactorial,but pre-LT BMI and intraoperative volume shifts are major contributors.展开更多
The present study aimed to estimate the occurrence of Iron Deficiency anemia (IDA) in school and college going students (aged 11 - 18 years). Anemia is the most public health problem in school age children. It has a w...The present study aimed to estimate the occurrence of Iron Deficiency anemia (IDA) in school and college going students (aged 11 - 18 years). Anemia is the most public health problem in school age children. It has a wide range of adverse results involving, poor cognitive performance, poor development of infants, preschool and school-aged children. Anemia also causes the impairment of physical capacity, work performance of adolescents and adults, reduction in immune competence and increased morbidity from infections in all age groups. Our study based on 1686 volunteers was randomly selected from different Government High schools and colleges. A Questionnaire was utilized for data collection. BMI was also calculated by dividing weight in kg by the square of height in meters. Hemoglobin (Hb), Hematocrite (Hct), Mean Corpuscular volume (MCV), Mean Corpuscular hemoglobin concentration (MCHC), white blood cell (WBC) and red blood cell was examined using Sysmex kx-21N hemoglobin auto analyzer (Hedwin, 2008). The total percentage of anaemic students (43.1%) and non-anaemic (56.9%) were observed in district Shaheed Benazirabad. The mean Hb level of anaemic students (11.1 ± 4.94) was observed. In males (12.7%) and females (30.4%) anemic was observed. The prevalence of anemia high (16.2%) was observed in the age of 14 - 16 years. The majority of anemic patients (30.2%) belonged to low income group. Area wise prevalence, in rural areas 27.8% and urban areas 15.3% volunteers anaemic was observed. Taluka wise occurrence of anaemia in taluka Sakrand was (14.6%), in taluka Kazi Ahmed (15.0%), in taluka Daur (8.0%) and in taluka Nawabshah was (5.5%). Clinically signs and symptoms showed, pale skin 57.7% and weakness 42.3% were observed in school children.展开更多
目的研究中国的乳腺癌流行病学现状,乳腺癌发病率和死亡率在1990~2019年间的变化趋势及预后相关的危险因素。方法提取全球疾病负担研究数据库的中国女性1990~2019年的乳腺癌发病、死亡数据,及其相关的年龄标化率(age-standardized rate,...目的研究中国的乳腺癌流行病学现状,乳腺癌发病率和死亡率在1990~2019年间的变化趋势及预后相关的危险因素。方法提取全球疾病负担研究数据库的中国女性1990~2019年的乳腺癌发病、死亡数据,及其相关的年龄标化率(age-standardized rate,ASR)和危险因素相关数据,并从相关文献中提取了中国34个省份的乳腺癌伤残调整寿命年(disability-adjusted life years,DALY)数据。采用联结点回归模型分析ASR的变化趋势,分析各个危险因素的暴露风险及增加的乳腺癌疾病负担情况。结果1990~2019年间,中国女性乳腺癌的发病率逐年增加,从1990年的17.07/10万增加到2019年的35.61/10万,而死亡率呈现出下降、上升而后又下降,2016年后又开始呈上升的趋势(1990年的9.16/10万到2019年的9.02/10万)。在中国的34个省份中,乳腺癌疾病负担最严重的是山东省,最低的是澳门特别行政区。在与预后相关的7个危险因素中,高体质量指数(BMI)与预后风险有更明显相关。近30年来,高红肉饮食的暴露风险呈现明显增长趋势,因此高红肉饮食所致的疾病负担也在逐年增加。结论中国女性乳腺癌的发病率仍不断增加,随着社会经济水平发展及人们饮食习惯的改变,中国的乳腺癌疾病负担也可能会越来越重。因此,要做好“三早”防治,提倡健康合理的饮食和生活习惯,以降低乳腺癌疾病负担,获得更好的乳腺癌预后和生活质量。展开更多
基金Supported by the Croatian Science Foundation grant“The Role of Notch Signalling Pathway in Pathogenesis of Hepatic Fibrosis”,No.UIP-2017-05-1965.
文摘BACKGROUND Acute kidney injury(AKI)after liver transplantation(LT)is a frequent and multifactorial event related to increased morbidity and mortality.Risk factors for AKI after LT still need to be clarified.AIM To identify the predictors of acute kidney injury after liver transplantation.METHODS The frequency and pre-and intraoperative predictors of AKI within the first 7 d after LT were evaluated in adult liver transplant candidates in a single LT center in Croatia.AKI was defined according to the Kidney Disease:Improving Global Outcomes criteria.RESULTS Out of 205 patients(mean age 57±10 years;73.7%males,52.7%with alcoholrelated liver disease)93(45.36%)developed AKI,and the majority of them(58.06%)had stage 1.Only 5.38%of patients required renal replacement therapy after LT.The majority of patients(82.8%)developed AKI within the first two days after the procedure.Multivariate logistic regression identified pre-LT body mass index(OR=1.1,95%CI:1.05-1.24)and red blood cell transfusion(OR=1.66,95%CI:1.09-2.53)as independent predictors of early post-LT AKI occurrence.30-d survival after LT was significantly better for patients without AKI(P=0.01).CONCLUSION Early AKI after LT is a frequent event that negatively impacts short-term survival.The pathogenesis of AKI is multifactorial,but pre-LT BMI and intraoperative volume shifts are major contributors.
文摘The present study aimed to estimate the occurrence of Iron Deficiency anemia (IDA) in school and college going students (aged 11 - 18 years). Anemia is the most public health problem in school age children. It has a wide range of adverse results involving, poor cognitive performance, poor development of infants, preschool and school-aged children. Anemia also causes the impairment of physical capacity, work performance of adolescents and adults, reduction in immune competence and increased morbidity from infections in all age groups. Our study based on 1686 volunteers was randomly selected from different Government High schools and colleges. A Questionnaire was utilized for data collection. BMI was also calculated by dividing weight in kg by the square of height in meters. Hemoglobin (Hb), Hematocrite (Hct), Mean Corpuscular volume (MCV), Mean Corpuscular hemoglobin concentration (MCHC), white blood cell (WBC) and red blood cell was examined using Sysmex kx-21N hemoglobin auto analyzer (Hedwin, 2008). The total percentage of anaemic students (43.1%) and non-anaemic (56.9%) were observed in district Shaheed Benazirabad. The mean Hb level of anaemic students (11.1 ± 4.94) was observed. In males (12.7%) and females (30.4%) anemic was observed. The prevalence of anemia high (16.2%) was observed in the age of 14 - 16 years. The majority of anemic patients (30.2%) belonged to low income group. Area wise prevalence, in rural areas 27.8% and urban areas 15.3% volunteers anaemic was observed. Taluka wise occurrence of anaemia in taluka Sakrand was (14.6%), in taluka Kazi Ahmed (15.0%), in taluka Daur (8.0%) and in taluka Nawabshah was (5.5%). Clinically signs and symptoms showed, pale skin 57.7% and weakness 42.3% were observed in school children.
文摘目的研究中国的乳腺癌流行病学现状,乳腺癌发病率和死亡率在1990~2019年间的变化趋势及预后相关的危险因素。方法提取全球疾病负担研究数据库的中国女性1990~2019年的乳腺癌发病、死亡数据,及其相关的年龄标化率(age-standardized rate,ASR)和危险因素相关数据,并从相关文献中提取了中国34个省份的乳腺癌伤残调整寿命年(disability-adjusted life years,DALY)数据。采用联结点回归模型分析ASR的变化趋势,分析各个危险因素的暴露风险及增加的乳腺癌疾病负担情况。结果1990~2019年间,中国女性乳腺癌的发病率逐年增加,从1990年的17.07/10万增加到2019年的35.61/10万,而死亡率呈现出下降、上升而后又下降,2016年后又开始呈上升的趋势(1990年的9.16/10万到2019年的9.02/10万)。在中国的34个省份中,乳腺癌疾病负担最严重的是山东省,最低的是澳门特别行政区。在与预后相关的7个危险因素中,高体质量指数(BMI)与预后风险有更明显相关。近30年来,高红肉饮食的暴露风险呈现明显增长趋势,因此高红肉饮食所致的疾病负担也在逐年增加。结论中国女性乳腺癌的发病率仍不断增加,随着社会经济水平发展及人们饮食习惯的改变,中国的乳腺癌疾病负担也可能会越来越重。因此,要做好“三早”防治,提倡健康合理的饮食和生活习惯,以降低乳腺癌疾病负担,获得更好的乳腺癌预后和生活质量。
