This paper is devoted to the analysis of the nonlinear Stability of a clamped rodcarrying electric current in the magnetic field which is produced by the current frowingin a pair of inifinitely long parallel rigid wi...This paper is devoted to the analysis of the nonlinear Stability of a clamped rodcarrying electric current in the magnetic field which is produced by the current frowingin a pair of inifinitely long parallel rigid wires. The natural State of the rod is in theplane of the wires and is equidistant from them.Firstly under the assumption of apatial deformation, the governing equations of the problem are derived, and the linearizedproblem and critical currents are discussed. Secondly, it ls proved that the buckledstates of the rod are always in planes. Finally. the global responses of the bifurcationproblem of the rod are compuled numerically and the distributions of the deflections.axial forces and bending monents are obtained. The results show that the buckledslates of the rod may be either supercritical or Subcritical. depending on the distancebetween the rod and the wires. Furthermore, it is found that -there exists a limit pointon the branch solution of the supercritical buckled State. This is distinctively differentfrom the buckled slate of the elastic compressive rods.展开更多
目的基于质量源于设计(quality by design,QbD)理念,剖析对照药的处方组成及关键工艺参数(CPPs),运用星点设计-效应面法优化蜡骨架缓释片的处方。方法以氯化钾为模型药物,运用失败模式和影响分析法(failure mode and effect analysis,FM...目的基于质量源于设计(quality by design,QbD)理念,剖析对照药的处方组成及关键工艺参数(CPPs),运用星点设计-效应面法优化蜡骨架缓释片的处方。方法以氯化钾为模型药物,运用失败模式和影响分析法(failure mode and effect analysis,FMEA)进行风险评估,确定CPPs,并采用星点设计-效应面法对CPPs进行优化,建立统计模型,得到最优的处方工艺。结果基于QbD理念,通过星点设计-效应面法对CPPs进行优化,以粉衣层明胶比例、粉衣层增重、隔离层层数、糖衣层增重为自变量,以0.25、0.5、1、2、4、6和8 h的累积释放百分率为因变量,绘制优化模型的效应面图,最终得到了最优的包衣工艺。建立了CPPs与CQAs的关联,并对最优包衣工艺进行验证,释放结果与预测值基本一致,自制片与参比制剂的体外释放行为一致。结论基于QbD理念,得到了优化模型的产品,符合预期的QTPP且质量稳定、可控。展开更多
文摘This paper is devoted to the analysis of the nonlinear Stability of a clamped rodcarrying electric current in the magnetic field which is produced by the current frowingin a pair of inifinitely long parallel rigid wires. The natural State of the rod is in theplane of the wires and is equidistant from them.Firstly under the assumption of apatial deformation, the governing equations of the problem are derived, and the linearizedproblem and critical currents are discussed. Secondly, it ls proved that the buckledstates of the rod are always in planes. Finally. the global responses of the bifurcationproblem of the rod are compuled numerically and the distributions of the deflections.axial forces and bending monents are obtained. The results show that the buckledslates of the rod may be either supercritical or Subcritical. depending on the distancebetween the rod and the wires. Furthermore, it is found that -there exists a limit pointon the branch solution of the supercritical buckled State. This is distinctively differentfrom the buckled slate of the elastic compressive rods.
文摘目的基于质量源于设计(quality by design,QbD)理念,剖析对照药的处方组成及关键工艺参数(CPPs),运用星点设计-效应面法优化蜡骨架缓释片的处方。方法以氯化钾为模型药物,运用失败模式和影响分析法(failure mode and effect analysis,FMEA)进行风险评估,确定CPPs,并采用星点设计-效应面法对CPPs进行优化,建立统计模型,得到最优的处方工艺。结果基于QbD理念,通过星点设计-效应面法对CPPs进行优化,以粉衣层明胶比例、粉衣层增重、隔离层层数、糖衣层增重为自变量,以0.25、0.5、1、2、4、6和8 h的累积释放百分率为因变量,绘制优化模型的效应面图,最终得到了最优的包衣工艺。建立了CPPs与CQAs的关联,并对最优包衣工艺进行验证,释放结果与预测值基本一致,自制片与参比制剂的体外释放行为一致。结论基于QbD理念,得到了优化模型的产品,符合预期的QTPP且质量稳定、可控。
